Detailed information for compound 767194

Basic information

Technical information
  • TDR Targets ID: 767194
  • Name: 6-[[1-(2-ethylphenyl)-2,5-dimethylpyrrol-3-yl ]methylidene]-5-imino-2-methyl-[1,3]thiazolo[ 3,2-a]pyrimidin-7-one
  • MW: 390.501 | Formula: C22H22N4OS
  • H donors: 0 H acceptors: 1 LogP: 4.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccccc1n1c(C)cc(c1C)C=C1C(=O)N=c2n(C1=N)cc(s2)C
  • InChi: 1S/C22H22N4OS/c1-5-16-8-6-7-9-19(16)26-13(2)10-17(15(26)4)11-18-20(23)25-12-14(3)28-22(25)24-21(18)27/h6-12,23H,5H2,1-4H3/b18-11-,23-20?
  • InChiKey: KQPSCAGBTHLAOU-IKTSRZDXSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[1-(2-ethylphenyl)-2,5-dimethyl-pyrrol-3-yl]methylene]-5-imino-2-methyl-thiazolo[3,2-a]pyrimidin-7-one
  • 6-[[1-(2-ethylphenyl)-2,5-dimethyl-3-pyrrolyl]methylene]-5-imino-2-methyl-7-thiazolo[3,2-a]pyrimidinone
  • 6-[[1-(2-ethylphenyl)-2,5-dimethyl-pyrrol-3-yl]methylidene]-5-imino-2-methyl-[1,3]thiazolo[3,2-a]pyrimidin-7-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0178 0.0834
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0028 0.1824
Leishmania major proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 0.0016 0.0013 0.0132
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0008 0.0025
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0241
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0082 0.0948
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0182 0.0711
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0029 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0086 0.0399
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.0104
Echinococcus multilocularis pyruvate kinase 0.0017 0.0016 0.0012
Trypanosoma brucei ISWI complex protein 0.0016 0.0013 0.0138
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0028 0.0183
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0082 0.0314
Loa Loa (eye worm) hypothetical protein 0.0044 0.0097 0.0373
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0112 0.0542
Brugia malayi Pre-SET motif family protein 0.006 0.0146 0.0562
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0073
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0072
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0096 0.0368
Echinococcus granulosus geminin 0.0341 0.0982 0.3824
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0116 0.1335
Schistosoma mansoni ap endonuclease 0.004 0.0086 0.0334
Onchocerca volvulus 0.0027 0.0045 0.0067
Brugia malayi hypothetical protein 0.0025 0.004 0.0149
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0035 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0116 0.0454
Echinococcus multilocularis sodium bile acid cotransporter 0.0872 0.2561 0.2558
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.0096
Echinococcus multilocularis musashi 0.0027 0.0045 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0086 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0029 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.0104
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0086 0.0327
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0034 0.0247
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0045 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0198 0.0774
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.0024
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0016 0.0013 0.0035
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.0041
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0479
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0565
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0082 0.038
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.014 0.0542
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0116 0.0112
Loa Loa (eye worm) hypothetical protein 0.0487 0.1417 0.5528
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0447
Entamoeba histolytica hypothetical protein 0.0049 0.0112 0.0464
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0029 0.0104
Echinococcus granulosus pyruvate kinase 0.0017 0.0016 0.0046
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0063 0.0241
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.014
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0029 0.0002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0091 0.035
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0016 0.0976
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0317 0.1233
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0028 0.1818
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.049 0.1424 0.5557
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0028 0.1824
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0029 0.0024
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0063 0.0241
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0002 0.0009
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0063 0.4282
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0034 0.221
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0116 0.0112
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0124 0.1299
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0028 0.03
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0002 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0082 0.094
Brugia malayi intermediate filament protein 0.0027 0.0045 0.0169
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0098 0.6696
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.004 0.2652
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.0104
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0016 0.0976
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0098 0.0527
Echinococcus granulosus X box binding protein 1 0.0285 0.0814 0.3169
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0021 0.0028 0.1816
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.0259 0.1003
Plasmodium falciparum importin beta, putative 0.006 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.049 0.1424 0.5557
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0028 0.0103
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0306 0.0876 1
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0116 0.0437
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0034 0.0065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0116 0.0447
Brugia malayi Bromodomain containing protein 0.0078 0.0197 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Echinococcus multilocularis snurportin 1 0.0645 0.1886 0.1883
