Detailed information for compound 770661

Basic information

Technical information
  • TDR Targets ID: 770661
  • Name: (E)-3-[2-(4-chlorophenoxy)-9-methyl-4-oxopyri do[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-propan- 2-yloxypropyl)prop-2-enamide
  • MW: 480.943 | Formula: C25H25ClN4O4
  • H donors: 1 H acceptors: 3 LogP: 3.51 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)Cl)nc2n(c1=O)cccc2C)C(=O)NCCCOC(C)C
  • InChi: 1S/C25H25ClN4O4/c1-16(2)33-13-5-11-28-23(31)18(15-27)14-21-24(34-20-9-7-19(26)8-10-20)29-22-17(3)6-4-12-30(22)25(21)32/h4,6-10,12,14,16H,5,11,13H2,1-3H3,(H,28,31)/b18-14+
  • InChiKey: ORFKNUNMLHGTPO-NBVRZTHBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[2-(4-chlorophenoxy)-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-isopropoxypropyl)prop-2-enamide
  • (E)-3-[2-(4-chlorophenoxy)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-cyano-N-(3-isopropoxypropyl)prop-2-enamide
  • (E)-3-[2-(4-chlorophenoxy)-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-isopropoxypropyl)acrylamide
  • (E)-3-[2-(4-chlorophenoxy)-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-cyano-N-(3-propan-2-yloxypropyl)prop-2-enamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0241 0.0338
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0026 0.0277 0.0371
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0277 0.034
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0039 0.0023
Mycobacterium leprae Probable lipase LipE 0.0041 0.0476 0.0684
Mycobacterium tuberculosis Probable oxidoreductase 0.003 0.0326 0.0471
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0203 0.0212
Schistosoma mansoni lamin 0.0028 0.0298 0.0426
Loa Loa (eye worm) thymidylate synthase 0.0338 0.439 0.5002
Mycobacterium ulcerans hypothetical protein 0.0028 0.0295 0.0401
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.049 0.6401 0.8005
Brugia malayi Smad1 0.0009 0.0055 0.0063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0232
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0394
Onchocerca volvulus 0.0043 0.0504 0.0481
Treponema pallidum thioredoxin 0.0024 0.0249 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0025 0.0258 0.0325
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0241 0.0261
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0476 0.0581
Echinococcus granulosus lamin 0.0028 0.0298 0.0426
Echinococcus granulosus histone lysine methyltransferase setb 0.0096 0.1201 0.1833
Echinococcus multilocularis geminin 0.0058 0.0695 0.0791
Onchocerca volvulus 0.0012 0.0088 0.0065
Onchocerca volvulus 0.0026 0.0277 0.0253
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0232
Brugia malayi hypothetical protein 0.0161 0.2053 0.2339
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0116
Brugia malayi dihydrofolate reductase family protein 0.0493 0.6444 0.7341
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0277 0.0371
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Toxoplasma gondii hypothetical protein 0.0043 0.0504 0.0617
Loa Loa (eye worm) hypothetical protein 0.0096 0.1201 0.1368
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0203 0.028
Schistosoma mansoni smad 0.0009 0.0055 0.0048
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0889 0.1347
Onchocerca volvulus 0.0041 0.0476 0.0453
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0026 0.0277 0.0306
Chlamydia trachomatis oxoacy-ACP reductase 0.0026 0.0277 0.0117
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0298 0.0339
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.065 0.8514 1
Brugia malayi Dihydrofolate reductase 0.0493 0.6444 0.7341
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0295 0.3283
Brugia malayi MH2 domain containing protein 0.0137 0.1737 0.1979
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0596 0.7805 0.9761
Mycobacterium ulcerans lipase LipD 0.0041 0.0476 0.0684
Echinococcus multilocularis e3 ubiquitin protein ligase RNF13 0.0016 0.0141 0.0138
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0295 0.0336
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Schistosoma mansoni dihydropteridine reductase 0.0026 0.0277 0.0393
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0241 0.0275
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Plasmodium falciparum 1-cys peroxiredoxin 0.0094 0.1173 0.1461
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0476 0.0684
Toxoplasma gondii ABC1 family protein 0.0041 0.0476 0.0582
Brugia malayi Protein kinase domain containing protein 0.0007 0.0027 0.0031
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0232
Brugia malayi PA domain containing protein 0.0016 0.0141 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0291 0.0332
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0258 0.0254
Schistosoma mansoni nicalin (M28 family) 0.0043 0.0504 0.0747
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0476 0.0472
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.0336
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0039 0.0023
Mycobacterium tuberculosis Conserved protein 0.0041 0.0476 0.0705
Loa Loa (eye worm) hypothetical protein 0.0018 0.0174 0.0198
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0039 0.0042
