Detailed information for compound 771737

Basic information

Technical information
  • TDR Targets ID: 771737
  • Name: N-[(8-hydroxy-5-nitroquinolin-7-yl)-(4-propan -2-ylphenyl)methyl]-2-methylpropanamide
  • MW: 407.462 | Formula: C23H25N3O4
  • H donors: 2 H acceptors: 5 LogP: 5.19 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)C)NC(c1cc([N+](=O)[O-])c2c(c1O)nccc2)c1ccc(cc1)C(C)C
  • InChi: 1S/C23H25N3O4/c1-13(2)15-7-9-16(10-8-15)20(25-23(28)14(3)4)18-12-19(26(29)30)17-6-5-11-24-21(17)22(18)27/h5-14,20,27H,1-4H3,(H,25,28)
  • InChiKey: OVHTXSKBEMIRAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(8-hydroxy-5-nitro-7-quinolyl)-(4-isopropylphenyl)methyl]-2-methyl-propanamide
  • N-[(8-hydroxy-5-nitro-7-quinolyl)-(4-isopropylphenyl)methyl]-2-methylpropanamide
  • N-[(8-hydroxy-5-nitro-7-quinolyl)-(4-isopropylphenyl)methyl]-2-methyl-propionamide
  • N-[(8-hydroxy-5-nitro-quinolin-7-yl)-(4-propan-2-ylphenyl)methyl]-2-methyl-propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.0054 0.0352 0.0352
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.2686 0.4336
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0148 0.0401
Trichomonas vaginalis heat shock protein, putative 0.005 0.0298 0.0749
Schistosoma mansoni hypothetical protein 0.0043 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0535 0.619 1
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0161 0.0405
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0064 0.0097
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0199 0.0199
Echinococcus multilocularis GPCR, family 2 0.0097 0.0871 0.0871
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0359 0.0575
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0199 0.0199
Schistosoma mansoni importin beta-1 0.0029 0.0046 0.0046
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0915 0.0915
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0407 0.0407
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.1165 0.1165
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0123 0.0445
Echinococcus granulosus cpg binding protein 0.0096 0.0857 0.0857
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.003 0.0064 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1044 0.5185
Brugia malayi hypothetical protein 0.0094 0.0843 0.131
Schistosoma mansoni hypothetical protein 0.0035 0.0123 0.0123
Echinococcus multilocularis lysine specific demethylase 5A 0.0114 0.1075 0.1075
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0039 0.0007
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1915 0.1915
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0039 0.0215
Loa Loa (eye worm) hypothetical protein 0.0059 0.0414 0.0663
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0208 0.0884
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0188 0.0246
Plasmodium vivax heat shock protein, putative 0.0188 0.1979 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0403 0.0403
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0199 0.0199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1044 0.1044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0199 0.0315
Brugia malayi HSF-type DNA-binding domain containing protein 0.0106 0.0987 0.1544
Brugia malayi RNA binding protein 0.0255 0.2792 0.4477
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0064 0.0097
Echinococcus multilocularis peregrin 0.0038 0.0158 0.0158
Brugia malayi hypothetical protein 0.0033 0.0099 0.0102
Trypanosoma cruzi heat shock protein 85, putative 0.0046 0.0249 0.0763
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0199 0.0199
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0199 0.014
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0208 0.0884
Brugia malayi F/Y-rich N-terminus family protein 0.0042 0.0207 0.0277
Schistosoma mansoni hypothetical protein 0.0849 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0199 0.0199
Echinococcus granulosus GPCR family 2 0.0097 0.0871 0.0871
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1789 1
Leishmania major hypothetical protein, conserved 0.0051 0.0321 0.1023
Brugia malayi MH2 domain containing protein 0.0246 0.2686 0.4305
Leishmania major hypothetical protein, conserved 0.0257 0.2815 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0055 0.0066
Giardia lamblia PHD finger protein 15 0.0035 0.0123 0.0219
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0399 0.4542 0.4542
Plasmodium falciparum heat shock protein 90, putative 0.0188 0.1979 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.003 0.0064 0.0139
Trypanosoma cruzi heat shock protein 90, putative 0.0054 0.0346 0.1112
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0148 0.0828
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Giardia lamblia Heat shock protein HSP 90-alpha 0.0046 0.0249 0.0537
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0148 0.0148
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0352 0.0513
Schistosoma mansoni zinc finger protein 0.0029 0.0044 0.0044
Trypanosoma cruzi heat shock protein 90, putative 0.0046 0.0249 0.0763
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0199 0.0199
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.081 0.081
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.0473
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Leishmania major heat shock protein, putative 0.0034 0.0114 0.0278
