Detailed information for compound 770818

Basic information

Technical information
  • TDR Targets ID: 770818
  • Name: propan-2-yl 2-(2,5-dimethylphenyl)-1,3-dioxoi soindole-5-carboxylate
  • MW: 337.369 | Formula: C20H19NO4
  • H donors: 0 H acceptors: 3 LogP: 3.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(OC(=O)c1ccc2c(c1)C(=O)N(C2=O)c1cc(C)ccc1C)C
  • InChi: 1S/C20H19NO4/c1-11(2)25-20(24)14-7-8-15-16(10-14)19(23)21(18(15)22)17-9-12(3)5-6-13(17)4/h5-11H,1-4H3
  • InChiKey: SFSWCILRVXHWJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • isopropyl 2-(2,5-dimethylphenyl)-1,3-dioxo-isoindoline-5-carboxylate
  • 2-(2,5-dimethylphenyl)-1,3-dioxo-5-isoindolinecarboxylic acid isopropyl ester
  • 2-(2,5-dimethylphenyl)-1,3-diketo-isoindoline-5-carboxylic acid isopropyl ester
  • propan-2-yl 2-(2,5-dimethylphenyl)-1,3-dioxo-isoindole-5-carboxylate
  • ZINC00191301
  • STK267747
  • Oprea1_655476
  • BAS 00315789
  • Oprea1_712593
  • EU-0044968

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0749 0.0873
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.001 0.0187 0.0147
Schistosoma mansoni cpg binding protein 0.0029 0.0771 0.0832
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0014 0.03 0.0351
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Plasmodium vivax vivapain-2 0.0016 0.0379 0.0404
Schistosoma mansoni hypothetical protein 0.0015 0.035 0.0377
Entamoeba histolytica cysteine proteinase 2 0.0008 0.0131 0.1673
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0099 0.0099
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0014 0.03 0.4594
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.035 0.0377
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Entamoeba histolytica cysteine protease, putative 0.0016 0.0379 0.5956
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0087 0.0101
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0033 0.0902 0.1037
Loa Loa (eye worm) fibroinase 0.0016 0.0379 0.0409
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0826 0.0891
Brugia malayi MH1 domain containing protein 0.0004 0.0006 0.0008
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0131 0.0133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2702 0.2916
Onchocerca volvulus 0.0016 0.0377 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0902 0.1189
Echinococcus multilocularis 0.001 0.0192 0.0208
Echinococcus granulosus Smad4 0.0008 0.0117 0.0126
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0379 0.0442
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0613 0.0776
Schistosoma mansoni DNA helicase recq5 0.0006 0.0047 0.0051
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0006 0.0047 0.0051
Loa Loa (eye worm) hypothetical protein 0.0015 0.035 0.0377
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0006 0.0067 0.0073
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Loa Loa (eye worm) hypothetical protein 0.0018 0.0425 0.0459
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0087 0.0072
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0442 0.0477
Mycobacterium ulcerans thymidylate synthase 0.0153 0.4683 0.678
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0131 0.1673
Mycobacterium tuberculosis Possible oxidoreductase 0.0014 0.03 0.0358
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0613 0.0776
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.001 0.0187 0.0191
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0087 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0613 0.0893
Brugia malayi MH2 domain containing protein 0.0008 0.0117 0.017
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0131 0.0142
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0442 0.0442
Brugia malayi hypothetical protein 0.0073 0.2159 0.3144
Echinococcus multilocularis son of sevenless 1 0.0006 0.0067 0.0073
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.03 0.0334
Loa Loa (eye worm) hypothetical protein 0.0018 0.0425 0.0459
Brugia malayi Pre-SET motif family protein 0.0209 0.6428 0.9363
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.001 0.0192 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0127 0.0137
Echinococcus granulosus mitogen activated protein kinase 3 0.0033 0.0902 0.0973
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0014 0.03 0.0324
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0006 0.0067 0.0073
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0006 0.0047 0.0051
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0087 0.0101
Loa Loa (eye worm) hypothetical protein 0.0005 0.0037 0.004
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0379 0.5956
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0006 0.0047 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0127 0.0137
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0131 0.0142
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Echinococcus multilocularis smad 0.0008 0.0117 0.0126
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Echinococcus granulosus cathepsin l1 0.0016 0.0379 0.0409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Brugia malayi Pre-SET motif family protein 0.003 0.0826 0.1203
Loa Loa (eye worm) Smad1 0.0008 0.0117 0.0126
Onchocerca volvulus Netrin receptor homolog 0.0009 0.016 0.0127
Brugia malayi hypothetical protein 0.0009 0.0147 0.0215
Echinococcus multilocularis snurportin 1 0.0299 0.9266 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0613 0.0662
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0087 0.0127
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0442 0.4625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2702 0.2916
