Detailed information for compound 768365

Basic information

Technical information
  • TDR Targets ID: 768365
  • Name: methyl (4Z)-4-[(4-hydroxy-3-methoxyphenyl)met hylidene]-2-methyl-5-oxo-1-prop-2-enylpyrrole -3-carboxylate
  • MW: 329.347 | Formula: C18H19NO5
  • H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1C(=O)C(=Cc2ccc(c(c2)OC)O)C(=C1C)C(=O)OC
  • InChi: 1S/C18H19NO5/c1-5-8-19-11(2)16(18(22)24-4)13(17(19)21)9-12-6-7-14(20)15(10-12)23-3/h5-7,9-10,20H,1,8H2,2-4H3/b13-9-
  • InChiKey: HRBGWBHQCYXSMT-LCYFTJDESA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-[(4-hydroxy-3-methoxyphenyl)methylidene]-2-methyl-5-oxo-1-prop-2-enylpyrrole-3-carboxylate
  • methyl 1-allyl-4-[(4-hydroxy-3-methoxy-phenyl)methylene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • methyl (4Z)-1-allyl-4-[(4-hydroxy-3-methoxy-phenyl)methylene]-2-methyl-5-oxo-pyrrole-3-carboxylate
  • 1-allyl-4-[(4-hydroxy-3-methoxyphenyl)methylene]-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester
  • (4Z)-1-allyl-4-[(4-hydroxy-3-methoxyphenyl)methylene]-2-methyl-5-oxo-3-pyrrolecarboxylic acid methyl ester
  • 1-allyl-4-(4-hydroxy-3-methoxy-benzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • (4Z)-1-allyl-4-(4-hydroxy-3-methoxy-benzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • methyl 4-[(4-hydroxy-3-methoxy-phenyl)methylidene]-2-methyl-5-oxo-1-prop-2-enyl-pyrrole-3-carboxylate
  • methyl (4Z)-4-[(4-hydroxy-3-methoxy-phenyl)methylidene]-2-methyl-5-oxo-1-prop-2-enyl-pyrrole-3-carboxylate
  • BAS 00881080
  • ZINC00112603
  • STOCK2S-52810