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0098 0.6689
Onchocerca volvulus 0.049 0.1424 0.5511
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0269 0.1038
Onchocerca volvulus 0.048 0.1394 0.5393
Schistosoma mansoni ran 0.0044 0.0098 0.0383
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0299 0.0855 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0082 0.0918
Plasmodium falciparum phd finger protein, putative 0.0028 0.005 0.3375
Schistosoma mansoni hypothetical protein 0.0341 0.0982 0.3833
Echinococcus multilocularis pyruvate kinase 0.0033 0.0063 0.0059
Brugia malayi Bromodomain containing protein 0.004 0.0084 0.0321
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0029 0.0111
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0178 0.2066
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0028 0.1824
Leishmania major hypothetical protein, conserved 0.0025 0.004 0.0447
Leishmania major DNA polymerase eta, putative 0.0039 0.0082 0.094
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0012 0.0724
Schistosoma mansoni hypothetical protein 0.0067 0.0166 0.0648
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0122
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0082 0.03
Echinococcus granulosus pyruvate kinase 0.0017 0.0016 0.0046
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0178 0.2016
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0178 0.0689
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0063 0.0277
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0028 0.0183
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0082 0.0321
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0626 0.183 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Giardia lamblia Non ATPase subunit MPR1 of 26S proteasome 0.0016 0.0013 0.0062
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0058 0.0054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0146 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.005 0.0197
Brugia malayi CHE-14 protein 0.0044 0.0096 0.0368
Loa Loa (eye worm) hypothetical protein 0.0073 0.0184 0.0711
Echinococcus multilocularis GPCR, family 2 0.0031 0.0058 0.0054
Schistosoma mansoni hypothetical protein 0.0285 0.0814 0.318
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0063 0.0722
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0029 0.0104
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0116 0.1335
Brugia malayi PHD-finger family protein 0.0028 0.005 0.019
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0029 0.0104
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0063 0.073
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0479
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0178 0.0689
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0146 0.0142
Echinococcus multilocularis zinc finger protein 0.002 0.0026 0.0022
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0124 0.853
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0525
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0269 0.1046
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0098 0.0368
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0116 0.0454
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0724
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0116 0.0454
Echinococcus multilocularis pyruvate kinase 0.0017 0.0016 0.0012
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0029 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0116 0.0447
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0116 0.1335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0018 0.0056
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0228
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.015 0.057
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0228
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0082 0.0321
Toxoplasma gondii proteasome regulatory subunit 0.0021 0.0028 0.1816
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0084 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0626 0.183 1
Schistosoma mansoni survival motor neuron protein 0.0099 0.0262 0.1022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0146 0.0569
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.014
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.0041
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0063 0.4282
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0306 0.0876 1
Brugia malayi RNA, U transporter 1 0.0172 0.0477 0.1857
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0074 0.0289
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0124 0.1402
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0028 0.0024
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0198 0.076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0029 0.0096
Echinococcus granulosus GPCR family 2 0.0031 0.0058 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.0096
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0028 0.011
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0028 0.0183
Echinococcus multilocularis sodium bile acid cotransporter 0.0872 0.2561 0.2558
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0032
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0116 0.0624
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0086 0.5824
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0116 0.1343
Loa Loa (eye worm) proteasome 26S subunit 0.0016 0.0013 0.0044
Brugia malayi Sodium Bile acid symporter family protein 0.0872 0.2561 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.0096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0034 0.0125
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.002 0.0072
Brugia malayi MAP kinase sur-1 0.005 0.0116 0.0445
Echinococcus multilocularis importin subunit beta 1 0.006 0.0146 0.0142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0178 0.1769
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0028 0.0103
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0116 0.0437
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0063 0.073
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0024
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0029 0.0111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0096 0.0092
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.0259 0.1003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0058 0.0054
Brugia malayi Bromodomain containing protein 0.0031 0.0058 0.0218
