TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.48 | Formula: C26H24N2O4
H donors: 2 H acceptors: 5 LogP: 5.44 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)c(ccc2)C(=O)O
InChi: 1S/C26H24N2O4/c1-2-3-11-23-27-22-10-6-9-21(26(31)32)24(22)28(23)16-17-12-14-18(15-13-17)19-7-4-5-8-20(19)25(29)30/h4-10,12-15H,2-3,11,16H2,1H3,(H,29,30)(H,31,32)
InChiKey: WACVBEZAIMATFO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	324 aa	24.1 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.2 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.5 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	362 aa	24.3 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	21.8 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	24.6 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	381 aa	19.7 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	292 aa	25.7 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	339 aa	21.2 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	24.9 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	22.7 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	23.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	303 aa	25.4 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	300 aa	28.0 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	20.5 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	403 aa	18.9 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	366 aa	20.8 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	355 aa	23.9 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	20.4 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	23.1 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	349 aa	25.5 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.8 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	26.4 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.1 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	360 aa	22.2 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.8 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	338 aa	23.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	coup transcription factor	0.002	0.0661	0.0661
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0661	0.0858
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0661	0.1885
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.3056	1
Schistosoma mansoni	nuclear hormone receptor	0.002	0.0661	0.0661
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.002	0.0661	0.0661
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0649	0.1925
Loa Loa (eye worm)	RNA binding protein	0.0062	0.3373	1
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.1048	0.3108
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.2581	0.8027
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0649	0.0843
Schistosoma mansoni	intermediate filament proteins	0.0026	0.1048	0.1048
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.8706	0.8706
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.2581	0.3475
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0031	0.0091
Echinococcus granulosus	tar DNA binding protein	0.0062	0.3373	0.4554
Schistosoma mansoni	phosphoglucomutase	0.0044	0.2172	0.2172
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.2581	0.8027
Echinococcus granulosus	lamin	0.0026	0.1048	0.1387
Giardia lamblia	Ribonuclease H	0.0044	0.2172	0.6325
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.1048	0.3045
Brugia malayi	RNase H family protein	0.0044	0.2172	0.6406
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.2581	0.3475
Schistosoma mansoni	lamin	0.0026	0.1048	0.1048
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0661	0.1959
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.1048	0.3108
Schistosoma mansoni	rab6-interacting	0.002	0.0605	0.0605
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0661	0.1885
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.2581	0.8027
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.2581	0.8027
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0661	0.0858
Schistosoma mansoni	phosphoglucomutase	0.0044	0.2172	0.2172
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.2581	0.8027
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0661	0.1885
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0661	0.1959
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0031	0.0091
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.2908	0.3921
Echinococcus granulosus	lamin dm0	0.0026	0.1048	0.1387
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0649	0.0713
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0661	0.1885
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0661	0.1885
Echinococcus multilocularis	musashi	0.0026	0.1048	0.1173
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0047	0.2413	0.1887
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0125	0.0371
Brugia malayi	steroid hormone receptor	0.002	0.0661	0.1885
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0031	0.0091
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Trypanosoma brucei	ribonuclease H1	0.0044	0.2172	0.1628
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0661	0.1885
Brugia malayi	nuclear hormone receptor	0.002	0.0661	0.1885
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0157	0.0145
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.3373	0.3853
Brugia malayi	RNase H family protein	0.0044	0.2172	0.6406
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1048	0.3108
Echinococcus granulosus	bloom syndrome protein	0.002	0.0649	0.0843
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0661	0.1885