Loa Loa (eye worm) retinol dehydrogenase 12 0.0026 0.0277 0.0315
Leishmania major hypothetical protein, conserved 0.0041 0.0476 0.059
Brugia malayi hypothetical protein 0.0072 0.0889 0.1013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0295 0.0401
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.085 0.1084
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0025 0.0258 0.0325
Echinococcus granulosus geminin 0.0058 0.0695 0.1046
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0241 0.2673
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0026 0.0277 0.0393
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0504 0.0499
Loa Loa (eye worm) hypothetical protein 0.0026 0.0277 0.0315
Trichomonas vaginalis chaperonin, putative 0.0023 0.0241 0.0236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0203 0.0257
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0043 0.0504 0.0565
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0096 0.1201 0.1386
Schistosoma mansoni lamin 0.0028 0.0298 0.0426
Onchocerca volvulus Fxna peptidase homolog 0.0043 0.0504 0.0481
Schistosoma mansoni mannosyl-oligosaccharidealpha-12-mannosidase-r el ated 0.0016 0.0141 0.0183
Schistosoma mansoni smad1 5 8 and 0.0009 0.0055 0.0048
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0024 0.0249 0.0351
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0025 0.0258 0.0325
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0043 0.0504 0.0747
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.341 0.5275
Onchocerca volvulus 0.0028 0.0298 0.0274
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0241 0.0338
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0189 0.0257
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0036 0.0404 0.0447
Mycobacterium tuberculosis Hypothetical protein 0.0161 0.2053 0.3161
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0295 0.3283
Trypanosoma brucei protein kinase, putative 0.0025 0.0258 0.0319
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0258 0.0254
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.003 0.0326 0.0449
Echinococcus multilocularis Ankyrin 0.0007 0.0025 0.0001
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0476 0.0705
Echinococcus granulosus lamin dm0 0.0028 0.0298 0.0426
Loa Loa (eye worm) RecQ helicase 0.001 0.0069 0.0078
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0096 0.1201 0.1513
Entamoeba histolytica hypothetical protein 0.0072 0.0889 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0174 0.0198
Echinococcus multilocularis dihydrofolate reductase 0.0493 0.6444 0.7562
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0174 0.0176
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0026 0.0277 0.0117
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0241 0.0303
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.085 0.1058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0025 0.0258 0.0319
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0109 0.0132
Echinococcus granulosus GPCR family 2 0.0018 0.0174 0.0233
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0039 0.0023
Echinococcus multilocularis GPCR, family 2 0.0018 0.0174 0.0176
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0039 0.0023
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0055 0.0048
Loa Loa (eye worm) Smad1 0.0009 0.0055 0.0063
Brugia malayi Pre-SET motif family protein 0.067 0.8777 1
Toxoplasma gondii redoxin domain-containing protein 0.0094 0.1173 0.1477
Schistosoma mansoni intermediate filament proteins 0.0028 0.0298 0.0426
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0043 0.0504 0.0747
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0295 0.0401
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0039 0.0023
Onchocerca volvulus Fxna peptidase homolog 0.0043 0.0504 0.0481
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0039 0.0023
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0493 0.6444 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0277 0.0371
Brugia malayi nicalin 0.0043 0.0504 0.0574
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0596 0.7805 1
Echinococcus multilocularis musashi 0.0028 0.0298 0.0323
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0055 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0476 0.0472
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.085 0.1065
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0025 0.0258 0.0325
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0161 0.2053 0.2625
Loa Loa (eye worm) hypothetical protein 0.0008 0.0041 0.0047
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0026 0.0277 0.0394
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0277 0.0394
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0055 0.0036
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0241 0.028
Onchocerca volvulus Putative zinc finger protein 0.0016 0.0141 0.0118
Trypanosoma brucei PA domain containing protein, putative 0.0016 0.0141 0.0172
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0493 0.6444 1
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0241 0.0296
Brugia malayi intermediate filament protein 0.0028 0.0298 0.0339
