Detailed information for compound 76703

Basic information

Technical information
  • TDR Targets ID: 76703
  • Name: 1-[2-(decylamino)-2-phenylethyl]-3-[2,6-di(pr opan-2-yl)phenyl]urea
  • MW: 479.74 | Formula: C31H49N3O
  • H donors: 3 H acceptors: 1 LogP: 8.78 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCNC(c1ccccc1)CNC(=O)Nc1c(cccc1C(C)C)C(C)C
  • InChi: 1S/C31H49N3O/c1-6-7-8-9-10-11-12-16-22-32-29(26-18-14-13-15-19-26)23-33-31(35)34-30-27(24(2)3)20-17-21-28(30)25(4)5/h13-15,17-21,24-25,29,32H,6-12,16,22-23H2,1-5H3,(H2,33,34,35)
  • InChiKey: OZNHRYSPMWXMET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(decylamino)-2-phenyl-ethyl]-3-(2,6-diisopropylphenyl)urea
  • 1-[2-(decylamino)-2-phenylethyl]-3-(2,6-diisopropylphenyl)urea
  • 1-[2-(decylamino)-2-phenyl-ethyl]-3-[2,6-di(propan-2-yl)phenyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Alhambra homolog 0.003 0.024 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0953 0.1721
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0095 0.1008 0.1596
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0191 0.0191
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0468 0.5439 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0059 0.059 0.3343
Mycobacterium leprae MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) 0.0042 0.0389 0.1133
Brugia malayi PHD-finger family protein 0.003 0.024 0.0316
Echinococcus multilocularis peregrin 0.003 0.024 0.0381
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0152 0.02
Loa Loa (eye worm) hypothetical protein 0.0046 0.0437 0.0574
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.0191 0.0345
Brugia malayi Muscleblind-like protein 0.0155 0.1719 0.226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0953 0.151
Echinococcus granulosus GPCR family 2 0.0033 0.0281 0.0445
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0437 0.0691
Schistosoma mansoni hypothetical protein 0.0192 0.2163 0.3905
Giardia lamblia Kinase, CMGC MAPK 0.0059 0.059 0.1337
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0853 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0191 0.0125
Toxoplasma gondii ABC1 family protein 0.0073 0.0755 0.4276
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0042 0.0389 0.1133
Leishmania major glycerol uptake protein, putative 0.0026 0.0191 0.0191
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0152 0.0152
Mycobacterium ulcerans mycolic acid synthase PcaA 0.0042 0.0389 0.1028
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.133
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.059 0.1337
Echinococcus granulosus dnaJ subfamily B 0.0477 0.554 0.8773
Leishmania major hypothetical protein, conserved 0.0026 0.0191 0.0191
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0281 0.037
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0152 0.02
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0281 0.0096
Echinococcus multilocularis hedgehog 0.0217 0.2458 0.3892
Echinococcus granulosus geminin 0.0192 0.2163 0.3426
Schistosoma mansoni hypothetical protein 0.0077 0.0797 0.1439
Onchocerca volvulus 0.0074 0.0767 0.1913
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0191 0.0345
Brugia malayi MBOAT family protein 0.0026 0.0191 0.0251
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0191 0.0251
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1048 0.1659
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.3443 1
Brugia malayi MBOAT family protein 0.0026 0.0191 0.0251
Schistosoma mansoni hypothetical protein 0.0033 0.0281 0.0507
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.0191 0.0303
Loa Loa (eye worm) hypothetical protein 0.0059 0.0584 0.0768
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0315 0.0499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Mycobacterium tuberculosis Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) 0.0042 0.0389 0.0303
Leishmania major glycerol uptake protein, putative 0.0026 0.0191 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0026 0.034
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0755 0.1837
Trypanosoma cruzi Emopamil binding protein, putative 0.0156 0.1737 0.1737
Brugia malayi Cytochrome P450 family protein 0.0029 0.0231 0.0304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0281 0.037
Loa Loa (eye worm) hhat protein 0.0026 0.0191 0.0251
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0328 0.0328
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0808 0.1279
Loa Loa (eye worm) hypothetical protein 0.0214 0.2419 0.318
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0278 0.3185 0.4188
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0437 0.0691
Loa Loa (eye worm) hhat protein 0.0026 0.0191 0.0251
Plasmodium vivax polyprenol reductase, putative 0.0022 0.015 0.1985
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0111 0.1197 0.1574
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.0191 0.0251
Onchocerca volvulus 0.0111 0.1197 0.3246
Mycobacterium leprae POSSIBLE FATTY ACID SYNTHASE 0.0042 0.0389 0.1133
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0046 0.0437 0.0691
Brugia malayi MH2 domain containing protein 0.0116 0.1264 0.1662
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0158 0.1765 0.1765
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0755 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0152 0.0241
Loa Loa (eye worm) hypothetical protein 0.0033 0.0281 0.037
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0437 0.0437
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0737 0.0969
Trypanosoma brucei C-8 sterol isomerase, putative 0.0418 0.4842 0.4842
Brugia malayi Hhat protein 0.0026 0.0191 0.0251