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Schistosoma mansoni hypothetical protein 0.0341 0.0982 0.3833
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0018 0.0014
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0086 0.0982
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.0104
Schistosoma mansoni pyruvate kinase 0.0017 0.0016 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0139 0.0528
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0082 0.0948
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0028 0.0308
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0029 0.0111
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0028 0.0094
Loa Loa (eye worm) hypothetical protein 0.0103 0.0272 0.1057
Echinococcus multilocularis pyruvate kinase 0.0033 0.0063 0.0059
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.005 0.0181
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0063 0.0241
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0447
Loa Loa (eye worm) hypothetical protein 0.0067 0.0166 0.0641
Leishmania major DNA polymerase kappa, putative 0.0039 0.0082 0.094
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0028 0.0308
Plasmodium falciparum pyruvate kinase 0.0033 0.0063 0.4286
Brugia malayi nuclear hormone receptor 0.0021 0.0029 0.0104
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.1042
Onchocerca volvulus 0.0872 0.2561 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0034 0.0363
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0016 0.0013 0.0009
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0021 0.0028 0.0024
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0186 0.0726
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0146 0.1691
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.1999 0.7803
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0116 0.0452
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0178 0.2016
Schistosoma mansoni intermediate filament proteins 0.0027 0.0045 0.0176
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0028 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.0024
Brugia malayi hypothetical protein 0.0487 0.1417 0.5528
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0028 0.03
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0077 0.0284
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0029 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.0104
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0082 0.0948
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0063 0.0277
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0029 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.1999 0.1995
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0028 0.0183
Loa Loa (eye worm) hypothetical protein 0.0098 0.0259 0.1003
Schistosoma mansoni sodium-bile acid cotransporter 0.0518 0.1509 0.5891
Chlamydia trachomatis pyruvate kinase 0.0033 0.0063 0.3286
Echinococcus multilocularis Protein lozenge 0.0061 0.0149 0.0145
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Echinococcus granulosus sodium bile acid cotransporter 0.0872 0.2561 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0028 0.0308
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0086 0.0327
Echinococcus granulosus pyruvate kinase 0.0017 0.0016 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0029 0.0111
Onchocerca volvulus 0.0081 0.0207 0.0707
Echinococcus multilocularis dna polymerase eta 0.0039 0.0082 0.0078
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0028 0.03
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0063 0.0705
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0116 0.1198
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0131
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0058 0.0213
Echinococcus multilocularis tumor protein p63 0.0704 0.2061 0.2058
Brugia malayi nuclear receptor NHR-88 0.0021 0.0029 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0116 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.0104
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0207 0.0809
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.0111
Brugia malayi PHD-finger family protein 0.0026 0.0043 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0082 0.0948
Schistosoma mansoni pyruvate kinase 0.0033 0.0063 0.0248
Brugia malayi hypothetical protein 0.0073 0.0182 0.0704
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0029 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.0104
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0012 0.0724
Echinococcus multilocularis Niemann Pick C1 protein 0.0146 0.04 0.0396
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0116 0.1198
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0029 0.0024
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0091 0.1042
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0082 0.094
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0008
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0098 0.6689
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0178 0.2016
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0274 0.107
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0002 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0086 0.099
Giardia lamblia DINP protein human, muc B family 0.0039 0.0082 0.0439
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0116 0.1335
Echinococcus granulosus snurportin 1 0.0645 0.1886 0.7359
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0116 0.1335
Echinococcus multilocularis pyruvate kinase 0.0026 0.0043 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0028 0.03
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0029 0.0024
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0074 0.0282
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0028 0.03
Echinococcus multilocularis protein patched 0.0044 0.0096 0.0092
Echinococcus multilocularis X box binding protein 1 0.0285 0.0814 0.0811
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0479
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0016 0.0977
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0028 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0086 0.0319
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0002 0.0007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0262 0.1015
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0002 0.0009
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0028 0.0183
Echinococcus multilocularis protein dispatched 1 0.005 0.0114 0.011
