Detailed information for compound 772644

Basic information

Technical information
  • TDR Targets ID: 772644
  • Name: 1-(3-prop-2-enoxyphenyl)-2-(1,3,4-thiadiazol- 2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • MW: 417.437 | Formula: C22H15N3O4S
  • H donors: 0 H acceptors: 4 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCOc1cccc(c1)C1N(c2nncs2)C(=O)c2c1c(=O)c1c(o2)cccc1
  • InChi: 1S/C22H15N3O4S/c1-2-10-28-14-7-5-6-13(11-14)18-17-19(26)15-8-3-4-9-16(15)29-20(17)21(27)25(18)22-24-23-12-30-22/h2-9,11-12,18H,1,10H2
  • InChiKey: PNFKVWMOVDWULE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-allyloxyphenyl)-2-(1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-(3-allyloxyphenyl)-2-(1,3,4-thiadiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0332 0.339 0.339
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0176 0.1728 0.1728
Plasmodium falciparum thioredoxin reductase 0.0056 0.0443 0.7504
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0151 0.1139
Leishmania major hypothetical protein, conserved 0.0029 0.0151 0.1139
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0018 0.0018
Onchocerca volvulus 0.0027 0.0137 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0202 0.0202
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0573 0.6023
Brugia malayi hypothetical protein 0.0029 0.0151 0.0261
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0128 0.1208 0.4222
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0573 0.6023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0202 0.0349
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0172 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0151 0.0261
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0128 0.1208 0.4222
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0307 0.2939
Echinococcus multilocularis dual specificity 0.01 0.0917 0.0917
Mycobacterium ulcerans glutaminase 0.03 0.3051 1
Echinococcus multilocularis lamin dm0 0.0027 0.0137 0.0137
Trichomonas vaginalis CMGC family protein kinase 0.0068 0.0573 0.1735
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0172 0.0172
Echinococcus granulosus GPCR family 2 0.0176 0.1728 0.1728
Schistosoma mansoni intermediate filament proteins 0.0027 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0032
Onchocerca volvulus 0.0027 0.0137 0.0511
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0307 0.053
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0068 0.0573 0.0989
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0172 0.0172
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0176 0.1728 0.1728
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0189 0.0189
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0917 1
Schistosoma mansoni tar DNA-binding protein 0.0332 0.339 0.339
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0295 0.0295
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.2967 0.2967
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.01 0.0917 0.1582
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.01 0.0917 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.0307 0.0927
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0558 0.5793 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0172 0.0298
Echinococcus multilocularis 0.0067 0.0562 0.0562
Mycobacterium tuberculosis Probable reductase 0.0128 0.1208 0.4222
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0172 0.0172
Trichomonas vaginalis glutaminase, putative 0.03 0.3051 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0172 0.0172
Brugia malayi Calcitonin receptor-like protein seb-1 0.0558 0.5793 1
Leishmania major protein kinase, putative 0.0068 0.0573 0.6023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.2967 0.2967
Brugia malayi TAR-binding protein 0.0332 0.339 0.5852
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0172 0.0172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0172 0.0172
Brugia malayi hypothetical protein 0.0016 0.0018 0.0032
Brugia malayi Pre-SET motif family protein 0.0033 0.0202 0.0349
Echinococcus granulosus lamin 0.0027 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0176 0.1728 0.1728
Brugia malayi hypothetical protein 0.0042 0.0295 0.0509
Echinococcus granulosus dual specificity 0.01 0.0917 0.0917
Brugia malayi intermediate filament protein 0.0027 0.0137 0.0236
Trypanosoma cruzi trypanothione reductase, putative 0.0056 0.0443 0.4519
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.2967 0.2967
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0172 0.0298
Brugia malayi Pre-SET motif family protein 0.0233 0.233 0.4021
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0053 0.5
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0307 0.0927
Giardia lamblia Kinase, CMGC CLK 0.0068 0.0573 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0172 0.0172
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0053 0.0091
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0151 0.1892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0172 0.0298
Brugia malayi beta-lactamase family protein 0.0043 0.0307 0.053
Loa Loa (eye worm) hypothetical protein 0.0558 0.5793 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0151 0.1139
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0307 0.0846