Brugia malayi Pre-SET motif family protein 0.0216 0.2448 0.322
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0328 0.1857
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 0.0042 0.0389 0.1028
Onchocerca volvulus 0.0042 0.0389 0.0742
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0808 0.1279
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0152 0.0397
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0437 0.0871
Schistosoma mansoni cpg binding protein 0.0033 0.0283 0.051
Loa Loa (eye worm) hypothetical protein 0.0238 0.2709 0.3562
Loa Loa (eye worm) hypothetical protein 0.0155 0.1719 0.226
Brugia malayi beta-lactamase family protein 0.0073 0.0755 0.0992
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0418 0.4842 0.4842
Trichomonas vaginalis esterase, putative 0.0073 0.0755 0.1837
Loa Loa (eye worm) RecQ helicase 0.0022 0.0152 0.02
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0022 0.015 0.039
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0338 0.0535
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0328 0.054
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0021 0.0284
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0191 0.051
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.024 0.0381
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0281 0.0358
Loa Loa (eye worm) hypothetical protein 0.0042 0.0389 0.0512
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0755 0.376
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.0191 0.0303
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Loa Loa (eye worm) hypothetical protein 0.0542 0.6315 0.8304
Mycobacterium ulcerans hypothetical protein 0.0158 0.1765 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0152 0.0863
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0152 0.0007
Schistosoma mansoni hypothetical protein 0.0033 0.0281 0.0507
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0755 0.0992
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0755 0.1005
Echinococcus multilocularis ubiquitin specific protease 41 0.0046 0.0437 0.0691
Schistosoma mansoni cytochrome P450 0.0029 0.0231 0.0418
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0416 0.4815 0.6331
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1136 0.1493
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0755 0.1837
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0231 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0338 0.0444
Loa Loa (eye worm) hypothetical protein 0.0032 0.0261 0.0343
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0755 0.1005
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.0197
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0191 0.0251
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1136 0.1493
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0459 0.0604
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0755 0.1005
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0022 0.015 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0191 0.0125
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0158 0.1765 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0389 0.0512
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0281 0.037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0328 0.0328
Mycobacterium ulcerans methoxy mycolic acid synthase 2, MmaA2 0.0042 0.0389 0.1028
Trichomonas vaginalis porcupine, putative 0.0026 0.0191 0.0125
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0737 0.0969
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0152 0.0241
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.015 0.0849
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0755 0.3412
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0191 0.0345
Loa Loa (eye worm) hypothetical protein 0.0072 0.074 0.0973
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0808 0.1458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0953 0.151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Schistosoma mansoni hypothetical protein 0.0026 0.0191 0.0345
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0046 0.0437 0.0574
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1737 0.1737
Mycobacterium tuberculosis Conserved protein 0.0073 0.0755 0.1005
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.015 0.027
Mycobacterium ulcerans methoxy mycolic acid synthase 4, MmaA4 0.0042 0.0389 0.1028
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.0191 0.0303
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0231 0.0231
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0328 0.0627
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0032
Loa Loa (eye worm) beta-lactamase 0.0073 0.0755 0.0992
Mycobacterium ulcerans beta-lactamase 0.0073 0.0755 0.3412
Trypanosoma brucei Sterol methyltransferase, putative 0.0853 1 1
Brugia malayi RNA binding protein 0.0072 0.0737 0.0969
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.0191 0.0251
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0152 0.0241
Mycobacterium tuberculosis Mycolic acid synthase PcaA (cyclopropane synthase) 0.0042 0.0389 0.0303
Mycobacterium ulcerans methoxy mycolic acid synthase 5 MmaA5 0.0042 0.0389 0.1028
Brugia malayi Cytochrome P450 family protein 0.0029 0.0231 0.0304
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1737 0.1737
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0152 0.0007
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0158 0.1765 0.2321
Mycobacterium tuberculosis Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) 0.0042 0.0389 0.0303
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.3014 0.4773
