Detailed information for compound 767755

Basic information

Technical information
  • TDR Targets ID: 767755
  • Name: ethyl 8-carbamoyl-2,3,4,9-tetrahydro-1H-carba zole-1-carboxylate
  • MW: 286.326 | Formula: C16H18N2O3
  • H donors: 2 H acceptors: 2 LogP: 2.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCCc2c1[nH]c1c2cccc1C(=O)N
  • InChi: 1S/C16H18N2O3/c1-2-21-16(20)12-8-4-6-10-9-5-3-7-11(15(17)19)13(9)18-14(10)12/h3,5,7,12,18H,2,4,6,8H2,1H3,(H2,17,19)
  • InChiKey: LCEFRVUZORZBAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-Carbamoyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylic acid ethyl ester
  • ethyl 8-aminocarbonyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxylate
  • STOCK2S-77015
  • SMR000146415
  • MLS000554098
  • Oprea1_559133

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.1956 0.4996
Echinococcus granulosus zinc finger protein 0.0024 0.0533 0.0533
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.1417 0.6416
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0085 0.0085
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.1956 0.1956
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1579 0.1579
Echinococcus multilocularis survival motor neuron protein 1 0.0251 1 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) acetyltransferase 0.0149 0.5728 0.5728
Loa Loa (eye worm) phosphofructokinase 0.0105 0.3914 0.3914
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.2208 0.5631
Entamoeba histolytica hypothetical protein 0.0073 0.2567 0.6557
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.1417 0.3619
Schistosoma mansoni hypothetical protein 0.0073 0.2567 0.4481
Toxoplasma gondii exonuclease III APE 0.0058 0.1956 0.8859
Onchocerca volvulus 0.0031 0.0816 0.1156
Echinococcus multilocularis synaptojanin 1 0.0012 0.0008 0.0008
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0008 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Echinococcus granulosus synaptojanin 1 0.0012 0.0008 0.0008
Brugia malayi 6-phosphofructokinase 0.0105 0.3914 0.3914
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.3914 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.1956 0.4986
Schistosoma mansoni ap endonuclease 0.0058 0.1956 0.3414
Echinococcus granulosus survival motor neuron protein 1 0.0251 1 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0515 0.0515
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.3914 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0012 0.0008 0.0042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.1175 0.1664
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0012 0.0008 0.0014
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0012 0.0008 0.0008
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1301 0.3324
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.1956 0.4986
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.0704 0.1798
Entamoeba histolytica hypothetical protein 0.0073 0.2567 0.6557
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0008 0.0021
Onchocerca volvulus 0.0051 0.1654 0.2343
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1589 0.4059
Schistosoma mansoni kinase 0.0051 0.1644 0.287
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0272 0.0474
Loa Loa (eye worm) hypothetical protein 0.0047 0.1471 0.1471
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.5728 0.5728
Onchocerca volvulus 0.0012 0.0008 0.0012
Echinococcus multilocularis neutral sphingomyelinase 0.0012 0.0008 0.0008
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0012 0.0008 0.0021
Schistosoma mansoni chromobox protein 0.0071 0.2476 0.4322
Schistosoma mansoni cript-related 0.0012 0.0008 0.0014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0272 0.0474
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.3914 1
Schistosoma mansoni zinc finger protein 0.0024 0.0533 0.0931
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.706 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0704 0.3599
Trichomonas vaginalis CAMK family protein kinase 0.005 0.1589 0.4059
Echinococcus granulosus neutral sphingomyelinase 0.0012 0.0008 0.0008
Schistosoma mansoni carbon catabolite repressor protein 0.0012 0.0008 0.0014
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0012 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2208 0.3854
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.0704 0.1883
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0272 0.0272
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0008 0.0042
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.069 0.1764
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.3914 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.1956 0.527
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0085 0.0085
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0012 0.0008 0.0021
Schistosoma mansoni synaptojanin 0.0012 0.0008 0.0014
Onchocerca volvulus 0.0012 0.0008 0.0012
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2208 0.1287
Schistosoma mansoni hypothetical protein 0.0051 0.1654 0.2888
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.1417 0.7243
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0018 0.0272 0.0272
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.3704 0.3704
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.0704 0.3599
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.1956 0.4986
Plasmodium falciparum DNase I-like protein, putative 0.0012 0.0008 0.0042
Echinococcus multilocularis deoxyribonuclease 1 2 0.0012 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.1956 0.4986
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.3914 0.6833
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1175 0.3002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.2208 0.2208
Schistosoma mansoni hypothetical protein 0.0016 0.0194 0.0338
Loa Loa (eye worm) hypothetical protein 0.0049 0.1556 0.1556
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1162 0.5941
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.0704 0.1798
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.3914 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1579 0.2757
Echinococcus multilocularis chromobox protein 1 0.0071 0.2476 0.2476
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.1417 0.3619
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.3704 0.3704
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.3704 0.3704
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0008 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.3914 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.018 0.706 0.706
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.069 0.1764
Brugia malayi Heterochromatin protein 1 0.0071 0.2476 0.2476
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0272 0.0272
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0008 0.0042
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Trypanosoma brucei ISWI complex protein 0.0016 0.0194 0.0475
Schistosoma mansoni serine/threonine protein kinase 0.01 0.3704 0.6466
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1579 0.1579
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.1417 0.1417
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.5452 0.5452
Loa Loa (eye worm) hypothetical protein 0.0031 0.0816 0.0816
Trypanosoma cruzi ISWI complex protein 0.0016 0.0194 0.0475
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.1109 0.1109
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.2567 0.2567
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.3704 0.9461
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.0704 0.3188
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Echinococcus granulosus chromobox protein 1 0.0071 0.2476 0.2476
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0085 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1579 0.2757
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.2208 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.3704 0.5246
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.1956 0.1956
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1579 0.1579
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.3914 1
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Plasmodium vivax exodeoxyribonuclease III, putative 0.0012 0.0008 0.0042
Brugia malayi chromobox protein homolog 3 0.004 0.1175 0.1175
