Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.348 | 0.3605 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.8342 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.348 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.0738 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.0738 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0738 | 1 |
Onchocerca volvulus | 0.0092 | 0.4981 | 0.5 | |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.0738 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0738 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 0.348 | 0.296 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0738 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.0738 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.348 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0738 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 0.348 | 0.3605 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.0738 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.8342 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0738 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 0.348 | 0.296 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.0738 | 0.0738 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0738 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.0738 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.0738 | 0.0738 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.0738 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.348 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0738 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 0.348 | 1 |
Brugia malayi | hypothetical protein | 0.0072 | 0.348 | 0.348 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.