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved protein 0.0108 0.0653 0.1324
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0198 0.0198
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0008 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0008 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.0375
Plasmodium falciparum flap endonuclease 1 0.0025 0.0045 0.5
Echinococcus multilocularis tumor protein p63 0.0347 0.2405 0.2405
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Schistosoma mansoni hypothetical protein 0.0071 0.0383 0.0382
Echinococcus multilocularis microtubule associated protein 2 0.1383 1 1
Loa Loa (eye worm) hypothetical protein 0.0345 0.2393 0.5154
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Loa Loa (eye worm) RNA binding protein 0.0652 0.4642 1
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0008 0.0016
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0129 0.0618
Entamoeba histolytica hypothetical protein 0.0071 0.0383 1
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0653 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0198 0.5174
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0653 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0653 0.6315
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0008 0.0016
Echinococcus multilocularis tar DNA binding protein 0.0652 0.4642 0.4641
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0652 0.4642 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.4928 1
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0232 0.0231
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0198 0.3033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0642
Brugia malayi beta-lactamase 0.0108 0.0653 0.1405
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0008 0.0016
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0125 0.0124
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0653 0.1324
Echinococcus multilocularis thyroid hormone receptor alpha 0.0273 0.1859 0.1859
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0008 0.0007
Brugia malayi PHD-finger family protein 0.0025 0.0043 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0129 0.197
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.1033 0.2096
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0008 0.0016
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0653 0.1324
Schistosoma mansoni zinc finger protein 0.002 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0062 0.0941
Schistosoma mansoni bromodomain containing protein 0.0064 0.0327 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0642
Loa Loa (eye worm) TAR-binding protein 0.0652 0.4642 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0505 0.3565 0.7681
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0008 0.0007
Loa Loa (eye worm) beta-lactamase 0.0108 0.0653 0.1405
Echinococcus granulosus flap endonuclease 1 0.0025 0.0045 0.0044
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0008 0.0016
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0008 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0652 0.4642 0.4641
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0111 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0642
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0198 0.0198
Brugia malayi hypothetical protein 0.0071 0.0383 0.0824
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0071 0.0382 0.0822
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0008 0.0007
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0129 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Toxoplasma gondii ABC1 family protein 0.0108 0.0653 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.2088 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0008 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.016 0.1032 0.2222
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.016 0.1032 0.1031
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2088 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0062 0.0941
Giardia lamblia GTOR 0.0046 0.0198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0149 0.2273
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0241 0.1153
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0045 0.0212
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0653 0.1324
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0198 0.0426
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0505 0.3565 0.7681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Brugia malayi ecdysteroid receptor 0.002 0.0008 0.0016
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0653 0.1324
Echinococcus granulosus GPCR family 2 0.016 0.1032 0.1031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0087 0.1322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0638
Entamoeba histolytica hypothetical protein 0.0071 0.0383 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0198 0.0948
Entamoeba histolytica hypothetical protein 0.0071 0.0383 1
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0653 0.3125
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0008 0.0016
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0008 0.0007
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0008 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0008 0.0016
Schistosoma mansoni hypothetical protein 0.0021 0.0012 0.0011
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0173 0.0825
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0914 0.4376
Brugia malayi latrophilin 2 splice variant baaae 0.0345 0.2393 0.5154
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0198 0.5174
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0383 0.0382
Leishmania major hypothetical protein, conserved 0.0108 0.0653 0.3124
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0198 0.0426
Loa Loa (eye worm) latrophilin receptor protein 2 0.016 0.1032 0.2222
Schistosoma mansoni hypothetical protein 0.016 0.1032 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0653 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0012 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.016 0.1032 0.2222
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0653 1
Brugia malayi Bromodomain containing protein 0.0039 0.0142 0.0306
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0129 0.0617
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0026 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0652 0.4642 0.4641
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.016 0.1032 0.1031
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0198 0.0948
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0198 0.3033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.016 0.1032 0.1031
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0045 0.0212
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0129 0.197
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0045 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Mycobacterium ulcerans lipase LipD 0.0108 0.0653 0.6315
Brugia malayi TAR-binding protein 0.0652 0.4642 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0638
Echinococcus granulosus FTZ F1 alpha 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Echinococcus granulosus tumor protein p63 0.0347 0.2405 0.2405
Brugia malayi Bromodomain containing protein 0.0076 0.0413 0.089
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.016 0.0344
Mycobacterium tuberculosis Conserved protein 0.0108 0.0653 0.1324
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0026 0.0025
Trichomonas vaginalis esterase, putative 0.0108 0.0653 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0008 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.2088 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0045 0.0679
Echinococcus multilocularis GPCR, family 2 0.016 0.1032 0.1031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0129 0.197
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0383 0.0382
Echinococcus multilocularis zinc finger protein 0.002 0.0004 0.0003
Schistosoma mansoni nuclear hormone receptor 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0653 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0062 0.0941
Loa Loa (eye worm) hypothetical protein 0.0505 0.3565 0.7681
Brugia malayi nuclear hormone receptor 0.002 0.0008 0.0016
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.002 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0198 0.3033
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0173 0.0827
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0008 0.0007
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0026 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0008 0.0007
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0653 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Schistosoma mansoni hypothetical protein 0.016 0.1032 0.1031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0653 0.0652
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0008 0.0007
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0198 0.0949
Schistosoma mansoni microtubule-associated protein tau 0.1383 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0008 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.0232 0.0499
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0008 0.0007
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0045 0.0044
Mycobacterium ulcerans beta-lactamase 0.0108 0.0653 0.6315
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0079 0.121
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0198 0.0948
Mycobacterium leprae Probable lipase LipE 0.0108 0.0653 0.5
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0252 0.1711 0.171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.03 0.03
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0008 0.0007
Onchocerca volvulus 0.0051 0.0232 0.3474
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0914 0.4377
Brugia malayi RNA binding protein 0.0652 0.4642 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0008 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0008 0.0007
Schistosoma mansoni coup transcription factor 0.002 0.0008 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0008 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.0002
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.016 0.1032 0.1031
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0653 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0653 0.1405
Brugia malayi beta-lactamase family protein 0.0108 0.0653 0.1405
Schistosoma mansoni hypothetical protein 0.0252 0.1711 0.171
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0653 0.1324
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0 0.0002
Mycobacterium ulcerans hypothetical protein 0.0108 0.0653 0.6315
Schistosoma mansoni flap endonuclease-1 0.0023 0.0027 0.0026
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0198 0.0949
Brugia malayi Calcitonin receptor-like protein seb-1 0.0505 0.3565 0.7681
Brugia malayi Flap endonuclease-1 0.0025 0.0045 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0653 0.0652
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0383 0.0382
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0653 0.0652
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0008 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0653 0.3124
Schistosoma mansoni tar DNA-binding protein 0.0652 0.4642 0.4641
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0008 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0273 0.1859 0.1859
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0252 0.1711 0.171
Schistosoma mansoni tar DNA-binding protein 0.0652 0.4642 0.4641
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0008 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0638
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0914 0.4376
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.091
Onchocerca volvulus 0.0108 0.0653 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Echinococcus granulosus zinc finger protein 0.002 0.0004 0.0003
Brugia malayi nuclear receptor NHR-88 0.002 0.0008 0.0016
Toxoplasma gondii hypothetical protein 0.0049 0.0219 0.2863
Schistosoma mansoni hypothetical protein 0.016 0.1032 0.1031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.016 0.1032 0.1031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0173 0.0825
Mycobacterium tuberculosis Conserved protein 0.0108 0.0653 0.1324
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0125 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0008 0.0016
Brugia malayi steroid hormone receptor 0.002 0.0008 0.0016
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0008 0.0016
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0173 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0008 0.0016
Brugia malayi RNA recognition motif domain containing protein 0.0652 0.4642 1
Echinococcus granulosus tar DNA binding protein 0.0652 0.4642 0.4641
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0008 0.0016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0143 0.0307
Mycobacterium ulcerans hypothetical protein 0.016 0.1033 1
Entamoeba histolytica hypothetical protein 0.0071 0.0383 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0008 0.0016
Brugia malayi beta-lactamase family protein 0.0108 0.0653 0.1405
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0045 0.0214
Trypanosoma brucei unspecified product 0.0019 0 0.0002
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0045 0.1158
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0653 0.1405
Loa Loa (eye worm) hypothetical protein 0.002 0.0008 0.0016
Onchocerca volvulus 0.0108 0.0653 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0129 0.197
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0653 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0008 0.0016
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.2088 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0653 0.1405
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0198 0.0948
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0008 0.0007
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0008 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0 0.0002
Brugia malayi Latrophilin receptor protein 2 0.016 0.1032 0.2222
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0653 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0008 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0111 0.1701
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0653 0.1324
Schistosoma mansoni hypothetical protein 0.0345 0.2393 0.2392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.006 0.091
Schistosoma mansoni thyroid hormone receptor 0.0273 0.1859 0.1859
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0653 0.3124
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0045 0.2238
Onchocerca volvulus 0.0108 0.0653 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0129 0.197
Schistosoma mansoni tar DNA-binding protein 0.0652 0.4642 0.4641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0642
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0653 0.6315

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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