Detailed information for compound 767838

Basic information

Technical information
  • TDR Targets ID: 767838
  • Name: 2-[(4-ethoxybenzoyl)amino]-5,6-dihydro-4H-cyc lopenta[d]thiophene-3-carboxamide
  • MW: 330.401 | Formula: C17H18N2O3S
  • H donors: 2 H acceptors: 2 LogP: 3.22 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C(=O)Nc1sc2c(c1C(=O)N)CCC2
  • InChi: 1S/C17H18N2O3S/c1-2-22-11-8-6-10(7-9-11)16(21)19-17-14(15(18)20)12-4-3-5-13(12)23-17/h6-9H,2-5H2,1H3,(H2,18,20)(H,19,21)
  • InChiKey: IWJOYRGCTJVWQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(4-ethoxyphenyl)-oxomethyl]amino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxamide
  • 2-[(4-ethoxyphenyl)carbonylamino]-5,6-dihydro-4H-cyclopenta[d]thiophene-3-carboxamide
  • Oprea1_134701
  • BAS 06179890
  • Oprea1_577164
  • ZINC00432224
  • Enamine_002359
  • IVK/9149973

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 1 0.0331 0.1679 0.1678
Brugia malayi Muscleblind-like protein 0.0331 0.1679 0.1679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Schistosoma mansoni alpha glucosidase 0.004 0.0104 0.0096
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0155 0.0348
Loa Loa (eye worm) hypothetical protein 0.0235 0.1157 0.1156
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0055 0.0053
Echinococcus granulosus excitatory amino acid transporter 2 0.1868 1 1
Schistosoma mansoni survival motor neuron protein 0.0048 0.0147 0.0139
Echinococcus granulosus importin subunit beta 1 0.0061 0.0218 0.0217
Mycobacterium tuberculosis Probable lipase LipD 0.0149 0.0693 0.0667
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.017 0.0809 0.0784
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0216 0.1059 0.1059
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.0287 0.028
Toxoplasma gondii exonuclease III APE 0.0056 0.0193 0.1605
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0118 0.0117
Plasmodium vivax glutathione reductase, putative 0.0075 0.0292 0.3971
Plasmodium falciparum carbonic anhydrase 0.0216 0.1059 1
Mycobacterium tuberculosis Probable esterase LipL 0.0149 0.0693 0.0667
Loa Loa (eye worm) hypothetical protein 0.0216 0.1059 0.1058
Echinococcus multilocularis neutral amino acid transporter A 0.1868 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0923 0.0921
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0076 0.0075
Mycobacterium leprae conserved hypothetical protein 0.0149 0.0693 0.1487
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0193 0.0549
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.1457 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0055 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.0861 0.086
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0193 0.0848
Trichomonas vaginalis ran, putative 0.0045 0.0131 0.0281
Echinococcus granulosus neuropeptide s receptor 0.0462 0.2389 0.2388
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0062
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.0287 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0055 0.0055
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0055 0.0053
Echinococcus multilocularis neutral amino acid transporter A 0.1868 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0055 0.0055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0055 0.0055
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0193 0.0451
Toxoplasma gondii thioredoxin reductase 0.0075 0.0292 0.256
Loa Loa (eye worm) hypothetical protein 0.0048 0.0147 0.0146
Onchocerca volvulus 0.0048 0.0147 0.0092
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0056
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0193 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0055 0.0055
Brugia malayi jmjC domain containing protein 0.0058 0.0203 0.0203
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0055 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0055 0.0053
Echinococcus granulosus microtubule associated protein 2 0.071 0.3731 0.373
Echinococcus multilocularis protein dispatched 1 0.0049 0.015 0.0149
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0055 0.0053
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0155 0.0423
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0155 0.1237
Treponema pallidum glutamate transporter 0.0828 0.437 1
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.0654 0.0653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.017 0.0809 0.0784
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1868 1 1
Brugia malayi nuclear hormone receptor 0.0031 0.0055 0.0055
Trypanosoma brucei trypanothione reductase 0.0075 0.0292 0.0876
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0443 0.0443
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0118 0.0117
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0221 0.022
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0055 0.0055
Schistosoma mansoni ap endonuclease 0.0056 0.0193 0.0186
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0583 0.3043 0.3038
Treponema pallidum glutamate/aspartate transporter 0.0828 0.437 1
Echinococcus granulosus tumor protein p63 0.0328 0.1661 0.166
Echinococcus multilocularis excitatory amino acid transporter 2 0.1868 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0374 0.0372
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1868 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Mycobacterium tuberculosis Conserved protein 0.0149 0.0693 0.0667
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0104 0.0207
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.0048 0.0147 0.0139
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0055 0.0053
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0583 0.3043 1
Leishmania major importin beta-1 subunit, putative 0.0049 0.0155 0.0423
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0583 0.3043 0.3043
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0287 0.0286
Echinococcus multilocularis carbonic anhydrase 0.0216 0.1059 0.1058
Loa Loa (eye worm) excitatory amino acid transporter 0.1868 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1457 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Brugia malayi Pre-SET motif family protein 0.009 0.0374 0.0374
