Detailed information for compound 772377

Basic information

Technical information
  • TDR Targets ID: 772377
  • Name: 2-ethyl-1,2,3,4-tetrahydroacridine-9-carboxyl ic acid
  • MW: 255.312 | Formula: C16H17NO2
  • H donors: 1 H acceptors: 3 LogP: 3.74 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1CCc2c(C1)c(C(=O)O)c1c(n2)cccc1
  • InChi: 1S/C16H17NO2/c1-2-10-7-8-14-12(9-10)15(16(18)19)11-5-3-4-6-13(11)17-14/h3-6,10H,2,7-9H2,1H3,(H,18,19)
  • InChiKey: UMZDTQJCQBRJLQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0050036
  • IVK/9097134
  • Oprea1_787902

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0017 0.0106 0.0227
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0235 0.0202
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0025 0.0216 0.0216
Echinococcus multilocularis allatostatin A receptor 0.0025 0.0216 0.0216
Schistosoma mansoni neuropeptide f receptor 76f 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Brugia malayi ORL1-like opioid receptor 0.0025 0.0216 0.0464
Brugia malayi hypothetical protein 0.0169 0.2181 0.4684
Schistosoma mansoni hypothetical protein 0.0017 0.0106 0.0106
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0014 0.0063 0.0135
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0022 0.0169 0.0059
Echinococcus granulosus lamin 0.0019 0.0137 0.0137
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0014 0.0063 0.0135
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0014 0.0063 0.0063
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) intermediate filament protein 0.0019 0.0137 0.0295
Echinococcus granulosus tumor protein p63 0.0169 0.2168 0.2168
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0025 0.0216 0.0464
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0025 0.0216 0.0216
Chlamydia trachomatis DNA polymerase III subunit beta 0.0548 0.7332 0.5
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0019 0.0137 0.0295
Onchocerca volvulus 0.0025 0.0216 0.6267
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0093 0.1136 0.244
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Onchocerca volvulus 0.0019 0.0137 0.3986
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi MH1 domain containing protein 0.0021 0.0155 0.0334
Leishmania major cathepsin L-like protease 0.0034 0.0336 0.0253
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Brugia malayi MH1 domain containing protein 0.0011 0.003 0.0064
Onchocerca volvulus 0.0025 0.021 0.6092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni lamin 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0063 0.0063
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0216 0.0216
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0063 0.0063
Onchocerca volvulus 0.0014 0.0063 0.1819
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0216 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni neuropeptide receptor 0.0025 0.0216 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus granulosus intermediate filament protein 0.0019 0.0137 0.0137
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0014 0.0063 0.0135
Schistosoma mansoni myosin xvIII 0.0025 0.0216 0.0216
Brugia malayi putative neuropeptide receptor 0.0025 0.0216 0.0464
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0336 0.0253
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0216 0.0216
Brugia malayi G protein-coupled receptor 0.0025 0.0216 0.0464
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0017 0.0111 0.0111
Echinococcus granulosus allatostatin A receptor 0.0025 0.0216 0.0216
Brugia malayi Cytochrome P450 family protein 0.0015 0.0084 0.0181
Echinococcus multilocularis mothers against decapentaplegic 5 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Onchocerca volvulus 0.0025 0.0216 0.6267
Brugia malayi Tachykinin-like peptides receptor 99D 0.0025 0.0216 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0049 0.0015
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trypanosoma cruzi major cysteine proteinase, putative 0.0027 0.0237 0.0154
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis survival motor neuron protein 1 0.0169 0.2181 0.2181
Schistosoma mansoni alpha-1 adrenergic receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0014 0.0063 0.0063
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0025 0.0216 0.0464
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Onchocerca volvulus 0.0014 0.0063 0.1819
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0014 0.0063 0.0063
Brugia malayi T-complex protein 1, beta subunit 0.0017 0.0111 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0744 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0169 0.0136
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0026 0.0235 0.0207
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni hypothetical protein 0.0121 0.1527 0.1527
Echinococcus granulosus orexin receptor type 2 0.0025 0.0216 0.0216
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0744 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Loa Loa (eye worm) hypothetical protein 0.0025 0.021 0.0451