Schistosoma mansoni hypothetical protein 0.0477 0.554 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0741 0.1338
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.059 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0755 0.0755
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0158 0.1765 0.4905
Loa Loa (eye worm) hypothetical protein 0.0158 0.1765 0.2321
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0059 0.059 0.0776
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0114 0.0205
Schistosoma mansoni DNA helicase recq5 0.0022 0.0152 0.0275
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0021 0.0021
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0231 0.0366
Echinococcus multilocularis mitogen activated protein kinase 3 0.0059 0.059 0.0934
Schistosoma mansoni hypothetical protein 0.0192 0.2163 0.3905
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.133
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0853 1 1
Echinococcus multilocularis cpg binding protein 0.0035 0.0305 0.0483
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0251
Brugia malayi Pre-SET motif family protein 0.0032 0.0261 0.0343
Loa Loa (eye worm) hypothetical protein 0.0022 0.0152 0.02
Plasmodium vivax hypothetical protein, conserved 0.003 0.024 0.3184
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0328 0.0328
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0283 0.0371
Schistosoma mansoni hypothetical protein 0.0033 0.0281 0.0507
Loa Loa (eye worm) hypothetical protein 0.0416 0.4815 0.6331
Loa Loa (eye worm) hypothetical protein 0.0051 0.0494 0.0649
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0042 0.0389 0.0389
Schistosoma mansoni hypothetical protein 0.001 0.0001 0.0003
Schistosoma mansoni hypothetical protein 0.0033 0.0281 0.0507
Echinococcus granulosus bloom syndrome protein 0.0022 0.0152 0.0241
Brugia malayi diacylglycerol acyltransferase 0.0026 0.0191 0.0251
Brugia malayi MBOAT family protein 0.0026 0.0191 0.0251
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0059 0.059 0.059
Entamoeba histolytica hypothetical protein 0.0078 0.0808 0.231
Mycobacterium tuberculosis Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) 0.0042 0.0389 0.0303
Echinococcus multilocularis muscleblind protein 0.0155 0.1719 0.2722
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0023 0.0036
Leishmania major C-8 sterol isomerase-like protein 0.0418 0.4842 0.4842
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0191 0.0191
Echinococcus granulosus cpg binding protein 0.0035 0.0305 0.0483
Onchocerca volvulus 0.0073 0.0755 0.1875
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0152 0.0863
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.133
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0261 0.0413
Mycobacterium leprae Probable lipase LipE 0.0073 0.0755 0.376
Schistosoma mansoni DNA helicase recq1 0.0022 0.0152 0.0275
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0206 0.233 0.369
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0737 0.0969
Schistosoma mansoni inositol monophosphatase 0.0037 0.0328 0.0591
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0046 0.0437 0.0788
Echinococcus multilocularis GPCR, family 2 0.0033 0.0281 0.0445
Loa Loa (eye worm) hypothetical protein 0.003 0.024 0.0316
Schistosoma mansoni hypothetical protein 0.0078 0.0808 0.1458
Brugia malayi MAP kinase sur-1 0.0059 0.059 0.0776
Loa Loa (eye worm) hypothetical protein 0.0059 0.0584 0.0768
Mycobacterium ulcerans hypothetical protein 0.0073 0.0755 0.3412
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0152 0.0152
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0046 0.0437 0.0691
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0755 0.3412
Loa Loa (eye worm) hypothetical protein 0.0418 0.4842 0.6367
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0437 0.0871
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0231 0.0231
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.0191 0.1083
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0042 0.0389 0.0303
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0021 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0338 0.0609
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0755 0.1195
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0231 0.1311
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0022 0.015 0.027
Brugia malayi bZIP transcription factor family protein 0.0095 0.1008 0.1325
Echinococcus granulosus muscleblind protein 0.0155 0.1719 0.2722
Schistosoma mansoni inositol monophosphatase 0.0037 0.0328 0.0591
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.059 0.1337
Brugia malayi beta-lactamase 0.0073 0.0755 0.0992
Brugia malayi TAR-binding protein 0.0072 0.0737 0.0969
Trypanosoma brucei protein kinase, putative 0.0059 0.059 0.059
Loa Loa (eye worm) hypothetical protein 0.0278 0.3185 0.4188
Echinococcus granulosus peregrin 0.003 0.024 0.0381
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1048 0.1659
Leishmania major cytochrome p450-like protein 0.0029 0.0231 0.0231
Mycobacterium tuberculosis Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) 0.0042 0.0389 0.0303
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0152 0.6335
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0418 0.4842 0.6367
Onchocerca volvulus 0.0026 0.0191 0.0128
Brugia malayi Inositol-1 0.0037 0.0328 0.0431
Brugia malayi hypothetical protein 0.0294 0.3375 0.4438
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0281 0.0445
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.0191 0.0303
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0059 0.059 0.059
