Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0664 | 0.2313 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.1424 | 0.1424 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1424 | 1 |
Onchocerca volvulus | 0.0039 | 0.1424 | 1 | |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.1288 | 0.4488 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0711 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2025 | 0.7058 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.1424 | 0.2692 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1424 | 0.1424 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.2025 | 0.3829 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1424 | 0.1424 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.1424 | 1 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0038 | 0.0071 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.2869 | 0.5424 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.003 | 0.0103 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.1424 | 0.5833 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0175 | 0.0607 |
Trichomonas vaginalis | sphingomyelinase C 2 precursor, putative | 0.0004 | 0 | 0.0003 |
Trichomonas vaginalis | type IV inositol 5-phosphatase, putative | 0.0004 | 0 | 0.0003 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0664 | 0.1254 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1424 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0175 | 0.0607 |
Onchocerca volvulus | 0.0039 | 0.1424 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Echinococcus granulosus | smad | 0.0009 | 0.0204 | 0.0711 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1424 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.2869 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1424 | 1 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0 | 0.0003 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1424 | 0.2692 |
Onchocerca volvulus | 0.0039 | 0.1424 | 1 | |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.2869 | 0.5424 |
Schistosoma mansoni | smad | 0.0009 | 0.0204 | 0.0711 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0204 | 0.0711 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.2869 | 0.5424 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0175 | 0.0607 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.2869 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.1424 | 0.1424 |
Echinococcus multilocularis | smad | 0.0009 | 0.0204 | 0.0711 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.1424 | 0.2692 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.1424 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0664 | 0.4662 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.5289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0664 | 0.4662 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.2869 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.1424 | 0.1424 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0204 | 0.0711 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2025 | 0.7058 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0204 | 0.0386 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0204 | 0.0711 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.2025 | 0.7058 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.1424 | 0.1424 |
Trichomonas vaginalis | ocrl type II inositol 5-phosphatase, putative | 0.0004 | 0 | 0.0003 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.2025 | 0.3829 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.1424 | 0.5 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0 | 0.0003 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0038 | 0.0071 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0204 | 0.0386 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.1209 | 0.2286 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0204 | 0.0386 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0175 | 0.0607 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2025 | 0.7058 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0711 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0204 | 0.0711 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.1424 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0664 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.2869 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.2869 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.2869 | 1 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.2869 | 0.5424 |
Trichomonas vaginalis | skeletal muscle/kidney enriched inositol 5-phosphatase, putative | 0.0004 | 0 | 0.0003 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1209 | 0.4214 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0664 | 0.2719 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.1424 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0175 | 0.0607 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.2869 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.1288 | 0.4488 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.1424 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0664 | 0.466 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0204 | 0.0711 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0664 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2025 | 0.7058 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.1424 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.1424 | 1 |
Brugia malayi | beta-lactamase | 0.0039 | 0.1424 | 0.2692 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.1424 | 0.2692 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0038 | 0.0071 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0204 | 0.0711 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0664 | 0.2313 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.2869 | 0.5424 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.1424 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.2025 | 0.7058 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Trichomonas vaginalis | Phospholipase C precursor, putative | 0.0004 | 0 | 0.0003 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0204 | 0.0711 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0253 | 0.0478 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.1424 | 0.1424 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.1209 | 0.2286 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.1424 | 0.4962 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.1424 | 0.4962 |
Brugia malayi | Smad1 | 0.0009 | 0.0204 | 0.0386 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0259 | 0.09 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0664 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.5289 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.2025 | 0.7058 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.1288 | 0.4488 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.1288 | 0.4488 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0664 | 0.1254 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.1424 | 0.1424 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.1424 | 0.1424 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0664 | 0.466 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0072 | 0.2753 | 0.9594 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.1424 | 0.2692 |
Trichomonas vaginalis | carbon catabolite repressor protein, putative | 0.0004 | 0 | 0.0003 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0064 | 0.2441 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1424 | 0.4962 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.1424 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1424 | 0.2692 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.5289 | 1 |
Onchocerca volvulus | 0.0034 | 0.1209 | 0.8492 | |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0204 | 0.0386 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.1424 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0259 | 0.09 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0038 | 0.0071 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0145 | 0.1015 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0664 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0664 | 0.466 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0204 | 0.0711 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0664 | 0.2313 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0204 | 0.0386 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0664 | 0.0663 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0664 | 0.466 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.1424 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.1424 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0204 | 0.0386 |
Trichomonas vaginalis | type II inositol 5-phosphatase, putative | 0.0004 | 0 | 0.0003 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0204 | 0.0711 |
Brugia malayi | RNA binding protein | 0.0075 | 0.2869 | 0.5424 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.1424 | 0.4962 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0664 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0204 | 0.0386 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0145 | 0.1015 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0259 | 0.0488 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.1424 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0145 | 0.1015 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.1424 | 0.1424 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0664 | 0.2313 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0664 | 0.466 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.