Detailed information for compound 770898

Basic information

Technical information
  • TDR Targets ID: 770898
  • Name: [2-(4-bromophenyl)-2-oxoethyl] 4-[(4-hydroxyp henyl)amino]-4-oxobutanoate
  • MW: 406.227 | Formula: C18H16BrNO5
  • H donors: 2 H acceptors: 4 LogP: 2.6 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OCC(=O)c1ccc(cc1)Br)CCC(=O)Nc1ccc(cc1)O
  • InChi: 1S/C18H16BrNO5/c19-13-3-1-12(2-4-13)16(22)11-25-18(24)10-9-17(23)20-14-5-7-15(21)8-6-14/h1-8,21H,9-11H2,(H,20,23)
  • InChiKey: FMCDQNMNWWHEFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(4-bromophenyl)-2-oxo-ethyl] 4-[(4-hydroxyphenyl)amino]-4-oxo-butanoate
  • 4-[(4-hydroxyphenyl)amino]-4-oxobutanoic acid [2-(4-bromophenyl)-2-oxoethyl] ester
  • 4-[(4-hydroxyphenyl)amino]-4-keto-butyric acid [2-(4-bromophenyl)-2-keto-ethyl] ester
  • STK267802
  • N-(4-Hydroxy-phenyl)-succinamic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester
  • ZINC02054533
  • BAS 00368382
  • AG-690/09696022

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0025 0.0635
Brugia malayi Guanylyl cyclase protein 23 0.0344 0.0968 0.2064
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0153 0.0404 0.2987
Echinococcus granulosus neutral amino acid transporter A 0.0941 0.2734 0.2734
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0333 0.037
Onchocerca volvulus 0.0072 0.0164 0.0474
Echinococcus multilocularis GPCR, family 2 0.0051 0.0103 0.0103
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0153 0.0404 0.2987
Echinococcus granulosus excitatory amino acid transporter 3 0.0941 0.2734 0.2734
Onchocerca volvulus 0.0072 0.0164 0.0474
Trypanosoma cruzi extracellular receptor, putative 0.0344 0.0968 1
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0941 0.2734 0.3043
Echinococcus granulosus glutamate receptor 1 0.0077 0.0178 0.0178
Echinococcus granulosus glutamate receptor 2 0.1947 0.5708 0.5708
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Schistosoma mansoni tyrosine kinase 0.0344 0.0968 0.1078
Loa Loa (eye worm) hypothetical protein 0.0907 0.2632 0.5611
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0025 0.0079
Schistosoma mansoni ATP-binding cassette transporter 0.1527 0.4465 0.497
Loa Loa (eye worm) hypothetical protein 0.0162 0.043 0.0916
Echinococcus granulosus cpg binding protein 0.0035 0.0054 0.0054
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0103 0.0219
Brugia malayi MH2 domain containing protein 0.0241 0.0663 0.1414
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0344 0.0968 0.2064
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0084 0.0199 0.0425
Leishmania major hypothetical protein, conserved 0.0072 0.0164 0.1477
Schistosoma mansoni cellular tumor antigen P53 0.0104 0.026 0.0289
Echinococcus granulosus nmda type glutamate receptor 0.0693 0.2001 0.2001
Loa Loa (eye worm) excitatory amino acid transporter 0.0941 0.2734 0.5827
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.009 0.009
Echinococcus multilocularis GPCR, family 3, C terminal 0.0084 0.0199 0.0199
Echinococcus multilocularis cpg binding protein 0.0035 0.0054 0.0054
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0153 0.0404 0.2987
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0117 0.0298 0.1071
Onchocerca volvulus 0.0344 0.0968 0.3211
Loa Loa (eye worm) hypothetical protein 0.0077 0.0178 0.0379
Loa Loa (eye worm) glutamate receptor 0.0203 0.0552 0.1177
Treponema pallidum glutamate transporter 0.0417 0.1185 1
Onchocerca volvulus Poor gastrulation protein homolog 0.0084 0.0199 0.0594
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0941 0.2734 0.2734
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Echinococcus multilocularis neutral amino acid transporter A 0.0941 0.2734 0.2734
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0053
Echinococcus granulosus glutamate receptor 2 0.1371 0.4005 0.4005
Schistosoma mansoni metabotropic glutamate receptor 0.0547 0.1568 0.1746
Echinococcus granulosus muscleblind protein 0.0153 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0206 0.056 0.1195
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.043 0.0916
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0006 0.0011
Mycobacterium leprae Probable lipase LipE 0.0072 0.0164 1
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0164 0.5402
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0417 0.1185 0.1185
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0103 0.0219
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0006 0.5
Schistosoma mansoni cpg binding protein 0.0035 0.0054 0.006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0129 0.0333 1
Brugia malayi hypothetical protein 0.0076 0.0177 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Brugia malayi metabotropic glutamate receptor type 2 0.0547 0.1568 0.3344
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0428 0.1216 0.2592
Echinococcus granulosus geminin 0.0174 0.0466 0.0466
Treponema pallidum glutamate/aspartate transporter 0.0417 0.1185 1