Loa Loa (eye worm) hypothetical protein 0.0013 0.0102 0.0116
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0026 0.0277 0.0342
Echinococcus multilocularis bloom syndrome protein 0.001 0.0069 0.0053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0476 0.0705
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0026 0.0277 0.0325
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0024 0.0249 0.0329
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0295 0.0336
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0025 0.0258 0.0294
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0295 0.0336
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0476 0.0594
Brugia malayi beta-lactamase family protein 0.0041 0.0476 0.0543
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0024 0.0249 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0504 0.0499
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0241 0.0275
Trypanosoma brucei pteridine reductase 1 0.0607 0.7946 1
Echinococcus multilocularis mitogen activated protein kinase 0.0025 0.0258 0.0276
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0039 0.0023
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0039 0.0042
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.0336
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0026 0.0277 0.0394
Echinococcus multilocularis mitogen activated protein kinase 3 0.0025 0.0258 0.0276
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.003 0.0326 0.0449
Onchocerca volvulus 0.0008 0.0039 0.0015
Echinococcus multilocularis smad 0.0009 0.0055 0.0036
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0476 0.0705
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Mycobacterium ulcerans short chain dehydrogenase 0.003 0.0326 0.0449
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0298 0.0339
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1737 0.1979
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0889 0.1347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0189 0.0257
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0189 0.0257
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0043 0.0504 0.0565
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.085 0.1287
Onchocerca volvulus 0.0028 0.0295 0.0272
Schistosoma mansoni protease 0.0016 0.0141 0.0183
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0026 0.0277 0.3072
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0277 0.0371
Trichomonas vaginalis DNA helicase recq1, putative 0.001 0.0069 0.0064
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0596 0.7805 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0096 0.1201 0.1833
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.085 0.1084
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0039 0.0043
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0055 0.0048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0476 0.0543
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0039 0.0023
Plasmodium vivax peroxiredoxin, putative 0.0094 0.1173 0.1476
Schistosoma mansoni Smad4 0.0009 0.0055 0.0048
Brugia malayi beta-lactamase family protein 0.0041 0.0476 0.0543
Onchocerca volvulus 0.0096 0.1201 0.1179
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0295 0.0363
Onchocerca volvulus Glutaminyl cyclase homolog 0.0043 0.0504 0.0481
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0174 0.0198
Trypanosoma brucei glutaminyl cyclase, putative 0.0043 0.0504 0.0628
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0258 0.0254
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0295 0.0363
Toxoplasma gondii peptidase, M28 family protein 0.0043 0.0504 0.0617
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0476 0.0705
Mycobacterium ulcerans oxidoreductase 0.0026 0.0277 0.0371
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0055 0.0036
Loa Loa (eye worm) hypothetical protein 0.0043 0.0504 0.0574
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0696 0.0793
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0055 0.0063
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0026 0.0277 0.5
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0025 0.0258 0.0302
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0043 0.0504 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0504 0.0499
Trypanosoma cruzi glutaminyl cyclase, putative 0.0043 0.0504 0.0639
Brugia malayi MH2 domain containing protein 0.0009 0.0055 0.0063
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Brugia malayi MH1 domain containing protein 0.0009 0.0055 0.0063
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0476 0.0472
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0039 0.0023
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0026 0.0277 0.0325
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0039 0.0023
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0128 0.0146
Onchocerca volvulus 0.0041 0.0476 0.0453
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0007 0.0024 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0295 0.0423
Chlamydia trachomatis dihydrofolate reductase 0.0493 0.6444 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0055 0.0048
