TDR Targets

Basic information

Technical information

TDR Targets ID: 766038
Name: 5-(5-chloro-2-methoxyphenyl)-4-methyl-2H-1,2, 4-triazole-3-thione
MW: 255.724 | Formula: C10H10ClN3OS
H donors: 0 H acceptors: 2 LogP: 2.17 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1c1nnc(n1C)S)Cl
InChi: 1S/C10H10ClN3OS/c1-14-9(12-13-10(14)16)7-5-6(11)3-4-8(7)15-2/h3-5H,1-2H3,(H,13,16)
InChiKey: VHILZAPMAFFGCD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(5-chloro-2-methoxy-phenyl)-4-methyl-2H-1,2,4-triazole-3-thione
IVK/1416515
A2961/0124718
5-(5-chloro-2-methoxyphenyl)-4-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
MLS000534024
SMR000141460
SDCCGMLS-0065189.P001
EU-0012672
ZINC00082860
ZINC01301987

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	bromodomain adjacent to zinc finger domain, 2B	Starlite/ChEMBL	No references
Homo sapiens	euchromatic histone-lysine N-methyltransferase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Onchocerca volvulus		Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	set domain proteins, putative	Get druggable targets OG5_131470	All targets in OG5_131470
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	Get druggable targets OG5_131570	All targets in OG5_131570
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Bromodomain containing protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Pre-SET motif family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Cleft lip and palate transmembrane protein 1-like protein, putative	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_131570	All targets in OG5_131570
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	Get druggable targets OG5_131470	All targets in OG5_131470
Schistosoma japonicum	ko:K01549 ATP synthase [EC3.6.3.14], putative	Get druggable targets OG5_131570	All targets in OG5_131570

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.012	0.013
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Plasmodium vivax	hypothetical protein, conserved	0.0177	0.1336	0.1894
Brugia malayi	RNA binding protein	0.0376	0.3048	0.3041
Echinococcus granulosus	lysine specific demethylase 5A	0.0045	0.0204	0.0229
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0347	0.2799	0.2792
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0045	0.0203	0.0228
Echinococcus granulosus	ferritin	0.0034	0.0109	0.0117
Echinococcus granulosus	FTZ F1 alpha	0.0042	0.0181	0.0202
Schistosoma mansoni	microtubule-associated protein tau	0.0701	0.5842	0.8929
Schistosoma mansoni	ferritin light chain	0.0034	0.0109	0.0152
Brugia malayi	MH2 domain containing protein	0.0036	0.0128	0.0118
Loa Loa (eye worm)	MH1 domain-containing protein	0.0081	0.0512	0.0511
Schistosoma mansoni	Smad4	0.0081	0.0512	0.0768
Loa Loa (eye worm)	beta-lactamase	0.0177	0.1336	0.1335
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0026	0.0001
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.027	0.2134	0.3149
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0204	0.0297
Schistosoma mansoni	hypothetical protein	0.011	0.0761	0.115
Mycobacterium tuberculosis	Probable lipase LipE	0.0177	0.1336	0.1304
Onchocerca volvulus		0.0036	0.0127	0.001
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Schistosoma mansoni	hypothetical protein	0.0375	0.3039	0.4638
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.011	0.0761	0.0886
Echinococcus granulosus	Smad4	0.0081	0.0512	0.0592
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0042	0.0181	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0128	0.0127
Brugia malayi	Bromodomain containing protein	0.0046	0.0215	0.0206
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	1
Onchocerca volvulus		0.0899	0.7542	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0026	0.0001
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0042	0.0181	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0347	0.2799	0.2799
Mycobacterium ulcerans	lipase LipD	0.0177	0.1336	0.1908
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0042	0.0181	0.0262
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0026	0.0001
Loa Loa (eye worm)	Smad1	0.0081	0.0512	0.0511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0203	0.0789
Mycobacterium leprae	Probable lipase LipE	0.0177	0.1336	0.1908
Schistosoma mansoni	peptidase Clp (S14 family)	0.0783	0.6541	1
Schistosoma mansoni	smad	0.0081	0.0512	0.0768
Schistosoma mansoni	intermediate filament proteins	0.0135	0.098	0.1485
Brugia malayi	PHD-finger family protein	0.003	0.0076	0.0066
Echinococcus multilocularis	GPCR, family 2	0.011	0.0761	0.0886
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0042	0.0181	0.018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0076	0.0225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0124	0.0439
Brugia malayi	glutaminase DH11.1	0.0269	0.2131	0.2123
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0081	0.0512	0.0592
Loa Loa (eye worm)	MH2 domain-containing protein	0.0081	0.0512	0.0511
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0042	0.0181	0.0262
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0027	0.0052	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.0808	0.0941
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0027	0.0052	0.0064
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1336	0.2031
Echinococcus multilocularis	smad	0.0081	0.0512	0.0592