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0301 0.0365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0394 0.0496
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0379 0.0409
Echinococcus granulosus smad 0.0008 0.0117 0.0126
Echinococcus granulosus importin 5 0.0005 0.0035 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.046 0.052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.035 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.001 0.0192 0.0199
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0749 0.0808
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0613 0.0818
Onchocerca volvulus 0.0024 0.0613 0.0751
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0033 0.0902 0.0902
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0087 0.0053
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0301 0.0325
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0127 0.0137
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0277 0.8571 0.8571
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.035 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.001 0.0192 0.0199
Brugia malayi DIX domain containing protein 0.0009 0.0147 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0087 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2702 0.2916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2702 0.2916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0014 0.03 0.0315
Schistosoma mansoni hypothetical protein 0.0033 0.0908 0.098
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1613 0.1881
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0377 0.0346
Leishmania major oxidoreductase-like protein 0.0016 0.0377 0.0377
Schistosoma mansoni dishevelled 0.0009 0.0147 0.0159
Loa Loa (eye worm) histone methyltransferase 0.001 0.0182 0.0196
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0147 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.001 0.0192 0.0199
Trichomonas vaginalis peroxiredoxin, putative 0.001 0.0187 0.0208
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0006 0.0047 0.0051
Onchocerca volvulus 0.0016 0.0379 0.0429
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.001 0.0192 0.0199
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.03 0.0438
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0131 0.0137
Schistosoma mansoni smad1 5 8 and 0.0008 0.0117 0.0126
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.03 0.03
Echinococcus multilocularis mitogen activated protein kinase 3 0.0033 0.0902 0.0973
Plasmodium vivax importin-beta 2, putative 0.0028 0.0749 0.0836
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0087 0.0072
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0035 0.004
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0035 0.004
Plasmodium vivax vivapain-2 0.0016 0.0379 0.0404
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0131 0.0137
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0006 0.0067 0.0073
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0425 0.0457
Loa Loa (eye worm) hypothetical protein 0.0018 0.0425 0.0459
Onchocerca volvulus 0.0009 0.0147 0.011
Echinococcus granulosus importin subunit beta 1 0.0028 0.0749 0.0808
Brugia malayi Cathepsin L-like precursor 0.0011 0.021 0.0306
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0016 0.0377 0.0428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0131 0.0142
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0014 0.03 0.0351
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0192 0.0208
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0087 0.0127
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0014 0.03 0.0358
Loa Loa (eye worm) thymidylate synthase 0.0153 0.4683 0.5054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0182 0.0196
Trypanosoma cruzi hypothetical protein 0.0006 0.0067 0.0062
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0005 0.0037 0.0054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0131 0.0098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0379 0.0409
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0902 0.1189
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.001 0.0192 0.0155
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.001 0.0192 0.0155
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Plasmodium vivax vivapain-3 0.0008 0.0131 0.0113
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0379 0.0442
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0087 0.0085
Onchocerca volvulus 0.0238 0.7335 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.001 0.0192 0.0155
Loa Loa (eye worm) hypothetical protein 0.0028 0.0749 0.0808
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0377 0.0424
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0613 0.0776
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.03 0.0315
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0442 0.0516
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.03 0.0358
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.6428 0.6938
Echinococcus multilocularis Ankyrin 0.0009 0.0162 0.0175
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0377 0.0428
Schistosoma mansoni netrin receptor unc5 0.0009 0.016 0.0173
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0006 0.0067 0.0073
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0147 0.0215
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0032 0.0035
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0087 0.0053
Mycobacterium tuberculosis Probable oxidoreductase 0.0016 0.0377 0.0471
Leishmania major cathepsin L-like protease 0.0062 0.1815 0.1815
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0379 0.0409
