Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.108 | 0.108 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0075 | 0.0075 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1866 | 0.174 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1659 | 0.1659 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1866 | 0.1804 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.1796 | 0.723 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1241 | 0.1241 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.0928 | 0.0859 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1241 | 0.4996 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1241 | 0.1174 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0381 | 0.0381 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1241 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0733 | 0.0733 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1241 | 0.1105 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1659 | 0.6681 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0605 | 0.0605 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0248 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0063 | 0.2312 | 0.9308 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0453 | 0.1825 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0381 | 0.0381 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.1241 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.2987 | 0.2879 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0733 | 0.295 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1241 | 0.4996 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.1241 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0381 | 0.1533 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1238 | 0.1238 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1241 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0248 | 1 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0426 | 0.1717 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.1241 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1866 | 0.1804 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1241 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.1339 | 0.1205 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0018 | 0.0453 | 0.0453 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1241 | 0.1105 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.108 | 0.4349 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1241 | 0.1105 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1659 | 0.153 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0426 | 0.0426 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1659 | 0.1596 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1241 | 0.1241 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0733 | 0.0733 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.1241 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1241 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.108 | 0.108 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1241 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.1796 | 1 | |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0351 | 0.1413 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.1241 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1241 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.1238 | 0.1238 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1597 | 0.1533 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1659 | 0.1659 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0021 | 0.058 | 0.0509 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0075 | 0.0075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1866 | 0.174 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.1241 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.0928 | 0.0787 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.058 | 0.2336 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0381 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1342 | 0.1277 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0426 | 0.1717 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0381 | 0.1533 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.1241 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.2134 | 1 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1241 | 0.1105 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1179 | 0.1112 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.108 | 0.4349 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0605 | 0.2437 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0018 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0381 | 0.0308 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1659 | 0.6681 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0381 | 0.0308 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1241 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1179 | 0.4746 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0381 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0453 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1241 | 0.1174 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.233 | 0.233 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0351 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2733 | 0.2678 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.2484 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.233 | 0.233 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0238 | 0.958 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1659 | 0.6681 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1444 | 0.1379 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1241 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0381 | 0.1533 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0381 | 0.0381 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0426 | 0.0426 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0605 | 0.0605 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0018 | 0.0453 | 0.1825 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0381 | 0.0381 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0381 | 0.0381 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0928 | 0.3735 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0381 | 0.1533 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0453 | 0.038 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.1796 | 0.723 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0381 | 0.0381 |
Onchocerca volvulus | 0.0037 | 0.1241 | 0.3608 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1241 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.1796 | 0.1669 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1659 | 0.1659 |
Onchocerca volvulus | 0.0037 | 0.1241 | 0.3608 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1241 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1659 | 0.1659 |
Onchocerca volvulus | 0.0037 | 0.1241 | 0.3608 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1241 | 0.1174 |
Loa Loa (eye worm) | hypothetical protein | 0.0248 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1179 | 0.1042 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0834 | 0.0692 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.