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0304	0.0451
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0181	0.0172
Loa Loa (eye worm)	latrophilin receptor protein 2	0.011	0.0761	0.076
Echinococcus granulosus	mothers against decapentaplegic 2	0.0036	0.0128	0.0139
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0177	0.1336	0.1328
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0177	0.1336	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0181	0.0172
Schistosoma mansoni	thyroid hormone receptor	0.0417	0.3402	0.5194
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0045	0.0203	0.0648
Brugia malayi	RNA recognition motif domain containing protein	0.0376	0.3048	0.3041
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0959	0.0958
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Brugia malayi	MH1 domain containing protein	0.0045	0.0201	0.0192
Echinococcus granulosus	tumor protein p63	0.101	0.8492	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0043	0.0191	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0048	0.01
Echinococcus granulosus	peregrin	0.0038	0.0145	0.0159
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0177	0.1336	0.1908
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1336	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0042	0.0181	0.0262
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0068	0.0188
Echinococcus granulosus	tar DNA binding protein	0.0376	0.3048	0.3582
Mycobacterium ulcerans	glutaminase	0.0269	0.2131	0.3144
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Mycobacterium ulcerans	hypothetical protein	0.0177	0.1336	0.1908
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0042	0.0181	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0181	0.0172
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0375	0.3039	0.3571
Schistosoma mansoni	Smad4	0.0036	0.0128	0.0181
Schistosoma mansoni	Smad4	0.0036	0.0128	0.0181
Schistosoma mansoni	ferritin	0.0034	0.0109	0.0152
Schistosoma mansoni	cellular tumor antigen P53	0.0148	0.1087	0.165
Schistosoma mansoni	zinc finger protein	0.0024	0.0021	0.0017
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0513	0.4225	0.4969
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0035	0.0116	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Echinococcus granulosus	peptidase Clp S14 family	0.0513	0.4225	0.4969
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0135	0.098	0.0979
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1336	0.5826
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0042	0.0181	0.0202
Echinococcus granulosus	intermediate filament protein	0.0135	0.098	0.1144
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0042	0.0181	0.0202
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.027	0.2134	0.3149
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0177	0.1336	0.2031
Mycobacterium ulcerans	esterase/lipase LipP	0.0177	0.1336	0.1908
Trypanosoma cruzi	hypothetical protein, conserved	0.0177	0.1336	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0036	0.0128	0.0127
Echinococcus granulosus	ecdysone induced protein 78C	0.0042	0.0181	0.0202
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.012	0.0119
Brugia malayi	TAR-binding protein	0.0376	0.3048	0.3041
Echinococcus granulosus	lamin	0.0135	0.098	0.1144
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0417	0.3402	0.4
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0203	0.0789
Onchocerca volvulus	Protein ultraspiracle homolog	0.0042	0.0181	0.0082
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0081	0.0512	0.0768
Loa Loa (eye worm)	glutaminase	0.0269	0.2131	0.213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Brugia malayi	Smad1	0.0081	0.0512	0.0502
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0036	0.0128	0.001
Brugia malayi	MH2 domain containing protein	0.0081	0.0512	0.0502
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1129	0.9519	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.098	0.0979
Onchocerca volvulus		0.0177	0.1336	0.1638
Brugia malayi	nuclear hormone receptor	0.0042	0.0181	0.0172
Brugia malayi	MH2 domain containing protein	0.0081	0.0512	0.0502
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0512	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.0009
Echinococcus multilocularis	Smad4	0.0081	0.0512	0.0592
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0437	0.0504
Brugia malayi	hypothetical protein	0.0899	0.7542	0.7539
Brugia malayi	jmjC domain containing protein	0.0045	0.0204	0.0194
Schistosoma mansoni	hypothetical protein	0.0237	0.1856	0.2827
Brugia malayi	intermediate filament protein	0.0135	0.098	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0379	0.0378
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0375	0.3039	0.3571
Echinococcus granulosus	histone lysine methyltransferase setb	0.0057	0.0304	0.0347
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0783	0.6541	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0124	0.0135
Brugia malayi	cytoplasmic intermediate filament protein	0.0072	0.044	0.0431
Brugia malayi	Pre-SET motif family protein	0.0036	0.0127	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.0009
Brugia malayi	Bromodomain containing protein	0.0091	0.0596	0.0587
Echinococcus granulosus	beta LACTamase domain containing family member	0.0177	0.1336	0.1564
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0357	0.0356
