Detailed information for compound 766961

Basic information

Technical information
  • TDR Targets ID: 766961
  • Name: 4-butoxy-N-[3-(8-methylimidazo[1,2-a]pyridin- 2-yl)phenyl]benzenesulfonamide
  • MW: 435.539 | Formula: C24H25N3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.53 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)c1cn2c(n1)c(C)ccc2
  • InChi: 1S/C24H25N3O3S/c1-3-4-15-30-21-10-12-22(13-11-21)31(28,29)26-20-9-5-8-19(16-20)23-17-27-14-6-7-18(2)24(27)25-23/h5-14,16-17,26H,3-4,15H2,1-2H3
  • InChiKey: MAEPOMMKJZDCIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-butoxy-N-[3-(8-methyl-2-imidazo[1,2-a]pyridinyl)phenyl]benzenesulfonamide
  • EU-0082763

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0535 0.0595
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0056 0.5662 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.9228 1
Schistosoma mansoni hypothetical protein 0.0023 0.0191 0.0212
Giardia lamblia Kinase, CMGC MAPK 0.0056 0.5662 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.8999 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.8999 0.8892
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.2951 0.3279
Echinococcus multilocularis mitogen activated protein kinase 0.0056 0.5662 0.6292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.5241 0.5824
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0056 0.5662 0.6054
Loa Loa (eye worm) hypothetical protein 0.0047 0.4163 0.4395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.5241 0.5824
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.724 0.8045
Trypanosoma brucei protein kinase, putative 0.0056 0.5662 0.5
Loa Loa (eye worm) TAR-binding protein 0.0076 0.8999 0.9746
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.2951 0.3279
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0056 0.5662 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.5241 0.5824
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0056 0.5662 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.5241 0.5588
Schistosoma mansoni tar DNA-binding protein 0.0076 0.8999 1
Echinococcus granulosus mitogen activated protein kinase 0.0056 0.5662 0.6292
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.5662 0.6292
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.5241 0.5824
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0056 0.5662 0.5
Echinococcus multilocularis tar DNA binding protein 0.0076 0.8999 1
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.5662 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.5662 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0056 0.5662 0.6292
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.724 0.8045
Brugia malayi MAP kinase sur-1 0.0056 0.5662 0.52
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.5662 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.5241 0.5824
Schistosoma mansoni tar DNA-binding protein 0.0076 0.8999 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.3391 0.3541
Schistosoma mansoni bromodomain containing protein 0.0069 0.7886 0.8763
Loa Loa (eye worm) RNA binding protein 0.0076 0.8999 0.9746
Schistosoma mansoni tar DNA-binding protein 0.0076 0.8999 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0056 0.5662 0.5
Brugia malayi Bromodomain containing protein 0.0042 0.3378 0.2673
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0535 0.0595
Echinococcus granulosus tar DNA binding protein 0.0076 0.8999 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.3818 0.4014
Brugia malayi RNA binding protein 0.0076 0.8999 0.8892
Brugia malayi TAR-binding protein 0.0076 0.8999 0.8892
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.5241 0.4734
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0535 0.0595
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.5662 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.5241 0.5824
Trichomonas vaginalis CMGC family protein kinase 0.0056 0.5662 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.5241 0.5824
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0056 0.5662 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.8999 0.9746
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0056 0.5662 0.5
Echinococcus granulosus mitogen activated protein kinase 3 0.0056 0.5662 0.6292
Schistosoma mansoni tar DNA-binding protein 0.0076 0.8999 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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