Loa Loa (eye worm) hypothetical protein 0.0428 0.1216 0.2592
Leishmania major extracellular receptor, putative 0.0344 0.0968 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0941 0.2734 0.5
Echinococcus granulosus sodium:dicarboxylate symporter 0.0941 0.2734 0.2734
Brugia malayi Receptor family ligand binding region containing protein 0.0344 0.0968 0.2064
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0025 0.0053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.009 0.0193
Echinococcus multilocularis glutamate receptor 2 0.1947 0.5708 0.5708
Schistosoma mansoni hypothetical protein 0.0051 0.0103 0.0114
Echinococcus multilocularis glutamate receptor 2 0.1371 0.4005 0.4005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.009 0.0101
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0164 0.0589
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0164 0.035
Echinococcus granulosus glutamate receptor subunit protein glur 0.0653 0.1881 0.1881
Echinococcus multilocularis neutral amino acid transporter A 0.0941 0.2734 0.2734
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.043 0.0916
Loa Loa (eye worm) glutamate receptor 0.0787 0.2279 0.4859
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.3399 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0129 0.0333 0.0333
Echinococcus granulosus neutral amino acid transporter 0.0941 0.2734 0.2734
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0164 0.4834
Echinococcus granulosus tyrosine kinase 0.0344 0.0968 0.0968
Schistosoma mansoni hypothetical protein 0.0051 0.0103 0.0114
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.3399 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.0663 0.1414
Loa Loa (eye worm) hypothetical protein 0.0111 0.0278 0.0594
Echinococcus granulosus excitatory amino acid transporter 2 0.0941 0.2734 0.2734
Echinococcus granulosus Excitatory amino acid transporter 0.0941 0.2734 0.2734
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0164 0.0589
Brugia malayi Metabotropic glutamate receptor precursor. 0.0787 0.2279 0.4859
Brugia malayi latrophilin 2 splice variant baaae 0.0111 0.0278 0.0594
Loa Loa (eye worm) RGC/RGC protein kinase 0.0344 0.0968 0.2064
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.0404 1
Onchocerca volvulus 0.0129 0.0333 0.1048
Loa Loa (eye worm) hypothetical protein 0.0077 0.0178 0.0379
Schistosoma mansoni hypothetical protein 0.0174 0.0466 0.0519
Brugia malayi Pre-SET motif family protein 0.0129 0.0333 0.0709
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0025 0.0635
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0177 0.0197
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0164 0.5402
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0124 0.0317 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0333 0.037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0103 0.0103
Onchocerca volvulus 0.1018 0.2962 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0103 0.0103
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0941 0.2734 0.2734
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0103 0.0103
Echinococcus granulosus receptor type guanylyl cyclase 0.0344 0.0968 0.0968
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0053
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0153 0.0405 0.0863
Onchocerca volvulus 0.0072 0.0164 0.0474
Brugia malayi beta-lactamase family protein 0.0072 0.0164 0.035
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.2222 0.652 0.652
Brugia malayi CXXC zinc finger family protein 0.0033 0.0048 0.0103
Schistosoma mansoni cpg binding protein 0.0033 0.0048 0.0054
Loa Loa (eye worm) RGC/RGC protein kinase 0.0344 0.0968 0.2064
Schistosoma mansoni hypothetical protein 0.0084 0.0199 0.0222
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0344 0.0968 0.0968
Trypanosoma brucei hypothetical protein, conserved 0.0153 0.0404 1
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0153 0.0404 0.2987
Echinococcus multilocularis receptor type guanylyl cyclase 0.0344 0.0968 0.0968
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0576 0.1654 0.1654
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0051 0.0103 0.0219
Trichomonas vaginalis set domain proteins, putative 0.1018 0.2962 1
Schistosoma mansoni hypothetical protein 0.0111 0.0278 0.031
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0576 0.1654 0.1842
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.3399 1 1
Echinococcus granulosus tumor protein p63 0.0713 0.206 0.206
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Loa Loa (eye worm) hypothetical protein 0.0153 0.0405 0.0863
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0417 0.1185 0.1319
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0025 0.0635
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0941 0.2734 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.0164 0.035
Toxoplasma gondii ABC1 family protein 0.0072 0.0164 0.0823
