TDR Targets

Basic information

Technical information

TDR Targets ID: 769370
Name: ethyl 6-chloro-4-(3-hydroxypropylamino)-8-met hylquinoline-3-carboxylate
MW: 322.787 | Formula: C16H19ClN2O3
H donors: 2 H acceptors: 3 LogP: 3.61 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OCCCNc1c(cnc2c1cc(Cl)cc2C)C(=O)OCC
InChi: 1S/C16H19ClN2O3/c1-3-22-16(21)13-9-19-14-10(2)7-11(17)8-12(14)15(13)18-5-4-6-20/h7-9,20H,3-6H2,1-2H3,(H,18,19)
InChiKey: TYIZBYNMSGHVBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 6-chloro-4-(3-hydroxypropylamino)-8-methyl-quinoline-3-carboxylate
6-chloro-4-(3-hydroxypropylamino)-8-methyl-3-quinolinecarboxylic acid ethyl ester
6-chloro-4-(3-hydroxypropylamino)-8-methyl-quinoline-3-carboxylic acid ethyl ester
BAS 04807942

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.0473	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0015	0.0094	0.1426
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.0473	0.1361
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.1123	0.1931
Echinococcus granulosus	expressed protein	0.0033	0.0328	0.0532
Plasmodium vivax	glutathione reductase, putative	0.0042	0.0444	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0432	0.1275
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0432	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Mycobacterium ulcerans	lipase LipD	0.0041	0.0432	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.0432	0.1041
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0473	0.1361
Brugia malayi	latrophilin 2 splice variant baaae	0.0177	0.2155	0.6699
Echinococcus granulosus	lamin dm0	0.0056	0.0623	0.1051
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Trypanosoma brucei	trypanothione reductase	0.0042	0.0444	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0473	0.1361
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0097	0.1132	0.8368
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0082	0.0948	0.0925
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0318	0.6901
Schistosoma mansoni	hypothetical protein	0.019	0.2312	0.4011
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0315	0.086
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0259	0.3195	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.0473	0.0788
Loa Loa (eye worm)	intermediate filament protein	0.0056	0.0623	0.1562
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0473	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.005	0.0025
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.0473	0.0788
Brugia malayi	cytoplasmic intermediate filament protein	0.003	0.0291	0.0783
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0015	0.0094	0.0883
Loa Loa (eye worm)	thioredoxin reductase	0.0042	0.0444	0.1076
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.0473	0.1153
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0432	0.1069
Brugia malayi	steroid hormone receptor	0.0045	0.0473	0.1361
Schistosoma mansoni	hypothetical protein	0.0301	0.3719	0.6477
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0097	0.1132	0.3285
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.0473	0.0449
Schistosoma mansoni	nuclear receptor nhr-48	0.0021	0.0174	0.0262
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0069	0.0788	0.1338
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.017	0.0146
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.0473	0.1361
Echinococcus granulosus	nuclear receptor nhr 48	0.0021	0.0174	0.0263
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.1123	0.1925
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0015	0.0094	0.0069
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0024	0.0206	0.0182
Loa Loa (eye worm)	glutathione reductase	0.0042	0.0444	0.1076
Schistosoma mansoni	lamin	0.0056	0.0623	0.1049
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0432	0.1069
Brugia malayi	hypothetical protein	0.0043	0.0448	0.1281
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0056	0.0623	0.1562
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0094	0.1426
Echinococcus granulosus	dnaJ subfamily B	0.0458	0.5712	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0448	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.0432	0.0715
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0354	0.0576
Mycobacterium tuberculosis	Conserved protein	0.0041	0.0432	0.1069
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.005	0.0044
Mycobacterium tuberculosis	Probable reductase	0.0097	0.1132	0.3285
Brugia malayi	hypothetical protein	0.0021	0.0174	0.0413
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.0473	0.093
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0197	0.0582
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0094	0.1426
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0197	0.0582
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.0473	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0024	0.0206	0.0318
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0015	0.0094	0.012
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0265	0.024
Loa Loa (eye worm)	hypothetical protein	0.0026	0.024	0.0518
Echinococcus multilocularis	expressed protein	0.0033	0.0328	0.0303
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0021	0.0174	0.0339
Brugia malayi	nuclear receptor RXR	0.0021	0.0174	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.1123	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0055	0.061	0.1526
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.1123	0.3425
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.0473	0.1153
Echinococcus multilocularis	geminin	0.019	0.2312	0.2293
Brugia malayi	ecdysone receptor	0.0021	0.0174	0.0413
Echinococcus multilocularis	GPCR, family 2	0.0082	0.0948	0.0925
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.0473	0.0785
Schistosoma mansoni	zinc finger protein	0.0021	0.0174	0.0262
Schistosoma mansoni	importin beta-1	0.0028	0.0265	0.042
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0415	0.5163	0.9034
Onchocerca volvulus		0.0274	0.3385	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.0473	0.1153