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.001 0.0192 0.0155
Schistosoma mansoni DNA helicase recq1 0.0006 0.0047 0.0051
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0582 0.075
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0009 0.016 0.0173
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Brugia malayi Cytochrome P450 family protein 0.001 0.0192 0.028
Echinococcus granulosus translational activator gcn1 0.0005 0.0035 0.0037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.035 0.0377
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0147 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.046 0.0496
Leishmania major lanosterol 14-alpha-demethylase, putative 0.001 0.0192 0.0192
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0379 0.0379
Schistosoma mansoni smad 0.0008 0.0117 0.0126
Echinococcus multilocularis translational activator gcn1 0.0005 0.0035 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Trypanosoma cruzi hypothetical protein 0.0006 0.0067 0.0062
Echinococcus granulosus dihydrofolate reductase 0.0223 0.6866 0.741
Brugia malayi CXXC zinc finger family protein 0.0029 0.0771 0.1123
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.001 0.0192 0.0155
Giardia lamblia Kinase, CMGC MAPK 0.0033 0.0902 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.001 0.0192 0.0155
Loa Loa (eye worm) hypothetical protein 0.0009 0.016 0.0173
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0442 0.0567
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0047 0.0055
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0379 0.0442
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0772 0.0833
Brugia malayi MH1 domain containing protein 0.0008 0.0117 0.017
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0127 0.0137
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0045
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0147 0.0159
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0067 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Entamoeba histolytica recQ family helicase, putative 0.0007 0.0099 0.112
Schistosoma mansoni ap endonuclease 0.0018 0.0442 0.0477
Chlamydia trachomatis dihydrofolate reductase 0.0223 0.6866 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.001 0.0192 0.0199
Mycobacterium ulcerans oxidoreductase 0.0014 0.03 0.0315
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.001 0.0192 0.0199
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.001 0.0192 0.0155
Brugia malayi cathepsin F-like cysteine proteinase 0.0005 0.0037 0.0054
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0613 1
Leishmania major cathepsin L-like protease 0.0016 0.0379 0.0379
Trypanosoma cruzi cysteine peptidase, putative 0.0005 0.0037 0.0026
Mycobacterium tuberculosis Possible oxidoreductase 0.0014 0.03 0.0358
Echinococcus granulosus mitogen activated protein kinase 0.0033 0.0902 0.0973
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0033 0.0902 0.0902
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0379 0.0409
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0182 0.0196
Loa Loa (eye worm) oxidoreductase 0.0007 0.0087 0.0094
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.001 0.0192 0.0155
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0249 0.029
Echinococcus multilocularis GPCR, family 2 0.0015 0.035 0.0377
Echinococcus granulosus GPCR family 2 0.0015 0.035 0.0377
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0131 0.1673
Echinococcus multilocularis transportin 1 0.0005 0.0035 0.0037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0442 0.0477
Leishmania major cathepsin L-like protease 0.0016 0.0379 0.0379
Brugia malayi Importin beta-1 subunit 0.0028 0.0749 0.109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.021 0.0241
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0047 0.0055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Loa Loa (eye worm) hypothetical protein 0.0005 0.0037 0.004
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.001 0.0192 0.0199
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0181 0.5542 0.7533
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0087 0.0094
Entamoeba histolytica cysteine proteinase 1, putative 0.0008 0.0131 0.1673
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0442 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.001 0.0192 0.0224
Leishmania major cytochrome p450-like protein 0.001 0.0192 0.0192
Echinococcus granulosus son of sevenless 1 0.0006 0.0067 0.0073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0771 0.0832
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.046 0.055
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0006 0.0047 0.0051
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1815 0.2105
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0014 0.03 0.0351
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0442 0.0478
Trypanosoma brucei cytochrome P450, putative 0.0019 0.046 0.043
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0613 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Onchocerca volvulus 0.0029 0.0771 0.0968
Plasmodium vivax SET domain protein, putative 0.003 0.0826 0.0927
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0087 0.0085
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0117 0.0126
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0014 0.03 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Brugia malayi Cathepsin L-like precursor 0.0005 0.0037 0.0054
Loa Loa (eye worm) hypothetical protein 0.0181 0.5542 0.598
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0033 0.0902 0.0877
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Echinococcus multilocularis thymidylate synthase 0.0153 0.4683 0.5054
