Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1909 | 0.1909 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.5359 | 0.5359 |
Echinococcus multilocularis | lamin | 0.0026 | 0.5359 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5359 | 0.5359 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.3341 | 0.5 |
Schistosoma mansoni | lamin | 0.0026 | 0.5359 | 0.5359 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.4511 | 0.4511 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.513 | 0.513 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.513 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.5359 | 0.5359 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.513 | 1 |
Onchocerca volvulus | 0.0026 | 0.5359 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.5359 | 0.5359 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.3341 | 0.5 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.513 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.3341 | 0.6513 |
Schistosoma mansoni | lamin | 0.0026 | 0.5359 | 0.5359 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.2263 | 0.2263 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.3341 | 0.3341 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.3341 | 0.6513 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.513 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.3341 | 0.6513 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3341 | 0.3341 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.513 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.5359 | 0.5359 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.3341 | 0.3341 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.5359 | 0.5359 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1909 | 0.1909 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.5359 | 0.5359 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.513 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.3341 | 0.3341 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.3341 | 0.6513 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.3341 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.3341 | 0.6513 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.513 | 1 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.513 | 0.513 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.5359 | 0.5359 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.5359 | 0.5359 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.3341 | 0.6513 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1787 | 0.1787 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.3341 | 0.3341 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.3341 | 0.6513 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.513 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.3341 | 0.6513 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.2263 | 0.2263 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.3341 | 0.6513 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.3341 | 0.3341 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1787 | 0.1787 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.5359 | 0.5359 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.5359 | 0.5359 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.5237 | 0.5237 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.513 | 0.513 |
Onchocerca volvulus | 0.0026 | 0.5359 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 1 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.513 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.3341 | 0.6513 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.513 | 0.513 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.3341 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.3341 | 0.6513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.