Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1663 | 0.8892 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.392 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.1628 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1871 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0208 | 0.1109 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.1871 | 0.1871 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0208 | 0.0208 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.1871 | 0.1871 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.1663 | 0.8892 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.202 | 0.202 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1871 | 0.1871 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0208 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1514 | 0.8091 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.1812 | 0.1812 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0208 | 0.0208 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.392 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.1812 | 0.4623 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.1628 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.1871 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.392 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.1871 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1871 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1871 | 0.5 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.1871 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.1812 | 0.9686 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.1871 | 0.1871 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.392 | 0.392 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0208 | 0.0208 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1871 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.202 | 0.202 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.1812 | 0.1812 |
Brugia malayi | hypothetical protein | 0.0071 | 0.392 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0208 | 0.0208 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.392 | 0.392 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.392 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0208 | 0.0208 |
Brugia malayi | Inositol-1 | 0.0038 | 0.1871 | 0.4772 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.1871 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.1871 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.392 | 0.392 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0208 | 0.0529 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.1871 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.392 | 0.392 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.1871 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.