Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | immunophilin | 0.0053 | 0.288 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0053 | 0.288 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0053 | 0.288 | 0.2367 |
Echinococcus multilocularis | fk506 binding protein | 0.0053 | 0.288 | 0.0735 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0053 | 0.288 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0053 | 0.288 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0053 | 0.288 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0053 | 0.288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0053 | 0.288 | 0.5 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0053 | 0.288 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.288 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.288 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0053 | 0.288 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0053 | 0.288 | 0.0735 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0053 | 0.288 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.288 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 1 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0053 | 0.288 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2315 | 0.1762 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0053 | 0.288 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0671 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0053 | 0.288 | 0.288 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0053 | 0.288 | 0.2367 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0053 | 0.288 | 0.5 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.288 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0053 | 0.288 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0053 | 0.288 | 0.0735 |
Leishmania major | fk506-binding protein 1-like protein | 0.0053 | 0.288 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0053 | 0.288 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0671 | 0.0671 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0053 | 0.288 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0053 | 0.288 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0053 | 0.288 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0053 | 0.288 | 0.0735 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0053 | 0.288 | 0.288 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.