Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4129 | 0.4129 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.4129 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.4129 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.4129 | 0.4129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4129 | 0.4129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4129 | 0.4129 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.4129 | 0.4129 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4129 | 0.4129 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 0.4129 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.4129 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.4129 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.4129 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.4129 | 0.4129 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 80 uM | PubChem BioAssay. Dose response counterscreen for EBI2 assay utilizing the enzyme, b-galactosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.