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0338 0.439 0.6794
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0596 0.7805 1
Onchocerca volvulus 0.0008 0.0039 0.0015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0295 0.0401
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.085 0.9566
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.003 0.0326 0.0389
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0025 0.0258 0.0317
Schistosoma mansoni zinc finger protein 0.0016 0.0141 0.0183
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0596 0.7805 0.9823
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0258 0.0365
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0096 0.1201 0.1386
Echinococcus multilocularis lamin dm0 0.0028 0.0298 0.0323
Leishmania major pteridine reductase 1 0.0611 0.7996 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.085 0.0969
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0295 0.0401
Echinococcus granulosus intermediate filament protein 0.0028 0.0298 0.0426
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0476 0.0684
Trypanosoma cruzi oxidoreductase-like protein, putative 0.003 0.0326 0.0412
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0454 0.0517
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0128 0.0146
Schistosoma mansoni hypothetical protein 0.004 0.0454 0.067
Brugia malayi beta-lactamase 0.0041 0.0476 0.0543
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0277 0.0371
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0043 0.0504 0.0499
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0039 0.0042
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0039 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0109 0.0124
Echinococcus granulosus Ankyrin 0.0007 0.0025 0.0001
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0249 0.0244
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0476 0.0705
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0476 0.0604
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.067 0.8777 1
Schistosoma mansoni hypothetical protein 0.0072 0.0889 0.1347
Echinococcus granulosus transcription factor Dp 1 0.004 0.0464 0.0685
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0007 0.0024 0.000000091097
Schistosoma mansoni ankyrin 23/unc44 0.0007 0.0024 0.000000091097
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0476 0.0604
Schistosoma mansoni hypothetical protein 0.0018 0.0174 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0504 0.0574
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0295 0.0401
Schistosoma mansoni smad1 5 8 and 0.0009 0.0055 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Mycobacterium ulcerans thymidylate synthase 0.0338 0.439 0.6794
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0338 0.439 0.6801
Trypanosoma cruzi glutaminyl cyclase, putative 0.0043 0.0504 0.0639
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0241 0.0338
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0059 0.0713 0.1053
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0241 0.0279
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0059 0.0713 0.1074
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0277 0.0348
Entamoeba histolytica hypothetical protein 0.0072 0.0889 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0696 0.0793
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0026 0.0277 0.0371
Trichomonas vaginalis esterase, putative 0.0041 0.0476 0.0472
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Leishmania major hypothetical protein, conserved 0.0043 0.0504 0.0624
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0241 0.0297
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0277 0.0371
Echinococcus granulosus thymidylate synthase 0.0338 0.439 0.6801
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0026 0.0277 0.0371
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0039 0.0043
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0043 0.0504 0.0747
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0476 0.0684
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0026 0.0277 0.0393
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0039 0.0042
Schistosoma mansoni blooms syndrome DNA helicase 0.0008 0.004 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0476 0.0472
Echinococcus granulosus er degradation enhancing alpha mannosidase 0.0016 0.0141 0.0183
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.085 0.0973
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0174 0.0198
Entamoeba histolytica hypothetical protein 0.0072 0.0889 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0295 0.3283
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0277 0.0371
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0025 0.0258 0.0317
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0039 0.0042
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0039 0.0017
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0426 0.5555 0.8616
Loa Loa (eye worm) PA domain-containing protein 0.0016 0.0141 0.0161
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Trypanosoma brucei oxidoreductase-like protein 0.003 0.0326 0.0405