Schistosoma mansoni importin beta-1 0.0061 0.0218 0.021
Loa Loa (eye worm) beta-lactamase 0.0149 0.0693 0.0692
Echinococcus multilocularis Excitatory amino acid transporter 0.1868 1 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0828 0.437 0.4369
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.009 0.0374 0.0372
Schistosoma mansoni ap endonuclease 0.0056 0.0193 0.0186
Mycobacterium ulcerans lipase LipD 0.0149 0.0693 0.6983
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0654 0.658
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0055 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0055 0.0047
Schistosoma mansoni carbonic anhydrase-related 0.0216 0.1059 0.1052
Echinococcus multilocularis excitatory amino acid transporter 3 0.1868 1 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0104 0.0737
Brugia malayi follicle stimulating hormone receptor 0.0483 0.25 0.25
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.0654 0.0653
Brugia malayi hypothetical protein 0.0049 0.0155 0.0155
Brugia malayi Pre-SET motif family protein 0.0618 0.3235 0.3235
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Echinococcus multilocularis muscleblind protein 0.0331 0.1679 0.1678
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0131 0.0129
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0583 0.3043 1
Schistosoma mansoni aldehyde dehydrogenase 0.0202 0.098 0.0973
Mycobacterium tuberculosis Probable lipase LipE 0.0149 0.0693 0.0667
Mycobacterium tuberculosis Probable oxidoreductase 0.0189 0.0912 0.0887
Plasmodium vivax hypothetical protein, conserved 0.0149 0.0693 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0374 0.0366
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0287 0.0861
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0008 0.0006
Toxoplasma gondii ABC1 family protein 0.0149 0.0693 0.6446
Echinococcus multilocularis Excitatory amino acid transporter 0.1868 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0055 0.0053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.0292 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0041 0.0109 0.0102
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0028 0.002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Schistosoma mansoni hypothetical protein 0.0041 0.0109 0.0102
Leishmania major hypothetical protein, conserved 0.0149 0.0693 0.2205
Plasmodium falciparum importin beta, putative 0.0061 0.0218 0.1843
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0828 0.437 0.4365
Schistosoma mansoni hypothetical protein 0.0651 0.3412 0.3407
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0155 0.1237
Loa Loa (eye worm) hypothetical protein 0.0216 0.1059 0.1058
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0055 0.0053
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0055 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0055 0.0047
Brugia malayi ecdysteroid receptor 0.0031 0.0055 0.0055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.095 0.5031 0.5017
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0155 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.0287 0.0707
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.0287 0.0286
Onchocerca volvulus 0.0149 0.0693 0.0642
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0374 0.0366
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0149 0.0693 0.6983
Leishmania major GTP-binding protein, putative 0.0045 0.0131 0.0341
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0055 0.0053
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0131 0.072
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0374 0.3353
Schistosoma mansoni hypothetical protein 0.0339 0.1721 0.1714
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0193 0.1159
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0155 0.1237
Brugia malayi nuclear receptor NHR-88 0.0031 0.0055 0.0055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0374 0.0372
Echinococcus granulosus dnaJ subfamily B 0.0816 0.4307 0.4306
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0583 0.3043 0.3043
Mycobacterium leprae Probable lipase LipE 0.0149 0.0693 0.1487
Mycobacterium ulcerans hypothetical protein 0.0149 0.0693 0.6983
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0693 0.1812
Schistosoma mansoni hypothetical protein 0.0041 0.0109 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0374 0.0366
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0028 0.0026
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0193 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0062
Schistosoma mansoni ran 0.0045 0.0131 0.0123
Echinococcus granulosus expressed conserved protein 0.0093 0.0391 0.039
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0374 0.0372
Schistosoma mansoni cpg binding protein 0.0061 0.0216 0.0208
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1868 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0055 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0693 0.0686
Entamoeba histolytica Ran family GTPase 0.0045 0.0131 0.0395
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0104 0.0207
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0104 0.0104
Echinococcus multilocularis microtubule associated protein 2 0.071 0.3731 0.373
Echinococcus multilocularis neuropeptide receptor A26 0.0462 0.2389 0.2388
Echinococcus granulosus sodium:dicarboxylate symporter 0.1868 1 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0267 0.0266
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Schistosoma mansoni aldehyde dehydrogenase 0.0202 0.098 0.0973
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0155 0.0348
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0202 0.098 0.0979
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0202 0.098 0.0955
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0028 0.0028
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1868 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0055 0.0055
Echinococcus granulosus carbonic anhydrase II 0.0583 0.3043 0.3042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0221 0.0214