Trypanosoma brucei glucosidase, putative 0.0041 0.0188 0.0545
Mycobacterium ulcerans hypothetical protein 0.0111 0.1044 0.5833
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.0037 0.0092
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0039 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Schistosoma mansoni hypothetical protein 0.0097 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0209 0.2235 0.3607
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0223 0.0223
Brugia malayi intermediate filament protein 0.0055 0.0359 0.0525
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1789 1
Brugia malayi latrophilin 2 splice variant baaae 0.0209 0.2235 0.3573
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0188 0.0473
Schistosoma mansoni endoplasmin 0.0054 0.0346 0.0346
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0188 0.0473
Echinococcus granulosus ribosomal protein L19 0.0028 0.0037 0.0037
Brugia malayi nuclear hormone receptor 0.0041 0.0199 0.0263
Trypanosoma cruzi Heat shock protein 83, putative 0.0054 0.0346 0.1112
Schistosoma mansoni intermediate filament proteins 0.0055 0.0359 0.0359
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0188 0.0473
Mycobacterium ulcerans lipase LipD 0.0111 0.1044 0.5833
Toxoplasma gondii ABC1 family protein 0.0111 0.1044 0.5185
Schistosoma mansoni hypothetical protein 0.0097 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0321 0.1464
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.2256
Echinococcus granulosus peregrin 0.0038 0.0158 0.0158
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.2792 0.4507
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0068
Schistosoma mansoni cpg binding protein 0.0096 0.0857 0.0857
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0123 0.0123
Schistosoma mansoni sex comb on midleg homolog 0.0101 0.0925 0.0925
Brugia malayi Calcitonin receptor-like protein seb-1 0.0306 0.3411 0.5483
Onchocerca volvulus Alhambra homolog 0.0035 0.0123 0.0015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.081 0.1303
Plasmodium vivax heat shock protein 86, putative 0.0054 0.0346 0.1591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0199 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0199 0.0199
Echinococcus multilocularis citrate lyase subunit beta protein 0.003 0.0055 0.0055
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1044 0.2621
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0148 0.0148
Trichomonas vaginalis heat shock protein, putative 0.005 0.0298 0.0749
Plasmodium vivax endoplasmin, putative 0.0054 0.0346 0.1591
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0306 0.3411 0.5507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0199 0.0199
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Echinococcus multilocularis dna polymerase eta 0.0054 0.0352 0.0352
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0044 0.0044
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Brugia malayi CXXC zinc finger family protein 0.0088 0.0768 0.1189
Echinococcus multilocularis heat shock protein 0.0054 0.0346 0.0346
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0039 0.0215
Schistosoma mansoni endoplasmin 0.0054 0.0346 0.0346
Brugia malayi jmjC domain containing protein 0.003 0.0064 0.0044
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0664 0.0664
Echinococcus multilocularis heat shock protein 90 0.0046 0.0249 0.0249
Brugia malayi jmjC domain containing protein 0.003 0.0064 0.0044
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1915 0.1915
Loa Loa (eye worm) hypothetical protein 0.0026 0.0016 0.002
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0578 0.0929
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0148 0.497
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0452 0.0452
Brugia malayi steroid hormone receptor 0.0041 0.0199 0.0263
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0346 0.1112
Loa Loa (eye worm) inositol-1 0.0037 0.0148 0.0233
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0097 0.0871 0.0871
Echinococcus granulosus neuropeptide s receptor 0.0479 0.5518 0.5518
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3981 1
Brugia malayi Pre-SET motif family protein 0.0038 0.0157 0.0195
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0199 0.014
Loa Loa (eye worm) heat shock protein 90 0.0054 0.0346 0.0552
Leishmania major hypothetical protein, conserved 0.0111 0.1044 0.3624
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0055 0.0307
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0199 0.0199
Trichomonas vaginalis set domain proteins, putative 0.0288 0.3192 0.8019
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0256 0.0256
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0121 0.0121
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0987 0.2408
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0399 0.4542 0.4542
Mycobacterium ulcerans hypothetical protein 0.003 0.0055 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0208 0.0523
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0101 0.0121
Brugia malayi jmjC domain containing protein 0.0121 0.1165 0.1833
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0044 0.0064
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0188 0.0473