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0153 0.4683 0.5054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0826 0.0891
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0016 0.0377 0.0428
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.139 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0087 0.0045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0157 0.0184
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0058 0.0062
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0014 0.03 0.0315
Echinococcus granulosus thymidylate synthase 0.0153 0.4683 0.5054
Brugia malayi RasGEF domain containing protein 0.0006 0.0067 0.0098
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.001 0.0192 0.0155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2702 0.2916
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Echinococcus granulosus ras GTP exchange factor 0.0006 0.0067 0.0073
Onchocerca volvulus 0.0007 0.0087 0.0027
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Toxoplasma gondii hypothetical protein 0.0009 0.0147 0.0172
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Schistosoma mansoni hypothetical protein 0.0299 0.9266 1
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0131 0.1673
Schistosoma mansoni hypothetical protein 0.0009 0.016 0.0173
Echinococcus granulosus bloom syndrome protein 0.0014 0.0301 0.0325
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0087 0.0045
Onchocerca volvulus 0.0009 0.0164 0.0133
Echinococcus multilocularis mitogen activated protein kinase 0.0033 0.0902 0.0973
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.001 0.0192 0.0155
Echinococcus multilocularis netrin receptor unc 5 0.0009 0.016 0.0173
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.001 0.0192 0.0155
Onchocerca volvulus 0.0016 0.0379 0.0429
Brugia malayi kap beta 3 protein 0.0005 0.0035 0.0051
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.03 0.0315
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0749 0.0722
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.3513 0.3791
Leishmania major cathepsin L-like protease 0.0016 0.0379 0.0379
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0153 0.4683 0.6794
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Loa Loa (eye worm) hypothetical protein 0.0024 0.0613 0.0662
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0087 0.0045
Loa Loa (eye worm) RecQ helicase 0.0014 0.0301 0.0325
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0087 0.0045
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.001 0.0192 0.0199
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0067 0.0073
Loa Loa (eye worm) cytochrome P450 0.001 0.0192 0.0208
Schistosoma mansoni cytochrome P450 0.001 0.0192 0.0208
Leishmania major importin beta-1 subunit, putative 0.0023 0.0582 0.0582
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.046 0.052
Onchocerca volvulus 0.0007 0.0087 0.0027
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0067 0.0045
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0147 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.0613 0.0662
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0014 0.03 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0613 0.0613
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0131 0.0191
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0117 0.0126
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0147 0.0159
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0379 0.0409
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0613 0.0818
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0007 0.0087 0.0094
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Brugia malayi Cytochrome P450 family protein 0.0019 0.046 0.067
Schistosoma mansoni importin-beta 2 0.0005 0.0035 0.0037
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0014 0.03 0.0324
Brugia malayi MH1 domain containing protein 0.0008 0.0117 0.017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.016 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.2159 0.2911
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0147 0.0159
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.001 0.0192 0.0199
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.03 0.0315
Brugia malayi Death domain containing protein 0.0009 0.016 0.0233
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0223 0.6866 1
Mycobacterium ulcerans thiol peroxidase 0.001 0.0187 0.0147
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.001 0.0192 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0277 0.8571 1
Brugia malayi RasGEF domain containing protein 0.0006 0.0067 0.0098
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0067 0.0073
Loa Loa (eye worm) cysteine protease 0.0016 0.0379 0.0409
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Loa Loa (eye worm) hypothetical protein 0.0009 0.0147 0.0159
Onchocerca volvulus 0.0011 0.021 0.0197
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0301 0.0365
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0047 0.0068
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0073 0.2159 0.2506
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Echinococcus multilocularis cathepsin L 0.0008 0.0131 0.0142
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.03 0.0315
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0147 0.0159
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0147 0.0159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0613 0.0776
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0087 0.0094
Echinococcus multilocularis cysteine protease 0.0016 0.0379 0.0409