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0118 0.0117
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0432 0.0425
Chlamydia trachomatis glutamate symporter 0.1868 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0349 0.0348
Loa Loa (eye worm) hypothetical protein 0.0331 0.1679 0.1678
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0189 0.0912 0.0887
Schistosoma mansoni cpg binding protein 0.0061 0.0216 0.0208
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1868 1 1
Mycobacterium ulcerans esterase/lipase LipP 0.0149 0.0693 0.6983
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0131 0.0341
Onchocerca volvulus 0.0104 0.0451 0.0398
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0104 0.0252
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0149 0.0693 0.0693
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0216 0.1059 0.1059
Echinococcus granulosus neutral amino acid transporter A 0.1868 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0104 0.02
Brugia malayi beta-lactamase 0.0149 0.0693 0.0693
Toxoplasma gondii aldehyde dehydrogenase 0.0202 0.098 0.9231
Brugia malayi hypothetical protein 0.0235 0.1157 0.1157
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0218 0.063
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0216 0.1059 0.1059
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0216 0.1059 0.1058
Brugia malayi RNA, U transporter 1 0.0173 0.0826 0.0826
Brugia malayi hypothetical protein 0.0035 0.0076 0.0076
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0055 0.0053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0216 0.1059 0.1059
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0424 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0055 0.0053
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1157 0.1156
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0193 0.0166
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0028 0.0026
Trypanosoma brucei glucosidase, putative 0.004 0.0104 0.0252
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0563 0.0556
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0218 0.1843
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0693 0.2205
Loa Loa (eye worm) hypothetical protein 0.0052 0.017 0.0168
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0055 0.0047
Schistosoma mansoni ran 0.0045 0.0131 0.0123
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0923 0.0923
Echinococcus granulosus excitatory amino acid transporter 3 0.1868 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0193 0.1739
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0287 0.0707
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0155 0.0423
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0493 0.4512
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.0861 0.086
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.0297 0.0296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0055 0.0053
Echinococcus multilocularis neuropeptide s receptor 0.0462 0.2389 0.2388
Loa Loa (eye worm) hypothetical protein 0.0043 0.0118 0.0117
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0055 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0055 0.0053
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0601 0.06
Entamoeba histolytica hypothetical protein 0.0049 0.0155 0.0574
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0104 0.0207
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0601 0.06
Echinococcus granulosus neutral amino acid transporter 0.1868 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0056
Onchocerca volvulus 0.0057 0.0198 0.0144
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0654 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0055 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.0216 0.1059 0.1052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0055 0.0053
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0104 0.0102
Toxoplasma gondii hypothetical protein 0.0216 0.1059 1
Echinococcus granulosus muscleblind protein 0.0331 0.1679 0.1678
Schistosoma mansoni hypothetical protein 0.0035 0.0076 0.0068
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1868 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0287 0.0286
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0155 0.0423
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0828 0.437 0.4369
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0203 0.0202
Echinococcus granulosus beta LACTamase domain containing family member 0.0149 0.0693 0.0692
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0923 0.0921
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0055 0.0053
Echinococcus granulosus snurportin 1 0.0651 0.3412 0.3411
Schistosoma mansoni microtubule-associated protein tau 0.071 0.3731 0.3726
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0104 0.0207
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0424 0.2519
Echinococcus granulosus geminin 0.0339 0.1721 0.172
Schistosoma mansoni carbonic anhydrase-related 0.0216 0.1059 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0055 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0149 0.0693 0.0692
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0131 0.0341
Schistosoma mansoni patched 1 0.0043 0.0118 0.011
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0104 0.0102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0149 0.0693 0.0667
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.017 0.0809 0.6013
Schistosoma mansoni cpg binding protein 0.0057 0.0198 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0149 0.0693 0.0686
Echinococcus multilocularis expressed conserved protein 0.0093 0.0391 0.039
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0055 0.0055
Echinococcus multilocularis geminin 0.0339 0.1721 0.172
Mycobacterium tuberculosis Putative ferredoxin reductase 0.017 0.0809 0.0784
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0063 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0055 0.0053
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0583 0.3043 0.3042
Plasmodium vivax SET domain protein, putative 0.009 0.0374 0.5202