Echinococcus granulosus peregrin 0.0031 0.0058 0.021
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0098 0.0094
Schistosoma mansoni DNA polymerase eta 0.0039 0.0082 0.0321
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0021 0.0028 0.0102
Trichomonas vaginalis ran, putative 0.0044 0.0098 0.0468
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0009
Loa Loa (eye worm) oxidoreductase 0.0021 0.0028 0.0103
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0012 0.0725
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0178 0.2016
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0028 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.0031 0.0058 0.0221
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 11, putative 0.0016 0.0013 0.0132
Echinococcus granulosus zinc finger protein 0.002 0.0026 0.0086
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0387 0.451
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.1417 0.5524
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0086 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0013 0.0141
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0124 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0012 0.0122
Onchocerca volvulus 0.0103 0.0272 0.0964
Echinococcus multilocularis sodium bile acid cotransporter 0.0872 0.2561 0.2558
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.0855 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0028 0.0183
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0146 0.9989
Mycobacterium ulcerans hypothetical protein 0.0071 0.0178 0.2016
Loa Loa (eye worm) hypothetical protein 0.006 0.0146 0.0562
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0178 0.2016
Echinococcus granulosus tumor protein p63 0.0704 0.2061 0.8043
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0086 0.583
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0029 0.0111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0116 0.0439
Schistosoma mansoni lamin 0.0027 0.0045 0.0176
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.005 0.3371
Schistosoma mansoni patched 1 0.0044 0.0096 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Plasmodium vivax importin-beta 2, putative 0.006 0.0146 0.9989
Loa Loa (eye worm) hypothetical protein 0.0078 0.0198 0.0768
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0082 0.0078
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0035 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0042 0.0091 0.0357
Brugia malayi hypothetical protein 0.049 0.1424 0.5557
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Brugia malayi MH2 domain containing protein 0.0118 0.0317 0.1233
Schistosoma mansoni hypothetical protein 0.0099 0.0262 0.1022
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0058 0.0213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0082 0.0808
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0028 0.0308
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0034 0.0372
Echinococcus multilocularis peregrin 0.0031 0.0058 0.0054
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0269 0.0266
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0028 0.0308
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0034 0.2207
Schistosoma mansoni hypothetical protein 0.0031 0.0058 0.0228
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0021 0.0028 0.0094
Echinococcus granulosus pyruvate kinase 0.0033 0.0063 0.0232
Schistosoma mansoni lamin 0.0027 0.0045 0.0176
Echinococcus granulosus importin subunit beta 1 0.006 0.0146 0.0553
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0178 0.0834
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0028 0.1824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.0104
Brugia malayi Pre-SET motif family protein 0.0422 0.1221 0.4763
Leishmania major hypothetical protein, conserved 0.0016 0.0013 0.013
Schistosoma mansoni zinc finger protein 0.002 0.0026 0.0102
Brugia malayi hypothetical protein 0.0016 0.0014 0.0046
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0028 0.0183
Schistosoma mansoni hypothetical protein 0.0028 0.005 0.0197
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0317 0.1233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0299 0.0855 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0096 0.0457
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.0856
Schistosoma mansoni sodium-bile acid cotransporter related 0.0872 0.2561 1
Schistosoma mansoni importin beta-1 0.006 0.0146 0.0568
Echinococcus granulosus sodium bile acid cotransporter 0.0872 0.2561 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0058 0.0221
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0029 0.0002
Toxoplasma gondii hypothetical protein 0.0048 0.0109 0.7461
Schistosoma mansoni lozenge 0.0061 0.0149 0.058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0024
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0086 0.0982
Toxoplasma gondii exonuclease III APE 0.004 0.0086 0.5824
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0198 0.0774
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.1221 0.4763
Schistosoma mansoni hypothetical protein 0.0042 0.0091 0.0357
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0028 0.0183
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0035 0.0122
Onchocerca volvulus 0.006 0.0146 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0116 0.0445
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.013
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0166 0.0641
Loa Loa (eye worm) hypothetical protein 0.0054 0.0125 0.0483
Echinococcus granulosus dna polymerase eta 0.0039 0.0082 0.0305
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0028 0.1826
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0082 0.0808
Giardia lamblia Pyruvate kinase 0.0017 0.0016 0.0077
Loa Loa (eye worm) hypothetical protein 0.004 0.0084 0.0321
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0028 0.0316
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0008 0.0025
Schistosoma mansoni bromodomain containing protein 0.0066 0.0161 0.0628
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0689
Giardia lamblia PHD finger protein 15 0.0028 0.005 0.0265
Loa Loa (eye worm) hypothetical protein 0.0081 0.0207 0.0802
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.005
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0098 0.0376
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0082 0.0918
