Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0185 | 0.769 | 0.7701 |
Brugia malayi | hypothetical protein | 0.0235 | 0.9982 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0206 | 0.8694 | 0.8708 |
Brugia malayi | Pre-SET motif family protein | 0.0206 | 0.8694 | 0.8708 |
Echinococcus multilocularis | geminin | 0.0185 | 0.769 | 0.7701 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.1428 | 0.1858 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0012 | 0.0015 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0593 | 0.0583 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0361 | 0.0351 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2215 | 0.221 |
Brugia malayi | RNA binding protein | 0.0131 | 0.5226 | 0.5231 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0266 | 0.0255 |
Schistosoma mansoni | lamin | 0.0029 | 0.0561 | 0.073 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0561 | 0.0551 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0593 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0213 | 0.0277 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1444 | 0.1437 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1364 | 0.1357 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1996 | 0.2596 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.769 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.3597 | 0.3596 |
Schistosoma mansoni | lamin | 0.0029 | 0.0561 | 0.073 |
Trypanosoma cruzi | ISWI complex protein | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0561 | 0.0551 |
Trypanosoma brucei | ISWI complex protein | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0561 | 0.0551 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0235 | 0.9982 | 1 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0561 | 0.0551 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0593 | 0.0583 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.2393 | 0.3113 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.5226 | 0.5231 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1996 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1996 | 0.199 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.5226 | 0.5231 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5226 | 0.6797 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.1147 | 0.1139 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1269 | 0.1261 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.5226 | 0.5231 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0012 | 0.0015 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0911 | 0.1184 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0088 | 0.0114 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0561 | 0.073 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0213 | 0.0202 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0361 | 0.047 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0012 | 0.0015 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0479 | 0.0469 |
Echinococcus granulosus | lamin | 0.0029 | 0.0561 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0012 | 0.0015 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0911 | 0.0902 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0019 | 0.0088 | 0.0076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5226 | 0.6797 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3597 | 0.3596 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0048 | 0.1444 | 0.1437 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.2215 | 0.221 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.1428 | 0.1421 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1996 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0048 | 0.1444 | 0.1437 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0118 | 0.0107 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0266 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.9982 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1029 | 0.1021 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0561 | 0.0551 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0235 | 0.9982 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1996 | 0.199 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0019 | 0.0088 | 0.0076 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.1685 | 0.1679 |
Trichomonas vaginalis | set domain proteins, putative | 0.0235 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3597 | 0.3596 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0561 | 0.0551 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0213 | 0.0202 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.769 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3597 | 0.4678 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0019 | 0.0088 | 0.0114 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1444 | 0.1878 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1996 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.1996 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0561 | 0.0551 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.5226 | 0.5231 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0561 | 0.0551 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.1029 | 0.1021 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5226 | 0.6797 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.3597 | 0.3596 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0593 | 0.0771 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5226 | 0.6797 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1151 | 0.1143 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.5226 | 0.5231 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1996 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3597 | 0.4678 |
Onchocerca volvulus | 0.0048 | 0.1428 | 0.0919 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0543 | 0.0533 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0561 | 0.0551 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.1428 | 0.1858 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.1685 | 0.1679 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2765 | 0.2761 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.5226 | 0.5231 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.3597 | 0.3596 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0048 | 0.1444 | 0.1878 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0561 | 0.0551 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0361 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0911 | 0.0902 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.3597 | 0.4678 |
Onchocerca volvulus | 0.003 | 0.0593 | 0.0034 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1996 | 0.2596 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.5226 | 0.5231 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.1685 | 0.1679 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.1996 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0537 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1685 | 0.1679 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0593 | 0.0771 |
Brugia malayi | Bromodomain containing protein | 0.0082 | 0.2978 | 0.2975 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5226 | 0.6797 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.3597 | 0.3596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.