Schistosoma mansoni hypothetical protein 0.0209 0.2235 0.2235
Plasmodium vivax JmjC domain containing protein 0.003 0.0064 0.0139
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0664 0.1019
Mycobacterium tuberculosis Conserved protein 0.0111 0.1044 0.1256
Entamoeba histolytica hypothetical protein 0.0028 0.0039 0.0005
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.1915 0.3053
Schistosoma mansoni lipoxygenase 0.0067 0.0505 0.0505
Brugia malayi Pre-SET motif family protein 0.0253 0.2771 0.4443
Loa Loa (eye worm) hypothetical protein 0.0286 0.3163 0.5107
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0321 0.1023
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0452 0.0452
Onchocerca volvulus Huntingtin homolog 0.0148 0.1492 0.2268
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0223 0.0223
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0208 0.0523
Toxoplasma gondii histone lysine methyltransferase SET1 0.0172 0.1779 0.897
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Echinococcus granulosus JmjC domain containing protein 4 0.003 0.0064 0.0064
Schistosoma mansoni cpg binding protein 0.0088 0.0768 0.0768
Schistosoma mansoni eyes absent homolog 0.0094 0.0843 0.0843
Echinococcus granulosus lysine specific demethylase 6a 0.003 0.0064 0.0064
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0064 0.0143
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1044 0.5833
Loa Loa (eye worm) hypothetical protein 0.0054 0.0347 0.0555
Plasmodium falciparum heat shock protein 90 0.0054 0.0346 0.1591
Toxoplasma gondii heat shock protein 90, putative 0.0054 0.0346 0.1591
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0223 0.0223
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0118 0.0118
Echinococcus multilocularis Protein lozenge 0.0067 0.051 0.051
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0199 0.0263
Onchocerca volvulus 0.0041 0.0199 0.014
Toxoplasma gondii Hsp90 domain-containing protein 0.0188 0.1979 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0046 0.0049
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.005 0.0298 0.0941
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0157 0.0157
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0407 0.0407
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0199 0.0199
Echinococcus granulosus tar DNA binding protein 0.0255 0.2792 0.2792
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0055 0.0066
Schistosoma mansoni transient receptor potential channel 0.0094 0.084 0.084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0223 0.0223
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0188 0.0473
Echinococcus multilocularis lamin 0.0055 0.0359 0.0359
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0199 0.0199
Brugia malayi hypothetical protein 0.0148 0.1492 0.2365
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.1915 0.309
Mycobacterium tuberculosis Conserved protein 0.0111 0.1044 0.1256
Schistosoma mansoni hypothetical protein 0.0097 0.0871 0.0871
Echinococcus multilocularis lysine specific demethylase 6a 0.003 0.0064 0.0064
Echinococcus multilocularis jumonji domain containing 1A 0.003 0.0064 0.0064
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0435 0.0435
Schistosoma mansoni hypothetical protein 0.0616 0.7172 0.7172
Echinococcus granulosus transcription factor btf3 0.0042 0.0208 0.0208
Brugia malayi jmjC domain containing protein 0.003 0.0064 0.0044
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0097 0.0871 0.0871
Schistosoma mansoni hypothetical protein 0.0058 0.0403 0.0403
Brugia malayi Peptidase family M28 containing protein 0.011 0.1027 0.161
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1044 0.5833
Trypanosoma brucei hypothetical protein, conserved 0.0257 0.2815 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0321 0.1464
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0199 0.0199
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1044 0.1256
Schistosoma mansoni phd/f-box containing protein 0.003 0.0064 0.0064
Leishmania major hypothetical protein, conserved 0.003 0.0064 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0479 0.5518 0.5518
Loa Loa (eye worm) hypothetical protein 0.0148 0.1492 0.2406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0199 0.0315
Schistosoma mansoni cpg binding protein 0.0096 0.0857 0.0857
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0199 0.0199
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0435 0.0523
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.0473
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1789 0.2154
Echinococcus multilocularis ribosomal protein L19 0.0028 0.0037 0.0037
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Echinococcus granulosus zinc finger protein 0.0029 0.0044 0.0044
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0094 0.084 0.1351
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0199 0.0315
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0097 0.0871 0.0871
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3163 0.3163
Loa Loa (eye worm) beta-lactamase 0.0111 0.1044 0.1681
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0505 0.0505
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.003 0.0055 0.0307
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.1915 0.1915
