Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0065 | 0.1397 | 0.3265 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.065 | 0.151 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0108 | 0.2519 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0093 | 0.2117 | 0.2117 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0966 | 0.2195 |
Echinococcus multilocularis | cpg binding protein | 0.0029 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.017 | 0.4107 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0966 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0189 | 0.0133 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0599 | 0.1392 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0108 | 0.2519 | 1 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.229 | 0.229 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.229 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0189 | 0.0133 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0438 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3839 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0644 | 0.0644 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0014 | 0.0083 | 0.0125 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.2091 | 0.5346 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0189 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0966 | 0.2352 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0189 | 0.0189 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0438 | 0.0438 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0966 | 0.2195 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.0891 | 0.3319 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.3661 | 0.449 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.0966 | 0.2195 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0099 | 0.229 | 0.229 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0189 | 0.0526 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0599 | 0.1392 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0083 | 0.0125 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0644 | 0.1494 |
Echinococcus multilocularis | peregrin | 0.0028 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.065 | 0.151 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Brugia malayi | Bromodomain containing protein | 0.0028 | 0.0449 | 0.0974 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.0966 | 0.2195 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0966 | 0.2352 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.035 | 0.0335 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0449 | 0.1502 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0322 | 0.8052 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0159 | 0.3839 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0028 | 0.0449 | 0.0449 |
Plasmodium vivax | hypothetical protein, conserved | 0.0028 | 0.0449 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.065 | 0.151 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.2091 | 0.2091 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0065 | 0.1397 | 0.5394 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.2091 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0176 | 0.0248 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0045 | 0.0888 | 0.101 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0014 | 0.0083 | 0.0125 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0108 | 0.2519 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0045 | 0.0888 | 0.101 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0034 | 0.0603 | 0.0603 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0108 | 0.2519 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0039 | 0.0736 | 0.0736 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0058 | 0.1229 | 0.3052 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.0966 | 0.2293 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.035 | 0.0335 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.0966 | 0.2195 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0028 | 0.0449 | 0.0974 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.0034 | 0.0609 | 0.1415 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0093 | 0.2117 | 0.2117 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0966 | 0.2352 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.2091 | 0.8163 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0053 | 0.1084 | 0.4109 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0189 | 0.0434 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0059 | 0.1247 | 0.1247 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.2091 | 0.252 |
Plasmodium falciparum | phd finger protein, putative | 0.0028 | 0.0449 | 0.1502 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0099 | 0.229 | 0.2769 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0028 | 0.0449 | 0.0449 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3976 | 0.3976 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0014 | 0.0083 | 0.0083 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0888 | 0.101 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0028 | 0.0449 | 0.0449 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0189 | 0.0434 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0108 | 0.2519 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0033 | 0.0569 | 0.061 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0966 | 0.4399 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0099 | 0.229 | 0.5875 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0189 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0048 | 0.0966 | 0.4399 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0083 | 0.0125 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0099 | 0.229 | 0.5875 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.035 | 0.1094 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0014 | 0.0083 | 0.0125 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.035 | 0.0335 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0083 | 0.0125 |
Mycobacterium ulcerans | hypothetical protein | 0.017 | 0.4107 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0125 | 0.0112 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0966 | 0.1108 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0966 | 0.2352 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.035 | 0.1094 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.8052 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.0891 | 0.3319 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0189 | 0.0263 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0189 | 0.0133 |
Onchocerca volvulus | Alhambra homolog | 0.0028 | 0.0449 | 0.1822 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0152 | 0.3661 | 0.449 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0449 | 0.0974 |
Echinococcus granulosus | jumonji domain containing protein | 0.0039 | 0.0736 | 0.0736 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.0966 | 0.2293 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0028 | 0.0449 | 0.1502 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0108 | 0.2519 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0189 | 0.0189 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0397 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.2091 | 0.2091 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.0966 | 0.2195 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.065 | 0.1517 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0014 | 0.0083 | 0.0083 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0108 | 0.2519 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.229 | 0.5484 |
Brugia malayi | jmjC domain containing protein | 0.0093 | 0.2117 | 0.5414 |
Giardia lamblia | PHD finger protein 15 | 0.0028 | 0.0449 | 0.1116 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0014 | 0.0083 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3976 | 0.3976 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.065 | 0.2329 |
Echinococcus granulosus | peregrin | 0.0028 | 0.0449 | 0.0449 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0189 | 0.0133 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.2091 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.065 | 0.151 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0152 | 0.3661 | 0.449 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0014 | 0.0083 | 0.0125 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.2091 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0028 | 0.0449 | 0.0449 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0479 | 0.0479 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0014 | 0.0083 | 0.0125 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0189 | 0.0189 |
Schistosoma mansoni | jumonji domain containing protein | 0.0074 | 0.1623 | 0.1623 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.0966 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.0966 | 0.2195 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.229 | 0.2769 |
Echinococcus multilocularis | muscleblind protein | 0.0159 | 0.3839 | 0.3839 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3976 | 0.3976 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0599 | 0.1392 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0322 | 0.8052 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.2091 | 0.2091 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.0966 | 0.2195 |
Echinococcus granulosus | cpg binding protein | 0.0029 | 0.0479 | 0.0479 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0438 | 0.0945 |
Schistosoma mansoni | hypothetical protein | 0.0397 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0189 | 0.0434 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0045 | 0.0888 | 0.101 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0644 | 0.1494 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0189 | 0.0281 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0099 | 0.229 | 1 |
Schistosoma mansoni | kinase | 0.0047 | 0.0923 | 0.0923 |
Brugia malayi | hypothetical protein | 0.0024 | 0.035 | 0.071 |
Onchocerca volvulus | 0.0028 | 0.0438 | 0.1768 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0966 | 0.2352 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0189 | 0.0434 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0099 | 0.229 | 0.229 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.2091 | 0.252 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0016 | 0.0135 | 0.0135 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.035 | 0.1094 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.2091 | 0.5346 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.0599 | 0.1392 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.065 | 0.2329 |
Echinococcus granulosus | muscleblind protein | 0.0159 | 0.3839 | 0.3839 |
Onchocerca volvulus | 0.0048 | 0.0966 | 0.4399 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0644 | 0.0644 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0189 | 0.0385 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0322 | 0.8052 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0189 | 0.0281 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0159 | 0.3839 | 0.3839 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.0083 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0972 | 0.2368 |
Echinococcus granulosus | geminin | 0.0164 | 0.3976 | 0.3976 |
Trypanosoma cruzi | Glucose-6-phosphate dehydrogenase, putative | 0.0032 | 0.0544 | 0.0578 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0014 | 0.0083 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.035 | 0.071 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0055 | 0.1144 | 0.1332 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2091 | 0.8243 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.0966 | 0.2352 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0644 | 0.0644 |
Toxoplasma gondii | hypothetical protein | 0.0052 | 0.106 | 0.4012 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0099 | 0.229 | 0.2769 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.0966 | 0.4399 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.065 | 0.151 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0036 | 0.065 | 0.141 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0966 | 0.1108 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0014 | 0.0083 | 0.0083 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.035 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0449 | 0.0974 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.0966 | 0.1108 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.2091 | 0.252 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0189 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.3839 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.035 | 0.1094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 7600 nM | Concentration required for half-maximal inhibition of CpG-ODN effect on thymidine uptake by WEHI 231 murine B-cells in the presence of alpha-sIgM. | ChEMBL. | 10406648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.