Detailed information for compound 771803

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 484.366 | Formula: C22H18BrN3O3S
  • H donors: 0 H acceptors: 1 LogP: 4.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)OCCOc1ccc(cc1Br)C=C1C(=O)N=c2n(C1=N)ccs2
  • InChi: 1S/C22H18BrN3O3S/c1-14-2-5-16(6-3-14)28-9-10-29-19-7-4-15(13-18(19)23)12-17-20(24)26-8-11-30-22(26)25-21(17)27/h2-8,11-13,24H,9-10H2,1H3/b17-12-,24-20?
  • InChiKey: ZZDAOGBJMYFMEJ-WPTKKBASSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0132 0.0431
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0132 0.1652
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0658 0.2148
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0046
Brugia malayi Hsp90 protein 0.0013 0.0208 0.0678
Loa Loa (eye worm) Smad1 0.0008 0.0081 0.0263
Echinococcus multilocularis tar DNA binding protein 0.0128 0.3063 0.3063
Trichomonas vaginalis esterase, putative 0.0037 0.08 0.1038
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Echinococcus granulosus FTZ F1 alpha 0.001 0.0132 0.0132
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0007 0.0044 0.0044
Treponema pallidum heat shock protein 90 0.0025 0.0515 0.0646
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0208 0.0208
Schistosoma mansoni hypothetical protein 0.0031 0.0658 0.0658
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0658 0.0658
Mycobacterium ulcerans hypothetical protein 0.0037 0.08 0.2174
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0515 0.0647
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0099 0.0323
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0341 0.1474
Brugia malayi nuclear receptor NHR-88 0.001 0.0132 0.0431
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.08 0.1326
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0341 0.1114
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0088 0.2061 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.08 0.3746
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0592 0.1934
Echinococcus multilocularis heat shock protein 0.0032 0.0677 0.0677
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0044 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Schistosoma mansoni ap endonuclease 0.0018 0.0341 0.0341
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0341 0.0408
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0132 0.1652
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0037 0.08 1
Echinococcus multilocularis cpg binding protein 0.003 0.0633 0.0633
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0515 0.0826
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.3521 0.6099
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0081 0.0081
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0999 0.0999
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0132 0.0431
Schistosoma mansoni coup transcription factor 0.001 0.0132 0.0132
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0677 0.3137
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0046
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0081 0.0263
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0044 0.0001
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0208 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0046
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.08 0.2174
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0007 0.0044 0.0143
Onchocerca volvulus 0.0037 0.08 1
Schistosoma mansoni pyruvate dehydrogenase 0.0007 0.0044 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.08 0.1038
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.08 0.1038
Schistosoma mansoni hypothetical protein 0.0407 1 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.0658 0.0658
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0132 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3063 0.3063
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Trichomonas vaginalis heat shock protein, putative 0.002 0.037 0.0448
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0341 0.1474
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0515 0.0515
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.08 0.08
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0059 0.0059
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0677 0.3137
Echinococcus granulosus heat shock protein 90 0.0025 0.0515 0.0515
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0515 0.0647
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0351 0.1523
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0007 0.0044 0.0549
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0515 0.2335
Echinococcus granulosus tar DNA binding protein 0.0128 0.3063 0.3063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0081 0.0263
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.7331 1
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.5745 1
Onchocerca volvulus 0.0037 0.08 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0999 0.0999
Brugia malayi Smad1 0.0008 0.0081 0.0263
Echinococcus granulosus heat shock protein 0.0032 0.0677 0.0677
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0132 0.0132
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1228 1
Echinococcus multilocularis Smad4 0.0008 0.0081 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.08 0.1038
Onchocerca volvulus 0.0037 0.08 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0658 0.2148
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0143
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0014 0.0046
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0677 0.0868
Echinococcus multilocularis heat shock protein 90 0.0025 0.0515 0.0515
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Schistosoma mansoni heat shock protein 0.0032 0.0677 0.0677
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.7331 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0431
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0515 0.2335
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0046
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0007 0.0044 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0132 0.0431
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0007 0.0044 0.0044
Echinococcus multilocularis smad 0.0008 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0208 0.0812
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.2061 1
Toxoplasma gondii ABC1 family protein 0.0037 0.08 0.6383
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.2061 0.2061
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0677 0.0868
Brugia malayi nuclear hormone receptor 0.001 0.0132 0.0431
Mycobacterium ulcerans lipase LipD 0.0037 0.08 0.2174
Echinococcus multilocularis heat shock protein 90 0.0032 0.0677 0.0677
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3063 0.3063
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0431
Loa Loa (eye worm) hypothetical protein 0.0087 0.205 0.6692
Plasmodium falciparum heat shock protein 90 0.0032 0.0677 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0677 0.3137
Giardia lamblia Grp94/Hsp90 0.0025 0.0515 0.0646
