Detailed information for compound 770943

Basic information

Technical information
  • TDR Targets ID: 770943
  • Name: propyl 2-cyclohexyl-1,3-dioxoisoindole-5-carb oxylate
  • MW: 315.364 | Formula: C18H21NO4
  • H donors: 0 H acceptors: 3 LogP: 3.46 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOC(=O)c1ccc2c(c1)C(=O)N(C2=O)C1CCCCC1
  • InChi: 1S/C18H21NO4/c1-2-10-23-18(22)12-8-9-14-15(11-12)17(21)19(16(14)20)13-6-4-3-5-7-13/h8-9,11,13H,2-7,10H2,1H3
  • InChiKey: YSUKUXBPLGLIEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • propyl 2-cyclohexyl-1,3-dioxo-isoindoline-5-carboxylate
  • 2-cyclohexyl-1,3-dioxo-5-isoindolinecarboxylic acid propyl ester
  • 2-cyclohexyl-1,3-diketo-isoindoline-5-carboxylic acid propyl ester
  • propyl 2-cyclohexyl-1,3-dioxo-isoindole-5-carboxylate
  • AK-918/11642004
  • STK247397
  • Oprea1_769067
  • EU-0011638

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0082 0.0026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0304 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Trypanosoma brucei hypothetical protein, conserved 0.0232 0.2178 1
Brugia malayi beta-lactamase family protein 0.0073 0.0559 0.0467
Echinococcus multilocularis neutral amino acid transporter A 0.0376 0.3648 0.4839
Plasmodium vivax SET domain protein, putative 0.0126 0.1097 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0201 0.055
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0201 0.0146
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0346 0.1241
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0171 0.0785
Echinococcus multilocularis muscleblind protein 1 0.0157 0.1414 0.1832
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0559 0.1054
Mycobacterium tuberculosis Conserved protein 0.0073 0.0559 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0167 0.1513 0.1966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0304 0.0338
Brugia malayi hypothetical protein 0.0148 0.1323 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Echinococcus multilocularis excitatory amino acid transporter 2 0.0376 0.3648 0.4839
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Brugia malayi Muscleblind-like protein 0.0157 0.1414 0.146
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0559 0.0506
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0263 0.0208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.031 0.2967 0.3265
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0263 0.0283
Treponema pallidum glutamate/aspartate transporter 0.0167 0.1513 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0304 0.0338
Loa Loa (eye worm) hypothetical protein 0.0052 0.0346 0.0169
Echinococcus granulosus excitatory amino acid transporter 3 0.0376 0.3648 0.4839
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0559 0.2262
Echinococcus granulosus Excitatory amino acid transporter 0.0376 0.3648 0.4839
Treponema pallidum glutamate transporter 0.0167 0.1513 0.5
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0559 0.1054
Schistosoma mansoni microtubule-associated protein tau 0.0753 0.7483 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0171 0.0116
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0263 0.0845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0079 0.0024
Echinococcus granulosus GPCR family 2 0.0098 0.0811 0.1022
Loa Loa (eye worm) hypothetical protein 0.0126 0.1097 0.1047
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0559 0.1054
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0201 0.0051
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0263 0.0283
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1073 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0376 0.3648 0.4839
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.1097 0.1406
Onchocerca volvulus 0.0148 0.1323 0.1024
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.2308 0.246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0082 0.0026
Echinococcus granulosus excitatory amino acid transporter 2 0.0376 0.3648 0.4839
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0263 0.0845
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0304 0.017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0559 0.1054
Brugia malayi follicle stimulating hormone receptor 0.0245 0.2308 0.2499
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0304 0.0338
Onchocerca volvulus 0.0073 0.0559 0.0233
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0559 0.4793
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0559 0.0506
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0098 0.0811 0.1022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0171 0.0116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0559 0.1054
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1559 0.2028
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0201 0.055
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0263 0.0123
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0098 0.0811 0.1022
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0559 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1073 0.1374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0105 0.005
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0201 0.0561
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0167 0.1513 0.1966
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0263 0.1205