Echinococcus granulosus mothers against decapentaplegic 5 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Schistosoma mansoni opsin-like receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0022 0.0169 0.0169
Schistosoma mansoni hypothetical protein 0.0045 0.0482 0.0482
Echinococcus granulosus smad 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0169 0.2181 0.4684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0049 0.0015
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Brugia malayi GnHR receptor homolog 0.0025 0.0216 0.0464
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0014 0.0063 0.0063
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0109 0.0025
Schistosoma mansoni smad1 5 8 and 0.0021 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0035 0.0345 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0066 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0109 0.0076
Brugia malayi MH1 domain containing protein 0.0021 0.0155 0.0334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Entamoeba histolytica hypothetical protein 0.0045 0.0482 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0025 0.0213 0.0457
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0035 0.0345 0.0741
Loa Loa (eye worm) T-complex protein 1 0.0017 0.0111 0.0237
Brugia malayi G-protein coupled receptor 0.0025 0.0216 0.0464
Brugia malayi DNA polymerase III, beta subunit 0.0237 0.3106 0.6672
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0216 0.0464
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0216 0.0216
Brugia malayi Calcitonin receptor-like protein seb-1 0.0025 0.0213 0.0457
Echinococcus granulosus Smad4 0.0021 0.0155 0.0155
Echinococcus multilocularis lamin 0.0019 0.0137 0.0137
Loa Loa (eye worm) melatonin receptor type 1A 0.0025 0.0216 0.0464
Echinococcus granulosus peptide allatostatin:somatostatin 0.0025 0.0216 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0216 0.0216
Echinococcus granulosus neuropeptide receptor A26 0.0025 0.0216 0.0216
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0025 0.0216 0.0216
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0025 0.0216 0.0216
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0744 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0336 0.0253
Schistosoma mansoni opsin-like receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.005 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0169 0.0136
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0744 1 1
Brugia malayi Cation transporter family protein 0.0014 0.0063 0.0135
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0014 0.0063 0.0135
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0652 0.8749 0.8749
Echinococcus granulosus neuropeptide receptor 0.0025 0.0216 0.0216
Schistosoma mansoni growth hormone secretagogue receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi MH2 domain containing protein 0.0021 0.0155 0.0334
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus granulosus g-protein coupled receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0485 0.647 0.647
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0216 0.0216
Echinococcus granulosus lamin dm0 0.0019 0.0137 0.0137
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0025 0.0216 0.6267
Echinococcus granulosus somatostatin receptor 0.0025 0.0216 0.0216
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0189 0.2449 0.2449
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0063 0.0735 0.0735
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) neuropeptide F receptor 0.0025 0.0216 0.0464
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0025 0.0216 0.0464
Brugia malayi sulfakinin receptor protein 0.0025 0.0216 0.0464
Echinococcus granulosus TGF beta signal transducer SmadC 0.0021 0.0155 0.0155
Brugia malayi MH2 domain containing protein 0.0021 0.0155 0.0334
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0336 0.0253
Loa Loa (eye worm) inositol-1 0.0026 0.0235 0.0504
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Echinococcus granulosus neuropeptide receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) MH2 domain-containing protein 0.0021 0.0155 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0109 0.0076
Brugia malayi T-complex protein 1, beta subunit 0.0017 0.0111 0.0237
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0022 0.0169 0.0085
Onchocerca volvulus 0.0025 0.0216 0.6267
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0063 0.0063
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Mycobacterium leprae Probable DNA polymerase III, [beta] subunit DnaN 0.0548 0.7332 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0025 0.0216 0.0216
Schistosoma mansoni biogenic amine receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) Smad1 0.0021 0.0155 0.0334
Onchocerca volvulus 0.0025 0.0216 0.6267
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0216 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0109 0.0076
Schistosoma mansoni inositol monophosphatase 0.0026 0.0235 0.0235