Onchocerca volvulus 0.0008 0.0039 0.0015
Echinococcus granulosus nuclear factor of activated T cells 5 0.0036 0.0404 0.0591
Loa Loa (eye worm) leucyl aminopeptidase 0.0043 0.0504 0.0574
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0338 0.439 0.6801
Loa Loa (eye worm) oxidoreductase 0.0008 0.0039 0.0044
Loa Loa (eye worm) hypothetical protein 0.004 0.0454 0.0517
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0026 0.0277 0.0324
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0476 0.0705
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0039 0.0043
Echinococcus granulosus mitogen activated protein kinase 3 0.0025 0.0258 0.0365
Onchocerca volvulus Fxna peptidase homolog 0.0043 0.0504 0.0481
Onchocerca volvulus 0.003 0.0326 0.0303
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0039 0.002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0394
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0007 0.0024 0.000000068886
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0476 0.0705
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0077 0.0088
Schistosoma mansoni hypothetical protein 0.0018 0.0174 0.0233
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0026 0.0277 0.0315
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0249 0.0244
Trichomonas vaginalis set domain proteins, putative 0.0762 0.9999 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0298 0.0339
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0043 0.0504 0.0565
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0277 0.0348
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0026 0.0277 0.0297
Giardia lamblia Kinase, CMGC MAPK 0.0025 0.0258 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0493 0.6444 1
Onchocerca volvulus 0.0338 0.439 0.4377
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0476 0.0705
Brugia malayi MH1 domain containing protein 0.0009 0.0055 0.0063
Loa Loa (eye worm) hypothetical protein 0.0008 0.0039 0.0044
Brugia malayi FXNA 0.0043 0.0504 0.0574
Brugia malayi Peptidase family M28 containing protein 0.0043 0.0504 0.0574
Brugia malayi Death domain containing protein 0.0007 0.0024 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0295 0.0423
Echinococcus granulosus dihydrofolate reductase 0.0493 0.6444 1
Schistosoma mansoni zinc finger protein 0.0016 0.0141 0.0183
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0039 0.038
Brugia malayi Bloom's syndrome protein homolog 0.001 0.0069 0.0078
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0039 0.0044
Loa Loa (eye worm) oxidoreductase 0.0026 0.0277 0.0315
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0277 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0295 0.0401
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0241 0.0236
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0026 0.0277 0.0394
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0174 0.0176
Schistosoma mansoni hypothetical protein 0.0018 0.0174 0.0233
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0476 0.0705
Loa Loa (eye worm) hypothetical protein 0.0007 0.0024 0.0027
Mycobacterium tuberculosis Conserved protein 0.0041 0.0476 0.0705
Schistosoma mansoni dihydrofolate reductase 0.0493 0.6444 1
Leishmania major oxidoreductase-like protein 0.003 0.0326 0.0402
Leishmania major glutaminyl cyclase, putative 0.0043 0.0504 0.0624
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0039 0.0034
Echinococcus multilocularis er degradation enhancing alpha mannosidase er degradation enhancer mannosidase alpha 0.0016 0.0141 0.0138
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.0336
Mycobacterium ulcerans hypothetical protein 0.0041 0.0476 0.0684
Brugia malayi leucyl aminopeptidase 0.0043 0.0504 0.0574
Trichomonas vaginalis DNA helicase recq, putative 0.001 0.0069 0.0064
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.0039 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0277 0.0315
Loa Loa (eye worm) hypothetical protein 0.0007 0.0025 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.1201 0.1833
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0039 0.0023
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0277 0.0371
Echinococcus granulosus expressed protein 0.0016 0.0141 0.0183
Loa Loa (eye worm) dihydrofolate reductase 0.0493 0.6444 0.7341
Loa Loa (eye worm) hypothetical protein 0.0607 0.7942 0.9048
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0009 0.0052 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0295 0.0401
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0024 0.0249 0.0351
Loa Loa (eye worm) beta-lactamase 0.0041 0.0476 0.0543
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0026 0.0277 0.0394
Plasmodium vivax SET domain protein, putative 0.0096 0.1201 0.1512
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0476 0.0533
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0241 0.0275
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0026 0.0277 0.0371
Schistosoma mansoni hypothetical protein 0.0058 0.0695 0.1046
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0007 0.0025 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0476 0.0543
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0109 0.01