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0513	0.4225	0.6399
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0783	0.6541	0.77
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0045	0.0203	1
Schistosoma mansoni	hypothetical protein	0.011	0.0761	0.115
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0783	0.6541	0.77
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.001	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0551	0.055
Brugia malayi	Latrophilin receptor protein 2	0.011	0.0761	0.0752
Brugia malayi	ecdysteroid receptor	0.0042	0.0181	0.0172
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0042	0.0181	0.0172
Onchocerca volvulus		0.0177	0.1336	0.1638
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1336	0.1304
Onchocerca volvulus		0.0177	0.1336	0.1638
Schistosoma mansoni	smad	0.0036	0.0128	0.0181
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0042	0.0181	0.0172
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0036	0.0125	0.0932
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0042	0.0181	0.018
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0045	0.0204	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.0009
Brugia malayi	Nuclear hormone receptor-like 1	0.0042	0.0181	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0357	0.0356
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0783	0.6541	1
Toxoplasma gondii	ABC1 family protein	0.0177	0.1336	0.1914
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1336	0.5826
Echinococcus multilocularis	lamin	0.0135	0.098	0.1144
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0513	0.4225	0.4374
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0181	0.0202
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0036	0.0127	0.0139
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0036	0.0128	0.0139
Onchocerca volvulus	Bile acid receptor homolog	0.0042	0.0181	0.0082
Trichomonas vaginalis	esterase, putative	0.0177	0.1336	0.5826
Loa Loa (eye worm)	MH2 domain-containing protein	0.1185	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.026	0.0259
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0042	0.0181	0.0202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Onchocerca volvulus		0.0135	0.098	0.1159
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0042	0.0181	0.0172
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0181	0.0202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0124	0.0439
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1336	0.5826
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0442	0.0441
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0181	0.0172
Echinococcus multilocularis	lamin dm0	0.0135	0.098	0.1144
Schistosoma mansoni	thyroid hormone receptor	0.0417	0.3402	0.5194
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0081	0.0512	0.0592
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0512	0.0768
Echinococcus granulosus	microtubule associated protein 2	0.0701	0.5842	0.6876
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0026	0.0001
Onchocerca volvulus		0.0042	0.0181	0.0082
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0474	0.0711
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0036	0.0127	0.018
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0045	0.0203	0.0648
Schistosoma mansoni	retinoic acid receptor RXR	0.0042	0.0181	0.0262
Brugia malayi	steroid hormone receptor	0.0042	0.0181	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Schistosoma mansoni	glutaminase	0.0269	0.2131	0.3248
Echinococcus multilocularis	zinc finger protein	0.0024	0.0021	0.0013
Brugia malayi	latrophilin 2 splice variant baaae	0.0237	0.1856	0.1848
Schistosoma mansoni	lamin	0.0135	0.098	0.1485
Brugia malayi	MH1 domain containing protein	0.0081	0.0512	0.0502
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0042	0.0181	0.018
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Echinococcus multilocularis	ecdysone induced protein 78C	0.0042	0.0181	0.0202
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0045	0.0203	0.152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0038	0.0147	0.0539
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0181	0.0202
Schistosoma mansoni	hypothetical protein	0.011	0.0761	0.115
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0042	0.0181	0.018
Loa Loa (eye worm)	MH1 domain-containing protein	0.0036	0.0128	0.0127
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0045	0.0203	0.152
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.012	0.0169
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0045	0.0203	0.0193
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.0009
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0124	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0046	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0042	0.0181	0.0172
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0181	0.0202
Schistosoma mansoni	tar DNA-binding protein	0.0376	0.3048	0.4652
Brugia malayi	Pre-SET motif family protein	0.0251	0.1977	0.1969
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0036	0.0128	0.0139
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	0.5
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0304	0.0303
Schistosoma mansoni	lamin	0.0135	0.098	0.1485
Loa Loa (eye worm)	hypothetical protein	0.0783	0.6541	0.6541
Brugia malayi	beta-lactamase family protein	0.0177	0.1336	0.1328