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0025 0.0216 0.0464
Schistosoma mansoni lamin 0.0019 0.0137 0.0137
Trichomonas vaginalis inositol monophosphatase, putative 0.0026 0.0235 0.0202
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus multilocularis Smad4 0.0021 0.0155 0.0155
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0026 0.0235 0.0202
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0014 0.0063 0.0135
Echinococcus multilocularis g-protein coupled receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0017 0.0111 0.0111
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0025 0.0216 0.0464
Loa Loa (eye worm) MH2 domain-containing protein 0.0303 0.3998 0.8588
Echinococcus granulosus geminin 0.0121 0.1527 0.1527
Schistosoma mansoni survival motor neuron protein 0.0035 0.0345 0.0345
Brugia malayi Melatonin receptor type 1A 0.0025 0.0216 0.0464
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0022 0.0169 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) TYRA-2 protein 0.0025 0.0216 0.0464
Onchocerca volvulus 0.0025 0.0216 0.6267
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Brugia malayi neuropeptide F receptor 0.0025 0.0216 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0109 0.0076
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0015
Brugia malayi Dopamine receptor 0.0025 0.0216 0.0464
Echinococcus multilocularis dro:myosuppressin receptor 0.0025 0.0216 0.0216
Onchocerca volvulus 0.0014 0.0063 0.1819
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0025 0.0216 0.0216
Onchocerca volvulus 0.0019 0.0137 0.3986
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0133 0.0285
Echinococcus multilocularis thyroid hormone receptor alpha 0.0068 0.0804 0.0804
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Brugia malayi Inositol-1 0.0026 0.0235 0.0504
Leishmania major cathepsin L-like protease 0.0034 0.0336 0.0253
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0025 0.0216 0.0464
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0022 0.0169 0.0155
Echinococcus granulosus neuropeptide Y receptor 0.0025 0.0216 0.0216
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0235 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Leishmania major cathepsin L-like protease 0.0034 0.0336 0.0253
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0744 1 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0017 0.0111 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0045 0.0482 0.0482
Echinococcus multilocularis conserved hypothetical protein 0.0383 0.5086 0.5086
Brugia malayi latrophilin 2 splice variant baaae 0.0017 0.0106 0.0227
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0025 0.0216 0.0216
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0216 0.0216
Echinococcus granulosus inositol monophosphatase 1 0.0026 0.0235 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0039
Toxoplasma gondii t-complex protein beta subunit 0.0017 0.0111 0.1212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Onchocerca volvulus 0.0025 0.0216 0.6267
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0063 0.0063
Echinococcus granulosus g protein coupled receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis glycine receptor subunit beta 0.0014 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0025 0.0216 0.0216
Brugia malayi hypothetical protein 0.0045 0.0482 0.1035
Loa Loa (eye worm) glutaminase 2 0.0137 0.1744 0.3746
Trichomonas vaginalis glutaminase, putative 0.0137 0.1744 0.1716
Brugia malayi putative neuropeptide receptor NPR1 0.0025 0.0216 0.0464
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.1136 0.1136
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0017 0.0111 0.0078
Echinococcus multilocularis neuropeptide receptor A26 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Loa Loa (eye worm) hypothetical protein 0.0351 0.4655 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0014 0.0063 0.0063
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0336 0.0253
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0014 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus multilocularis smad 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus multilocularis neuropeptide s receptor 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0169 0.0136
Echinococcus multilocularis G-protein coupled receptor, putative 0.0025 0.0216 0.0216
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0014 0.0063 0.0063
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0025 0.0216 0.0216
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0022 0.0169 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0025 0.0216 0.0216
Loa Loa (eye worm) MH1 domain-containing protein 0.0021 0.0155 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0064
Echinococcus multilocularis orexin receptor type 2 0.0025 0.0216 0.0216
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0045 0.0482 0.0482
Onchocerca volvulus 0.0025 0.0216 0.6267
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0022 0.0169 0.0169