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0096 0.036
Echinococcus granulosus dna polymerase kappa 0.0039 0.0082 0.0305
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0082 0.0314
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0019 0.0083
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0178 0.0689
Echinococcus multilocularis lamin dm0 0.0027 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0689
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0086 0.085
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0045 0.0169
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0112 0.1286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.0039 0.0082 0.0314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.0096
Echinococcus granulosus jumonji domain containing protein 0.004 0.0084 0.0311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.0024
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0028 0.0308
Brugia malayi jmjC domain containing protein 0.0093 0.0243 0.0942
Trypanosoma brucei unspecified product 0.0027 0.0046 0.0525
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0243 0.0934
Onchocerca volvulus 0.0071 0.0178 0.0592
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0207 0.0203
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0116 0.792
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0479
Onchocerca volvulus 0.0099 0.0262 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.0104
Schistosoma mansoni hypothetical protein 0.0645 0.1886 0.7364
Echinococcus granulosus Niemann Pick C1 protein 0.0146 0.04 0.1548
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0565
Echinococcus multilocularis lamin 0.0027 0.0045 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0002 0.0009
Leishmania major importin beta-1 subunit, putative 0.0049 0.0112 0.1286
Mycobacterium ulcerans hypothetical protein 0.0157 0.0434 0.4946
Echinococcus granulosus intermediate filament protein 0.0027 0.0045 0.0161
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0008
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0028 0.0308
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0028 0.0316
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0021 0.0028 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.0096
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0029 0.0096
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0029 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0525
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0063 0.014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0178 0.0834
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0028 0.0083
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0082 0.094
Echinococcus granulosus lamin dm0 0.0027 0.0045 0.0161
Schistosoma mansoni sodium-bile acid cotransporter related 0.0354 0.1018 0.3975
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0028 0.03
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0086 0.0959
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0569
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0034 0.0125
Schistosoma mansoni ap endonuclease 0.004 0.0086 0.0334
Trichomonas vaginalis set domain proteins, putative 0.048 0.1394 0.7603
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0002 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0198 0.0194
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0034 0.0363
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0006 0.0016
Trypanosoma cruzi ISWI complex protein 0.0016 0.0013 0.013
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0178 0.2016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0086 0.0082
Schistosoma mansoni hypothetical protein 0.0042 0.0091 0.0357
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.0041
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0021 0.0028 0.0102
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0207 0.0794
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0096 0.036
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0118 0.1363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0082 0.094
Onchocerca volvulus Alhambra homolog 0.0028 0.005 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.0111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0028 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0116 0.1198
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0034 0.2207
Giardia lamblia Fructose-bisphosphate aldolase 0.0626 0.183 1
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0034 0.0033
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0098 0.0376
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0082 0.038
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0178 0.2016
Leishmania major GTP-binding protein, putative 0.0044 0.0098 0.1128
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0029 0.0111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.0434 0.4885
Echinococcus multilocularis geminin 0.0341 0.0982 0.0978
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0074 0.0274
Schistosoma mansoni cellular tumor antigen P53 0.0103 0.0272 0.1063
Echinococcus granulosus pyruvate kinase 0.0033 0.0063 0.0232
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0306 0.0876 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0178 0.192
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0164
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0028 0.03
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0034 0.2207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0074 0.0289
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0086 0.032
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0091 0.105
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0028 0.03
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0565
Schistosoma mansoni hypothetical protein 0.0021 0.0029 0.0115
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0082 0.0305
Loa Loa (eye worm) runx1 0.0061 0.0149 0.0574
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.0856
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0086 0.029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0058 0.0221
Loa Loa (eye worm) hypothetical protein 0.0102 0.0269 0.1046
Schistosoma mansoni coup transcription factor 0.0021 0.0029 0.0111
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.0259 0.1003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0243 0.0239
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.004 0.265