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0164 0.0589
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0164 0.0183
Loa Loa (eye worm) glutamate receptor 1 0.1603 0.4691 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0563 0.1616 0.1798
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0025 0.0053
Entamoeba histolytica hypothetical protein 0.0076 0.0177 0.1609
Echinococcus granulosus histone lysine methyltransferase setb 0.0129 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0895 0.2597 0.5535
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0117 0.0298 1
Echinococcus multilocularis Excitatory amino acid transporter 0.0941 0.2734 0.2734
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0164 0.0164
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0153 0.0404 0.2987
Echinococcus granulosus neutral amino acid transporter A 0.0941 0.2734 0.2734
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0117 0.0298 0.1081
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0084 0.0199 0.0594
Echinococcus granulosus glutamate receptor ionotropic kainate 0.2105 0.6173 0.6173
Echinococcus multilocularis excitatory amino acid transporter 3 0.0941 0.2734 0.2734
Schistosoma mansoni glutamate receptor kainate 0.3055 0.8984 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0048 0.0103
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0589
Echinococcus multilocularis microtubule associated protein 2 0.289 0.8496 0.8496
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0704 0.2032 0.2032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.131 0.4785
Brugia malayi N-terminal motif family protein 0.0206 0.056 0.1195
Mycobacterium ulcerans hypothetical protein 0.0025 0.0025 0.0635
Brugia malayi Pre-SET motif family protein 0.0895 0.2597 0.5535
Echinococcus multilocularis excitatory amino acid transporter 2 0.0941 0.2734 0.2734
Schistosoma mansoni protein kinase 0.0344 0.0968 0.1078
Chlamydia trachomatis glutamine binding protein 0.0117 0.0298 0.1071
Onchocerca volvulus 0.0033 0.0048 0.008
Echinococcus multilocularis glutamate receptor 2 0.1603 0.4691 0.4691
Onchocerca volvulus 0.0344 0.0968 0.3211
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0164 0.0589
Echinococcus granulosus nmda type glutamate receptor 0.0344 0.0968 0.0968
Mycobacterium ulcerans hypothetical protein 0.0072 0.0164 0.5402
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0025 0.0635
Onchocerca volvulus 0.0104 0.026 0.0801
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0417 0.1185 0.1319
Echinococcus granulosus GPCR family 3 C terminal 0.0084 0.0199 0.0199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0333 0.037
Brugia malayi beta-lactamase 0.0072 0.0164 0.035
Schistosoma mansoni hypothetical protein 0.0076 0.0177 0.0197
Schistosoma mansoni tyrosine kinase 0.0344 0.0968 0.1078
Echinococcus multilocularis NMDA receptor 0.2105 0.6173 0.6173
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0428 0.1216 0.2592
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0344 0.0968 0.3211
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.043 0.0916
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0025 0.0635
Echinococcus multilocularis nmda type glutamate receptor 0.0344 0.0968 0.0968
Entamoeba histolytica hypothetical protein 0.0076 0.0177 0.1609
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0171 0.019
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.1947 0.5708 0.5708
Echinococcus multilocularis tyrosine kinase 0.0344 0.0968 0.0968
Brugia malayi Glutamate receptor 2 precursor 0.1603 0.4691 1
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0417 0.1185 0.1185
Echinococcus multilocularis tumor protein p63 0.0713 0.206 0.206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Schistosoma mansoni glutamate receptor kainate 0.1527 0.4465 0.497
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.009 0.0193
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.1947 0.5708 0.5708
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0103 0.0219
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.0663 0.1414
Echinococcus multilocularis geminin 0.0174 0.0466 0.0466
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0164 0.035
Brugia malayi beta-lactamase family protein 0.0072 0.0164 0.035
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0907 0.2632 0.2632
Mycobacterium ulcerans beta-lactamase 0.0072 0.0164 0.5402
Entamoeba histolytica hypothetical protein 0.0344 0.0968 1
Plasmodium vivax SET domain protein, putative 0.0129 0.0333 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0103 0.0103
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0444 0.1263 0.2692
Loa Loa (eye worm) RGC/RGC protein kinase 0.0344 0.0968 0.2064
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Loa Loa (eye worm) hypothetical protein 0.0084 0.0199 0.0425
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.2105 0.6173 0.6173
Schistosoma mansoni hypothetical protein 0.0174 0.0466 0.0519
