Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0165 | 0.4101 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.3351 | 0.3966 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0739 | 0.0739 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0432 | 0.0467 |
Brugia malayi | Probable ClpP-like protease | 0.0165 | 0.4101 | 0.4101 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3326 | 0.3936 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0064 | 0.1275 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 0.4432 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0096 | 0.0103 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.084 | 0.084 |
Echinococcus granulosus | snurportin 1 | 0.0317 | 0.8449 | 0.913 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0499 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2101 | 0.2486 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2101 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0224 | 0.0224 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0499 | 0.054 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0499 | 0.1218 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0064 | 0.1275 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.3326 | 0.3326 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0165 | 0.4101 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.3326 | 0.3326 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0098 | 0.0098 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0129 | 0.3055 | 0.3302 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3326 | 0.3936 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0317 | 0.8449 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0376 | 0.0445 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0524 | 0.0566 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.1774 | 0.1774 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0025 | 0.0098 | 0.0106 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0499 | 0.0591 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.1285 | 0.1388 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0499 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3326 | 0.3936 |
Loa Loa (eye worm) | Smad1 | 0.0025 | 0.0098 | 0.0098 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0025 | 0.0098 | 0.0106 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0025 | 0.0098 | 0.0098 |
Brugia malayi | Smad1 | 0.0025 | 0.0098 | 0.0098 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0129 | 0.3055 | 0.3302 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2101 | 0.2486 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0432 | 0.8653 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0499 | 0.0591 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.082 | 0.0971 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0001 | 0.0001 |
Echinococcus multilocularis | tumor protein p63 | 0.0345 | 0.9254 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0098 | 0.0098 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.084 | 0.084 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0499 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.084 | 0.084 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0432 | 0.8653 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0139 | 0.3351 | 0.3621 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0224 | 0.0547 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.3326 | 0.3326 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0224 | 0.0243 |
Leishmania major | importin beta-1 subunit, putative | 0.0024 | 0.0064 | 0.1275 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0224 | 0.0547 |
Schistosoma mansoni | Smad4 | 0.0025 | 0.0098 | 0.0116 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0025 | 0.0098 | 0.0106 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0098 | 0.0116 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0057 | 0.1003 | 0.2445 |
Onchocerca volvulus | 0.0051 | 0.082 | 0.5 | |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.1399 | 0.1656 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0376 | 0.0376 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0224 | 0.4493 |
Brugia malayi | RNA binding protein | 0.0138 | 0.3326 | 0.3326 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.3326 | 0.3326 |
Brugia malayi | MH1 domain containing protein | 0.0025 | 0.0098 | 0.0098 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0376 | 0.0376 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0108 | 0.2473 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0025 | 0.0098 | 0.0098 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0224 | 0.0547 |
Echinococcus granulosus | Smad4 | 0.0025 | 0.0098 | 0.0106 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0224 | 0.4493 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0371 | 1 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.0224 | 0.0243 |
Echinococcus multilocularis | Smad4 | 0.0025 | 0.0098 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.4101 | 0.4101 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3326 | 0.3936 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.2101 | 0.2486 |
Echinococcus multilocularis | snurportin 1 | 0.0317 | 0.8449 | 0.913 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0084 | 0.1792 | 0.1792 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0371 | 1 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0024 | 0.0064 | 0.1275 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0499 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.2101 | 0.2101 |
Trichomonas vaginalis | importin beta-1, putative | 0.0024 | 0.0064 | 0.1275 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0057 | 0.1003 | 0.2445 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0108 | 0.2473 | 0.4744 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0098 | 0.0116 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0165 | 0.4101 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0432 | 0.0432 |
Echinococcus granulosus | smad | 0.0025 | 0.0098 | 0.0106 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0499 | 0.1218 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0524 | 0.0566 |
Schistosoma mansoni | thyroid hormone receptor | 0.0139 | 0.3351 | 0.3966 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.2101 | 0.2101 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0035 | 0.0035 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0108 | 0.2473 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0224 | 0.0224 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0499 | 0.1218 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0171 | 0.0171 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0165 | 0.4101 | 0.4854 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0432 | 0.0512 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0025 | 0.0098 | 0.0106 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1637 | 0.1637 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.3326 | 0.3326 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.082 | 0.082 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0165 | 0.4101 | 0.4432 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.084 | 0.084 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0678 | 0.0678 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0432 | 0.0467 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.1003 | 0.2445 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0108 | 0.2473 | 0.2672 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0499 | 0.054 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0057 | 0.1003 | 0.1398 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.3055 | 0.3616 |
Echinococcus granulosus | tumor protein p63 | 0.0345 | 0.9254 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0108 | 0.2473 | 0.2672 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0165 | 0.4101 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0499 | 0.0499 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0317 | 0.8449 | 0.8449 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0499 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3326 | 0.3936 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0035 | 0.0041 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0096 | 0.0103 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.2101 | 0.227 |
Schistosoma mansoni | smad | 0.0025 | 0.0098 | 0.0116 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0096 | 0.0113 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0432 | 0.8653 |
Schistosoma mansoni | smad1 5 8 and | 0.0025 | 0.0098 | 0.0116 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0025 | 0.0098 | 0.0098 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0432 | 0.0512 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.06 | 0.06 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.0224 | 0.0266 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.1285 | 0.1388 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.0499 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0025 | 0.0098 | 0.0116 |
Echinococcus multilocularis | tar DNA binding protein | 0.0138 | 0.3326 | 0.3594 |
Echinococcus multilocularis | smad | 0.0025 | 0.0098 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0602 | 0.0602 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0499 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0138 | 0.3326 | 0.3594 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0024 | 0.0064 | 0.1275 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0432 | 0.8653 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0499 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2101 | 0.227 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.2101 | 0.227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.