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0059 0.059 0.059
Schistosoma mansoni hypothetical protein 0.003 0.024 0.0434
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.0191 0.0345
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0445 0.516 0.516
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0264 0.3014 0.3964
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0046 0.0437 0.0788
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0059 0.059 0.059
Brugia malayi Hint module family protein 0.0059 0.0584 0.0768
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.074 0.0973
Loa Loa (eye worm) inositol-1 0.0037 0.0328 0.0431
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.0191 0.0303
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0022 0.015 0.0237
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0059 0.059 0.059
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0379 0.0601
Echinococcus granulosus synaptic glycoprotein sc2 0.0022 0.015 0.0237
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0261 0.047
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0021 0.0121
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0206 0.233 0.369
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0191 0.0303
Brugia malayi Cytochrome P450 family protein 0.0029 0.0231 0.0304
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0809 0.146
Mycobacterium ulcerans mycolic acid synthase UmaA 0.0042 0.0389 0.1028
Schistosoma mansoni hypothetical protein 0.0111 0.1197 0.216
Schistosoma mansoni hypothetical protein 0.0158 0.1759 0.3175
Mycobacterium tuberculosis Possible fatty acid synthase 0.0042 0.0389 0.0303
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0953 0.151
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0437 0.0437
Brugia malayi Cytochrome P450 family protein 0.0048 0.0459 0.0604
Plasmodium falciparum polyprenol reductase, putative 0.0022 0.015 0.6234
Onchocerca volvulus 0.0032 0.0261 0.0343
Schistosoma mansoni survival motor neuron protein 0.0111 0.1197 0.216
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0618 0.0813
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0755 0.1362
Brugia malayi hypothetical protein 0.0074 0.0767 0.1008
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0046 0.0437 0.0437
Onchocerca volvulus 0.0073 0.0755 0.1875
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2801 0.8052
Brugia malayi PHD-finger family protein 0.0012 0.0024 0.0032
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0001 0.0008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0046 0.0437 0.0437
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2448 0.322
Loa Loa (eye worm) hypothetical protein 0.0042 0.0389 0.0512
Onchocerca volvulus 0.0294 0.3375 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0261 0.0413
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.0191 0.7951
Mycobacterium ulcerans methoxy mycolic acid synthase 3, MmaA3 0.0042 0.0389 0.1028
Loa Loa (eye worm) RNA binding protein 0.0072 0.0737 0.0969
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0261 0.047
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0853 1 1
Entamoeba histolytica hypothetical protein 0.0026 0.0191 0.051
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0152 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.059 0.1337
Brugia malayi Synaptic glycoprotein SC2 0.0022 0.015 0.0197
Brugia malayi hypothetical protein 0.0078 0.0808 0.1062
Leishmania major hypothetical protein, conserved 0.0156 0.1737 0.1737
Loa Loa (eye worm) PHD-finger family protein 0.003 0.024 0.0316
Schistosoma mansoni hypothetical protein 0.0029 0.0231 0.0418
Echinococcus multilocularis survival motor neuron protein 1 0.0542 0.6315 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0651 0.369
Trypanosoma cruzi GUP1, putative 0.0026 0.0191 0.0191
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.0191 0.0345
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0152 0.0241
Brugia malayi beta-lactamase family protein 0.0073 0.0755 0.0992
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3443 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0156 0.1737 0.1737
Brugia malayi Bromodomain containing protein 0.003 0.024 0.0316
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.1623 0.9076
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.3443 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0028
Leishmania major cytochrome p450-like protein 0.0029 0.0231 0.0231
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.024 0.0381
Brugia malayi cytochrome P450 0.0029 0.0231 0.0304
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.133
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0953 0.1721
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0152 0.02
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0281 0.0445
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0023 0.0036
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.0191 0.2532
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0231 0.0304
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0158 0.1765 0.5103
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.0191 0.051
Loa Loa (eye worm) hypothetical protein 0.0073 0.0755 0.0992
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0231 0.0231
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0953 0.1254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0261 0.047
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0755 0.1837
Trypanosoma brucei Emopamil binding protein, putative 0.0156 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0155 0.1719 0.226
Mycobacterium tuberculosis Conserved protein 0.0073 0.0755 0.1005
