Detailed information for compound 767988

Basic information

Technical information
  • TDR Targets ID: 767988
  • Name: 4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyran o[5,6-c]quinoline-2,5-dione
  • MW: 335.353 | Formula: C20H17NO4
  • H donors: 0 H acceptors: 2 LogP: 2.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1CC(=O)Oc2c1c(=O)n(c1c2cccc1)C
  • InChi: 1S/C20H17NO4/c1-21-16-6-4-3-5-14(16)19-18(20(21)23)15(11-17(22)25-19)12-7-9-13(24-2)10-8-12/h3-10,15H,11H2,1-2H3
  • InChiKey: DHSQWXVDPLFNPV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-methoxyphenyl)-6-methyl-3,4-dihydropyrano[5,6-c]quinoline-2,5-quinone
  • 4-(4-Methoxy-phenyl)-6-methyl-4,6-dihydro-3H-pyrano[3,2-c]quinoline-2,5-dione
  • BAS 13474797

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0181 0.0656 0.118
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0398 0.5673
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0188 0.0337
Toxoplasma gondii ABC1 family protein 0.0185 0.0669 0.9554
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0067 0.0201 0.0391
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0078 0.0395
Schistosoma mansoni hypothetical protein 0.0044 0.0109 0.0194
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.0928 0.1804
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Schistosoma mansoni ap endonuclease 0.004 0.0092 0.0163
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0701 1
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0118
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0195 0.0713 0.1282
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0078 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Echinococcus granulosus microtubule associated protein 2 0.1406 0.5549 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0094 0.0167
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0059 0.0111
Mycobacterium tuberculosis Conserved protein 0.0185 0.0669 0.1145
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0078 0.0395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0059 0.0104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Echinococcus granulosus Excitatory amino acid transporter 0.1303 0.5135 0.9253
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0037 0.0531
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0059 0.0104
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0068 0.0204 0.3022
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0068 0.0204 0.6744
Schistosoma mansoni mixed-lineage leukemia protein mll 0.013 0.0453 0.0814
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Brugia malayi nuclear hormone receptor 0.0032 0.0059 0.0115
Mycobacterium ulcerans lipase LipD 0.0185 0.0669 0.9488
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0092 0.1348
Echinococcus multilocularis neutral amino acid transporter A 0.1303 0.5135 0.5134
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.0337 0.0487
Brugia malayi beta-lactamase 0.0185 0.0669 0.1304
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.0701 1
Leishmania major hypothetical protein, conserved 0.0026 0.0037 0.0507
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0059 0.0104
Onchocerca volvulus 0.006 0.0173 0.0225
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Toxoplasma gondii thioredoxin reductase 0.004 0.0092 0.1288
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0577 0.2238 0.4032
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0092 0.0175
Echinococcus granulosus importin 5 0.0017 0.0002 0.0001
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0231 0.1192
Plasmodium vivax glutathione reductase, putative 0.004 0.0092 0.1348
Echinococcus granulosus translational activator gcn1 0.0017 0.0002 0.0001
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0092 0.0468
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0059 0.0058
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0078 0.1089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0059 0.0111
Echinococcus multilocularis protein patched 0.0046 0.0115 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0015
Echinococcus granulosus neutral amino acid transporter A 0.1303 0.5135 0.9253
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0243 0.0473
Schistosoma mansoni hypothetical protein 0.0044 0.0109 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.0882 0.1587
Echinococcus multilocularis excitatory amino acid transporter 2 0.1303 0.5135 0.5134
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0986 0.387 0.7536
Loa Loa (eye worm) hypothetical protein 0.047 0.181 0.3522
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.0882 0.0881
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0059 0.0104
Schistosoma mansoni alpha-glucosidase 0.0142 0.0498 0.0895
Toxoplasma gondii HEAT repeat-containing protein 0.0092 0.0301 0.4281
Schistosoma mansoni hypothetical protein 0.0181 0.0656 0.118
Schistosoma mansoni hypothetical protein 0.0986 0.387 0.6974
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0092 0.0000031861
Echinococcus multilocularis Excitatory amino acid transporter 0.1303 0.5135 0.5134
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0078 0.0152
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0068 0.0204 0.0393
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0083 0.0262 0.2265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0188 0.0337
Brugia malayi jmjC domain containing protein 0.0065 0.0191 0.0373
Echinococcus multilocularis excitatory amino acid transporter 3 0.1303 0.5135 0.5134
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.0701 1
Brugia malayi Pre-SET motif family protein 0.0064 0.0188 0.0366
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.0882 0.1587
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0243 0.0435
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0104 0.0347 0.4901
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.0542 0.0541
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0078 0.0395
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0059 0.0058
Trypanosoma brucei trypanothione reductase 0.004 0.0092 0.1348
Loa Loa (eye worm) hypothetical protein 0.0478 0.1842 0.3586
