Detailed information for compound 76902

Basic information

Technical information
  • TDR Targets ID: 76902
  • Name: 1-[2,6-di(propan-2-yl)phenyl]-3-[2-phenyl-2-( pyridin-3-ylmethylamino)ethyl]urea
  • MW: 430.585 | Formula: C27H34N4O
  • H donors: 3 H acceptors: 2 LogP: 4.7 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c(cccc1C(C)C)C(C)C)NCC(c1ccccc1)NCc1cccnc1
  • InChi: 1S/C27H34N4O/c1-19(2)23-13-8-14-24(20(3)4)26(23)31-27(32)30-18-25(22-11-6-5-7-12-22)29-17-21-10-9-15-28-16-21/h5-16,19-20,25,29H,17-18H2,1-4H3,(H2,30,31,32)
  • InChiKey: XXQAELFWFGIAAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,6-diisopropylphenyl)-3-[2-phenyl-2-(3-pyridylmethylamino)ethyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Acyl coenzyme A:cholesterol acyltransferase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma mansoni sterol O-acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
Echinococcus granulosus sterol O acyltransferase 1 Get druggable targets OG5_133487 All targets in OG5_133487
Schistosoma japonicum ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative Get druggable targets OG5_133487 All targets in OG5_133487
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133487 All targets in OG5_133487
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum diacylglycerol O-acyltransferase 1 Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 547 aa 22.3 %
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 24.1 %
Neospora caninum sterol O-acyltransferase, putative Acyl coenzyme A:cholesterol acyltransferase 1   545 aa 510 aa 21.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0259 0.0259
Loa Loa (eye worm) hhat protein 0.0026 0.025 0.0361
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0026 0.025 0.025
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0026 0.025 0.025
Entamoeba histolytica vacuolar protein sorting 26 0.0026 0.025 0.4793
Trichomonas vaginalis transmembrane protein nessy, putative 0.0026 0.025 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.025 0.025
Echinococcus granulosus neutral amino acid transporter A 0.0126 0.3065 0.3065
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0066 0.0096
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0259 0.0259
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0066 0.0066
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0066 0.0096
Brugia malayi MBOAT family protein 0.0026 0.025 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Trypanosoma cruzi GUP1, putative 0.0026 0.025 0.1885
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0521 0.0521
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0126 0.3065 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.025 0.4793
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0066 0.0096
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1232 0.1232
Leishmania major cathepsin L-like protease 0.0064 0.1325 1
Entamoeba histolytica hypothetical protein 0.0019 0.0066 0.1272
Loa Loa (eye worm) hhat protein 0.0026 0.025 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Schistosoma mansoni zinc finger protein 0.0026 0.025 0.0361
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.025 0.4793
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0026 0.025 0.0361
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0066 0.0096
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0066 0.0096
Schistosoma mansoni survival motor neuron protein 0.0048 0.0882 0.1275
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1232 0.9298
Echinococcus granulosus excitatory amino acid transporter 3 0.0126 0.3065 0.3065
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0126 0.3065 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0066 0.0096
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.025 0.1885
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0026 0.025 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Toxoplasma gondii hypothetical protein 0.0026 0.025 0.2027
Leishmania major cathepsin L-like protease 0.0064 0.1325 1
Echinococcus multilocularis excitatory amino acid transporter 2 0.0126 0.3065 0.3065
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.025 0.4793
Brugia malayi Hhat protein 0.0026 0.025 0.0405
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0026 0.025 0.0361
Echinococcus granulosus Excitatory amino acid transporter 0.0126 0.3065 0.3065
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0026 0.025 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.025 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0026 0.025 0.1881
Chlamydia trachomatis neutral amino acid transporter 0.0056 0.1096 0.3461
Echinococcus multilocularis neutral amino acid transporter A 0.0126 0.3065 0.3065
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0361
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0066 0.0096
Chlamydia trachomatis glutamate symporter 0.0126 0.3065 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0066 0.0066
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0066 0.0096
Brugia malayi hypothetical protein 0.0019 0.0066 0.0108
Brugia malayi PXA domain containing protein 0.0019 0.0066 0.0108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1232 1
Entamoeba histolytica hypothetical protein 0.0019 0.0066 0.1272
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0066 0.0066
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0126 0.3065 0.4433
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.025 0.0361
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.025 0.1885
Loa Loa (eye worm) excitatory amino acid transporter 0.0126 0.3065 0.4433
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1232 0.3913
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0066 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0026 0.025 0.025
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0066 0.0108
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1232 0.1782
Treponema pallidum glutamate transporter 0.0056 0.1096 1
Brugia malayi hypothetical protein 0.0019 0.0066 0.0108
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1232 0.1232
Leishmania major glycerol uptake protein, putative 0.0026 0.025 0.1885
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.0096
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0066 0.2653
Echinococcus multilocularis neutral amino acid transporter A 0.0126 0.3065 0.3065
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0521 0.0754
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0066 0.0066
Brugia malayi MBOAT family protein 0.0026 0.025 0.0405
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.025 0.025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0026 0.025 1
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0026 0.025 0.0361
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0066 0.0066
Brugia malayi diacylglycerol acyltransferase 0.0026 0.025 0.0405
Leishmania major glycerol uptake protein, putative 0.0026 0.025 0.1885
Brugia malayi Excitatory amino acid transporter 0.0126 0.3065 0.4973
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0066 0.0108
Brugia malayi MBOAT family protein 0.0026 0.025 0.0405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0882 0.1431
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.1096 0.1585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Onchocerca volvulus 0.0048 0.0882 0.2877
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.0096
Onchocerca volvulus 0.0026 0.025 0.0815
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0066 0.0096
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.025 0.0361