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0082	0.0948	0.2447
Loa Loa (eye worm)	nuclear hormone receptor	0.0021	0.0174	0.0339
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0082	0.0948	0.1622
Echinococcus multilocularis	nuclear receptor nhr 48	0.0021	0.0174	0.015
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0021	0.0174	0.0262
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.0473	0.1153
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.0473	0.0785
Plasmodium falciparum	glutathione reductase	0.0042	0.0444	1
Trichomonas vaginalis	glutathione reductase, putative	0.0015	0.0094	0.0277
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.0473	0.093
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Schistosoma mansoni	thyroid hormone receptor	0.0459	0.5728	1
Onchocerca volvulus		0.0045	0.0473	0.093
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.0473	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0473	0.1361
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.0473	0.1153
Schistosoma mansoni	thyroid hormone receptor	0.0459	0.5728	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Plasmodium falciparum	thioredoxin reductase	0.0042	0.0444	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0027	0.0253	0.0401
Brugia malayi	Pre-SET motif family protein	0.0241	0.2964	0.9268
Toxoplasma gondii	ABC1 family protein	0.0041	0.0432	0.6
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.0473	0.0449
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.0473	0.0788
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0354	0.4819
Mycobacterium ulcerans	hypothetical protein	0.0041	0.0432	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.0473	0.0785
Brugia malayi	nuclear hormone receptor	0.0045	0.0473	0.1361
Toxoplasma gondii	NADPH-glutathione reductase	0.0015	0.0094	0.0883
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0432	0.1275
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.0432	0.123
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.0432	0.1069
Schistosoma mansoni	ran	0.0021	0.017	0.0255
Echinococcus multilocularis	snurportin 1	0.0301	0.3719	0.3703
Loa Loa (eye worm)	beta-lactamase	0.0041	0.0432	0.1041
Echinococcus granulosus	geminin	0.019	0.2312	0.4022
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.0473	0.0449
Schistosoma mansoni	hypothetical protein	0.0043	0.0448	0.0742
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.0473	0.093
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.0432	0.0408
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.0432	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Onchocerca volvulus		0.0032	0.0315	0.0439
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0174	0.0413
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.3719	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0259	0.3195	0.8571
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0094	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0432	0.9686
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0432	0.0713
Echinococcus granulosus	intermediate filament protein	0.0056	0.0623	0.1051
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0473	0.0449
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0206	0.0514
Brugia malayi	Nuclear hormone receptor E75	0.0021	0.0174	0.0413
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0452	0.075
Schistosoma mansoni	hypothetical protein	0.0082	0.0948	0.1618
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0.0094	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0048	0.0012
Schistosoma mansoni	cpg binding protein	0.0034	0.0338	0.055
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0015	0.0094	0.1426
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0174	0.0263
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.0473	0.0788
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.0473	0.1361
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0021	0.0174	0.0262
Onchocerca volvulus		0.0041	0.0432	0.0801
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0265	0.0421
Brugia malayi	nuclear receptor NHR-67	0.0021	0.0174	0.0413
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0448	0.0742
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0328	0.0899
Trichomonas vaginalis	ran, putative	0.0021	0.017	0.0503
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0107	0.1269	1
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.0473	0.0785
Entamoeba histolytica	hypothetical protein	0.0043	0.0448	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0318	0.6901
Brugia malayi	hypothetical protein	0.0024	0.0206	0.0514
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0015	0.0094	0.1426
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.0432	0.1275
Brugia malayi	Thioredoxin reductase	0.0042	0.0444	0.127
Echinococcus multilocularis	dnaJ subfamily B	0.0458	0.5712	0.5702
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.0432	0.1069
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0042	0.0444	0.111
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.0473	0.0449
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.0473	0.1361
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0174	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0354	0.0828
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0354	0.0576
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0021	0.0174	0.0413
Loa Loa (eye worm)	DR-78	0.0021	0.0174	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0253	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.1123	0.1925
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0426
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.1123	0.1925
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0473	0.1361
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0473	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Mycobacterium tuberculosis	Probable dehydrogenase	0.0097	0.1132	0.3285
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.0432	0.1069
Schistosoma mansoni	hypothetical protein	0.0458	0.5712	0.9972