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0661	0.0858
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0649	0.1851
Brugia malayi	RNase H family protein	0.0044	0.2172	0.6406
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.2581	0.294
Loa Loa (eye worm)	hypothetical protein	0.002	0.0605	0.1793
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0661	0.0858
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.3373	1
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0661	0.0858
Schistosoma mansoni	thyroid hormone receptor	0.0143	0.8706	0.8706
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0031	0.0091
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.2581	0.2066
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0661	0.1885
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0649	0.2516
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.2581	0.294
Schistosoma mansoni	DNA helicase recq1	0.002	0.0649	0.0649
Echinococcus multilocularis	lamin	0.0026	0.1048	0.1173
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.2581	0.8027
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.737	1
Schistosoma mansoni	hypothetical protein	0.0057	0.3056	0.3056
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0157	0.0464
Treponema pallidum	ribonuclease H (rnhA)	0.0044	0.2172	1
Trypanosoma brucei	ingi protein (ORF1)	0.0047	0.2413	0.1887
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.2581	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3373	0.3373
Toxoplasma gondii	ribonuclease HI protein	0.0044	0.2172	0.8413
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0605	0.0782
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0661	0.1959
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0661	0.0726
Onchocerca volvulus		0.0026	0.1048	0.2831
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0057	0.3056	0.3488
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.002	0.0661	0.0661
Loa Loa (eye worm)	hypothetical protein	0.002	0.0649	0.1925
Schistosoma mansoni	loxhd1	0.002	0.0605	0.0605
Brugia malayi	TAR-binding protein	0.0062	0.3373	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.2581	0.8027
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0031	0.0031
Schistosoma mansoni	steroid hormone receptor ad4bp	0.002	0.0661	0.0661
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0248	0.0736
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.2581	0.2581
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0649	0.0713
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0157	0.0172
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0661	0.1885
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.3056	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0057	0.3056	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0661	0.1959
Loa Loa (eye worm)	hypothetical protein	0.002	0.0605	0.1793
Trichomonas vaginalis	ribonuclease H1, putative	0.0044	0.2172	0.6325
Trypanosoma brucei	hypothetical protein, conserved	0.0047	0.2413	0.1887
Onchocerca volvulus	Ribonuclease H1 homolog	0.0044	0.2172	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0248	0.0651
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0661	0.0726
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0661	0.1885
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0661	0.1885
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0605	0.0662
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0649	0.2125
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0661	0.0726
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0649	0.1851
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.3056	1
Brugia malayi	intermediate filament protein	0.0026	0.1048	0.3045
Leishmania major	ribonuclease H1, putative	0.0044	0.2172	0.6325
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0057	0.3056	0.2574
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0661	0.0858
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0661	0.0858
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Echinococcus multilocularis	RUN	0.002	0.0605	0.0662
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0649	0.0713
Trypanosoma brucei	RNA helicase, putative	0.0163	1	1
Schistosoma mansoni	rab6-interacting	0.002	0.0605	0.0605
Schistosoma mansoni	lipoxygenase	0.0055	0.2908	0.2908
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3373	0.3373
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0605	0.0662
Loa Loa (eye worm)	RecQ helicase	0.002	0.0649	0.1925
Brugia malayi	Doublecortin family protein	0.002	0.0605	0.1718
Trypanosoma brucei	protein kinase, putative	0.005	0.2581	0.2066
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0661	0.1959
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0661	0.0726
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0605	0.0662
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0125	0.0371
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.2581	0.8027
Schistosoma mansoni	DNA helicase recq5	0.002	0.0649	0.0649
Brugia malayi	hypothetical protein	0.002	0.0605	0.1718
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0057	0.3056	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.002	0.0661	0.0356
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0661	0.1959
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0661	0.0726
Schistosoma mansoni	RAR-like nuclear receptor	0.002	0.0661	0.0661
Brugia malayi	RNA binding protein	0.0062	0.3373	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0661	0.0858
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.002	0.0661	0.0661