Plasmodium falciparum enoyl-acyl carrier reductase 0.0014 0.03 0.0351
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.001 0.0192 0.0155
Plasmodium vivax unspecified product 0.0005 0.0037 0.0003
Loa Loa (eye worm) ctsf protein 0.0016 0.0379 0.0409
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0014 0.03 0.0358
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1815 0.2105
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0117 0.0126
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0425 0.0496
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0131 0.0142
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0087 0.0045
Schistosoma mansoni ankyrin 23/unc44 0.0009 0.016 0.0173
Echinococcus granulosus cpg binding protein 0.003 0.0822 0.0887
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0613 0.0776
Leishmania major hypothetical protein, conserved 0.0005 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0425 0.0459
Leishmania major cytochrome p450-like protein 0.001 0.0192 0.0192
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0147 0.0159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Toxoplasma gondii redoxin domain-containing protein 0.004 0.1114 0.13
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.03 0.0358
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0009 0.0162 0.0175
Schistosoma mansoni hypothetical protein 0.0015 0.035 0.0377
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0153 0.4683 0.678
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0301 0.0439
Loa Loa (eye worm) hypothetical protein 0.0009 0.0162 0.0175
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0014 0.03 0.0311
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0826 0.0891
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Trypanosoma cruzi cruzipain precursor, putative 0.0005 0.0037 0.0026
Trichomonas vaginalis hypothetical protein 0.0014 0.03 0.0364
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0014 0.03 0.0358
Schistosoma mansoni hypothetical protein 0.0015 0.035 0.0377
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0009 0.016 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.001 0.0192 0.0199
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.3513 0.3791
Brugia malayi Cytochrome P450 family protein 0.0019 0.046 0.067
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0379 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0131 0.0133
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0147 0.0159
Schistosoma mansoni Smad4 0.0008 0.0117 0.0126
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0379 0.0409
Echinococcus granulosus cysteine protease 0.0008 0.0131 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0379 0.0472
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0047 0.0068
Onchocerca volvulus 0.0014 0.03 0.0321
Loa Loa (eye worm) hypothetical protein 0.0006 0.0047 0.0051
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0067 0.0073
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.021 0.0227
Plasmodium vivax peroxiredoxin, putative 0.004 0.1114 0.1265
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0087 0.0094
Leishmania major cathepsin L-like protease 0.0016 0.0379 0.0379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0087 0.0045
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0902 0.1189
Entamoeba histolytica cysteine proteinase, putative 0.0008 0.0131 0.1673
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.001 0.0192 0.0199
Echinococcus granulosus Ankyrin 0.0009 0.0162 0.0175
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0073 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0613 1
Mycobacterium ulcerans short chain dehydrogenase 0.0016 0.0377 0.0428
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0087 0.0101
Brugia malayi MH2 domain containing protein 0.0116 0.3513 0.5117
Loa Loa (eye worm) hypothetical protein 0.0011 0.021 0.0227
Plasmodium vivax vivapain-1 0.0008 0.0131 0.0113
Echinococcus multilocularis dihydrofolate reductase 0.0223 0.6866 0.741
Brugia malayi N-terminal motif family protein 0.0006 0.0067 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0613 0.0776
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Echinococcus multilocularis ras GTP exchange factor 0.0006 0.0067 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0007 0.0099 0.0089
Mycobacterium ulcerans hypothetical protein 0.0024 0.0613 0.0776
Trichomonas vaginalis peroxiredoxin, putative 0.001 0.0187 0.0208
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0442 0.7046
Brugia malayi Smad1 0.0008 0.0117 0.017
Brugia malayi dihydrofolate reductase family protein 0.0223 0.6866 1
Trichomonas vaginalis set domain proteins, putative 0.0238 0.7332 1
Mycobacterium leprae Conserved hypothetical protein 0.001 0.0192 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.03 0.0438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0087 0.0045
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.001 0.0192 0.0155
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0006 0.0067 0.0073
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0379 0.0409
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0442 0.0559
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0087 0.0045
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.001 0.0192 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0442 0.0644
Loa Loa (eye worm) hypothetical protein 0.0004 0.0006 0.0006
Echinococcus granulosus cathepsin l1 0.0011 0.021 0.0227
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0277 0.8571 1
Brugia malayi MH2 domain containing protein 0.0008 0.0117 0.017
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.1815 0.2105