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.1097 0.1406
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0559 0.4793
Echinococcus granulosus excitatory amino acid transporter 2 0.0376 0.3648 0.4839
Onchocerca volvulus 0.0073 0.0559 0.0233
Loa Loa (eye worm) hypothetical protein 0.0051 0.0334 0.0155
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0201 0.0146
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0559 0.1054
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0263 0.0845
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0559 0.1054
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.105 0.1343
Echinococcus multilocularis Excitatory amino acid transporter 0.0376 0.3648 0.4839
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0201 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0559 0.0506
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1073 0.1374
Schistosoma mansoni hypothetical protein 0.0098 0.0811 0.1022
Schistosoma mansoni hypothetical protein 0.0098 0.0811 0.1022
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0559 0.2839
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0376 0.3648 0.4839
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0201 0.0146
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0201 0.02
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0201 0.0146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0304 0.012
Onchocerca volvulus 0.0126 0.1097 0.079
Echinococcus multilocularis GPCR, family 2 0.0098 0.0811 0.1022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1073 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.1073 0.2199
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1097 0.1406
Echinococcus granulosus neutral amino acid transporter A 0.0376 0.3648 0.4839
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1073 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.0559 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0559 0.2262
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0098 0.0811 0.1022
Loa Loa (eye worm) excitatory amino acid transporter 0.0376 0.3648 0.4026
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0167 0.1513 0.1966
Brugia malayi Glycosyl hydrolases family 31 protein 0.0171 0.1559 0.1629
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0376 0.3648 0.4839
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0201 0.0146
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0559 0.0506
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0559 0.0682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0082 0.0026
Echinococcus granulosus muscleblind protein 0.0157 0.1414 0.1832
Brugia malayi Excitatory amino acid transporter 0.0376 0.3648 0.4056
Echinococcus granulosus tumor protein p63 0.0349 0.3366 0.446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0197 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.2178 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1092 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0171 0.0116
Echinococcus granulosus citrate lyase subunit beta protein 0.0027 0.0086 0.0045
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0171 0.0407
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0098 0.0811 0.076
Leishmania major hypothetical protein, conserved 0.0052 0.0346 0.1241
Brugia malayi beta-lactamase 0.0073 0.0559 0.0467
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0263 0.0283
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0376 0.3648 0.4839
Mycobacterium leprae Probable lipase LipE 0.0073 0.0559 0.5
Loa Loa (eye worm) hypothetical protein 0.0148 0.1323 0.1311
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.1073 0.1374
Echinococcus multilocularis lysosomal alpha glucosidase 0.0171 0.1559 0.2028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0559 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Schistosoma mansoni hypothetical protein 0.0098 0.0811 0.1022
Brugia malayi Pre-SET motif family protein 0.0878 0.8764 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0346 0.5
Echinococcus multilocularis muscleblind protein 0.0157 0.1414 0.1832
Echinococcus multilocularis microtubule associated protein 2 0.0753 0.7483 1
Echinococcus multilocularis neutral amino acid transporter A 0.0376 0.3648 0.4839
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0559 0.0506
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0263 0.1205
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1097 0.1406
Loa Loa (eye worm) hypothetical protein 0.031 0.2967 0.323
Leishmania major hypothetical protein, conserved 0.0232 0.2178 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1092 0.1041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.1073 0.4719
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.1073 0.1374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0878 0.8764 1
Schistosoma mansoni alpha-glucosidase 0.0147 0.1316 0.1701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0171 0.0116
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0098 0.0811 0.1022
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0346 0.1586
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0559 0.0682
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0304 0.0338
Schistosoma mansoni hypothetical protein 0.0098 0.0811 0.1022
