Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0009 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.5807 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4947 | 0.8519 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.5807 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.5807 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4947 | 0.8519 |
Brugia malayi | hypothetical protein | 0.0073 | 0.5807 | 0.1702 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4947 | 0.8519 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.0009 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.5807 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 1 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.5807 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4947 | 0.8519 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.5807 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.5807 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.4947 | 0.8519 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.5807 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.4947 | 0.8519 |
Trichomonas vaginalis | ferritin, putative | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.4947 | 0.8519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.