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.003	0.0291	0.0657
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.0432	0.1069
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.0473	0.0788
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0318	0.5306
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0329	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0426
Brugia malayi	Importin beta-1 subunit	0.0028	0.0265	0.0699
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0318	0.6901
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0448	0.0744
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Mycobacterium ulcerans	beta-lactamase	0.0041	0.0432	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.017	0.3301
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0107	0.1269	0.3717
Schistosoma mansoni	rotamase	0.0033	0.0328	0.0531
Schistosoma mansoni	hypothetical protein	0.0415	0.5163	0.9009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.0473	0.1153
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.0473	0.0785
Brugia malayi	RNA, U transporter 1	0.008	0.0923	0.2789
Schistosoma mansoni	cpg binding protein	0.0034	0.0338	0.055
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0315	0.0723
Brugia malayi	tailless protein	0.0021	0.0174	0.0413
Schistosoma mansoni	nuclear receptor	0.0021	0.0174	0.0262
Leishmania major	hypothetical protein, conserved	0.0041	0.0432	0.9686
Loa Loa (eye worm)	hypothetical protein	0.0026	0.024	0.0518
Echinococcus granulosus	GPCR family 2	0.0082	0.0948	0.1622
Trichomonas vaginalis	mercuric reductase, putative	0.0015	0.0094	0.0277
Echinococcus multilocularis	lamin	0.0056	0.0623	0.06
Brugia malayi	glutathione reductase	0.0042	0.0444	0.127
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0174	0.015
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0426
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0097	0.1132	0.3285
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0264	0.3255	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0024	0.0206	0.0319
Toxoplasma gondii	thioredoxin reductase	0.0042	0.0444	0.6194
Schistosoma mansoni	coup transcription factor	0.0045	0.0473	0.0785
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0082	0.0948	0.0925
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0354	0.0578
Trichomonas vaginalis	rotamase, putative	0.0033	0.0328	0.0968
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0024	0.0206	0.0318
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.1123	0.2925
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0015	0.0094	0.1426
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.017	0.3301
Echinococcus multilocularis	lamin dm0	0.0056	0.0623	0.06
Entamoeba histolytica	hypothetical protein	0.0043	0.0448	1
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0415	0.5163	0.5151
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Brugia malayi	nuclear hormone receptor	0.0021	0.0174	0.0413
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.0432	0.1069
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.0432	0.1069
Schistosoma mansoni	lamin	0.0056	0.0623	0.1049
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0021	0.0174	0.0339
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0174	0.015
Schistosoma mansoni	hypothetical protein	0.019	0.2312	0.4011
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0174	0.0263
Trypanosoma cruzi	trypanothione reductase, putative	0.0042	0.0444	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0107	0.1269	0.3717
Brugia malayi	intermediate filament protein	0.0056	0.0623	0.1837
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.0473	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0948	0.2447
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0015	0.0094	0.0121
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.0473	0.1153
Plasmodium falciparum	importin beta, putative	0.0028	0.0265	0.4874
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.0432	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0265	0.3472
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.017	0.2187
Trichomonas vaginalis	set domain proteins, putative	0.0274	0.3385	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0473	0.1361
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Plasmodium vivax	SET domain protein, putative	0.0035	0.0354	0.7412
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0174	0.0262
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0452	0.0428
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0062	0.0696	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0623	0.1562
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0265	0.5605
Schistosoma mansoni	hypothetical protein	0.0177	0.2155	0.3734
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.0473	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0426
Brugia malayi	hypothetical protein	0.0024	0.0206	0.0514
Onchocerca volvulus		0.0041	0.0432	0.0801
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.0473	0.1361
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0265	0.0586
Schistosoma mansoni	hypothetical protein	0.0082	0.0948	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Brugia malayi	beta-lactamase family protein	0.0041	0.0432	0.123
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0097	0.1132	0.3285
Brugia malayi	nuclear receptor RXR	0.0024	0.0206	0.0514
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0024	0.0206	0.0426
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0354	0.0576
Trichomonas vaginalis	esterase, putative	0.0041	0.0432	0.1275
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0015	0.0094	0.1426
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.0473	0.0785
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0448	0.0424
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.0432	0.0713
Brugia malayi	nuclear hormone receptor family member odr-7	0.0021	0.0174	0.0413
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.0432	0.9686
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0473	0.1153
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0473	0.1361