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0042	0.0181	0.0172
Mycobacterium tuberculosis	Probable lipase LipD	0.0177	0.1336	0.1304
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0216	0.0215
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0177	0.1336	0.1304
Toxoplasma gondii	hypothetical protein	0.027	0.2134	0.3153
Loa Loa (eye worm)	transcription factor SMAD2	0.1185	1	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0045	0.0203	0.0296
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Loa Loa (eye worm)	hypothetical protein	0.0022	0.001	0.0009
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0042	0.0181	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0035	0.012	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Loa Loa (eye worm)	steroid hormone receptor	0.0042	0.0181	0.018
Brugia malayi	Probable ClpP-like protease	0.0783	0.6541	0.6538
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0104	0.035
Schistosoma mansoni	tar DNA-binding protein	0.0376	0.3048	0.4652
Echinococcus granulosus	fetal alzheimer antigen falz	0.0027	0.0052	0.0049
Loa Loa (eye worm)	glutaminase 2	0.0269	0.2131	0.213
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0437	0.0504
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.0808	0.0941
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.0239	0.027
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0042	0.0181	0.018
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0177	0.1336	0.1304
Schistosoma mansoni	apoferritin-2	0.0034	0.0109	0.0152
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0177	0.1336	0.1564
Echinococcus multilocularis	FTZ F1 alpha	0.0042	0.0181	0.0202
Echinococcus multilocularis	musashi	0.0135	0.098	0.1144
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0036	0.0127	0.0036
Brugia malayi	MH1 domain containing protein	0.0045	0.0201	0.0192
Brugia malayi	beta-lactamase family protein	0.0177	0.1336	0.1328
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1087	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0201	0.02
Mycobacterium tuberculosis	Probable esterase LipL	0.0177	0.1336	0.1304
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0046	0.009
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0347	0.2799	0.2792
Onchocerca volvulus		0.0286	0.2275	0.2904
Brugia malayi	MH1 domain containing protein	0.0081	0.0512	0.0502
Echinococcus granulosus	lamin dm0	0.0135	0.098	0.1144
Leishmania major	hypothetical protein, conserved	0.0177	0.1336	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0042	0.0181	0.0172
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0783	0.6541	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0376	0.3048	0.3047
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0042	0.0181	0.0262
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0042	0.0181	0.0202
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0042	0.0181	0.0202
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0045	0.0203	0.0648
Loa Loa (eye worm)	PHD-finger family protein	0.0025	0.0032	0.0031
Trichomonas vaginalis	penicillin-binding protein, putative	0.0177	0.1336	0.5826
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0177	0.1336	0.1335
Trichomonas vaginalis	glutaminase, putative	0.0269	0.2131	0.936
Loa Loa (eye worm)	jmjC domain-containing protein	0.0045	0.0204	0.0203
Echinococcus multilocularis	tar DNA binding protein	0.0376	0.3048	0.3582
Echinococcus multilocularis	ferritin	0.0034	0.0109	0.0117
Schistosoma mansoni	ferritin light chain	0.0034	0.0109	0.0152
Brugia malayi	jmjC domain containing protein	0.0115	0.0808	0.0799
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0181	0.0262
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0072	0.044	0.0439
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0512	0.0768
Brugia malayi	Bromodomain containing protein	0.0038	0.0145	0.0135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0042	0.0181	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0049	0.024	0.0239
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0036	0.0127	0.018
Trypanosoma brucei	hypothetical protein, conserved	0.0177	0.1336	1
Brugia malayi	PHD-finger family protein	0.0035	0.012	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0899	0.7542	0.7541
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.011	0.0761	0.0886
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.011	0.0761	0.0886
Brugia malayi	hypothetical protein	0.0036	0.0124	0.0115
Loa Loa (eye worm)	intermediate filament protein	0.0135	0.098	0.0979
Schistosoma mansoni	hypothetical protein	0.011	0.0761	0.115
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0042	0.0181	0.0262
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.027	0.2134	0.3137
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.012	0.013
Echinococcus granulosus	zinc finger protein	0.0024	0.0021	0.0013
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0045	0.0203	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0783	0.6541	1
Echinococcus multilocularis	tumor protein p63	0.101	0.8492	1
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.0605	0.0911
Schistosoma mansoni	tar DNA-binding protein	0.0376	0.3048	0.4652
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0057	0.0304	0.0347
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	0.5
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.0239	0.027