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0295 0.0401
Echinococcus granulosus smad 0.0009 0.0055 0.0048
Echinococcus multilocularis expressed protein 0.0016 0.0141 0.0138
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.1154 0.176
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.085 0.0969
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0596 0.7805 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.003 0.0326 0.0449
Loa Loa (eye worm) hypothetical protein 0.0041 0.0476 0.0543
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0241 0.0256
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0026 0.0277 0.5
Loa Loa (eye worm) hypothetical protein 0.0442 0.5765 0.6568
Loa Loa (eye worm) hypothetical protein 0.0021 0.0203 0.0232
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0203 0.023
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0298 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.1201 0.1833
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0295 0.0363
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0039 0.0044
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0241 0.0338
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0026 0.0277 0.0325
Brugia malayi Pre-SET motif family protein 0.0096 0.1201 0.1368
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0043 0.0504 0.0747
Mycobacterium tuberculosis Conserved protein 0.0043 0.0504 0.0748
Echinococcus granulosus e3 ubiquitin protein ligase RNF13 0.0016 0.0141 0.0183
Brugia malayi thymidylate synthase 0.0338 0.439 0.5002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0189 0.0257
Mycobacterium ulcerans thiol peroxidase 0.0024 0.0249 0.0329
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0039 0.0034
Trichomonas vaginalis CMGC family protein kinase 0.0025 0.0258 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0096 0.1201 0.1833
Brugia malayi Cytochrome P450 family protein 0.0011 0.0077 0.0088
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0026 0.0277 0.0371
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0039 0.0018
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0277 0.034
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0026 0.0277 0.034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0696 0.0793
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0174 0.0233
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1737 0.1979
Entamoeba histolytica hypothetical protein 0.0072 0.0889 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0504 0.0726
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0026 0.0277 0.0324
Echinococcus multilocularis Smad4 0.0009 0.0055 0.0036
Echinococcus granulosus Smad4 0.0009 0.0055 0.0048
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0277 0.0371
Brugia malayi MAP kinase sur-1 0.0025 0.0258 0.0294
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0174 0.0233
Loa Loa (eye worm) hypothetical protein 0.0058 0.0696 0.0793
Onchocerca volvulus 0.0028 0.0298 0.0274
Loa Loa (eye worm) hypothetical protein 0.0666 0.8723 0.9938
Schistosoma mansoni hypothetical protein 0.0018 0.0174 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0161 0.2053 0.2049
Mycobacterium tuberculosis Conserved protein 0.0041 0.0476 0.0705
Trichomonas vaginalis hypothetical protein 0.0026 0.0277 0.0272
Echinococcus multilocularis thymidylate synthase 0.0338 0.439 0.5143
Echinococcus granulosus bloom syndrome protein 0.001 0.0069 0.0069
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0295 0.0401
Brugia malayi Immunoglobulin I-set domain containing protein 0.0007 0.0024 0.0027
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0504 0.0574
Trichomonas vaginalis peroxiredoxin, putative 0.0024 0.0249 0.0244
Schistosoma mansoni Fxna peptidase (M28 family) 0.0043 0.0504 0.0747
Schistosoma mansoni hypothetical protein 0.0058 0.0695 0.1046
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0476 0.0472
Brugia malayi MH2 domain containing protein 0.0009 0.0055 0.0063
Brugia malayi Uncoordinated protein 44 0.0007 0.0024 0.0027
Echinococcus multilocularis lamin 0.0028 0.0298 0.0323
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0055 0.0063
Plasmodium falciparum enoyl-acyl carrier reductase 0.0026 0.0277 0.0306
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0464 0.0518
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.085 0.1287
Onchocerca volvulus 0.0016 0.0141 0.0118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0476 0.0705
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0277 0.0371
Toxoplasma gondii hypothetical protein 0.0016 0.0141 0.0152
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0277 0.0315
Onchocerca volvulus 0.0041 0.0476 0.0453
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0039 0.0023
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0039 0.0023
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0039 0.0044
Mycobacterium ulcerans beta-lactamase 0.0041 0.0476 0.0684
Echinococcus granulosus mitogen activated protein kinase 0.0025 0.0258 0.0365
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0889 0.1019

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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