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0158 0.1765 0.1765
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0152 0.6335
Mycobacterium tuberculosis Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) 0.0042 0.0389 0.0303
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0328 0.0909
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.0191 0.0125
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0328 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0755 0.1005
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.1623 0.2673
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0231 0.0304
Brugia malayi Hint module family protein 0.0059 0.0584 0.0768
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.0191 0.0303
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0251
Toxoplasma gondii hypothetical protein 0.0026 0.0191 0.1083
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.0191 0.0303
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0231 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0953 0.1721
Brugia malayi jmjC domain containing protein 0.0098 0.1048 0.1378
Onchocerca volvulus 0.0246 0.2801 0.8221
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0755 0.0755
Loa Loa (eye worm) hypothetical protein 0.0011 0.0021 0.0028
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.0191 0.1083
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.015 0.015
Echinococcus multilocularis muscleblind protein 1 0.0155 0.1719 0.2722
Echinococcus multilocularis dnaJ subfamily B 0.0477 0.554 0.8773
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0095 0.1008 0.1596
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1264 0.1662
Onchocerca volvulus 0.0156 0.1737 0.492
Leishmania major glycerol uptake protein, putative 0.0026 0.0191 0.0191
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0261 0.0413
Schistosoma mansoni hypothetical protein 0.0072 0.074 0.1336
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0755 0.1837
Echinococcus multilocularis mitogen activated protein kinase 0.0059 0.059 0.0934
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0042 0.0389 0.1133
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0379 0.0601
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0046 0.0437 0.0871
Brugia malayi MBOAT family protein 0.0026 0.0191 0.0251
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0755 0.1005
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0059 0.059 0.059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0261 0.047
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0022 0.015 0.0849
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Echinococcus multilocularis 0.0029 0.0231 0.0366
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0755 0.1195
Entamoeba histolytica hypothetical protein 0.0022 0.015 0.039
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0158 0.1765 0.1765
Echinococcus multilocularis synaptic glycoprotein sc2 0.0022 0.015 0.0237
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0231 0.0231
Onchocerca volvulus 0.0073 0.0755 0.1875
Entamoeba histolytica hypothetical protein 0.0078 0.0808 0.231
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0011 0.0016 0.0215
Entamoeba histolytica hypothetical protein 0.0078 0.0808 0.231
Brugia malayi hypothetical protein 0.0542 0.6315 0.8304
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0755 0.0755
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0953 0.151
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.059 0.1065
Onchocerca volvulus 0.0033 0.0283 0.0411
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0953 0.1254
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0328 0.0519
Mycobacterium leprae CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC AC 0.0042 0.0389 0.1133
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0238 0.0377
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0737 0.1167
Schistosoma mansoni jun-related protein 0.0077 0.0797 0.1439
Trypanosoma cruzi GUP1, putative 0.0026 0.0191 0.0191
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0022 0.015 0.039
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0158 0.1765 0.1765
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0152 0.0007
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0001 0.0001
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0046 0.0437 0.1227
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0152 0.0241
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 0.0042 0.0389 0.1028
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0158 0.1765 0.4905
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0191 0.051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0251
Leishmania major cytochrome p450-like protein 0.0029 0.0231 0.0231
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.0191 0.0303
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0755 0.0992
Echinococcus multilocularis geminin 0.0192 0.2163 0.3426
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.015 0.015
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0042 0.0389 0.0303
Leishmania major glycerol uptake protein, putative 0.0026 0.0191 0.0191
Echinococcus granulosus tar DNA binding protein 0.0072 0.0737 0.1167
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0191 0.0303
Echinococcus granulosus ubiquitin specific protease 41 0.0046 0.0437 0.0691
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0294 0.3375 0.4438
Brugia malayi jmjC domain containing protein 0.0038 0.0338 0.0444
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0136 0.0179
Echinococcus granulosus mitogen activated protein kinase 0.0059 0.059 0.0934
