Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.012 | 0.6338 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.6338 | 0.6338 |
Echinococcus granulosus | peroxidasin | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0064 | 0.1955 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | Dual oxidase homolog | 0.012 | 0.6338 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0167 | 1 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 0.6338 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.628 | 0.628 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.6338 | 0.6338 |
Echinococcus granulosus | dihydrofolate reductase | 0.0167 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0167 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0064 | 0.1955 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0064 | 0.1955 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0167 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0167 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0167 | 1 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.012 | 0.6338 | 0.6338 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0064 | 0.1955 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0167 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | Peroxidasin homolog | 0.012 | 0.6338 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.628 | 0.628 |
Schistosoma mansoni | peroxidasin | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | 0.012 | 0.6338 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | Peroxidase homolog | 0.012 | 0.6338 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0064 | 0.1955 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Peroxidasin | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.628 | 0.628 |
Onchocerca volvulus | 0.012 | 0.6338 | 1 | |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0064 | 0.1955 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | Peroxidase homolog | 0.012 | 0.6338 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.6338 | 0.6338 |
Giardia lamblia | High cysteine protein | 0.0039 | 0 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Animal haem peroxidase family protein | 0.012 | 0.6338 | 0.6338 |
Onchocerca volvulus | 0.012 | 0.6338 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.6338 | 0.6338 |
Brugia malayi | Dihydrofolate reductase | 0.0167 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.