Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.049 | 0.1911 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.05 | 0.049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0585 | 0.2565 | 0.2557 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0144 | 0.049 | 0.3942 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0153 | 0.0531 | 0.0521 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0144 | 0.049 | 0.3942 |
Schistosoma mansoni | tar DNA-binding protein | 0.0585 | 0.2565 | 0.2557 |
Loa Loa (eye worm) | TAR-binding protein | 0.0585 | 0.2565 | 1 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0042 | 0.0011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0011 | 0.0042 |
Brugia malayi | AMP-binding enzyme family protein | 0.0144 | 0.049 | 0.1877 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0042 | 0.0011 | 0.0003 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0585 | 0.2565 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0102 | 0.0291 | 0.5844 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.017 | 0.0611 | 0.0604 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0144 | 0.049 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0585 | 0.2565 | 0.2559 |
Echinococcus multilocularis | tumor protein p63 | 0.1044 | 0.473 | 0.4726 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0102 | 0.0291 | 0.5844 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0176 | 0.0641 | 0.0631 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0319 | 0.1242 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0144 | 0.049 | 0.7611 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.0299 | 0.1128 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.0357 | 0.139 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0641 | 0.0631 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0042 | 0.0011 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0108 | 0.0319 | 0.2531 |
Loa Loa (eye worm) | glutaminase | 0.0301 | 0.1227 | 0.4784 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0144 | 0.049 | 1 |
Onchocerca volvulus | 0.0153 | 0.0531 | 1 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0176 | 0.0641 | 0.0634 |
Brugia malayi | AMP-binding enzyme family protein | 0.0144 | 0.049 | 0.1877 |
Schistosoma mansoni | tar DNA-binding protein | 0.0585 | 0.2565 | 0.2557 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0319 | 0.1242 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.05 | 0.049 |
Echinococcus multilocularis | lamin | 0.0086 | 0.0217 | 0.021 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0144 | 0.049 | 0.3942 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0042 | 0.0011 | 0.0003 |
Mycobacterium ulcerans | glutaminase | 0.0301 | 0.1227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0145 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0217 | 0.0848 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0046 | 0.0029 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0319 | 0.1242 |
Echinococcus granulosus | tumor protein p63 | 0.1044 | 0.473 | 0.4726 |
Brugia malayi | TAR-binding protein | 0.0585 | 0.2565 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0585 | 0.2565 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0585 | 0.2565 | 0.2557 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0108 | 0.0319 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0086 | 0.0217 | 0.0848 |
Schistosoma mansoni | tar DNA-binding protein | 0.0585 | 0.2565 | 0.2557 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0144 | 0.049 | 1 |
Brugia malayi | intermediate filament protein | 0.0086 | 0.0217 | 0.0809 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0319 | 0.1242 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0108 | 0.0319 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0144 | 0.049 | 0.1877 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0042 | 0.0011 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0301 | 0.1227 | 0.4762 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0007 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0531 | 0.2072 |
Trichomonas vaginalis | glutaminase, putative | 0.0301 | 0.1227 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0042 | 0.0011 | 0.0042 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.0641 | 1 |
Brugia malayi | hypothetical protein | 0.0176 | 0.0641 | 0.2466 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.0357 | 0.1354 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0145 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0299 | 0.1165 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.021 | 0.0819 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.0299 | 0.1128 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0144 | 0.049 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0086 | 0.0217 | 0.021 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.2163 | 1 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0144 | 0.049 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0144 | 0.049 | 0.3942 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0086 | 0.0217 | 0.0809 |
Toxoplasma gondii | propionate-CoA ligase | 0.0042 | 0.0011 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.0641 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0319 | 0.1242 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0108 | 0.0319 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0144 | 0.049 | 0.3942 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0086 | 0.0217 | 0.0848 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.049 | 0.1911 |
Echinococcus granulosus | lamin dm0 | 0.0086 | 0.0217 | 0.021 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0042 | 0.0011 | 0.0042 |
Echinococcus granulosus | intermediate filament protein | 0.0086 | 0.0217 | 0.021 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.0641 | 1 |
Onchocerca volvulus | 0.0144 | 0.049 | 0.9209 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 0.0611 | 0.0604 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0144 | 0.049 | 0.3942 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0042 | 0.0011 | 0.5 |
Onchocerca volvulus | 0.0098 | 0.0274 | 0.5058 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0144 | 0.049 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0585 | 0.2565 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0176 | 0.0641 | 0.0634 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.017 | 0.0611 | 0.0604 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0144 | 0.049 | 0.7611 |
Loa Loa (eye worm) | glutaminase 2 | 0.0301 | 0.1227 | 0.4784 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0042 | 0.0011 | 0.0042 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.017 | 0.0611 | 0.2351 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.049 | 0.1911 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0042 | 0.0011 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0585 | 0.2565 | 0.2559 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0042 | 0.0011 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0145 | 0.0524 |
Entamoeba histolytica | hypothetical protein | 0.0176 | 0.0641 | 1 |
Onchocerca volvulus | 0.0086 | 0.0217 | 0.397 | |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0042 | 0.0011 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0144 | 0.049 | 0.7611 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0144 | 0.049 | 0.3942 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0102 | 0.0291 | 0.5844 |
Echinococcus granulosus | lamin | 0.0086 | 0.0217 | 0.021 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.0357 | 0.139 |
Brugia malayi | RNA binding protein | 0.0585 | 0.2565 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0144 | 0.049 | 1 |
Schistosoma mansoni | glutaminase | 0.0301 | 0.1227 | 0.1218 |
Mycobacterium ulcerans | hypothetical protein | 0.0144 | 0.049 | 0.3942 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.017 | 0.0611 | 0.2383 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.0299 | 0.1165 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0108 | 0.0319 | 0.6421 |
Schistosoma mansoni | microtubule-associated protein tau | 0.2163 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0086 | 0.0217 | 0.0207 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0042 | 0.0011 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.0217 | 0.397 | |
Echinococcus multilocularis | musashi | 0.0086 | 0.0217 | 0.021 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0046 | 0.0029 | 0.0113 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0102 | 0.0291 | 0.5844 |
Schistosoma mansoni | lamin | 0.0086 | 0.0217 | 0.0207 |
Schistosoma mansoni | lamin | 0.0086 | 0.0217 | 0.0207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.