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0014 0.03 0.0315
Schistosoma mansoni smad1 5 8 and 0.0008 0.0117 0.0126
Echinococcus granulosus transportin 1 0.0005 0.0035 0.0037
Schistosoma mansoni dihydropteridine reductase 0.0014 0.03 0.0324
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0582 0.075
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0099 0.0099
Mycobacterium tuberculosis Hypothetical protein 0.0073 0.2159 0.3087
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0379 0.0409
Echinococcus granulosus nuclear factor of activated T cells 5 0.0048 0.1362 0.147
Echinococcus granulosus netrin receptor unc 5 0.0009 0.016 0.0173
Trichomonas vaginalis peroxiredoxin, putative 0.001 0.0187 0.0208
Schistosoma mansoni cpg binding protein 0.003 0.0822 0.0887
Echinococcus granulosus death domain containing protein 0.0009 0.016 0.0173
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Loa Loa (eye worm) hypothetical protein 0.003 0.0826 0.0891
Plasmodium falciparum 1-cys peroxiredoxin 0.004 0.1114 0.13
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0006 0.0067 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.001 0.0192 0.0199
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0007 0.0099 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0442 0.0412
Loa Loa (eye worm) hypothetical protein 0.0033 0.0908 0.098
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0117 0.0126
Onchocerca volvulus 0.003 0.0826 0.1044
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0394 0.0496
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0223 0.6866 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Loa Loa (eye worm) hypothetical protein 0.0007 0.0087 0.0094
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0014 0.03 0.0311
Loa Loa (eye worm) hypothetical protein 0.0048 0.139 0.15
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2702 0.2916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Plasmodium vivax unspecified product 0.0008 0.0131 0.0113
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0087 0.0087
Echinococcus granulosus snurportin 1 0.0299 0.9266 1
Brugia malayi MAP kinase sur-1 0.0033 0.0902 0.1314
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0425 0.019
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0192 0.0208
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0117 0.0126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.021 0.0241
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0009 0.0161 0.0148
Mycobacterium ulcerans short chain dehydrogenase 0.0014 0.03 0.0315
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.001 0.0192 0.0155
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0147 0.0215
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.001 0.0192 0.0199
Trichomonas vaginalis ras GTP exchange factor, putative 0.0006 0.0067 0.0045
Trypanosoma cruzi cytochrome p450-like protein, putative 0.001 0.0192 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.001 0.0187 0.0191
Brugia malayi Cathepsin L-like precursor 0.0016 0.0379 0.0552
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0147 0.0159
Loa Loa (eye worm) dihydrofolate reductase 0.0223 0.6866 0.741
Loa Loa (eye worm) hypothetical protein 0.0006 0.0067 0.0073
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0006 0.0044 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0826 0.0891
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0442 0.0524
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Brugia malayi Uncoordinated protein 44 0.0009 0.016 0.0233
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.021 0.0227
Onchocerca volvulus 0.0007 0.0087 0.0027
Brugia malayi cathepsin L-like precursor 0.0011 0.021 0.0306
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Toxoplasma gondii cathepsin CPL 0.0016 0.0379 0.0442
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Schistosoma mansoni cathepsin s 0.0005 0.0037 0.004
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0131 0.0137
Loa Loa (eye worm) RasGEF domain-containing protein 0.0006 0.0067 0.0073
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.021 0.3036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0127 0.0137
Schistosoma mansoni dishevelled 0.0009 0.0147 0.0159
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0006 0.0067 0.0045
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0014 0.03 0.0269
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0087 0.0085
Plasmodium falciparum importin beta, putative 0.0028 0.0749 0.0873
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0014 0.03 0.0315
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.1815 0.2105
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0014 0.03 0.0315
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0131 0.0098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0033 0.0902 0.0973
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.001 0.0192 0.0155
Loa Loa (eye worm) hypothetical protein 0.0005 0.0037 0.004
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0131 0.0191
Schistosoma mansoni cpg binding protein 0.003 0.0822 0.0887
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0087 0.0903
Onchocerca volvulus 0.0153 0.4683 0.6351
Schistosoma mansoni hypothetical protein 0.001 0.0192 0.0208
Entamoeba histolytica hypothetical protein 0.0023 0.0582 0.946
Onchocerca volvulus 0.0016 0.0379 0.0429
Leishmania major cathepsin L-like protease 0.0016 0.0379 0.0379
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.001 0.0192 0.0199
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0147 0.011
