Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.127 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.127 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.127 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1364 | 0.3902 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1137 | 0.1024 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3115 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1359 | 0.2673 |
Brugia malayi | Inositol-1 | 0.0037 | 0.127 | 0.2401 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.127 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0065 | 0.3115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.3495 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1137 | 0.2 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.0195 | 0.0559 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1646 | 0.4709 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.127 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3115 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1137 | 0.1024 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.127 | 0.1158 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0065 | 0.3115 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.127 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.127 | 0.1158 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.127 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0321 | 0.0198 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.3005 | 0.2916 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1203 | 0.1091 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.127 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1137 | 0.1024 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0065 | 0.3115 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0065 | 0.3115 | 0.3027 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.127 | 0.1158 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0065 | 0.3115 | 0.3027 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0321 | 0.0198 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1137 | 0.1024 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.1015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0195 | 0.0071 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3115 | 0.3027 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0321 | 0.0198 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.2769 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.152 | 0.4348 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0065 | 0.3115 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0075 | 0.3777 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.2769 | 0.2677 |
Echinococcus multilocularis | geminin | 0.017 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0065 | 0.3115 | 0.3027 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.1203 | 0.1091 |
Schistosoma mansoni | hypothetical protein | 0.017 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.127 | 0.3632 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.127 | 0.1158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.