Loa Loa (eye worm)	hypothetical protein	0.011	0.0761	0.076
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0042	0.0181	0.018
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0042	0.0181	0.0172
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0251	0.1977	0.1976
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1336	0.1304
Schistosoma mansoni	apoferritin-2	0.0034	0.0109	0.0152
Trichomonas vaginalis	set domain proteins, putative	0.0286	0.2275	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0042	0.0181	0.0262
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0783	0.6541	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0042	0.0181	0.0202
Echinococcus granulosus	smad	0.0081	0.0512	0.0592
Schistosoma mansoni	tar DNA-binding protein	0.0376	0.3048	0.4652
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0042	0.0181	0.0202
Mycobacterium ulcerans	beta-lactamase	0.0177	0.1336	0.1908
Echinococcus multilocularis	expressed protein	0.0034	0.0109	0.0117
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0203	0.0789
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0347	0.2799	0.2799
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.012	0.0025
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.011	0.0761	0.0886
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0181	0.018
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0184	0.0205
Mycobacterium tuberculosis	Probable hydrolase	0.0177	0.1336	0.1304
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0124	0.0175
Schistosoma mansoni	ferritin	0.0034	0.0109	0.0152
Echinococcus multilocularis	microtubule associated protein 2	0.0701	0.5842	0.6876
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0304	0.0451
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0513	0.4225	0.4374
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0065	0.0379	0.0435
Echinococcus granulosus	expressed protein	0.0034	0.0109	0.0117
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0065	0.0379	0.0435
Echinococcus granulosus	mothers against decapentaplegic 5	0.0081	0.0512	0.0592
Schistosoma mansoni	RAR-like nuclear receptor	0.0042	0.0181	0.0262
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0042	0.0181	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0042	0.0181	0.018
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.012	0.0025
Schistosoma mansoni	coup transcription factor	0.0042	0.0181	0.0262
Plasmodium vivax	SET domain protein, putative	0.0036	0.0127	0.0011
Giardia lamblia	GTOR	0.0045	0.0203	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0124	0.0175
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.011	0.0761	0.0752
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0081	0.0512	0.0592
Schistosoma mansoni	tar DNA-binding protein	0.0376	0.3048	0.4652
Loa Loa (eye worm)	phosphatidylinositol 3	0.0045	0.0203	0.0202
Schistosoma mansoni	hypothetical protein	0.0035	0.012	0.0169
Schistosoma mansoni	ferritin	0.0034	0.0109	0.0152
Loa Loa (eye worm)	RNA binding protein	0.0376	0.3048	0.3047
Onchocerca volvulus		0.0148	0.1087	0.1303
Echinococcus multilocularis	peregrin	0.0038	0.0145	0.0159
Brugia malayi	mothers against decapentaplegic homolog 3	0.0036	0.0128	0.0118
Schistosoma mansoni	hypothetical protein	0.0025	0.0032	0.0034
Trichomonas vaginalis	D-aminoacylase, putative	0.0177	0.1336	0.5826
Loa Loa (eye worm)	TAR-binding protein	0.0376	0.3048	0.3047
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0045	0.0203	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1336	0.1335
Brugia malayi	Steroid receptor seven-up type 2	0.0042	0.0181	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0124	0.0439
Trichomonas vaginalis	ferritin, putative	0.0034	0.0109	0.0371
Mycobacterium leprae	conserved hypothetical protein	0.0177	0.1336	0.1908
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0043	0.0191	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0042	0.0181	0.0172
Echinococcus granulosus	mothers against decapentaplegic 6	0.0036	0.0128	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0237	0.1856	0.1855
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0124	0.0439
Mycobacterium tuberculosis	Conserved protein	0.0177	0.1336	0.1304
Loa Loa (eye worm)	nuclear factor I	0.0045	0.0201	0.02
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.027	0.2134	0.3137
Onchocerca volvulus		0.0135	0.098	0.1159
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0048	0.01
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0042	0.0181	0.0202
Brugia malayi	Intermediate filament tail domain containing protein	0.0135	0.098	0.0971
Loa Loa (eye worm)	hypothetical protein	0.006	0.0336	0.0335
Brugia malayi	beta-lactamase	0.0177	0.1336	0.1328
Echinococcus granulosus	GPCR family 2	0.011	0.0761	0.0886
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0124	0.0439
Schistosoma mansoni	ferritin	0.0034	0.0109	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0048	0.01
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0045	0.0203	0.0648

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.122 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	= 14.1254 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	22.3872 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6427 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1372287
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 766038