Echinococcus multilocularis sex peptide receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi larval opioid receptor 0.0025 0.0216 0.0464
Loa Loa (eye worm) LGC-31 protein 0.0014 0.0063 0.0135
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0021 0.0155 0.0155
Schistosoma mansoni amine GPCR 0.0025 0.0216 0.0216
Echinococcus granulosus hypothetical protein 0.0408 0.5427 0.5427
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0009 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Echinococcus granulosus serotonin receptor 0.0025 0.0216 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0093 0.1136 0.244
Giardia lamblia GTOR 0.0022 0.0169 0.0059
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0235 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni smad1 5 8 and 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0022 0.0169 0.0085
Echinococcus granulosus neuropeptide FF receptor 2 0.0025 0.0216 0.0216
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0017 0.0111 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni amine GPCR 0.0025 0.0216 0.0216
Echinococcus multilocularis tumor protein p63 0.0169 0.2168 0.2168
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0045 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni opsin-like receptor 0.0025 0.0216 0.0216
Brugia malayi Serotonin receptor 0.028 0.369 0.7927
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0025 0.0216 0.0464
Brugia malayi G protein-coupled receptor F59B2.13 0.0025 0.0216 0.0464
Schistosoma mansoni biogenic amine (5HT) receptor 0.0652 0.8749 0.8749
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0014 0.0063 0.0063
Brugia malayi G-protein coupled receptor 0.0025 0.0216 0.0464
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Echinococcus granulosus tm gpcr rhodopsin 0.0025 0.0216 0.0216
Schistosoma mansoni smad 0.0021 0.0155 0.0155
Mycobacterium ulcerans glutaminase 0.0137 0.1744 0.2289
Echinococcus multilocularis geminin 0.0121 0.1527 0.1527
Brugia malayi AKH receptor 0.0025 0.0216 0.0464
Schistosoma mansoni histamine h1 receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Brugia malayi MH2 domain containing protein 0.0303 0.3998 0.8588
Echinococcus multilocularis serotonin receptor 0.0093 0.1136 0.1136
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) glutaminase 0.0137 0.1744 0.3746
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0063 0.0135
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0031 0.0296 0.0213
Echinococcus multilocularis neuropeptide Y receptor 0.0025 0.0216 0.0216
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0109 0.0025
Onchocerca volvulus 0.0025 0.0216 0.6267
Trichomonas vaginalis chaperonin, putative 0.0017 0.0111 0.0078
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0014 0.0063 0.0063
Schistosoma mansoni intermediate filament proteins 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0109 0.0076
Onchocerca volvulus 0.0025 0.0216 0.6267
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0014 0.0063 0.0135
Onchocerca volvulus Neuropeptide F receptor homolog 0.0025 0.0216 0.6267
Echinococcus granulosus fmrfamide receptor 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Schistosoma mansoni amine GPCR 0.0025 0.0216 0.0216
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0063 0.0135
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Brugia malayi DNA polymerase III, beta subunit 0.0237 0.3106 0.6672
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus granulosus 7TM GPCR rhodopsin 0.0025 0.0216 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0216 0.0216
Brugia malayi Cytochrome P450 family protein 0.0015 0.0083 0.0177
Schistosoma mansoni hypothetical protein 0.0025 0.0216 0.0216
Echinococcus granulosus glycine receptor subunit beta 0.0014 0.0063 0.0063
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0022 0.0169 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0014 0.0063 0.0135
Brugia malayi Intermediate filament tail domain containing protein 0.0019 0.0137 0.0295
Schistosoma mansoni hypothetical protein 0.0063 0.0735 0.0735
Brugia malayi cytoplasmic intermediate filament protein 0.001 0.0015 0.0033
Onchocerca volvulus 0.0025 0.0216 0.6267
Brugia malayi Dopamine receptor protein 1 0.0025 0.0216 0.0464
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0235 0.0221
Echinococcus multilocularis g protein coupled receptor 0.0025 0.0216 0.0216
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0189 0.2449 0.5262
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0017 0.0111 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0014 0.0063 0.0063
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Echinococcus multilocularis lamin dm0 0.0019 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni glutaminase 0.0137 0.1744 0.1744
Brugia malayi intermediate filament protein 0.0019 0.0137 0.0295
Schistosoma mansoni cellular tumor antigen P53 0.0025 0.021 0.021
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0025 0.0213 0.0457