Schistosoma mansoni cpg binding protein 0.0035 0.0305 0.0551
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.3014 0.4773
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0152 0.0007
Leishmania major glycerol uptake protein, putative 0.0026 0.0191 0.0191
Loa Loa (eye worm) MBOAT family protein 0.0026 0.0191 0.0251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.1623 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0328 0.054
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0021 0.0039
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0046 0.0437 0.0871
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0338 0.0609
Schistosoma mansoni zinc finger protein 0.0026 0.0191 0.0345
Loa Loa (eye worm) hypothetical protein 0.0022 0.015 0.0197
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0021 0.0015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0022 0.0034
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0755 0.1005
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.0191 0.0303
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0231 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0191 0.0125
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0755 0.1837
Trypanosoma brucei glycerol uptake protein, putative 0.0026 0.0191 0.0191
Echinococcus granulosus mitogen activated protein kinase 3 0.0059 0.059 0.0934
Leishmania major sterol 24-c-methyltransferase, putative 0.0853 1 1
Trypanosoma cruzi Emopamil binding protein, putative 0.0156 0.1737 0.1737
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.015 0.6234
Loa Loa (eye worm) hypothetical protein 0.0651 0.7605 1
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0755 0.1005
Giardia lamblia PHD finger protein 15 0.003 0.024 0.0275
Entamoeba histolytica hypothetical protein 0.0078 0.0808 0.231
Brugia malayi MBOAT family protein 0.0026 0.0191 0.0251
Schistosoma mansoni cpg binding protein 0.0035 0.0305 0.0551
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0191 0.0303
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.3014 0.5441
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1264 0.1662
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0755 0.1362
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0191 0.0303
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0853 1 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.0191 0.0345
Mycobacterium ulcerans lipase LipD 0.0073 0.0755 0.3412
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0158 0.1765 0.4905
Mycobacterium tuberculosis Conserved protein 0.0073 0.0755 0.1005
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.0191 0.051
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.024 0.1362
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0152 0.02
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0853 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0261 0.1476
Echinococcus granulosus Desert hedgehog protein 0.0217 0.2458 0.3892
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0191 0.051
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0328 0.5
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0191 0.0191
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0022 0.015 0.1985
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0737 0.133
Plasmodium falciparum phd finger protein, putative 0.003 0.024 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.0191 0.0496
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.024 0.1362
Loa Loa (eye worm) cytochrome P450 0.0029 0.0231 0.0304
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.024 0.0434
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0026 0.1067
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0328 0.0328
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0016 0.0092
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.0191 0.0303
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.0191 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.3443 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.0191 0.0191
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.0191 0.0303
Brugia malayi AF-10 protein 0.001 0.0001 0.0002
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.3443 1
Brugia malayi small heat shock protein 0.0651 0.7605 1
Plasmodium vivax SET domain protein, putative 0.0032 0.0261 0.3452
Loa Loa (eye worm) hypothetical protein 0.0092 0.0977 0.1285
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0328 0.054
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.059 0.1337
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0016 0.0029
Echinococcus multilocularis jun protein 0.0095 0.1008 0.1596
Brugia malayi CXXC zinc finger family protein 0.0033 0.0283 0.0371
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0231 0.0231
Echinococcus granulosus jun protein 0.0095 0.1008 0.1596
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.0042 0.0389 0.0303
Leishmania major hypothetical protein, conserved 0.0073 0.0755 0.0755
Echinococcus granulosus survival motor neuron protein 1 0.0542 0.6315 1

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = 38 % Percent change in total cholesterol in cholic acid (0.5%)-cholesterol (1.5%)-peanut oil (5.5%)-fed rats ChEMBL. 8021920
clogP = 7.91 Calculated partition coefficient (clogP) ChEMBL. 8021920
IC50 (binding) = 0.083 uM In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]-oleolyl-CoA ChEMBL. 8021920
IC50 (binding) = 0.083 uM In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]-oleolyl-CoA ChEMBL. 8021920

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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