Echinococcus multilocularis translational activator gcn1 0.0017 0.0002 0.0001
Brugia malayi glutathione reductase 0.004 0.0092 0.0179
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.1685 0.3279
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0359 0.0699
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0059 0.0104
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0301 0.0583
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0011 0.0018
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1303 0.5135 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0067 0.0066
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0015 0.0029
Echinococcus granulosus neutral amino acid transporter 0.1303 0.5135 0.9253
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0059 0.0115
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1303 0.5135 0.5134
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0243 0.3249
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0046 0.0116 0.0993
Schistosoma mansoni survival motor neuron protein 0.0098 0.0322 0.0578
Onchocerca volvulus 0.0185 0.0669 0.1202
Echinococcus multilocularis importin subunit beta 1 0.0092 0.0301 0.03
Schistosoma mansoni ran 0.0068 0.0204 0.0365
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0243 0.3249
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0059 0.0104
Echinococcus multilocularis excitatory amino acid transporter 2 0.1303 0.5135 0.5134
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0589 0.1145
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0092 0.1288
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.0301 0.4481
Echinococcus multilocularis neuropeptide s receptor 0.0498 0.192 0.1919
Giardia lamblia Fructose-bisphosphate aldolase 0.0305 0.1152 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0078 0.0395
Onchocerca volvulus 0.0098 0.0322 0.0517
Brugia malayi hypothetical protein 0.0478 0.1842 0.3588
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.0669 0.1204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0669 0.1204
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0092 0.3008
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0037 0.1185
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Echinococcus granulosus Excitatory amino acid transporter 0.1303 0.5135 0.9253
Brugia malayi hypothetical protein 0.0026 0.0037 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0059 0.0104
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0191 0.0369
Echinococcus granulosus GTP binding nuclear protein Ran 0.0068 0.0204 0.0365
Plasmodium falciparum glutathione reductase 0.004 0.0092 0.3009
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0071 0.0217 0.1118
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0195 0.0713 0.0711
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0035 0.0071 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0035 0.0071 0.0532
Echinococcus granulosus transportin 1 0.0017 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0064 0.0188 0.0363
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0322 0.0627
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1179 0.4642 0.9024
Echinococcus granulosus neuropeptide s receptor 0.0498 0.192 0.3459
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0059 0.0104
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0243 0.0435
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0092 0.1348
Schistosoma mansoni hypothetical protein 0.086 0.3367 0.6067
Echinococcus granulosus muscleblind protein 0.047 0.181 0.326
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0359 0.3106
Echinococcus multilocularis expressed conserved protein 0.01 0.0333 0.0332
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0149 0.0528 0.7166
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0414 0.0803
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0359 0.0645
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0078 0.0662
Loa Loa (eye worm) hypothetical protein 0.0078 0.0243 0.0469
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0094 0.0093
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0243 0.0435
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0078 0.0662
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.1152 1
Onchocerca volvulus 0.0064 0.0188 0.0254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0238 0.0882 0.0881
Echinococcus multilocularis neutral amino acid transporter A 0.1303 0.5135 0.5134
Trypanosoma brucei glucosidase, putative 0.0037 0.0078 0.114
Brugia malayi Importin beta-1 subunit 0.0092 0.0301 0.0586
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0016 0.0027
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0035 0.0071 0.1035
Trichomonas vaginalis importin beta-1, putative 0.0075 0.0231 0.1192
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0032 0.0059 0.0337
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0092 0.1348
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0243 0.3607
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0243 0.0241
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0078 0.0138
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0092 0.0863
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0669 1
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0067 0.013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0059 0.0115
Treponema pallidum glutamate/aspartate transporter 0.0577 0.2238 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0305 0.1152 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0188 0.0337
Echinococcus granulosus sodium:dicarboxylate symporter 0.1303 0.5135 0.9253
Mycobacterium tuberculosis Conserved protein 0.0185 0.0669 0.1145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0358 0.0697
Trypanosoma cruzi importin beta-1 subunit, putative 0.0075 0.0231 0.3068
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0195 0.0713 0.1282
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.0669 0.1145
Plasmodium vivax SET domain protein, putative 0.0064 0.0188 0.2789
Brugia malayi RNA, U transporter 1 0.0263 0.0981 0.1911
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1303 0.5135 1