Echinococcus multilocularis carbonic anhydrase 0.0216 0.1059 0.1058
Echinococcus granulosus excitatory amino acid transporter 2 0.1868 1 1
Brugia malayi CHE-14 protein 0.0043 0.0118 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0693 0.1812
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0131 0.0998
Echinococcus granulosus neutral amino acid transporter A 0.1868 1 1
Onchocerca volvulus 0.0048 0.0147 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.0287 0.1528
Echinococcus multilocularis protein patched 0.0043 0.0118 0.0117
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0155 0.1919
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0055 0.0047
Onchocerca volvulus 0.0149 0.0693 0.0642
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0816 0.4307 0.4303
Loa Loa (eye worm) hypothetical protein 0.0074 0.0287 0.0286
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.0287 0.1815
Schistosoma mansoni carbonic anhydrase 0.0216 0.1059 0.1052
Echinococcus multilocularis snurportin 1 0.0651 0.3412 0.3411
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0008 0.0006
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.0287 0.0286
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.0861 0.086
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0193 0.1605
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0055 0.0055
Echinococcus multilocularis cpg binding protein 0.0061 0.0216 0.0214
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0149 0.0693 0.0667
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0131 0.0129
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0443 0.0443
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0055 0.0047
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0216 0.1059 0.1059
Echinococcus granulosus Excitatory amino acid transporter 0.1868 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0221 0.022
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0221 0.0214
Trypanosoma brucei hypothetical protein, conserved 0.0149 0.0693 0.2205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0923 0.0921
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.017 0.0809 0.0784
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.098 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0147 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0149 0.0693 0.1812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.098 1
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0193 0.0451
Brugia malayi steroid hormone receptor 0.0031 0.0055 0.0055
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0218 0.063
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.0292 0.0291
Loa Loa (eye worm) hypothetical protein 0.0099 0.0424 0.0423
Mycobacterium tuberculosis Probable hydrolase 0.0149 0.0693 0.0667
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0056
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0104 0.0207
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.0292 0.0876
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0193 0.249
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0055 0.0047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0055 0.0053
Brugia malayi Importin beta-1 subunit 0.0061 0.0218 0.0218
Trichomonas vaginalis esterase, putative 0.0149 0.0693 0.1812
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0055 0.0053
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.0292 0.3971
Echinococcus multilocularis dnaJ subfamily B 0.0816 0.4307 0.4306
Echinococcus multilocularis neutral amino acid transporter A 0.1868 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0193 0.0192
Schistosoma mansoni hypothetical protein 0.0339 0.1721 0.1714
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.0287 0.028
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0055 0.0055
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1457 1
Echinococcus multilocularis carbonic anhydrase 0.0216 0.1059 0.1058
Schistosoma mansoni alpha-glucosidase 0.0155 0.0726 0.0719
Leishmania major hypothetical protein, conserved 0.0049 0.0155 0.0423
Brugia malayi Thioredoxin reductase 0.0075 0.0292 0.0292
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0618 0.3235 0.3235
Loa Loa (eye worm) hypothetical protein 0.0103 0.0443 0.0442
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0218 0.0217
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0076 0.0068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0056
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0104 0.0252
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0055 0.0047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0104 0.0207
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0198 0.0197
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0055 0.0053
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.0287 0.0861
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0424 0.0424
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0483 0.25 0.2499
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0118 0.0246
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0104 0.0207
Mycobacterium tuberculosis Probable dehydrogenase 0.017 0.0809 0.0784
Brugia malayi glutathione reductase 0.0075 0.0292 0.0292
Echinococcus granulosus carbonic anhydrase 0.0216 0.1059 0.1058
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0118 0.0117
Leishmania major carbonic anhydrase-like protein 0.0583 0.3043 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0131 0.0341
Echinococcus granulosus Excitatory amino acid transporter 0.1868 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0923 0.0921
Mycobacterium ulcerans aldehyde dehydrogenase 0.0202 0.098 1
Echinococcus granulosus neuropeptide receptor A26 0.0462 0.2389 0.2388
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0149 0.0693 0.0667
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0131 0.0129
Echinococcus multilocularis GPCR, family 2 0.0032 0.0063 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0218 0.0217
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.162 0.866 0.866
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0104 0.0252