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0197	0.0582
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0328	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0259	0.3195	0.8571
Trichomonas vaginalis	rotamase, putative	0.0032	0.0318	0.0938
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0021	0.0174	0.0413
Echinococcus granulosus	cpg binding protein	0.0034	0.0338	0.0551
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0473	0.0788
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0459	0.5728	0.5718
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0027	0.0253	0.0228
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0354	0.033
Brugia malayi	hypothetical protein	0.0021	0.0174	0.0413
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0021	0.0174	0.0263
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.0473	0.1361
Brugia malayi	Latrophilin receptor protein 2	0.0082	0.0948	0.2868
Echinococcus granulosus	thyroid hormone receptor alpha	0.0021	0.0174	0.0263
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.017	0.2045
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.0432	0.1069
Schistosoma mansoni	hypothetical protein	0.0082	0.0948	0.1618
Schistosoma mansoni	cpg binding protein	0.0032	0.0315	0.0509
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0206	0.0426
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.0473	0.0785
Brugia malayi	ecdysteroid receptor	0.0045	0.0473	0.1361
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0241	0.2964	0.7943
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.0473	0.0788
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0021	0.0174	0.015
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.0432	1
Entamoeba histolytica	hypothetical protein	0.0043	0.0448	1
Echinococcus multilocularis	cpg binding protein	0.0034	0.0338	0.0314
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.017	0.0329
Brugia malayi	Pre-SET motif family protein	0.0035	0.0354	0.0982
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0082	0.0948	0.2868
Brugia malayi	beta-lactamase family protein	0.0041	0.0432	0.123
Leishmania major	trypanothione reductase	0.0042	0.0444	1
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0021	0.0174	0.015
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.0432	0.9686
Brugia malayi	nuclear receptor NHR-88	0.0045	0.0473	0.1361
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.1123	0.1931
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.017	0.3301
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0473	0.0788
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.0432	0.9634
Loa Loa (eye worm)	hypothetical protein	0.0177	0.2155	0.5737
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.017	0.0256
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0197	0.3955
Trypanosoma cruzi	trypanothione reductase, putative	0.0015	0.0094	0.1426
Onchocerca volvulus		0.0056	0.0623	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.0473	0.0785
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0174	0.0262
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0107	0.1269	0.3717
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.1123	0.1101
Onchocerca volvulus		0.0056	0.0623	0.1397
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0265	0.4874
Brugia malayi	conserved hypotetical protein	0.0021	0.0174	0.0413
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0318	0.4274
Leishmania major	GTP-binding protein, putative	0.0021	0.017	0.3301
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0473	0.1361
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0021	0.0174	0.0263
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0015	0.0094	0.0157
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0259	0.3195	1
Onchocerca volvulus		0.0041	0.0432	0.0801
Schistosoma mansoni	intermediate filament proteins	0.0056	0.0623	0.1049
Brugia malayi	beta-lactamase	0.0041	0.0432	0.123
Brugia malayi	Nuclear hormone receptor-like 1	0.0024	0.0206	0.0514
Schistosoma mansoni	nuclear receptor	0.0021	0.0174	0.0262
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0265	0.5605
Echinococcus multilocularis	musashi	0.0056	0.0623	0.06
Echinococcus granulosus	lamin	0.0056	0.0623	0.1051
Brugia malayi	orphan nuclear receptor NR2E1	0.0021	0.0174	0.0413
Brugia malayi	Intermediate filament tail domain containing protein	0.0056	0.0623	0.1837
Plasmodium vivax	thioredoxin reductase, putative	0.0042	0.0444	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0015	0.0094	0.1426
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.0473	0.1361
Schistosoma mansoni	hypothetical protein	0.0082	0.0948	0.1618
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0097	0.1132	0.3285
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0197	0.3955
Entamoeba histolytica	hypothetical protein	0.0023	0.0197	0.0963
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0432	0.1041
Schistosoma mansoni	ran	0.0021	0.017	0.0255
Onchocerca volvulus		0.0035	0.0354	0.0559
Treponema pallidum	NADH oxidase	0.0015	0.0094	0.5
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.017	0.04
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0021	0.0174	0.015
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0328	0.0757
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0174	0.0339
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0318	0.6901
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0015	0.0094	0.1426
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0354	0.033
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0082	0.0948	0.1622
Echinococcus granulosus	snurportin 1	0.0301	0.3719	0.6495
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.017	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.017	0.2187
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.0473	0.0788
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0015	0.0094	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.0473	0.1153
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0354	0.0576

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 769370