Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0376 | 1 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0376 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0376 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0376 | 1 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0376 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0376 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0376 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0376 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0039 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.