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0148 0.0401
Brugia malayi Bromodomain containing protein 0.0096 0.0857 0.1332
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.005 0.0298 1
Trypanosoma brucei heat shock protein 84, putative 0.0034 0.0114 0.0278
Echinococcus granulosus geminin 0.0205 0.218 0.218
Leishmania major DNA polymerase eta, putative 0.0038 0.0157 0.0433
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0101 0.0925 0.1336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0157 0.0619
Schistosoma mansoni transient receptor potential channel 0.0062 0.0452 0.0452
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.081 0.081
Mycobacterium ulcerans heat shock protein 90 0.005 0.0298 0.1666
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Schistosoma mansoni lozenge 0.0067 0.051 0.051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0188 0.0384
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0199 0.0263
Schistosoma mansoni sex comb on midleg homolog 0.0101 0.0925 0.0925
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1044 0.1636
Trichomonas vaginalis endoplasmin, putative 0.0038 0.0161 0.0405
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.0034
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0106 0.0987 0.1436
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0199 0.0199
Echinococcus granulosus snurportin 1 0.0308 0.3438 0.3438
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0034 0.0114 0.0114
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0115 0.1096 0.1721
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0199 0.0199
Onchocerca volvulus 0.0111 0.1044 0.153
Brugia malayi jmjC domain containing protein 0.003 0.0064 0.0044
Schistosoma mansoni hypothetical protein 0.0205 0.218 0.218
Giardia lamblia Grp94/Hsp90 0.005 0.0298 0.0663
Brugia malayi hypothetical protein 0.0051 0.0321 0.0462
Schistosoma mansoni alpha glucosidase 0.0041 0.0188 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0199 0.0263
Loa Loa (eye worm) hypothetical protein 0.0334 0.3748 0.6053
Trichomonas vaginalis heat shock protein, putative 0.003 0.0064 0.0162
Echinococcus granulosus histone acetyltransferase MYST2 0.0115 0.1096 0.1096
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1044 0.2621
Mycobacterium ulcerans hypothetical protein 0.003 0.0055 0.0307
Echinococcus multilocularis lamin dm0 0.0055 0.0359 0.0359
Brugia malayi RNA, U transporter 1 0.0082 0.0692 0.1066
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0097
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Echinococcus granulosus lamin 0.0055 0.0359 0.0359
Brugia malayi mbt repeat family protein 0.0101 0.0925 0.1444
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0346 0.0783
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.2256
Echinococcus granulosus intermediate filament protein 0.0055 0.0359 0.0359
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1044 0.1044
Brugia malayi Bromodomain containing protein 0.0046 0.0257 0.0358
Loa Loa (eye worm) hypothetical protein 0.0097 0.0871 0.1402
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1044 0.1044
Echinococcus multilocularis dnaJ subfamily B 0.0849 1 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0664 0.1589
Leishmania major DNA polymerase eta, putative 0.0054 0.0352 0.1135
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0148 0.0372
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0664 0.0664
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0121 0.0121
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0199 0.0263
Brugia malayi beta-lactamase 0.0111 0.1044 0.1636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0199 0.0199
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0199 0.0199
Onchocerca volvulus 0.0535 0.619 1
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.0037 0.0092
Echinococcus multilocularis geminin 0.0205 0.218 0.218
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0915 0.0915
Echinococcus granulosus neuropeptide receptor A26 0.0479 0.5518 0.5518
Loa Loa (eye worm) TAR-binding protein 0.0255 0.2792 0.4507
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0205 0.218 0.218
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0709 0.8308 1
Echinococcus multilocularis JmjC domain containing protein 4 0.003 0.0064 0.0064
Onchocerca volvulus Huntingtin homolog 0.0148 0.1492 0.2268
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0208 0.0435
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.003 0.0055 0.0307
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.0473
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.084 0.084
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0148 0.0372
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0101 0.0563
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0186 0.1958 0.1958
Brugia malayi jmjC domain containing protein 0.0186 0.1958 0.3122
Schistosoma mansoni tar DNA-binding protein 0.0255 0.2792 0.2792
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0435 0.243
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1044 0.1044
Echinococcus granulosus ribosomal protein L19 0.0028 0.0037 0.0037
Echinococcus granulosus heat shock protein 90 0.0046 0.0249 0.0249
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0038 0.0153 0.0153