Giardia lamblia GTOR 0.0044 0.0263 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0346 0.1241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0559 0.0418
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0376 0.3648 0.7933
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0201 0.0146
Leishmania major hypothetical protein, conserved 0.0073 0.0559 0.2262
Echinococcus granulosus microtubule associated protein 2 0.0753 0.7483 1
Brugia malayi beta-lactamase family protein 0.0073 0.0559 0.0467
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0334 0.0379
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0171 0.0407
Chlamydia trachomatis glutamate symporter 0.0376 0.3648 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.1097 0.1406
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0201 0.0146
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0167 0.1513 0.1966
Echinococcus granulosus sodium:dicarboxylate symporter 0.0376 0.3648 0.4839
Echinococcus multilocularis neutral amino acid transporter A 0.0376 0.3648 0.4839
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0027 0.0086 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0304 0.0338
Trypanosoma brucei glucosidase, putative 0.0038 0.0201 0.0922
Brugia malayi Pre-SET motif family protein 0.0126 0.1097 0.1093
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0346 0.2085
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0026 0.0119
Brugia malayi hypothetical protein 0.0052 0.0346 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.031 0.2967 0.3265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.031 0.2967 0.323
Loa Loa (eye worm) hypothetical protein 0.0098 0.0811 0.0713
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.2178 1
Echinococcus granulosus neutral amino acid transporter A 0.0376 0.3648 0.4839
Echinococcus multilocularis Excitatory amino acid transporter 0.0376 0.3648 0.4839
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0346 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0171 0.0116
Echinococcus multilocularis citrate lyase subunit beta protein 0.0027 0.0086 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0304 0.0338
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0201 0.02
Brugia malayi Latrophilin receptor protein 2 0.0098 0.0811 0.076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0079 0.0024
Echinococcus multilocularis excitatory amino acid transporter 2 0.0376 0.3648 0.4839
Mycobacterium tuberculosis Conserved protein 0.0073 0.0559 0.1054
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0376 0.3648 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0263 0.0845
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0171 0.1559 0.1586
Loa Loa (eye worm) hypothetical protein 0.0157 0.1414 0.1417
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0559 0.0682
Loa Loa (eye worm) hypothetical protein 0.0073 0.0559 0.0418
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0559 0.0682
Onchocerca volvulus 0.0099 0.0823 0.0506
Echinococcus granulosus neutral amino acid transporter 0.0376 0.3648 0.4839
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0147 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.1097 0.1406
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0263 1
Toxoplasma gondii ABC1 family protein 0.0073 0.0559 0.4333
Trichomonas vaginalis esterase, putative 0.0073 0.0559 0.0506
Mycobacterium ulcerans hypothetical protein 0.0073 0.0559 0.4793
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.1073 0.9745
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0263 0.0072
Brugia malayi MH2 domain containing protein 0.0126 0.1092 0.1087
Loa Loa (eye worm) hypothetical protein 0.0212 0.1969 0.2065
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0376 0.3648 0.3429
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0559 0.2566
Echinococcus granulosus Excitatory amino acid transporter 0.0376 0.3648 0.4839
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0263 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.1414 0.1417
Brugia malayi latrophilin 2 splice variant baaae 0.0212 0.1969 0.2106
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0201 0.055
Mycobacterium ulcerans beta-lactamase 0.0073 0.0559 0.4793
Echinococcus multilocularis tumor protein p63 0.0349 0.3366 0.446
Trichomonas vaginalis set domain proteins, putative 0.1 1 1
Schistosoma mansoni alpha-glucosidase 0.0147 0.1316 0.1701
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.1097 0.1406
Mycobacterium tuberculosis Conserved protein 0.0073 0.0559 0.1054
Echinococcus granulosus lysosomal alpha glucosidase 0.0171 0.1559 0.2028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0263 0.0208
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.1097 1
Mycobacterium ulcerans lipase LipD 0.0073 0.0559 0.4793
Onchocerca volvulus 0.0073 0.0559 0.0233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0098 0.0811 0.0713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0263 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0115 0.0059
Schistosoma mansoni alpha glucosidase 0.0038 0.0201 0.02
Schistosoma mansoni hypothetical protein 0.0212 0.1969 0.258
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.4576 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0201 0.0146

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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