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0155 0.0423
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0923 0.0921
Echinococcus granulosus cpg binding protein 0.0061 0.0216 0.0214
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0063 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0693 0.1812
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0193 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0923 0.0916
Trichomonas vaginalis penicillin-binding protein, putative 0.0149 0.0693 0.1812
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0651 0.3412 0.3411
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0131 0.0998
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0131 0.1548
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0062
Brugia malayi MH2 domain containing protein 0.0132 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0331 0.1679 0.1678
Schistosoma mansoni coup transcription factor 0.0031 0.0055 0.0047
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.0297 0.0296
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.0287 0.0286
Mycobacterium tuberculosis Conserved protein 0.0149 0.0693 0.0667
Onchocerca volvulus 0.0704 0.3697 0.3662
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.007 0.0267 0.026
Loa Loa (eye worm) hypothetical protein 0.0149 0.0693 0.0692
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0076 0.0075
Schistosoma mansoni alpha-glucosidase 0.0155 0.0726 0.0719
Mycobacterium tuberculosis Probable reductase 0.017 0.0809 0.0784
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0193 0.0549
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0104 0.0207
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0923 0.0916
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0267 0.0267
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.0287 0.0286
Mycobacterium tuberculosis Conserved protein 0.0149 0.0693 0.0667
Schistosoma mansoni carbonic anhydrase-related 0.0216 0.1059 0.1052
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0055 0.0047
Onchocerca volvulus 0.0149 0.0693 0.0642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0443 0.0442
Schistosoma mansoni hypothetical protein 0.0041 0.0109 0.0102
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0031 0.0055 0.0053
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0055 0.0055
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0104 0.02
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0189 0.0912 1
Echinococcus granulosus carbonic anhydrase 0.0216 0.1059 0.1058
Plasmodium falciparum glutathione reductase 0.0075 0.0292 0.256
Brugia malayi CXXC zinc finger family protein 0.0057 0.0198 0.0198
Loa Loa (eye worm) glutathione reductase 0.0075 0.0292 0.0291
Brugia malayi hypothetical protein 0.0032 0.006 0.006
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0287 0.0861
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0203 0.0196
Plasmodium falciparum thioredoxin reductase 0.0075 0.0292 0.256
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0055 0.0047
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0202 0.098 0.3158
Echinococcus granulosus GPCR family 2 0.0032 0.0063 0.0062
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0583 0.3043 0.3038
Brugia malayi beta-lactamase family protein 0.0149 0.0693 0.0693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0055 0.0047
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0216 0.1059 0.1058
Trypanosoma cruzi hypothetical protein, conserved 0.0149 0.0693 0.2205
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0189 0.0912 0.0887
Plasmodium vivax importin-beta 2, putative 0.0061 0.0218 0.2858
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0374 0.0366
Loa Loa (eye worm) carbonic anhydrase 3 0.0583 0.3043 0.3042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0155 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0149 0.0693 0.0692
Chlamydia trachomatis neutral amino acid transporter 0.0828 0.437 0.4354
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0203 0.0202
Echinococcus multilocularis carbonic anhydrase II 0.0583 0.3043 0.3042
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0104 0.0102
Trypanosoma brucei carbonic anhydrase-like protein 0.0583 0.3043 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0193 0.0192
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0147 0.014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.0287 0.0861
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0923 0.0916
Brugia malayi jmjC domain containing protein 0.0062 0.0221 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0055 0.0055
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0193 0.0166
Echinococcus multilocularis excitatory amino acid transporter 2 0.1868 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0193 0.0549
Leishmania major trypanothione reductase 0.0075 0.0292 0.0876
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0828 0.437 0.4365
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.0287 0.0707
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0062
Echinococcus multilocularis tumor protein p63 0.0328 0.1661 0.166
Trichomonas vaginalis set domain proteins, putative 0.0704 0.3697 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0424 0.0423
Onchocerca volvulus 0.009 0.0374 0.0321
Brugia malayi beta-lactamase family protein 0.0149 0.0693 0.0693
Mycobacterium ulcerans beta-lactamase 0.0149 0.0693 0.6983
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0203 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1457 0.3896
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1157 0.1156
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0055 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0193 0.0193
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.1457 0.3292
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0104 0.0207
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0202 0.098 0.0979
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.0861 0.086
Echinococcus granulosus carbonic anhydrase 0.0216 0.1059 0.1058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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