Echinococcus multilocularis SAM and MBT domain containing protein 0.0101 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0057 0.0382 0.0611
Schistosoma mansoni alpha-glucosidase 0.0157 0.1606 0.1606
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0046 0.0249 0.0249
Schistosoma mansoni phosphatidylserine receptor 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0106 0.0987 0.1589
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9814 0.9814
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0188 0.0188
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0188 0.0473
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0987 0.2408
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0188 0.0384
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.081 0.081
Brugia malayi hypothetical protein 0.0286 0.3163 0.508
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.1987 0.1987
Loa Loa (eye worm) hypothetical protein 0.0148 0.1492 0.2406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.081 0.081
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0664 0.0664
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0435 0.243
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0435 0.0435
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3163 0.3163
Plasmodium falciparum importin beta, putative 0.0029 0.0046 0.0049
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Onchocerca volvulus 0.0111 0.1044 0.153
Brugia malayi hypothetical protein 0.0535 0.619 1
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0346 0.1112
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0157 0.0157
Schistosoma mansoni alpha-glucosidase 0.0157 0.1606 0.1606
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.003 0.0055 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0199 0.0263
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0346 0.1112
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0188 0.0473
Echinococcus multilocularis transcription factor btf3 0.0042 0.0208 0.0208
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Onchocerca volvulus 0.0101 0.0925 0.1336
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1044 0.3624
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0321 0.1464
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0123 0.0123
Echinococcus granulosus lysine specific demethylase 5A 0.0121 0.1165 0.1165
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Trichomonas vaginalis Citrate lyase beta chain, putative 0.003 0.0055 0.0138
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1044 0.1256
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0208 0.0523
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0664 0.1066
Brugia malayi Hsp90 protein 0.0034 0.0114 0.0125
Giardia lamblia Heat shock protein HSP 90-alpha 0.0054 0.0346 0.0783
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0208 0.0618
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0039 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0199 0.0263
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0199 0.0263
Plasmodium falciparum endoplasmin, putative 0.0038 0.0161 0.0642
Brugia malayi beta-NAC-like protein 0.0042 0.0208 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0255 0.2792 0.2792
Loa Loa (eye worm) endoplasmin 0.0054 0.0346 0.0552
Brugia malayi nuclear receptor NHR-88 0.0041 0.0199 0.0263
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.2792 0.4477
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.084 0.084
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0121 0.0137
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0188 0.0473
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1044 0.1681
Brugia malayi Latrophilin receptor protein 2 0.0097 0.0871 0.1356
Schistosoma mansoni 60S ribosomal protein L19 0.0028 0.0037 0.0037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0148 0.0401
Echinococcus granulosus polycomb protein SCMH1 0.0101 0.0925 0.0925
Entamoeba histolytica hypothetical protein 0.0043 0.0223 0.0473
Loa Loa (eye worm) hypothetical protein 0.0085 0.0733 0.1178
Onchocerca volvulus 0.0055 0.0359 0.0404
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.005 0.0298 0.1666
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0352 0.1135
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0199 0.0199
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.3981 1
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.0802 0.0802
Brugia malayi heat shock protein 90 0.0054 0.0346 0.0502
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0435 0.0435
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0505 0.0505
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1044 0.1256
Echinococcus multilocularis cpg binding protein 0.0096 0.0857 0.0857
Echinococcus multilocularis histone acetyltransferase MYST2 0.0115 0.1096 0.1096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0117 0.0117
Echinococcus granulosus lamin dm0 0.0055 0.0359 0.0359
Echinococcus granulosus jumonji domain containing 1A 0.003 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0199 0.0199
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0046 0.0034
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0208 0.0618
Mycobacterium tuberculosis Conserved protein 0.0111 0.1044 0.1256
Echinococcus multilocularis neuropeptide s receptor 0.0479 0.5518 0.5518