Schistosoma mansoni importin-beta 2 0.0017 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.047 0.181 0.3522
Echinococcus multilocularis neutral amino acid transporter A 0.1303 0.5135 0.5134
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0071 0.06
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0188 0.0337
Echinococcus granulosus excitatory amino acid transporter 2 0.1303 0.5135 0.9253
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0243 0.1901
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0701 0.1261
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0059 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0669 0.3468
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0178 0.0318
Mycobacterium leprae conserved hypothetical protein 0.0185 0.0669 1
Brugia malayi steroid hormone receptor 0.0032 0.0059 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0059 0.0115
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Mycobacterium tuberculosis Probable reductase 0.0091 0.0297 0.0406
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0358 0.0694
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0078 0.0395
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.0337 0.0487
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0118
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0118
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1303 0.5135 0.9253
Onchocerca volvulus 0.0185 0.0669 0.1202
Plasmodium falciparum importin beta, putative 0.0092 0.0301 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0701 1
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0115 0.0206
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0104 0.0347 0.3001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0178 0.0318
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0297 0.0406
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0067 0.0118
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0078 0.1089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0092 0.0863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0059 0.0111
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.0669 0.1145
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0037 0.0507
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0243 0.3446
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0059 0.0104
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0059 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0078 0.0643
Brugia malayi Thioredoxin reductase 0.004 0.0092 0.0179
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0297 0.0406
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0037 0.0531
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0067 0.0127
Leishmania major hypothetical protein, conserved 0.0185 0.0669 0.9554
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0068 0.0204 0.3022
Schistosoma mansoni hypothetical protein 0.0044 0.0109 0.0194
Chlamydia trachomatis glutamate symporter 0.1303 0.5135 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0297 0.0406
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0092 0.0558
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.0669 0.1304
Leishmania major importin beta-1 subunit, putative 0.0075 0.0231 0.3283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Brugia malayi ecdysteroid receptor 0.0032 0.0059 0.0115
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.0701 0.1207
Brugia malayi nuclear receptor NHR-88 0.0032 0.0059 0.0115
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1303 0.5135 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0191 0.0343
Schistosoma mansoni cpg binding protein 0.006 0.0173 0.031
Brugia malayi Excitatory amino acid transporter 0.1303 0.5135 1
Leishmania major trypanothione reductase 0.004 0.0092 0.1288
Echinococcus multilocularis Excitatory amino acid transporter 0.1303 0.5135 0.5134
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0092 0.0298 0.058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0059 0.0104
Echinococcus multilocularis protein dispatched 1 0.0052 0.0141 0.014
Plasmodium vivax importin-beta 2, putative 0.0092 0.0301 0.4481
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0669 0.3468
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0669 0.3468
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0104 0.0347 0.4901
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0078 0.0395
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0035 0.0071 0.0359
Echinococcus multilocularis importin 5 0.0017 0.0002 0.0001
Echinococcus granulosus expressed conserved protein 0.01 0.0333 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0059 0.0115
Brugia malayi CHE-14 protein 0.0046 0.0115 0.0225
Echinococcus granulosus geminin 0.0181 0.0656 0.118
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0414 0.0803
Treponema pallidum glutamate transporter 0.0577 0.2238 1
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0577 0.2238 0.4032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0059 0.0111
Loa Loa (eye worm) beta-lactamase 0.0185 0.0669 0.13
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0104 0.0347 0.1794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0243 0.0435
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0067 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0669 0.1204
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0243 0.2093
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.1842 0.1841
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0035 0.0071 0.0359
Schistosoma mansoni alpha-glucosidase 0.0142 0.0498 0.0895
Schistosoma mansoni microtubule-associated protein tau 0.1406 0.5549 1
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1303 0.5135 0.5134
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0078 0.0643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0059 0.0111
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0078 0.0395
Leishmania major GTP-binding protein, putative 0.0068 0.0204 0.2887
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0092 0.0782
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0243 0.1251
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0059 0.0115