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0014 0.03 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Brugia malayi N-terminal motif family protein 0.0181 0.5542 0.8071
Leishmania major cytochrome p450-like protein 0.0019 0.046 0.046
Brugia malayi Cathepsin L-like precursor 0.0011 0.021 0.0306
Echinococcus multilocularis Smad4 0.0008 0.0117 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0379 0.0409
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0014 0.03 0.0315
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0826 0.0891
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0442 0.0559
Trypanosoma brucei pteridine reductase 1 0.032 0.9923 1
Schistosoma mansoni hypothetical protein 0.0015 0.035 0.0377
Echinococcus multilocularis importin 5 0.0005 0.0035 0.0037
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0379 0.0429
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Echinococcus granulosus Protein son of sevenless 0.0006 0.0067 0.0073
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.035 0.0509
Schistosoma mansoni ap endonuclease 0.0018 0.0442 0.0477
Loa Loa (eye worm) importin-beta domain-containing protein 0.0005 0.0035 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Entamoeba histolytica hypothetical protein 0.0006 0.0067 0.0563
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0379 0.0409
Schistosoma mansoni importin beta-1 0.0028 0.0749 0.0808
Onchocerca volvulus 0.0016 0.0379 0.0429
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0087 0.0127
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0014 0.03 0.0315
Brugia malayi thymidylate synthase 0.0153 0.4683 0.6821
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.001 0.0192 0.0199
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0178 0.026
Echinococcus multilocularis cpg binding protein 0.003 0.0822 0.0887
Trichomonas vaginalis CMGC family protein kinase 0.0033 0.0902 0.1189
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0087 0.0127
Loa Loa (eye worm) nuclear factor I 0.0004 0.0006 0.0006
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0087 0.0094
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0379 0.0429
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0087 0.0127
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.001 0.0192 0.0199
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0613 0.0776
Schistosoma mansoni ras GTP exchange factor 0.0006 0.0067 0.0073
Brugia malayi MH1 domain containing protein 0.0004 0.0006 0.0008
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0087 0.0085
Leishmania major pantothenate kinase subunit, putative 0.0005 0.0015 0.0015
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0908 0.1323
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Brugia malayi Protein kinase domain containing protein 0.001 0.0169 0.0246
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0425 0.0499
Brugia malayi Dihydrofolate reductase 0.0223 0.6866 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0067 0.0073
Brugia malayi RNA, U transporter 1 0.008 0.2372 0.3454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0277 0.8571 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0037 0.004
Toxoplasma gondii exonuclease III APE 0.0018 0.0442 0.0516
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.001 0.0192 0.0199
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0613 0.0776
Loa Loa (eye worm) hypothetical protein 0.0009 0.0147 0.0159
Schistosoma mansoni dihydrofolate reductase 0.0223 0.6866 0.741
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0277 0.8571 0.8633
Echinococcus multilocularis Protein son of sevenless 0.0006 0.0067 0.0073
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.001 0.0187 0.0191
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0613 0.0613
Brugia malayi RasGEF domain containing protein 0.0006 0.0067 0.0098
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1647 0.1907
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0902 0.1037
Trichomonas vaginalis helicase, putative 0.0007 0.0073 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.021 0.0227
Loa Loa (eye worm) hypothetical protein 0.0009 0.0136 0.0146
Loa Loa (eye worm) hypothetical protein 0.0014 0.03 0.0324
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0582 0.0663
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.9266 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0147 0.0159
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0147 0.0159
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0582 0.075
Loa Loa (eye worm) hypothetical protein 0.0011 0.0213 0.023
Loa Loa (eye worm) CYP4Cod1 0.0019 0.046 0.0496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0147 0.0215
Leishmania major cathepsin L-like protease 0.0062 0.1815 0.1815
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0048 0.1362 0.147
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0379 0.0472
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.139 0.15
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0006 0.0067 0.0563
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0826 0.0891
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0394 0.0496
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.001 0.0192 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0131 0.0137
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0131 0.0137
Brugia malayi cytochrome P450 0.001 0.0192 0.028
Onchocerca volvulus 0.0016 0.0379 0.0429
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0117 0.0126
Schistosoma mansoni dep domain containing protein 0.0009 0.0147 0.0159
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0087 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0826 0.0891