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.7331 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.2334 0.7619
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0677 0.3137
Schistosoma mansoni Smad4 0.0008 0.0081 0.0081
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0999 0.0999
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0431
Echinococcus granulosus dual specificity 0.0088 0.2061 0.2061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Mycobacterium tuberculosis Conserved protein 0.0037 0.08 0.1326
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0677 0.3137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0431
Echinococcus multilocularis endoplasmin 0.0025 0.0515 0.0515
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0044 0.0001
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Mycobacterium tuberculosis Conserved protein 0.0037 0.08 0.1326
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0658 0.0658
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0341 0.0409
Schistosoma mansoni cpg binding protein 0.0029 0.0592 0.0592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.2334 0.7619
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0046
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0677 0.087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3063 0.3063
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.08 0.1326
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0677 0.2209
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0677 0.8373
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0088 0.2061 0.6728
Echinococcus granulosus heat shock protein 90 0.0032 0.0677 0.0677
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.2061 0.2768
Brugia malayi TAR-binding protein 0.0128 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0208 0.0225
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Loa Loa (eye worm) RNA binding protein 0.0128 0.3063 1
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0677 0.3137
Brugia malayi beta-lactamase family protein 0.0037 0.08 0.261
Brugia malayi hypothetical protein 0.0005 0.0014 0.0046
Onchocerca volvulus 0.0029 0.0592 0.7409
Schistosoma mansoni endoplasmin 0.0032 0.0677 0.0677
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Trichomonas vaginalis receptor histidine kinase, putative 0.0007 0.0044 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0132 0.0132
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0677 0.5344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.08 0.261
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.08 0.1038
Brugia malayi kinase, mitochondrial precursor 0.0007 0.0044 0.0143
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0102 0.0333
Schistosoma mansoni hypothetical protein 0.0031 0.0658 0.0658
Echinococcus multilocularis dual specificity 0.0088 0.2061 0.2061
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0208 0.0812
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0677 0.3137
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0341 0.0408
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0341 0.0341
Schistosoma mansoni smad 0.0008 0.0081 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0341 0.4699
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Toxoplasma gondii exonuclease III APE 0.0018 0.0341 0.2511
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.08 0.1326
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0999 0.0999
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.2334 0.7619
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Brugia malayi Endoplasmin precursor 0.0032 0.0677 0.2209
Mycobacterium leprae conserved hypothetical protein 0.0037 0.08 0.2174
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0007 0.0044 0.0001
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0007 0.0044 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Echinococcus granulosus GPCR family 2 0.0031 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0341 0.1114
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0007 0.0044 0.0044
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0081 0.0081
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0208 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0431
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0341 0.1474
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Brugia malayi Probable DNA topoisomerase II 0.0007 0.0044 0.0143
Brugia malayi MH1 domain containing protein 0.0008 0.0081 0.0263
Loa Loa (eye worm) hypothetical protein 0.0087 0.205 0.6692
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0007 0.0044 0.0001
Schistosoma mansoni heat shock protein 0.0032 0.0677 0.0677
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0341 0.0408
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0143
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.2797 0.913
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.08 0.3746
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Trichomonas vaginalis DNA topoisomerase II, putative 0.0007 0.0044 0.0001
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.2061 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0999 0.0999
Brugia malayi ecdysteroid receptor 0.001 0.0132 0.0431
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0208 0.1383
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0431
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0658 0.2148
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.3521 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.08 0.1326
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Brugia malayi MH2 domain containing protein 0.0008 0.0081 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0431
Echinococcus granulosus endoplasmin 0.0025 0.0515 0.0515
Mycobacterium leprae Probable lipase LipE 0.0037 0.08 0.2174
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Loa Loa (eye worm) TOPoisomerase family member 0.0007 0.0044 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.08 0.08
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0208 0.1383
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0515 0.0646
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0999 0.3261
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.08 0.1326
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.08 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0132 0.0431
Brugia malayi RNA binding protein 0.0128 0.3063 1
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0208 0.2588
Plasmodium vivax endoplasmin, putative 0.0032 0.0677 0.8373
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0658 0.0658
Brugia malayi heat shock protein 90 0.0032 0.0677 0.2209
Schistosoma mansoni hypothetical protein 0.0067 0.1558 0.1558
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0341 0.1474
Echinococcus granulosus smad 0.0008 0.0081 0.0081
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0341 0.6314
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0132 0.0132
Mycobacterium ulcerans beta-lactamase 0.0037 0.08 0.2174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0132 0.0132