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0059 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0059 0.0115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Echinococcus multilocularis geminin 0.0181 0.0656 0.0655
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0068 0.0204 0.2631
Echinococcus granulosus dnaJ subfamily B 0.086 0.3367 0.6067
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0037 0.1185
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0068 0.0204 0.0396
Brugia malayi beta-lactamase family protein 0.0185 0.0669 0.1304
Trichomonas vaginalis set domain proteins, putative 0.0499 0.1927 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0068 0.0204 0.2631
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0092 0.0468
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0059 0.0104
Brugia malayi MH2 domain containing protein 0.0121 0.0414 0.0806
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0078 0.0395
Echinococcus granulosus importin subunit beta 1 0.0092 0.0301 0.054
Loa Loa (eye worm) hypothetical protein 0.0107 0.0358 0.0694
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0297 0.0406
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0069
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.0366 0.0657
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.0669 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0059 0.0115
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0115 0.0206
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0188 0.0187
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0628 0.122
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.0669 0.1145
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.0669 0.1145
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.0542 0.0976
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0046 0.0115 0.0221
Onchocerca volvulus 0.0185 0.0669 0.1202
Echinococcus multilocularis cpg binding protein 0.0064 0.0187 0.0186
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0188 0.0187
Loa Loa (eye worm) excitatory amino acid transporter 0.1303 0.5135 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0101 0.0335 0.2895
Schistosoma mansoni hypothetical protein 0.0034 0.0067 0.0118
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0075 0.0231 0.1192
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0115 0.0221
Echinococcus multilocularis transportin 1 0.0017 0.0002 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0071 0.0217 0.1118
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0178 0.0176
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0243 0.1251
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0149 0.0528 0.621
Schistosoma mansoni ap endonuclease 0.004 0.0092 0.0163
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0589 0.0588
Loa Loa (eye worm) hypothetical protein 0.0185 0.0669 0.13
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0223 0.0435
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0297 0.0406
Echinococcus granulosus neuropeptide receptor A26 0.0498 0.192 0.3459
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0188 0.2665
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0059 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0059 0.0115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0104 0.0347 0.1794
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0059 0.0111
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0178 0.0176
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0059 0.0111
Echinococcus multilocularis dnaJ subfamily B 0.086 0.3367 0.3366
Trichomonas vaginalis ran, putative 0.0068 0.0204 0.1048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0305 0.1152 0.5976
Echinococcus multilocularis microtubule associated protein 2 0.1406 0.5549 0.5548
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0115 0.0114
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0238 0.0882 0.1714
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0059 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0059 0.0111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0191 0.0343
Loa Loa (eye worm) hypothetical protein 0.0034 0.0067 0.0127
Schistosoma mansoni patched 1 0.0046 0.0115 0.0206
Loa Loa (eye worm) hypothetical protein 0.0067 0.0201 0.0388
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0059 0.0115
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0067 0.013
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0059 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0238 0.0882 0.1717
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0059 0.0104
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.0669 0.9488
Echinococcus granulosus neutral amino acid transporter A 0.1303 0.5135 0.9253
Treponema pallidum fructose-bisphosphate aldolase 0.0305 0.1152 0.494
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.0669 0.1145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.0149
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0059 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0078 0.0077
Schistosoma mansoni hypothetical protein 0.0098 0.0322 0.0578
Echinococcus granulosus excitatory amino acid transporter 2 0.1303 0.5135 0.9253
Echinococcus granulosus cpg binding protein 0.0064 0.0187 0.0335
Brugia malayi Pre-SET motif family protein 0.0439 0.1685 0.3282
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0243 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0059 0.0115
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0589 0.106
Entamoeba histolytica Ran family GTPase 0.0068 0.0204 0.1754
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0059 0.0058
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0035 0.0071 0.0359
Brugia malayi Muscleblind-like protein 0.047 0.181 0.3524
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0035 0.0071 0.0126
Trichomonas vaginalis esterase, putative 0.0185 0.0669 0.3468
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0078 0.0395
Schistosoma mansoni importin beta-1 0.0092 0.0301 0.054
Schistosoma mansoni alpha glucosidase 0.0037 0.0078 0.0138
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0059 0.0104