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.6162 0.6162
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Loa Loa (eye worm) MBOAT family protein 0.0026 0.025 0.0361
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0026 0.025 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Loa Loa (eye worm) hypothetical protein 0.0238 0.6191 0.8957
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0026 0.025 0.025
Echinococcus granulosus excitatory amino acid transporter 2 0.0126 0.3065 0.3065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1232 1
Trypanosoma cruzi GUP1, putative 0.0026 0.025 0.1885
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.025 0.025
Leishmania major glycerol uptake protein, putative 0.0026 0.025 0.1885
Brugia malayi MBOAT family protein 0.0026 0.025 0.0405
Leishmania major glycerol uptake protein, putative 0.0026 0.025 0.1885
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0026 0.025 0.0361
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.025 0.025
Echinococcus multilocularis neutral amino acid transporter A 0.0126 0.3065 0.3065
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0066 0.2653
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1325 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1232 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.025 1
Echinococcus granulosus neutral amino acid transporter A 0.0126 0.3065 0.3065
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0126 0.3065 0.3065
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0066 0.0108
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0066 0.0096
Loa Loa (eye worm) MBOAT family protein 0.0026 0.025 0.0361
Brugia malayi hypothetical protein 0.0237 0.6162 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0126 0.3065 0.3065
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0066 0.0096
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0066 0.0066
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.6162 0.6162
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1325 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0066 0.0096
Leishmania major hypothetical protein, conserved 0.0026 0.025 0.1885
Brugia malayi MBOAT family protein 0.0026 0.025 0.0405
Trichomonas vaginalis porcupine, putative 0.0026 0.025 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0066 0.0066
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0066 0.0066
Echinococcus multilocularis expressed protein 0.0374 1 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0056 0.1096 0.1096
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0056 0.1096 0.1585
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0026 0.025 0.025
Leishmania major cathepsin L-like protease 0.0064 0.1325 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1232 1
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0066 0.0066
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.1325 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0066 0.0096
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0026 0.025 0.025
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0126 0.3065 0.3065
Echinococcus granulosus neutral amino acid transporter 0.0126 0.3065 0.3065
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0026 0.025 0.025
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0035 0.0521 1
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.1325 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.0126 0.3065 0.3065
Brugia malayi hypothetical protein 0.0035 0.0521 0.0845
Entamoeba histolytica hypothetical protein 0.0019 0.0066 0.1272
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0066 0.0066
Entamoeba histolytica hypothetical protein 0.0026 0.025 0.4793
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0066 0.0108
Loa Loa (eye worm) MBOAT family protein 0.0026 0.025 0.0361
Leishmania major glycerol uptake protein, putative 0.0026 0.025 0.1885
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0066 0.0066
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0026 0.025 0.025
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0026 0.025 0.025
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0259 0.0259
Schistosoma mansoni sterol O-acyltransferase 1 0.0264 0.6912 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0066 0.0096
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0056 0.1096 0.1096
Brugia malayi PXA domain containing protein 0.0019 0.0066 0.0108
Schistosoma mansoni hypothetical protein 0.0048 0.0882 0.1275
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0026 0.025 0.2027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.094 0.7098
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1169 0.8824
Loa Loa (eye worm) hypothetical protein 0.0264 0.6912 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.6162 0.8915
Trypanosoma cruzi glycerol uptake protein, putative 0.0026 0.025 0.1885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0361
Echinococcus granulosus sterol O acyltransferase 1 0.0264 0.6912 0.6912
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.025 1
Echinococcus granulosus excitatory amino acid transporter 2 0.0126 0.3065 0.3065
Schistosoma mansoni hypothetical protein 0.0026 0.025 0.0361
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0066 0.0096
Treponema pallidum glutamate/aspartate transporter 0.0056 0.1096 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0026 0.025 0.025
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0026 0.025 0.4793
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0066 0.0096
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0026 0.025 0.0361
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0026 0.025 0.0361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0126 0.3065 0.3065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.1325 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0066 0.0096
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0066 0.0108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0521 0.0521
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0066 0.0066
Echinococcus multilocularis Excitatory amino acid transporter 0.0126 0.3065 0.3065
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1232 0.1782
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0035 0.0521 0.0754
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0126 0.3065 0.5
Echinococcus multilocularis excitatory amino acid transporter 2 0.0126 0.3065 0.3065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Echinococcus granulosus Excitatory amino acid transporter 0.0126 0.3065 0.3065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0066 0.0096
Echinococcus granulosus o acyltransferase membrane bound domain 0.0026 0.025 0.025
Echinococcus multilocularis sterol O acyltransferase 1 0.0264 0.6912 0.6912
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0026 0.025 0.2027
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0066 0.0108

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -26 % Percent change in total cholesterol in cholic acid (0.5%)-cholesterol (1.5%)-peanut oil (5.5%)-fed rats ChEMBL. 8021920
clogP = 4.17 Calculated partition coefficient (clogP) ChEMBL. 8021920
IC50 (binding) = 0.37 uM In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]-oleolyl-CoA ChEMBL. 8021920
IC50 (binding) = 0.37 uM In vitro inhibition of rat intestinal acyl coenzyme A:cholesterol acyltransferase using [1-14C]-oleolyl-CoA ChEMBL. 8021920

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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