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0053 0.0053
Plasmodium vivax SET domain protein, putative 0.0033 0.0202 0.287
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0307 0.0927
Entamoeba histolytica protein kinase, putative 0.01 0.0917 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0307 0.0846
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0142 0.136 0.4777
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.2967 0.2967
Brugia malayi hypothetical protein 0.0018 0.0043 0.0074
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0176 0.1728 0.2982
Loa Loa (eye worm) RNA binding protein 0.0332 0.339 0.5852
Toxoplasma gondii thioredoxin reductase 0.0056 0.0443 0.7504
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0172 0.0172
Leishmania major trypanothione reductase 0.0056 0.0443 0.4519
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0018 0.0032
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0172 0.0172
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0172 0.0298
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0172 0.0172
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0172 0.0298
Echinococcus granulosus intermediate filament protein 0.0027 0.0137 0.0137
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0018 0.0032
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0128 0.1208 0.4222
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0573 0.0573
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0293 0.2967 0.5122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0176 0.1728 0.2982
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0128 0.1208 0.8557
Echinococcus granulosus lamin dm0 0.0027 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.01 0.0917 1
Entamoeba histolytica protein kinase domain containing protein 0.01 0.0917 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0307 0.053
Schistosoma mansoni tar DNA-binding protein 0.0332 0.339 0.339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0202 0.0202
Schistosoma mansoni serine/threonine protein kinase 0.01 0.0917 0.0917
Onchocerca volvulus 0.0031 0.0172 0.0645
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0053 0.0053
Brugia malayi RNA recognition motif domain containing protein 0.0332 0.339 0.5852
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0068 0.0573 0.6023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0202 0.287
Mycobacterium tuberculosis Conserved protein 0.0043 0.0307 0.0927
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0172 0.0172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0172 0.0298
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0142 0.136 0.4777
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0172 0.0172
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0137 0.0236
Loa Loa (eye worm) beta-lactamase 0.0043 0.0307 0.053
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0068 0.0573 1
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0172 0.0645
Trichomonas vaginalis set domain proteins, putative 0.0265 0.2673 0.8737
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0307 0.0307
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0003
Plasmodium falciparum glutathione reductase 0.0056 0.0443 0.7504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Schistosoma mansoni glutaminase 0.03 0.3051 0.3051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0053 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0295 0.0295
Echinococcus multilocularis GPCR, family 2 0.0176 0.1728 0.1728
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0172 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0172 0.0298
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0307 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0172 0.0298
Mycobacterium tuberculosis Conserved protein 0.0043 0.0307 0.0927
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0018 0.0018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0172 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0332 0.339 0.339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0293 0.2967 0.2967
Schistosoma mansoni lamin 0.0027 0.0137 0.0137
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0172 0.0298
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0172 0.0172
Plasmodium vivax serine/threonine kinase-1, putative 0.0068 0.0573 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0307 0.0927
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0172 0.0298
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0307 0.0927
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0176 0.1728 0.1728
Brugia malayi hypothetical protein 0.0016 0.0018 0.0032
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0032
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0172 0.0172
Plasmodium vivax glutathione reductase, putative 0.0056 0.0443 0.7504
Schistosoma mansoni hypothetical protein 0.0952 1 1
Echinococcus multilocularis lamin 0.0027 0.0137 0.0137
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0151 0.1892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0131 0.0227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0172 0.0298
Treponema pallidum NADH oxidase 0.0019 0.0053 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0172 0.0298
