Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0403 | 1 |
Schistosoma mansoni | zinc finger protein | 0.003 | 0.008 | 0.0069 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0236 | 0.0505 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0119 | 0.0708 | 0.0697 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0895 | 0.0885 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0055 | 0.0257 | 0.0962 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.071 | 0.1572 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0125 | 0.0959 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.0403 | 0.0392 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0039 | 0.0144 | 0.1177 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0895 | 0.0885 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0046 | 0.0192 | 0.3934 |
Plasmodium falciparum | flap endonuclease 1 | 0.0027 | 0.0055 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0148 | 0.0918 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1423 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0046 | 0.0192 | 0.3934 |
Plasmodium vivax | hypothetical protein, conserved | 0.0148 | 0.0918 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.1073 | 0.0274 |
Echinococcus granulosus | zinc finger protein | 0.0039 | 0.014 | 0.0129 |
Onchocerca volvulus | 0.0148 | 0.0918 | 1 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0458 | 0.3122 | 0.7 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0148 | 0.0918 | 0.204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0458 | 0.3122 | 0.7 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.008 | 0.012 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0403 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0145 | 0.0895 | 0.1988 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0148 | 0.0918 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0148 | 0.0918 | 0.0907 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0041 | 0.0155 | 0.0324 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0187 | 0.0626 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0105 | 0.0094 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.0403 | 0.0392 |
Schistosoma mansoni | thyroid hormone receptor | 0.0279 | 0.1849 | 0.184 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.0234 | 0.2078 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0187 | 0.0626 |
Schistosoma mansoni | bromodomain containing protein | 0.0126 | 0.0758 | 0.0748 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0192 | 0.0181 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0034 | 0.0108 | 0.0614 |
Schistosoma mansoni | tar DNA-binding protein | 0.0645 | 0.4455 | 0.4449 |
Brugia malayi | PHD-finger family protein | 0.0049 | 0.0216 | 0.046 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0034 | 0.0105 | 0.0094 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0148 | 0.0918 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0027 | 0.0055 | 0.0044 |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.1073 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0041 | 0.0003 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0037 | 0.0125 | 0.0333 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0034 | 0.0105 | 0.0094 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0058 | 0.0196 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0034 | 0.0105 | 0.0094 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0046 | 0.0192 | 0.0406 |
Schistosoma mansoni | zinc finger protein | 0.0039 | 0.014 | 0.0129 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.216 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0105 | 0.0094 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0148 | 0.0918 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0279 | 0.1849 | 0.184 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0155 | 0.0144 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0258 | 0.1701 | 0.1692 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0027 | 0.0055 | 0.0254 |
Echinococcus multilocularis | zinc finger protein | 0.0039 | 0.014 | 0.0129 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0027 | 0.0055 | 0.0162 |
Echinococcus granulosus | tar DNA binding protein | 0.0645 | 0.4455 | 0.4449 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0105 | 0.0094 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0046 | 0.0192 | 0.0888 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0045 | 0.0187 | 0.0864 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0046 | 0.0192 | 0.0651 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0041 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0863 | 0.1918 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0148 | 0.0918 | 0.204 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0045 | 0.0182 | 0.0171 |
Brugia malayi | beta-lactamase | 0.0148 | 0.0918 | 0.204 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0148 | 0.0918 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.1701 | 0.1692 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0192 | 0.0888 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0467 | 0.1025 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0322 | 0.216 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0403 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0406 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Echinococcus multilocularis | GPCR, family 2 | 0.0145 | 0.0895 | 0.0885 |
Trypanosoma brucei | ISWI complex protein | 0.003 | 0.008 | 0.037 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0322 | 0.216 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0145 | 0.0895 | 0.0885 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0045 | 0.0182 | 0.0171 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0084 | 0.0492 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0077 | 0.0412 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.006 | 0.0218 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.044 | 0.0964 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1423 | 1 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0027 | 0.0055 | 0.0044 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0148 | 0.0918 | 0.4099 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0148 | 0.0918 | 0.0907 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0403 | 0.0882 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0192 | 0.1724 |
Onchocerca volvulus | 0.0148 | 0.0918 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0895 | 0.1988 |