Schistosoma mansoni hypothetical protein 0.0051 0.0103 0.0114
Echinococcus granulosus microtubule associated protein 2 0.289 0.8496 0.8496
Echinococcus granulosus metabotropic glutamate receptor 5 0.0907 0.2632 0.2632
Echinococcus granulosus metabotropic glutamate receptor 2 0.0704 0.2032 0.2032
Echinococcus multilocularis nmda type glutamate receptor 0.0693 0.2001 0.2001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.3399 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0467 0.1331 0.1331
Brugia malayi Receptor family ligand binding region containing protein 0.0428 0.1216 0.2592
Echinococcus granulosus atrial natriuretic peptide receptor 0.0344 0.0968 0.0968
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0025 0.0635
Echinococcus multilocularis muscleblind protein 1 0.0153 0.0405 0.0405
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0129 0.0333 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.009 0.0101
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.3399 1 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.1527 0.4465 0.4465
Entamoeba histolytica hypothetical protein 0.0076 0.0177 0.1609
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0153 0.0404 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0025 0.0635
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0589
Schistosoma mansoni hypothetical protein 0.0051 0.0103 0.0114
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.2105 0.6173 0.6173
Brugia malayi Excitatory amino acid transporter 0.0941 0.2734 0.5827
Schistosoma mansoni glutamate receptor AMPA 0.1527 0.4465 0.497
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0653 0.1881 0.1881
Brugia malayi Glutamate receptor 1 precursor 0.1603 0.4691 1
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0164 0.0589
Loa Loa (eye worm) hypothetical protein 0.0129 0.0333 0.0709
Schistosoma mansoni hypothetical protein 0.0467 0.1331 0.1482
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0164 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0941 0.2734 0.9223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0006 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0164 0.0183
Schistosoma mansoni microtubule-associated protein tau 0.289 0.8496 0.9457
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.1527 0.4465 0.4465
Entamoeba histolytica hypothetical protein 0.0076 0.0177 0.1609
Loa Loa (eye worm) hypothetical protein 0.0344 0.0968 0.2064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0129 0.0333 0.037
Schistosoma mansoni glutamate receptor NMDA 0.187 0.5481 0.6101
Chlamydia trachomatis glutamate symporter 0.0941 0.2734 1
Echinococcus granulosus Excitatory amino acid transporter 0.0941 0.2734 0.2734
Chlamydia trachomatis neutral amino acid transporter 0.0417 0.1185 0.4321
Schistosoma mansoni glutamate receptor NMDA 0.1527 0.4465 0.497
Schistosoma mansoni cpg binding protein 0.0035 0.0054 0.006
Brugia malayi Muscleblind-like protein 0.0153 0.0405 0.0863
Mycobacterium ulcerans lipase LipD 0.0072 0.0164 0.5402
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0576 0.1654 0.1654
Loa Loa (eye worm) hypothetical protein 0.0104 0.026 0.0554
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0025 0.0079
Echinococcus granulosus dnaJ subfamily B 0.0467 0.1331 0.1331
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0164 0.0589
Echinococcus multilocularis neutral amino acid transporter A 0.0941 0.2734 0.2734
Schistosoma mansoni glutamate receptor AMPA 0.1527 0.4465 0.497
Echinococcus granulosus glutamate receptor 4 0.0077 0.0178 0.0178
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0025 0.0053
Brugia malayi hypothetical protein 0.0344 0.0968 0.2064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.009 0.0101
Echinococcus granulosus GPCR family 2 0.0051 0.0103 0.0103
Loa Loa (eye worm) glutamate receptor 2 0.1527 0.4465 0.9518
Echinococcus granulosus excitatory amino acid transporter 2 0.0941 0.2734 0.2734
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0177 0.0177
Echinococcus multilocularis excitatory amino acid transporter 2 0.0941 0.2734 0.2734
Echinococcus multilocularis muscleblind protein 0.0153 0.0405 0.0405
Echinococcus multilocularis Excitatory amino acid transporter 0.0941 0.2734 0.2734
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0344 0.0968 0.2064
Echinococcus multilocularis glutamate receptor 4 0.0077 0.0178 0.0178
Schistosoma mansoni metabotropic glutamate receptor 0.0704 0.2032 0.2261
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.009 0.009
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0164 0.0589
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0177 0.0177
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0206 0.056 0.1824
Loa Loa (eye worm) hypothetical protein 0.0077 0.0178 0.0379
Schistosoma mansoni glutamate receptor kainate 0.3055 0.8984 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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