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0051 0.0077
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0039 0.0097
Loa Loa (eye worm) hypothetical protein 0.0306 0.3411 0.5507
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0199 0.0263
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0359 0.0575
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0034 0.0114 0.0196
Echinococcus granulosus heat shock protein 0.0054 0.0346 0.0346
Brugia malayi Cytochrome P450 family protein 0.003 0.0062 0.0041
Loa Loa (eye worm) hypothetical protein 0.0055 0.0359 0.0575
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0768 0.1236
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1165 0.1876
Trypanosoma brucei Heat shock protein 83, putative 0.0054 0.0346 0.1112
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.0802 0.0802
Echinococcus granulosus endoplasmin 0.005 0.0298 0.0298
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Brugia malayi PHD-finger family protein 0.0035 0.0122 0.0139
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Plasmodium falciparum JmjC domain-containing protein, putative 0.003 0.0064 0.0139
Echinococcus granulosus phd:f box containing protein 0.003 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0199 0.0263
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1044 0.1256
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1044 0.1256
Brugia malayi beta-lactamase family protein 0.0111 0.1044 0.1636
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0032 0.0087 0.0087
Leishmania major heat shock protein 83-1 0.0054 0.0346 0.1112
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0123 0.0193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0121 0.019
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0157 0.0157
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0435 0.205
Loa Loa (eye worm) hypothetical protein 0.0032 0.0083 0.0128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.081 0.081
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.2815 1
Loa Loa (eye worm) MBCTL1 0.0115 0.1096 0.1765
Brugia malayi hypothetical protein 0.0043 0.0223 0.0303
Mycobacterium leprae Probable lipase LipE 0.0111 0.1044 0.5833
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.081 0.081
Entamoeba histolytica hypothetical protein 0.0042 0.0208 0.0435
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0097 0.0871 0.0871
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0148 0.0372
Loa Loa (eye worm) hypothetical protein 0.0054 0.0352 0.0563
Loa Loa (eye worm) hypothetical protein 0.0115 0.1096 0.1765
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0062 0.0094
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Schistosoma mansoni tar DNA-binding protein 0.0255 0.2792 0.2792
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0039 0.1292
Plasmodium vivax SET domain protein, putative 0.0038 0.0157 0.0619
Loa Loa (eye worm) hypothetical protein 0.0094 0.0843 0.1356
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0148 0.0574
Trypanosoma cruzi heat shock protein 85, putative 0.0054 0.0346 0.1112
Trypanosoma brucei heat shock protein 90, putative 0.0054 0.0346 0.1112
Schistosoma mansoni transient receptor potential channel 0.0062 0.0452 0.0452
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0199 0.0199
Onchocerca volvulus Glutaminyl cyclase homolog 0.011 0.1027 0.1503
Onchocerca volvulus 0.01 0.0915 0.1318
Loa Loa (eye worm) hypothetical protein 0.01 0.0915 0.1472
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0064 0.0097
Onchocerca volvulus 0.0334 0.3748 0.5981
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0032 0.0087 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0188 0.0473
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1044 0.3624
Schistosoma mansoni jumonji domain containing protein 0.003 0.0064 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0097 0.0871 0.1356
Onchocerca volvulus 0.0288 0.3192 0.5066
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9814 0.9814
Loa Loa (eye worm) hypothetical protein 0.0094 0.0843 0.1356
Echinococcus multilocularis endoplasmin 0.005 0.0298 0.0298
Brugia malayi Inositol-1 0.0037 0.0148 0.0181
Onchocerca volvulus 0.0055 0.0359 0.0404
Brugia malayi TAR-binding protein 0.0255 0.2792 0.4477
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.0452 0.0452
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1044 0.2621
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0199 0.0199
Loa Loa (eye worm) heat shock protein 75 0.0034 0.0114 0.0178
Echinococcus multilocularis ribosomal protein L19 0.0028 0.0037 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0123 0.0445
Echinococcus multilocularis phd:f box containing protein 0.003 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0407 0.0407
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0148 0.0401
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0038 0.0153 0.0153
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0035 0.0123 0.0193
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Schistosoma mansoni tar DNA-binding protein 0.0255 0.2792 0.2792
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0016 0.0016
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.003 0.0064 0.0097
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0359 0.0525