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0085 0.0148
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0008 0.0008
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1579 0.1579
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0251 1 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0041 0.1217 0.1217
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0012 0.0008 0.0021
Brugia malayi Bromodomain containing protein 0.0083 0.299 0.299
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2208 0.1287
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.0704 0.3188
Leishmania major hypothetical protein, conserved 0.0016 0.0194 0.0475
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0012 0.0008 0.0008
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1162 0.2969
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0008 0.0042
Brugia malayi CHD4 protein 0.0014 0.0085 0.0085
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.1417 0.6416
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.3914 1
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Loa Loa (eye worm) hypothetical protein 0.0075 0.2651 0.2651
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0012 0.0008 0.0042
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.1956 0.4986
Echinococcus granulosus traf and tnf receptor associated protein 0.0012 0.0008 0.0008
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0272 0.0272
Giardia lamblia Kinase, PLK 0.01 0.3704 1
Brugia malayi PHD-finger family protein 0.003 0.077 0.077
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.3914 1
Trichomonas vaginalis Phospholipase C precursor, putative 0.0012 0.0008 0.0021
Schistosoma mansoni zinc finger protein 0.0016 0.0194 0.0338
Brugia malayi hypothetical protein 0.0073 0.2567 0.2567
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1162 0.3122
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.2208 0.2208
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1956 1
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.3914 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0704 0.3599
Schistosoma mansoni hypothetical protein 0.0022 0.043 0.0751
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.043 0.043
Brugia malayi 6-phosphofructokinase 0.0105 0.3914 0.3914
Schistosoma mansoni chromobox protein 0.0071 0.2476 0.4322
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1301 0.3324
Trypanosoma cruzi ISWI complex protein 0.0016 0.0194 0.0475
Schistosoma mansoni nocturnin 0.0012 0.0008 0.0014
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.2312 0.2312
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.2208 0.3854
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.3914 0.3914
Echinococcus multilocularis chromobox protein 1 0.0071 0.2476 0.2476
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.1956 0.4996
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.3704 0.3704
Echinococcus granulosus chromobox protein 1 0.0071 0.2476 0.2476
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0012 0.0008 0.0021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Onchocerca volvulus Putative neutral sphingomyelinase 0.0012 0.0008 0.0012
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.3704 0.9461
Brugia malayi phosphofructokinase 0.0105 0.3914 0.3914
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1579 0.1579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1579 0.1579
Schistosoma mansoni neutral sphingomyelinase 0.0012 0.0008 0.0014
Entamoeba histolytica hypothetical protein 0.0073 0.2567 0.6557
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.3914 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.2312 0.2312
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.0704 0.1798
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1301 0.1843
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0448 0.0448
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0012 0.0008 0.0042
Brugia malayi N-terminal motif family protein 0.018 0.706 0.706
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0008 0.0042
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.004 0.1175 0.1175
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0012 0.0008 0.0021
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0012 0.0008 0.0021
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0008 0.0021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0012 0.0008 0.0008
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.0704 0.3599
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.1956 0.1956
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1175 0.3002
Trypanosoma brucei polo-like protein kinase 0.01 0.3704 0.9461
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1579 0.2757
Echinococcus multilocularis traf and tnf receptor associated protein 0.0012 0.0008 0.0008
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.2208 0.1287
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.0704 0.1781
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0012 0.0008 0.0021
Brugia malayi CCR4 0.0012 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.01 0.3704 0.9462
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0012 0.0008 0.0021
Echinococcus multilocularis zinc finger protein 0.0024 0.0533 0.0533
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.3914 0.3914
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.3914 0.3914
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.3914 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0008 0.0008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.1956 0.1956
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.5728 0.5728
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0012 0.0008 0.0021
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.1956 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.2567 0.2567
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2476 0.6325
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.5728 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0272 0.0474
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0704 0.5
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0272 0.0474
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.2476 0.2476
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0515 0.0899
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.3914 1
Trichomonas vaginalis chromobox protein, putative 0.0071 0.2476 0.6325
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.3914 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0028 0.0704 0.5
Schistosoma mansoni ap endonuclease 0.0058 0.1956 0.3414
Entamoeba histolytica hypothetical protein 0.0073 0.2567 0.6557
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0012 0.0008 0.0008
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0012 0.0008 0.0021
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.3704 0.9461
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0014
Brugia malayi Bromodomain containing protein 0.0044 0.1363 0.1363
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.1956 0.4996
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.2208 0.5631
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0008 0.0008
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.0704 0.3188
Schistosoma mansoni bromodomain containing protein 0.0071 0.2471 0.4314
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.3914 0.6833
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.1956 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0012 0.0008 0.0008
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0272 0.0272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.1956 0.4986
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0515 0.0515
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.2567 0.4481
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.3704 0.9462
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0012 0.0008 0.0021
Schistosoma mansoni survival motor neuron protein 0.0051 0.1654 0.2888
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.1109 0.1109
Schistosoma mansoni synaptojanin 0.0012 0.0008 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0008
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.3914 0.3914

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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