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0014 0.03 0.0315
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0014 0.03 0.0358
Brugia malayi Latrophilin receptor protein 2 0.0015 0.035 0.0509
Loa Loa (eye worm) hypothetical protein 0.0011 0.021 0.0227
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.001 0.0192 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.001 0.0192 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Onchocerca volvulus 0.0016 0.0379 0.0429
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0902 0.0973
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.035 0.0377
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0442 0.0477
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0006 0.0047 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0379 0.0472
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.1357 0.1465
Plasmodium falciparum transportin 0.0005 0.0035 0.004
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0014 0.03 0.0324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2702 0.2916
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1817 0.1961
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0033 0.0902 0.1037
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0379 0.5956
Brugia malayi Cytochrome P450 family protein 0.0047 0.1357 0.1977
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0613 0.0776
Loa Loa (eye worm) hypothetical protein 0.0018 0.0425 0.0459
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Brugia malayi hypothetical protein 0.0009 0.0147 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0379 0.0426
Loa Loa (eye worm) kap beta 3 protein 0.0005 0.0035 0.0037
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.001 0.0192 0.0155
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0016 0.0377 0.044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0147 0.0159
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0033 0.0902 0.1037
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0379 0.0472
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0147 0.0159
Loa Loa (eye worm) oxidoreductase 0.0014 0.03 0.0324
Leishmania major cathepsin L-like protease 0.0062 0.1815 0.1815
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.1399 0.1618
Entamoeba histolytica cysteine protease, putative 0.0008 0.0131 0.1673
Loa Loa (eye worm) retinol dehydrogenase 12 0.0014 0.03 0.0324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0087 0.0045
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0425 0.0541
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.021 0.0306
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0033 0.0902 0.1052
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0379 0.0409
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.001 0.0192 0.0155
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0147 0.0159
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0014 0.03 0.0358
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0073 0.0052
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0087 0.0101
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0749 0.0722
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0223 0.6866 1
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.001 0.0192 0.0155
Trypanosoma brucei protein kinase, putative 0.0033 0.0902 0.0877
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0442 0.05
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0087 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0613 0.0613
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0379 0.0552
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2702 0.3935
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0613 0.0893
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0087 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0073 0.0052
Echinococcus multilocularis cysteine protease 0.0016 0.0379 0.0409
Mycobacterium leprae putative cytochrome p450 0.001 0.0192 0.0155
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0277 0.8571 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0442 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0008 0.0131 0.0153
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0014 0.03 0.0351
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.016 0.0233
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.1815 0.1801
Echinococcus granulosus cathepsin L 0.0008 0.0131 0.0142
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.046 0.0496
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0014 0.03 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.139 0.2024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0073 0.0052
Schistosoma mansoni smad1 5 8 and 0.0008 0.0117 0.0126
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0613 0.0893
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0394 0.0496
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0117 0.0126
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0442 0.05
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.001 0.0192 0.0159
Onchocerca volvulus 0.0016 0.0379 0.0429
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0826 0.0964
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2702 0.2916
Brugia malayi N-terminal motif family protein 0.0006 0.0067 0.0098
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0014 0.03 0.03
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0087 0.0045
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0006 0.0067 0.0062
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0207 0.6364 0.6364

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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