Mycobacterium ulcerans beta-lactamase 0.0185 0.0669 0.9488
Plasmodium falciparum thioredoxin reductase 0.004 0.0092 0.3009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0067 0.0066
Brugia malayi jmjC domain containing protein 0.0061 0.0178 0.0346
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0358 0.0697
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0059 0.0058
Onchocerca volvulus 0.0499 0.1927 0.3679
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0149 0.0528 0.0865
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.0669 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0115 0.059
Schistosoma mansoni cpg binding protein 0.0064 0.0187 0.0335
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0107 0.0359 0.0696
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0059 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0589 0.1148
Brugia malayi follicle stimulating hormone receptor 0.0249 0.0928 0.1807
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0059 0.0104
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.0337 0.0487
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0067 0.0201 0.036
Entamoeba histolytica hypothetical protein 0.0075 0.0231 0.1994
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0577 0.2238 0.2237
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0104 0.0347 0.1794
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.0669 0.1145
Entamoeba histolytica hypothetical protein 0.0083 0.0262 0.2265
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0347 0.0676
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0059 0.0115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0035 0.0071 0.06
Brugia malayi beta-lactamase family protein 0.0185 0.0669 0.1304
Mycobacterium ulcerans hypothetical protein 0.0185 0.0669 0.9488
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0092 0.0863
Echinococcus granulosus GPCR family 2 0.0034 0.0067 0.0118
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0068 0.0204 0.2887
Schistosoma mansoni cpg binding protein 0.0064 0.0187 0.0335
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0191 0.0343
Brugia malayi CXXC zinc finger family protein 0.006 0.0173 0.0337
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0059 0.0111
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0068 0.0204 0.1553
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0059 0.0104
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0059 0.0104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0059 0.0104
Mycobacterium leprae Probable lipase LipE 0.0185 0.0669 1
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.0669 0.1145
Echinococcus multilocularis GPCR, family 2 0.0034 0.0067 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0701 0.1261
Schistosoma mansoni hypothetical protein 0.0073 0.0223 0.04
Loa Loa (eye worm) hypothetical protein 0.0073 0.0223 0.0431
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.005 0.0132 0.0919
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0173 0.0334
Echinococcus multilocularis muscleblind protein 0.047 0.181 0.1809
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0243 0.0241
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0238 0.0882 0.1587
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0589 0.0588
Loa Loa (eye worm) glutathione reductase 0.004 0.0092 0.0175
Echinococcus multilocularis snurportin 1 0.0986 0.387 0.3869
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0059 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0669 1
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.1842 0.3319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.0669 0.13
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0669 0.3468
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.0337 0.1091
Onchocerca volvulus 0.0095 0.0312 0.0499
Schistosoma mansoni coup transcription factor 0.0032 0.0059 0.0104
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0092 0.0175
Echinococcus granulosus snurportin 1 0.0986 0.387 0.6974
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0068 0.0204 0.0202
Schistosoma mansoni ran 0.0068 0.0204 0.0365
Schistosoma mansoni hypothetical protein 0.0044 0.0109 0.0194
Echinococcus granulosus excitatory amino acid transporter 3 0.1303 0.5135 0.9253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.0882 0.1587
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0577 0.2238 0.2237
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0059 0.0058
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0243 0.1251
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0243 0.0435
Echinococcus multilocularis neuropeptide receptor A26 0.0498 0.192 0.1919
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0059 0.0115
Echinococcus multilocularis muscleblind protein 1 0.047 0.181 0.1809
Loa Loa (eye worm) hypothetical protein 0.0056 0.0157 0.0301
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0092 0.0179
Toxoplasma gondii exonuclease III APE 0.004 0.0092 0.1288
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0067 0.0201 0.02
Brugia malayi kap beta 3 protein 0.0017 0.0002 0.0004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.0669 0.9488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0188 0.0337
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0059 0.0104
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0701 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0092 0.0163
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0669 0.3468
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.0701 0.1261
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0059 0.0115
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.0701 0.0699
Mycobacterium tuberculosis Conserved protein 0.0185 0.0669 0.1145
Trypanosoma brucei importin beta-1 subunit, putative 0.0092 0.0301 0.4481
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0359 0.0358
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0238 0.0882 0.1587
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0174 0.0311

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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