Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0029 | 0.0109 | 0.0165 |
Onchocerca volvulus | 0.0074 | 0.0783 | 0.6379 | |
Entamoeba histolytica | hypothetical protein | 0.0147 | 0.1888 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.125 | 0.2572 |
Entamoeba histolytica | hypothetical protein | 0.0147 | 0.1888 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0554 | 0.0554 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0191 | 0.0345 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.3758 | 0.8225 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0074 | 0.0783 | 0.1847 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0783 | 0.1519 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0074 | 0.0783 | 0.1847 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0074 | 0.0783 | 0.1847 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0055 | 0.05 | 0.109 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0029 | 0.0109 | 0.0109 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0074 | 0.0783 | 0.3789 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0191 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0749 | 0.1441 |
Echinococcus granulosus | nibrin | 0.0029 | 0.0109 | 0.0109 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0455 | 0.0929 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0029 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.125 | 0.2572 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0166 | 0.0166 |
Treponema pallidum | DNA ligase (lig) | 0.0029 | 0.0109 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0322 | 0.4546 | 0.4546 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.1506 | 0.1506 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0074 | 0.0783 | 0.1847 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0029 | 0.0109 | 0.0165 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0074 | 0.0783 | 0.3789 |
Echinococcus multilocularis | tar DNA binding protein | 0.0322 | 0.4546 | 0.4546 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0074 | 0.0783 | 0.1847 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0191 | 0.0345 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.125 | 0.2694 |
Echinococcus granulosus | tar DNA binding protein | 0.0322 | 0.4546 | 0.4546 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0055 | 0.05 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0147 | 0.1888 | 0.1888 |
Echinococcus multilocularis | tumor protein p63 | 0.0677 | 0.9924 | 0.9924 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.0881 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0074 | 0.0783 | 1 |
Brugia malayi | hypothetical protein | 0.0147 | 0.1888 | 0.4107 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0191 | 0.0345 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0074 | 0.0783 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0322 | 0.4546 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0166 | 0.0166 |
Schistosoma mansoni | tar DNA-binding protein | 0.0322 | 0.4546 | 0.4546 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0199 | 0.0199 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0322 | 0.4546 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.3758 | 0.8255 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.1506 | 0.1506 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0191 | 0.2085 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0191 | 0.1209 |
Mycobacterium ulcerans | glutaminase | 0.027 | 0.3758 | 1 |
Schistosoma mansoni | topbp1 | 0.0029 | 0.0109 | 0.0109 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0191 | 0.0184 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0074 | 0.0783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.0881 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0191 | 0.0223 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0029 | 0.0109 | 0.5 |
Brugia malayi | topoisomerase | 0.0029 | 0.0109 | 0.0165 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0074 | 0.0783 | 0.2086 |
Entamoeba histolytica | hypothetical protein | 0.0147 | 0.1888 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0029 | 0.0109 | 0.0109 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.303 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0191 | 0.0223 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0322 | 0.4546 | 1 |
Brugia malayi | RNA binding protein | 0.0322 | 0.4546 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0677 | 0.9924 | 0.9924 |
Brugia malayi | TAR-binding protein | 0.0322 | 0.4546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.03 | 0.0428 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0749 | 0.1581 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0191 | 0.0223 |
Onchocerca volvulus | 0.0035 | 0.0191 | 0.0771 | |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.3758 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0191 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0191 | 0.0223 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0191 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.0607 | 0.0607 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0074 | 0.0783 | 0.2086 |
Schistosoma mansoni | tar DNA-binding protein | 0.0322 | 0.4546 | 0.4546 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0166 | 0.0166 |
Brugia malayi | AMP-binding enzyme family protein | 0.0074 | 0.0783 | 0.1658 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0455 | 0.0929 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0055 | 0.05 | 1 |
Echinococcus multilocularis | nibrin | 0.0029 | 0.0109 | 0.0109 |
Loa Loa (eye worm) | RNA binding protein | 0.0322 | 0.4546 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0055 | 0.05 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0191 | 0.0223 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0191 | 0.0191 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0191 | 0.0223 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0109 | 0.0165 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0074 | 0.0783 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0166 | 0.0166 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0074 | 0.0783 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0074 | 0.0783 | 0.3789 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0131 | 0.1654 | 0.1654 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0147 | 0.1888 | 0.1888 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0191 | 0.1209 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0236 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Brugia malayi | DKFZp564C0469 protein | 0.0029 | 0.0109 | 0.0165 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0166 | 0.0127 |
Schistosoma mansoni | glutaminase | 0.027 | 0.3758 | 0.3758 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0074 | 0.0783 | 0.1847 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.1888 | 0.1888 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0166 | 0.029 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0166 | 0.0166 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.1654 | 0.1654 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0682 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0235 | 0.0442 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0191 | 1 |
Onchocerca volvulus | 0.0035 | 0.0191 | 0.0771 | |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0099 | 0.1166 | 0.1166 |
Brugia malayi | AMP-binding enzyme family protein | 0.0074 | 0.0783 | 0.1658 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.0782 | 0.1655 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.0881 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0199 | 0.0199 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0191 | 0.0223 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.125 | 0.2694 |
Onchocerca volvulus | 0.0099 | 0.1166 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.0554 | 0.0554 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0718 | 0.1371 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0191 | 0.0223 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0147 | 0.1888 | 0.1888 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0191 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0749 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.0881 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0682 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1166 | 0.2381 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0191 | 0.0223 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0166 | 0.0166 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.1654 | 0.1654 |
Brugia malayi | AMP-binding enzyme family protein | 0.0074 | 0.0783 | 0.1658 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.3758 | 0.8225 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0029 | 0.0109 | 0.0165 |
Mycobacterium ulcerans | hypothetical protein | 0.0074 | 0.0783 | 0.1847 |
Schistosoma mansoni | tar DNA-binding protein | 0.0322 | 0.4546 | 0.4546 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0191 | 0.0223 |
Onchocerca volvulus | 0.0035 | 0.0191 | 0.0771 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0191 | 0.0191 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0455 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.05 | 0.0881 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0271 | 0.0364 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0166 | 0.0127 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0191 | 0.0223 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0029 | 0.0109 | 0.5 |
Schistosoma mansoni | topbp1 | 0.0029 | 0.0109 | 0.0109 |
Schistosoma mansoni | tar DNA-binding protein | 0.0322 | 0.4546 | 0.4546 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0191 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0783 | 0.1519 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.1506 | 0.1506 |
Schistosoma mansoni | DNA ligase IV | 0.0029 | 0.0109 | 0.0109 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0055 | 0.05 | 0.1071 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0783 | 0.1519 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0166 | 0.0166 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0074 | 0.0783 | 0.1847 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0166 | 0.029 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0191 | 0.0184 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0052 | 0.0455 | 0.0929 |
Entamoeba histolytica | hypothetical protein | 0.0147 | 0.1888 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.