Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3024 | 0.6848 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0102 | 0.4416 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0046 | 0.1338 | 0.303 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.1262 | 0.1154 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1039 | 0.1039 |
Brugia malayi | Phosphoglycerate kinase | 0.0037 | 0.0851 | 0.1927 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.1366 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.4416 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1811 | 0.1811 |
Echinococcus multilocularis | dna polymerase kappa | 0.0046 | 0.1338 | 0.1338 |
Giardia lamblia | Phosphoglycerate kinase | 0.0102 | 0.4416 | 1 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0102 | 0.4416 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2976 | 0.2976 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2976 | 0.674 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0102 | 0.4416 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0077 | 0.3024 | 0.6096 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0046 | 0.1338 | 0.1366 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.1366 |
Echinococcus multilocularis | geminin | 0.0203 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.1366 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.1366 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.1338 | 0.2048 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0077 | 0.3024 | 0.6404 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2976 | 0.674 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0102 | 0.4416 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2083 | 0.4717 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1811 | 0.4101 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0022 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.1366 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0046 | 0.1338 | 0.303 |
Trypanosoma brucei | phosphoglycerate kinase, putative | 0.0037 | 0.0851 | 0.079 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0102 | 0.4416 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0077 | 0.3024 | 0.6096 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1039 | 0.2353 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.1338 | 0.2048 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1811 | 0.1811 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 1 |
Treponema pallidum | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.5 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0102 | 0.4416 | 0.4416 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0077 | 0.3024 | 0.6848 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0077 | 0.3024 | 0.3024 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2976 | 0.674 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.1262 | 0.1154 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2976 | 0.2976 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2976 | 0.674 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0102 | 0.4416 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2976 | 0.674 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1039 | 0.2353 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.4416 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0046 | 0.1338 | 0.1338 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0046 | 0.1338 | 0.1338 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0102 | 0.4416 | 0.4416 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1811 | 0.1811 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.0077 | 0.3024 | 0.3024 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1811 | 0.1811 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2083 | 0.4717 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1811 | 0.1811 |
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0102 | 0.4416 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2976 | 0.2976 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.4416 |
Trypanosoma brucei | unspecified product | 0.0046 | 0.1338 | 0.2048 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0102 | 0.4416 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 1 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0102 | 0.4416 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0046 | 0.1338 | 0.1338 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0046 | 0.1338 | 0.1338 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2976 | 0.2976 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1811 | 0.4101 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2976 | 0.2976 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0077 | 0.3024 | 0.3024 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0102 | 0.4416 | 1 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0046 | 0.1338 | 0.1338 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0102 | 0.4416 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2083 | 0.4717 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2976 | 0.2976 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0046 | 0.1338 | 0.2048 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0046 | 0.1338 | 0.2048 |
Brugia malayi | Phosphoglycerate kinase | 0.0102 | 0.4416 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 1 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0037 | 0.0851 | 0.079 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2083 | 0.4717 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1811 | 0.1811 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2976 | 0.674 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2976 | 0.2976 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1811 | 0.1811 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Insoluble 0 ug ml-1 | Concentration that inhibits uninfected H9 cell growth by 50%.; Did not dissolve | ChEMBL. | 12729671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.