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0649	0.2516
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0661	0.1885
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0057	0.3056	1
Schistosoma mansoni	lamin	0.0026	0.1048	0.1048
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0661	0.0726
Onchocerca volvulus		0.0026	0.1048	0.2831
Brugia malayi	nuclear receptor NHR-88	0.002	0.0661	0.1885
Echinococcus granulosus	RUN	0.002	0.0605	0.0782
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3373	0.3373
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0605	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.2581	0.8027
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0649	0.0843
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0031	0.0091
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.2581	0.8027
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0649	1
Schistosoma mansoni	hypothetical protein	0.002	0.0605	0.0605
Schistosoma mansoni	hypothetical protein	0.0123	0.737	0.737
Trypanosoma cruzi	ribonuclease H1, putative	0.0044	0.2172	0.6325
Echinococcus multilocularis	lamin dm0	0.0026	0.1048	0.1173
Giardia lamblia	Rrm3p helicase	0.0057	0.3056	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0661	0.0858
Brugia malayi	hypothetical protein	0.002	0.0605	0.1718
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0057	0.3056	0.2574
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.3373	1
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0057	0.3056	1
Echinococcus multilocularis	ribonuclease H1	0.0044	0.2172	0.2468
Schistosoma mansoni	retinoic acid receptor RXR	0.002	0.0661	0.0661
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0661	0.0726
Brugia malayi	ecdysteroid receptor	0.002	0.0661	0.1885
Brugia malayi	MAP kinase sur-1	0.005	0.2581	0.7631
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0661	0.1959
Echinococcus granulosus	intermediate filament protein	0.0026	0.1048	0.1387
Onchocerca volvulus	Bile acid receptor homolog	0.002	0.0661	0.0356
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0143	0.8706	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0661	0.1885
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0044	0.2172	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0661	0.1885
Trypanosoma cruzi	ribonuclease H1, putative	0.0044	0.2172	0.6325
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.002	0.0661	0.0661
Schistosoma mansoni	polycystin 1-related	0.002	0.0605	0.0605
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.2581	0.8027
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0605	0.0782
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.002	0.0661	0.0661
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0661	0.1885
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3373	0.3373
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0605	0.0782
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0661	0.1885
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1017	0.3014
Trypanosoma brucei	unspecified product	0.0047	0.2413	0.1887
Echinococcus granulosus	ribonuclease H1	0.0044	0.2172	0.2917
Trypanosoma brucei	ingi protein (ORF1)	0.0047	0.2413	0.1887
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0661	0.1959
Onchocerca volvulus	Protein ultraspiracle homolog	0.002	0.0661	0.0356
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0661	0.0726
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0649	1
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0605	0.1793
Entamoeba histolytica	hypothetical protein, conserved	0.0057	0.3056	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.002	0.0661	0.0661
Loa Loa (eye worm)	hypothetical protein	0.002	0.0661	0.1959
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0031	0.0031
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.2581	0.7652
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.3373	1
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0057	0.3056	0.4122
Schistosoma mansoni	lipoxygenase	0.002	0.0605	0.0605
Onchocerca volvulus		0.002	0.0661	0.0356
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0649	0.1851
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.2908	0.3317
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.737	0.846
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.3373	0.3373
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0031	0.0091
Schistosoma mansoni	phosphoglucomutase	0.0044	0.2172	0.2172

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.18	Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane	ChEMBL.	No reference
IC50 (binding)	= 6.6 10'-7M	Displacement of [125I]angiotensin 2 from type-1 angiotensin 2 receptor in Bos taurus (bovine) adrenal cortical membrane	ChEMBL.	No reference
IC50 (binding)	= 0.00000066 M	In vitro for inhibition of specific binding of [125I]-angiotensin II (0.02 nM) to bovine adrenal cortex	ChEMBL.	8510105
Inhibition (functional)	= 2 %	In vivo inhibition of angiotensin II (0.1 ug/kg) induced increase in blood pressure in conscious male rat at 3 mg/kg for 3h/7h.	ChEMBL.	8510105
Inhibition (functional)	= 2 %	In vivo inhibition of angiotensin II (0.1 ug/kg) induced increase in blood pressure in conscious male rat at 3 mg/kg for 3h/7h.	ChEMBL.	8510105
Inhibition (functional)	= 46 %	In vivo for inhibition of the Angiotensin II (0.1 ug/kg) induced increase in blood pressure in conscious male rat at 30 mg/kg for 3h/7h	ChEMBL.	8510105

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL417196

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 76641