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0515 0.1355
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Brugia malayi Protein kinase domain containing protein 0.0088 0.2061 0.6728
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3063 0.3063
Schistosoma mansoni smad1 5 8 and 0.0008 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0431
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0132 0.0431
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.2334 0.7619
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.08 0.1326
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0025 0.0515 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0341 0.3934
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0007 0.0044 0.0549
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0208 0.2597
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0431
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0515 0.0647
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0431
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0677 0.0868
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0515 0.1355
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0081 0.0081
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.3063 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0081 0.0081
Schistosoma mansoni ap endonuclease 0.0018 0.0341 0.0341
Schistosoma mansoni endoplasmin 0.0032 0.0677 0.0677
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0132 0.1652
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0132 0.0132
Echinococcus multilocularis dnaJ subfamily B 0.0407 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Schistosoma mansoni smad1 5 8 and 0.0008 0.0081 0.0081
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0341 0.0855
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0067 0.1558 0.5086
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0088 0.2061 0.2768
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0007 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0132 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0341 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Schistosoma mansoni DNA topoisomerase II 0.0007 0.0044 0.0044
Chlamydia trachomatis DNA gyrase subunit B 0.0007 0.0044 0.5
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0341 0.0522
Loa Loa (eye worm) hypothetical protein 0.0007 0.0044 0.0143
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Brugia malayi beta-lactamase 0.0037 0.08 0.261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0431
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0999 0.0999
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.08 0.261
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.3063 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.08 0.08
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0431
Echinococcus granulosus cpg binding protein 0.003 0.0633 0.0633
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.08 0.3746
Schistosoma mansoni hypothetical protein 0.0031 0.0658 0.0658
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0999 0.3261
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0677 0.3137
Loa Loa (eye worm) beta-lactamase 0.0037 0.08 0.261
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0132 0.0132
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1389 0.1389
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0341 0.0341
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0007 0.0044 0.0549
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0132 0.0132
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0208 0.0226
Entamoeba histolytica protein kinase, putative 0.0088 0.2061 0.2768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0431
Brugia malayi hypothetical protein 0.0005 0.0014 0.0046
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.08 0.08
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0.0044 0.5
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.7331 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0592 0.1934
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0431
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0007 0.0044 0.0001
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.08 0.1326
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0658 0.2148
Brugia malayi MH2 domain containing protein 0.0117 0.2797 0.913
Leishmania major hypothetical protein, conserved 0.0037 0.08 0.3746
Loa Loa (eye worm) TAR-binding protein 0.0128 0.3063 1
Brugia malayi MH2 domain containing protein 0.0008 0.0081 0.0263
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0132 0.0431
Schistosoma mansoni tar DNA-binding protein 0.0128 0.3063 0.3063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0014 0.0014
Plasmodium falciparum endoplasmin, putative 0.002 0.037 0.5145
Brugia malayi beta-lactamase family protein 0.0037 0.08 0.261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0208 0.2588
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.08 0.2174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0999 0.0999
Schistosoma mansoni heat shock protein 0.0013 0.0208 0.0208
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0007 0.0044 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0658 0.0658
Mycobacterium tuberculosis Conserved protein 0.0037 0.08 0.1326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Onchocerca volvulus 0.001 0.0132 0.1652
Schistosoma mansoni nuclear hormone receptor 0.001 0.0132 0.0132
Leishmania major heat shock protein, putative 0.0013 0.0208 0.0812
Schistosoma mansoni hypothetical protein 0.0031 0.0658 0.0658
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0007 0.0044 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1558 0.5086
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0132 0.0132
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.3521 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.2797 0.913
Loa Loa (eye worm) endoplasmin 0.0032 0.0677 0.2209
Loa Loa (eye worm) hypothetical protein 0.0037 0.08 0.261
Entamoeba histolytica protein kinase, putative 0.0088 0.2061 0.2768
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0132 0.0132
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Trypanosoma brucei heat shock protein, putative 0.0032 0.0677 0.3137
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.2061 1
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0515 0.2335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.7331 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0677 0.5344
Trichomonas vaginalis endoplasmin, putative 0.002 0.037 0.0448
Brugia malayi MH1 domain containing protein 0.0008 0.0081 0.0263
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Brugia malayi steroid hormone receptor 0.001 0.0132 0.0431
Plasmodium vivax heat shock protein, putative 0.0013 0.0208 0.2167
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0208 0.2167
Echinococcus granulosus Smad4 0.0008 0.0081 0.0081
Leishmania major heat shock protein 83-1 0.0032 0.0677 0.3137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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