Toxoplasma gondii heat shock protein 75, putative 0.0034 0.0114 0.0398
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0199 0.0199
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.003 0.0064 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0321 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0199 0.0263
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9814 0.9814
Brugia malayi hypothetical protein 0.0334 0.3748 0.6032
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0291 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0257 0.2815 1
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.0037 0.0092
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0188 0.0545
Onchocerca volvulus 0.0058 0.0403 0.0476
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.003 0.0064 0.0064
Echinococcus granulosus importin subunit beta 1 0.0029 0.0046 0.0046
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0199 0.0263
Brugia malayi mbt repeat family protein 0.0101 0.0925 0.1444
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0199 0.0199
Loa Loa (eye worm) jmjC domain-containing protein 0.003 0.0064 0.0097
Onchocerca volvulus 0.0111 0.1044 0.153
Loa Loa (eye worm) runx1 0.0067 0.051 0.0819
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0044 0.0044
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0188 0.0298
Plasmodium vivax importin-beta 2, putative 0.0029 0.0046 0.0049
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.011 0.1027 0.1027
Treponema pallidum heat shock protein 90 0.005 0.0298 0.0749
Onchocerca volvulus 0.0106 0.098 0.1425
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0199 0.014
Brugia malayi ecdysteroid receptor 0.0041 0.0199 0.0263
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0321 0.1023
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0664 0.2256
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0306 0.3411 0.5483
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1044 0.3624
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.3438 0.5551
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0051 0.0024
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0199 0.0199
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.1165 0.1165
Toxoplasma gondii heat shock protein HSP90 0.0054 0.0346 0.1591
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0208 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0199 0.0263
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0632 0.0632
Leishmania major basic transcription factor 3a, putative 0.0042 0.0208 0.0618
Schistosoma mansoni coup transcription factor 0.0041 0.0199 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0199 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0255 0.2792 0.2792
Schistosoma mansoni inositol monophosphatase 0.0037 0.0148 0.0148
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0199 0.0199
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.005 0.0298 0.0359
Onchocerca volvulus 0.0038 0.0157 0.0071
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0188 0.0188
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Echinococcus granulosus heat shock protein 90 0.0054 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0051 0.0321 0.0513
Schistosoma mansoni bromodomain containing protein 0.0081 0.0685 0.0685
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1044 0.5833
Echinococcus granulosus citrate lyase subunit beta protein 0.003 0.0055 0.0055
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0039 0.0046
Echinococcus multilocularis zinc finger protein 0.0029 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0101 0.0925 0.149
Echinococcus granulosus fetal alzheimer antigen falz 0.0032 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.011 0.1027 0.1654
Loa Loa (eye worm) hypothetical protein 0.0049 0.0293 0.0467
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0123 0.0445
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0199 0.0199
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0157 0.062
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.011 0.1027 0.1027
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0199 0.0263
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0352 0.1135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0435 0.243
Echinococcus multilocularis heat shock protein 90 0.0054 0.0346 0.0346
Schistosoma mansoni heat shock protein 0.0034 0.0114 0.0114
Echinococcus multilocularis tar DNA binding protein 0.0255 0.2792 0.2792
Plasmodium falciparum phd finger protein, putative 0.0035 0.0123 0.0445
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0664 0.2256
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0016 0.0016
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0188 0.078
Trichomonas vaginalis heat shock protein, putative 0.0046 0.0249 0.0624
Schistosoma mansoni transcription factor btf3 0.0042 0.0208 0.0208
Loa Loa (eye worm) RNA binding protein 0.0255 0.2792 0.4507
Loa Loa (eye worm) hypothetical protein 0.0535 0.619 1
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0039 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0199 0.0199
Schistosoma mansoni heat shock protein 0.0054 0.0346 0.0346
Loa Loa (eye worm) mbt repeat family protein 0.0101 0.0925 0.149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0199 0.0315