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0744 1 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0019 0.0137 0.0295
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0084 0.0181
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Echinococcus multilocularis G protein coupled receptor 139 0.0025 0.0216 0.0216
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0017 0.0111 0.0026
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0109 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Onchocerca volvulus 0.0014 0.0063 0.1819
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus multilocularis fmrfamide receptor 0.0025 0.0216 0.0216
Schistosoma mansoni neuropeptide receptor 0.0025 0.0216 0.0216
Echinococcus granulosus neuropeptide s receptor 0.0025 0.0216 0.0216
Brugia malayi Dopamine receptor protein 2 0.0025 0.0216 0.0464
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0014 0.0063 0.0063
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Schistosoma mansoni inositol monophosphatase 0.0026 0.0235 0.0235
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0025 0.0216 0.0216
Entamoeba histolytica hypothetical protein 0.0045 0.0482 0.0376
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0744 1 1
Schistosoma mansoni hypothetical protein 0.0121 0.1527 0.1527
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.001 0.0015 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.005 0.0017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0063 0.0063
Treponema pallidum DNA polymerase III, subunit beta (dnaN) 0.0548 0.7332 0.5
Schistosoma mansoni hypothetical protein 0.0025 0.0216 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni smad1 5 8 and 0.0021 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0189 0.2449 0.5262
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0063 0.0735 0.0735
Echinococcus multilocularis neuropeptide FF receptor 2 0.0025 0.0216 0.0216
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0014 0.0063 0.0063
Schistosoma mansoni neuropeptide receptor 0.0025 0.0216 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0022 0.0169 0.0085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0216 0.0216
Schistosoma mansoni neuropeptide receptor 0.0025 0.0216 0.0216
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0014 0.0063 0.0135
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0025 0.0216 0.0216
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.1136 0.1136
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0084 0.0181
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Brugia malayi Serotonin receptor 0.0025 0.0216 0.0464
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0014 0.0063 0.0135
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0025 0.0216 0.0216
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0025 0.0216 0.0464
Loa Loa (eye worm) DEAH box polypeptide 35 0.0351 0.4655 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Entamoeba histolytica hypothetical protein 0.0045 0.0482 0.0376
Mycobacterium tuberculosis DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase) 0.0548 0.7332 1
Onchocerca volvulus Putative nachr subunit 0.0014 0.0063 0.1819
Brugia malayi Cytochrome P450 family protein 0.0015 0.0084 0.0181
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0581 0.7783 0.7783
Onchocerca volvulus 0.0025 0.0216 0.6267
Onchocerca volvulus 0.0025 0.0216 0.6267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0126 0.0093
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Onchocerca volvulus 0.0025 0.0216 0.6267
Schistosoma mansoni thyroid hormone receptor 0.0068 0.0804 0.0804
Schistosoma mansoni amine GPCR 0.0025 0.0216 0.0216
Echinococcus granulosus neuropeptides capa receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis somatostatin receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0025 0.0216 0.0216
Brugia malayi RE15519p 0.0025 0.0216 0.0464
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0017 0.0111 0.0097
Echinococcus granulosus g protein coupled receptor 0.0025 0.0216 0.0216
Brugia malayi neuropeptide F receptor 0.0025 0.0216 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0014 0.0063 0.0063
Brugia malayi MH1 domain containing protein 0.0011 0.003 0.0064
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0026 0.0235 0.0126
Brugia malayi Cation transporter family protein 0.0014 0.0063 0.0135
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Entamoeba histolytica hypothetical protein, conserved 0.0744 1 1
Onchocerca volvulus 0.0025 0.0216 0.6267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0025 0.0216 0.0464
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0025 0.0216 0.0216
Schistosoma mansoni Smad4 0.0021 0.0155 0.0155
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Mycobacterium ulcerans DNA polymerase III subunit beta 0.0548 0.7332 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Schistosoma mansoni hypothetical protein 0.0744 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0025 0.0216 0.0216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0457