Echinococcus granulosus sodium bile acid cotransporter 0.0872 0.2561 1
Brugia malayi steroid hormone receptor 0.0021 0.0029 0.0104
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0387 0.4515
Echinococcus granulosus lamin 0.0027 0.0045 0.0161
Schistosoma mansoni hypothetical protein 0.0042 0.0091 0.0357
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0103
Schistosoma mansoni hypothetical protein 0.0073 0.0182 0.0711
Trypanosoma brucei unspecified product 0.0039 0.0082 0.0948
Echinococcus multilocularis expressed conserved protein 0.0096 0.0251 0.0247
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0082 0.094
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0034 0.0381
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0029 0.0104
Brugia malayi jmjC domain containing protein 0.0036 0.0074 0.0282
Schistosoma mansoni hypothetical protein 0.0016 0.0013 0.005
Onchocerca volvulus 0.0021 0.0029 0.0002
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0098 0.1136
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.0104
Trypanosoma brucei unspecified product 0.0027 0.0046 0.0525
Leishmania major pyruvate kinase 0.0033 0.0063 0.0722
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0028 0.0183
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0626 0.183 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0269 0.134
Leishmania major mitochondrial DNA polymerase beta 0.0299 0.0855 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0082 0.0078
Schistosoma mansoni ran 0.0044 0.0098 0.0383
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0146 0.1691
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.004 0.0455
Brugia malayi ecdysteroid receptor 0.0021 0.0029 0.0104
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0116 0.1335
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0112 0.0542
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0091 0.1042
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0063 0.0241
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0178 0.192
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.0856
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0031
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0182 0.0178
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.015 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0046 0.0525
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0124 0.8521
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0012 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0116 0.0112
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.0856
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.005 0.3371
Echinococcus multilocularis pyruvate kinase 0.0017 0.0016 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0028 0.005 0.3371
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0116 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0082 0.094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0116 0.0439
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0029 0.0096
Loa Loa (eye worm) hypothetical protein 0.0049 0.0111 0.0426
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.004 0.265
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0063 0.0722
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.004 0.2652
Trypanosoma brucei proteasome regulatory non-ATPase subunit 11 0.0016 0.0013 0.0141
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0068 0.0064
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.005 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0178 0.2066
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0028 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0645 0.1886 0.7362
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0012 0.0131
Trypanosoma brucei protein kinase, putative 0.005 0.0116 0.1343
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0029 0.0104
Loa Loa (eye worm) hypothetical protein 0.0028 0.005 0.019
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0207 0.0802
Onchocerca volvulus 0.0027 0.0045 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0082 0.0948
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0082 0.0314
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0182 0.0696
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0072
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.1417 0.1413
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0029 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0116 0.0565
Plasmodium vivax SET domain protein, putative 0.006 0.0146 1
Brugia malayi Importin beta-1 subunit 0.006 0.0146 0.0562
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0098 0.1128
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0063 0.0593
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0479
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0387 0.451
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0098 0.1128
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0063 0.0417
Treponema pallidum fructose-bisphosphate aldolase 0.0626 0.183 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0029 0.0104
Leishmania major pyruvate kinase 0.0033 0.0063 0.0722
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0002 0.0009
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0045 0.0169
Giardia lamblia Pyruvate kinase 0.0033 0.0063 0.0337
Loa Loa (eye worm) hypothetical protein 0.0044 0.0096 0.0368
Schistosoma mansoni pyruvate kinase 0.0033 0.0063 0.0248
Loa Loa (eye worm) hypothetical protein 0.0071 0.0178 0.0689
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.005 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0178 0.1769
Entamoeba histolytica Ran family GTPase 0.0044 0.0098 0.0389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0104
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0178 0.2066
Echinococcus granulosus expressed conserved protein 0.0096 0.0251 0.0966
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0086 0.0399
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0028 0.03
Echinococcus granulosus microtubule associated protein 2 0.0683 0.1999 0.78
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0028 0.0103
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0086 0.0459
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0058 0.0221
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0112 0.0542
Loa Loa (eye worm) hypothetical protein 0.0872 0.2561 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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