Brugia malayi | Flap endonuclease-1 | 0.0027 | 0.0055 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0403 | 0.0392 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.0058 | 0.0196 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0145 | 0.0895 | 0.0885 |
Brugia malayi | Bromodomain containing protein | 0.0076 | 0.0405 | 0.0886 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0125 | 0.0959 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Brugia malayi | beta-lactamase family protein | 0.0148 | 0.0918 | 0.204 |
Schistosoma mansoni | thyroid hormone receptor | 0.0279 | 0.1849 | 0.184 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0045 | 0.0182 | 0.0171 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.216 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0105 | 0.021 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0046 | 0.0192 | 0.0651 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0046 | 0.0192 | 0.0651 |
Echinococcus granulosus | tumor protein p63 | 0.0357 | 0.2406 | 0.2398 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0153 | 0.095 | 0.44 |
Echinococcus multilocularis | tumor protein p63 | 0.0357 | 0.2406 | 0.2398 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0187 | 0.0626 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0037 | 0.0125 | 0.0579 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0148 | 0.0918 | 0.0907 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0236 | 0.0225 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.0403 | 0.0392 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0145 | 0.0895 | 0.1988 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0645 | 0.4455 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0148 | 0.0918 | 0.4099 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.006 | 0.0218 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0037 | 0.0125 | 0.0333 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.071 | 0.1572 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Trypanosoma cruzi | ISWI complex protein | 0.003 | 0.008 | 0.012 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0145 | 0.0895 | 0.0885 |
Schistosoma mansoni | tar DNA-binding protein | 0.0645 | 0.4455 | 0.4449 |
Brugia malayi | RNA binding protein | 0.0645 | 0.4455 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0645 | 0.4455 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0645 | 0.4455 | 0.4449 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0041 | 0.0003 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0022 | 0.0019 | 0.0087 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.071 | 0.1572 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0372 | 0.0361 |
Mycobacterium leprae | Probable lipase LipE | 0.0148 | 0.0918 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0192 | 0.1724 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.008 | 0.012 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0046 | 0.0192 | 0.0181 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0071 | 0.0372 | 0.0361 |
Loa Loa (eye worm) | hypothetical protein | 0.0458 | 0.3122 | 0.7 |
Schistosoma mansoni | flap endonuclease-1 | 0.0024 | 0.0036 | 0.0025 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0027 | 0.0055 | 0.0098 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0105 | 0.0094 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0148 | 0.0918 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0145 | 0.0895 | 0.0885 |
Giardia lamblia | GTOR | 0.0046 | 0.0192 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0125 | 0.0959 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0105 | 0.0094 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0119 | 0.0708 | 0.0697 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Schistosoma mansoni | tar DNA-binding protein | 0.0645 | 0.4455 | 0.4449 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0025 | 0.0041 | 0.0003 |
Onchocerca volvulus | 0.0148 | 0.0918 | 1 | |
Loa Loa (eye worm) | bromodomain containing protein | 0.0035 | 0.0113 | 0.023 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0153 | 0.095 | 0.4255 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0313 | 0.2091 | 0.468 |
Schistosoma mansoni | hypothetical protein | 0.0313 | 0.2091 | 0.2082 |
Echinococcus granulosus | GPCR family 2 | 0.0145 | 0.0895 | 0.0885 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0148 | 0.0918 | 0.4249 |
Onchocerca volvulus | 0.0052 | 0.0236 | 0.2478 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0458 | 0.3122 | 0.7 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.008 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0918 | 0.204 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0895 | 0.0885 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.006 | 0.0218 |
Mycobacterium leprae | conserved hypothetical protein | 0.0148 | 0.0918 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0645 | 0.4455 | 0.4449 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0125 | 0.0959 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0946 | 0.6597 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.0895 | 0.0885 |
Loa Loa (eye worm) | hypothetical protein | 0.0313 | 0.2091 | 0.468 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0145 | 0.0895 | 0.1988 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0258 | 0.1701 | 0.1692 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0148 | 0.0918 | 0.4099 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0046 | 0.0192 | 0.0406 |
Brugia malayi | beta-lactamase family protein | 0.0148 | 0.0918 | 0.204 |
Brugia malayi | TAR-binding protein | 0.0645 | 0.4455 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0125 | 0.0959 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0645 | 0.4455 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0645 | 0.4455 | 0.4449 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0046 | 0.0192 | 0.0651 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0046 | 0.0192 | 0.0181 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0153 | 0.095 | 0.4255 |
Trichomonas vaginalis | esterase, putative | 0.0148 | 0.0918 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0108 | 0.0765 |
Loa Loa (eye worm) | beta-lactamase | 0.0148 | 0.0918 | 0.204 |
Loa Loa (eye worm) | RNA binding protein | 0.0645 | 0.4455 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0046 | 0.0192 | 0.1724 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0148 | 0.0918 | 0.0907 |
Brugia malayi | Bromodomain containing protein | 0.0149 | 0.0924 | 0.2054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.