Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | unspecified product | 0.0019 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.5 | 0.5 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.5 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.5 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.5 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.5 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.5 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.5 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.5 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human ALDH1A1 using propionaldehyde as substrate preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 | |
IC50 (binding) | Inhibition of human ALDH2 using propionaldehyde as substrate preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 | |
IC50 (binding) | > 100000 nM | Inhibiton Assay | BINDINGDB. | No reference |
IC50 (binding) | > 100 uM | Inhibition of human ALDH3A1-mediated benzaldehyde oxidation preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 |
Inhibition (binding) | Inhibition of human ALDH1A3 using propionaldehyde as substrate up to 100 uM preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 | |
Inhibition (binding) | Inhibition of human ALDH1A2 using propionaldehyde as substrate up to 100 uM preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 | |
Inhibition (binding) | Inhibition of human ALDH1B1 using propionaldehyde as substrate up to 100 uM preincubated for 1 min followed by substrate addition by spectrophotometric analysis | ChEMBL. | 24387105 | |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.