Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0484 | 0.0512 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0336 | 0.0329 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0324 | 0.8152 | 1 |
Onchocerca volvulus | 0.0026 | 0.0566 | 0.9227 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0048 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.007 | 0.0029 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0566 | 0.9227 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0566 | 0.0613 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0566 | 0.9227 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0484 | 0.0512 |
Schistosoma mansoni | lamin | 0.0026 | 0.0566 | 0.0566 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0048 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0256 | 0.023 |
Schistosoma mansoni | hypothetical protein | 0.0396 | 1 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0324 | 0.8152 | 1 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0484 | 0.1356 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0484 | 0.0512 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0074 | 0.0004 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0126 | 0.3121 | 0.3073 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0324 | 0.8152 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.007 | 0.0029 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0484 | 0.0512 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.007 | 0.0037 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0324 | 0.8152 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0324 | 0.8152 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0126 | 0.3121 | 0.3073 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0336 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0221 | 0.2797 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0324 | 0.8152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0208 | 0.257 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0648 | 0.0582 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0554 | 0.8999 |
Onchocerca volvulus | 0.0023 | 0.0484 | 0.7697 | |
Onchocerca volvulus | 0.0026 | 0.0566 | 0.9227 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.4943 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0484 | 0.0512 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0648 | 0.0648 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.007 | 0.0029 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0566 | 0.0499 |
Schistosoma mansoni | lamin | 0.0026 | 0.0566 | 0.0566 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0126 | 0.3121 | 0.3073 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0484 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.4943 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.007 | 0.0029 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0484 | 0.0512 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0312 | 0.0328 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0484 | 0.0512 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0566 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0484 | 0.7697 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0324 | 0.8152 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0608 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0126 | 0.3121 | 0.3073 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0484 | 0.0512 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.007 | 0.0029 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0336 | 0.0329 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0566 | 0.9227 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0566 | 0.0499 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0336 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0484 | 0.0512 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0648 | 0.0648 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0324 | 0.8152 | 0.8152 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.1403 | 0.1403 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.007 | 0.0029 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 0.3775 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0566 | 0.0499 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.007 | 0.0029 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0484 | 0.0512 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0312 | 0.0328 |
Onchocerca volvulus | 0.0028 | 0.0608 | 1 | |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0007 | 0.007 | 0.0037 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0004 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0324 | 0.8152 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0324 | 0.8152 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0324 | 0.8152 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.007 | 0.0029 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0324 | 0.8152 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0324 | 0.8152 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0566 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.4943 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1242 | 0.145 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.4943 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.007 | 0.0029 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0008 | 0.0115 | 0.0055 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0484 | 0.1356 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0336 | 0.4943 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0256 | 0.3457 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0484 | 0.0512 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0484 | 0.054 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0221 | 0.0151 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0566 | 0.0613 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0484 | 0.0512 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0324 | 0.8152 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.0566 | 0.0499 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0484 | 0.7697 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0484 | 0.7697 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0324 | 0.8152 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.007 | 0.007 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0484 | 0.0512 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0396 | 1 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0484 | 0.0512 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0484 | 0.0512 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0648 | 0.0582 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.007 | 0.0029 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0004 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0566 | 0.0499 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0126 | 0.3121 | 0.3775 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0608 | 0.0665 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0484 | 0.0512 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0118 | 0.0884 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0126 | 0.3121 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0208 | 0.257 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0484 | 0.1356 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0221 | 0.0151 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0312 | 0.0328 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0336 | 0.0329 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0312 | 0.0328 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0007 | 0.0074 | 0.0004 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.007 | 0.0029 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.