Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.071 | 0.163 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0384 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.017 | 0.4355 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.4355 | 1 |
Echinococcus granulosus | geminin | 0.017 | 0.4355 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.4355 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0139 | 0.0318 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0384 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0139 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0026 | 0.0541 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0139 | 0.4422 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.5041 | 0.4971 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.071 | 0.163 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0139 | 0.4422 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1116 | 0.2318 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0026 | 0.0541 | 0.0408 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.3302 | 0.3208 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0384 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.071 | 0.0579 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.2555 | 0.2451 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.0457 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0026 | 0.0541 | 0.0953 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.071 | 0.1355 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0139 | 0.0318 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0026 | 0.0541 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.071 | 0.0579 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.1701 | 0.3906 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.2555 | 0.2451 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.2555 | 0.2451 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1116 | 0.2563 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.1701 | 0.1585 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.071 | 0.163 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1116 | 0.2563 |
Loa Loa (eye worm) | RecQ helicase | 0.0026 | 0.0541 | 0.0408 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.071 | 0.163 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.071 | 0.1355 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.071 | 0.1355 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.071 | 0.1355 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.071 | 0.1355 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0222 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1116 | 0.2318 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.1116 | 0.2318 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.1116 | 0.0991 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.002 | 0.0397 | 0.091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.1116 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.1701 | 0.1585 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.1116 | 0.2318 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0018 | 0.0319 | 0.5 |
Echinococcus multilocularis | bloom syndrome protein | 0.0026 | 0.0541 | 0.0953 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0313 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.071 | 0.1355 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.071 | 0.0579 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.1116 | 0.0991 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.071 | 0.0579 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.2555 | 0.2451 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.