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0188 0.0545
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0632 0.0632
Schistosoma mansoni lamin 0.0055 0.0359 0.0359
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.0987 0.2408
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0199 0.0199
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0157 0.0433
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0039 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0199 0.0263
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0039 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.2771 0.4473
Echinococcus multilocularis musashi 0.0055 0.0359 0.0359
Schistosoma mansoni inositol monophosphatase 0.0037 0.0148 0.0148
Trichomonas vaginalis esterase, putative 0.0111 0.1044 0.2621
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0188 0.0545
Brugia malayi Bromodomain containing protein 0.0038 0.0158 0.0197
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0915 0.1427
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0064 0.0097
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0291 0.0291
Trypanosoma cruzi heat shock protein, putative 0.0034 0.0114 0.0278
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0199 0.0263
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0223 0.0223
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0059 0.0407 0.0651
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1044 0.1256
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0115 0.1096 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0199 0.0263
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0199 0.0199
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0321 0.1464
Loa Loa (eye worm) hypothetical protein 0.0079 0.0659 0.1058
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0148 0.0283
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.003 0.0055 0.0066
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.3981 1
Trichomonas vaginalis 60S ribosomal protein L19, putative 0.0028 0.0037 0.0092
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0256 0.0256
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0208 0.033
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.081 0.1257
Plasmodium vivax heat shock protein 90, putative 0.0034 0.0114 0.0398
Mycobacterium tuberculosis Conserved protein 0.003 0.0055 0.0066
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.3981 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0097 0.0871 0.1402
Loa Loa (eye worm) hypothetical protein 0.0046 0.0258 0.0411
Entamoeba histolytica heat shock protein 90, putative 0.0054 0.0346 0.0783
Echinococcus granulosus dna polymerase eta 0.0054 0.0352 0.0352
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0034 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.0097 0.0871 0.0871
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1044 0.1256
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.081 0.081
Brugia malayi Endoplasmin precursor 0.0054 0.0346 0.0502
Schistosoma mansoni jumonji domain containing protein 0.0163 0.167 0.167
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0115 0.1096 0.1096
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0208 0.0884
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0403 0.0595
Schistosoma mansoni protein phosphatase 2C 0.003 0.0064 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0199 0.0315
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.0452 0.0452
Mycobacterium ulcerans beta-lactamase 0.0111 0.1044 0.5833
Onchocerca volvulus 0.0088 0.0768 0.1077
Schistosoma mansoni myelin transcription factor 1 myt1 0.0115 0.1096 0.1096
Echinococcus multilocularis snurportin 1 0.0308 0.3438 0.3438
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1044 0.2621
Schistosoma mansoni hypothetical protein 0.0308 0.3438 0.3438
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0435 0.0435
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0186 0.1958 0.1958
Schistosoma mansoni heat shock protein 0.0054 0.0346 0.0346
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0435 0.1433
Brugia malayi PHD-finger family protein 0.0035 0.0123 0.0141
Brugia malayi Importin beta-1 subunit 0.0029 0.0046 0.0015
Loa Loa (eye worm) hypothetical protein 0.0111 0.1044 0.1681
Brugia malayi beta-lactamase family protein 0.0111 0.1044 0.1636
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.3981 1
Schistosoma mansoni lamin 0.0055 0.0359 0.0359
Trypanosoma brucei heat shock protein, putative 0.0054 0.0346 0.1112
Echinococcus multilocularis polycomb protein SCMH1 0.0101 0.0925 0.0925
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0101 0.0925 0.0925
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.011 0.1027 0.1027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0199 0.0315
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0039 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0199 0.0315
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1044 0.2621
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0346 0.0868
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.2686 0.4336
Echinococcus granulosus SAM and MBT domain containing protein 0.0101 0.0925 0.0925

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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