Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0294 | 0.0366 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0784 | 0.1031 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0894 | 0.0667 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0784 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3464 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.7608 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.7608 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0784 | 0.0546 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7608 | 1 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.161 | 0.0896 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0784 | 0.0671 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0784 | 0.0671 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.1214 | 0.1257 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0294 | 0.0366 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3464 | 0.431 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0784 | 0.0671 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0784 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0784 | 0.0671 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0397 | 0.0114 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.9283 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3464 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0784 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0784 | 0.0976 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3464 | 0.4334 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0784 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3464 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3464 | 0.431 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0717 | 0.0891 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.7608 | 0.9466 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3464 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7608 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7437 | 0.9766 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0894 | 0.1112 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.8037 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.7608 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0717 | 0.0578 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0784 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0784 | 0.0671 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.4581 | 0.4769 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3864 | 0.3972 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.1214 | 0.1257 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0294 | 0.0366 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3853 | 0.3329 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.7608 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0784 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.1214 | 0.151 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.7608 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3456 | 0.4323 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0017 | 0.0294 | 0.0366 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3456 | 0.4323 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0784 | 0.0671 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3464 | 0.2907 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3464 | 0.4334 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0784 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7437 | 0.9766 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.4261 | 0.4413 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0784 | 0.0546 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0784 | 0.0976 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0784 | 0.1031 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0784 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0784 | 0.1031 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0717 | 0.0578 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0784 | 0.0976 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.7608 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.7608 | 0.9466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.