Echinococcus granulosus g protein coupled receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) transcription factor SMAD2 0.0303 0.3998 0.8588
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0084 0.0181
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0744 1 1
Brugia malayi follicle stimulating hormone receptor 0.0025 0.0216 0.0464
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Echinococcus granulosus glycine receptor subunit alpha 1 0.0014 0.0063 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0083 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0093 0.006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0189 0.2449 0.5262
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0084 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0025 0.0216 0.0216
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0014 0.0063 0.0135
Echinococcus granulosus 7tm_1 domain containing protein 0.0025 0.0216 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Giardia lamblia Rrm3p helicase 0.0744 1 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0014 0.0063 0.0135
Leishmania major T-complex protein 1, beta subunit, putative 0.0017 0.0111 0.0026
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Plasmodium falciparum T-complex protein 1 subunit beta 0.0017 0.0111 0.5
Echinococcus granulosus alpha 1A adrenergic receptor 0.0025 0.0216 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0022 0.0169 0.0363
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0014 0.0063 0.0063
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis musashi 0.0019 0.0137 0.0137
Echinococcus granulosus biogenic amine 5HT receptor 0.0652 0.8749 0.8749
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0026 0.0235 1
Brugia malayi hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni nAChR subunit 0.0014 0.0063 0.0063
Echinococcus multilocularis neuropeptides capa receptor 0.0025 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.0025 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0003
Brugia malayi Smad1 0.0021 0.0155 0.0334
Schistosoma mansoni adenoreceptor 0.0025 0.0216 0.0216
Echinococcus granulosus sex peptide receptor 0.0025 0.0216 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.005 0.0017
Loa Loa (eye worm) ACC-1 protein 0.0014 0.0063 0.0135
Entamoeba histolytica hypothetical protein 0.0045 0.0482 0.0376
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0014 0.0063 0.0135
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0014 0.0063 0.0063
Echinococcus granulosus tachykinin peptides receptor 99D 0.0025 0.0216 0.0216
Brugia malayi Probable ATP-dependent helicase DHX35 0.0351 0.4655 1
Echinococcus granulosus survival motor neuron protein 1 0.0169 0.2181 0.2181
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0025 0.0216 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0034 0.0336 0.0322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0169 0.0363
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0014 0.0063 0.0063
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0022 0.0169 0.0155
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0017 0.0111 0.0111
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0744 1 1
Onchocerca volvulus 0.0025 0.0216 0.6267
Onchocerca volvulus 0.0025 0.0216 0.6267
Schistosoma mansoni biogenic amine receptor 0.0025 0.0216 0.0216
Onchocerca volvulus 0.0025 0.0216 0.6267
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.0135
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0026 0.0235 0.0151
Echinococcus granulosus G protein coupled receptor 139 0.0025 0.0216 0.0216
Echinococcus multilocularis neuropeptide receptor 0.0025 0.0216 0.0216
Wolbachia endosymbiont of Brugia malayi DNA polymerase III beta clamp subunit 0.0548 0.7332 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0021 0.0155 0.0155
Echinococcus multilocularis rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Echinococcus multilocularis inositol monophosphatase 1 0.0026 0.0235 0.0235
Echinococcus multilocularis nAChR subunit 0.0014 0.0063 0.0063
Onchocerca volvulus 0.0014 0.0063 0.1819
Entamoeba histolytica DNA repair and recombination protein, putative 0.0744 1 1
Echinococcus granulosus nAChR subunit 0.0014 0.0063 0.0063
Loa Loa (eye worm) nuclear factor I 0.0011 0.003 0.0064
Onchocerca volvulus 0.0035 0.0345 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0464
Schistosoma mansoni biogenic amine receptor 0.0025 0.0216 0.0216
Brugia malayi Cation transporter family protein 0.0014 0.0063 0.0135
Echinococcus granulosus tm gpcr rhodopsin 0.0485 0.647 0.647
Brugia malayi glutaminase DH11.1 0.0137 0.1744 0.3746
Onchocerca volvulus 0.0014 0.0063 0.1819
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0025 0.0216 0.0216
Echinococcus multilocularis serotonin receptor 0.0093 0.1136 0.1136
Echinococcus granulosus rhodopsin orphan GPCR 0.0025 0.0216 0.0216
Schistosoma mansoni amine GPCR 0.0025 0.0216 0.0216

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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