Mycobacterium ulcerans beta-lactamase 0.0043 0.0307 0.0846
Loa Loa (eye worm) hypothetical protein 0.0027 0.0137 0.0236
Echinococcus multilocularis tar DNA binding protein 0.0332 0.339 0.339
Schistosoma mansoni hypothetical protein 0.0176 0.1728 0.1728
Loa Loa (eye worm) hypothetical protein 0.0176 0.1728 0.2982
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Loa Loa (eye worm) hypothetical protein 0.0099 0.0906 0.1563
Onchocerca volvulus 0.0265 0.2673 1
Echinococcus granulosus hypothetical protein 0.0067 0.0562 0.0562
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Brugia malayi Latrophilin receptor protein 2 0.0176 0.1728 0.2982
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0137 0.0236
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0128 0.1208 0.4222
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0307 0.0927
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0172 0.0645
Schistosoma mansoni hypothetical protein 0.0381 0.3912 0.3912
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0307 0.0846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0172 0.0298
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0293 0.2967 0.2967
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0307 0.0846
Mycobacterium tuberculosis Probable dehydrogenase 0.0128 0.1208 0.4222
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0293 0.2967 0.5122
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0018 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0307 0.0927
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0018 0.0032
Brugia malayi beta-lactamase 0.0043 0.0307 0.053
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.01 0.0917 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0942 0.989 0.989
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0172 0.0298
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0172 0.0172
Leishmania major hypothetical protein, conserved 0.0043 0.0307 0.2939
Onchocerca volvulus 0.0033 0.0202 0.0757
Loa Loa (eye worm) glutaminase 2 0.03 0.3051 0.5267
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0172 0.0298
Schistosoma mansoni coup transcription factor 0.0031 0.0172 0.0172
Loa Loa (eye worm) glutaminase 0.03 0.3051 0.5267
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.01 0.0917 1
Schistosoma mansoni hypothetical protein 0.0042 0.0295 0.0295
Mycobacterium ulcerans lipase LipD 0.0043 0.0307 0.0846
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0276 0.279 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0307 0.0846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0176 0.1728 0.1728
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0172 0.0298
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0151 0.1892
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0307 0.0846
Brugia malayi beta-lactamase family protein 0.0043 0.0307 0.053
Plasmodium vivax thioredoxin reductase, putative 0.0056 0.0443 0.7504
Brugia malayi RNA binding protein 0.0332 0.339 0.5852
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0068 0.0573 0.6023
Brugia malayi Protein kinase domain containing protein 0.01 0.0917 0.1582
Onchocerca volvulus 0.0043 0.0307 0.1148
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.233 0.4021
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0307 0.0927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0172 0.0298
Brugia malayi nuclear hormone receptor 0.0031 0.0172 0.0298
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0068 0.0573 0.6023
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.0443 0.0443
Trypanosoma brucei trypanothione reductase 0.0056 0.0443 0.4519
Onchocerca volvulus 0.0043 0.0307 0.1148
Leishmania major protein kinase, putative 0.0068 0.0573 0.6023
Brugia malayi nuclear receptor NHR-88 0.0031 0.0172 0.0298
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0172 0.0172
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0307 0.2939
Echinococcus granulosus dual specificity protein kinase clk2 0.0068 0.0573 0.0573
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0293 0.2967 0.2967
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0172 0.0172
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0019 0.0053 0.5
Brugia malayi steroid hormone receptor 0.0031 0.0172 0.0298
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0151 0.1892
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0202 0.0202
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0307 0.4879
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Loa Loa (eye worm) hypothetical protein 0.0099 0.0906 0.1563
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0172 0.0298
Schistosoma mansoni lamin 0.0027 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0176 0.1728 0.1728
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0202 0.0202
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0558 0.5793 1
Brugia malayi ecdysteroid receptor 0.0031 0.0172 0.0298
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0295 0.0295
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0056 0.0443 0.1426
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0172 0.0298
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0172 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0172 0.0298
Brugia malayi latrophilin 2 splice variant baaae 0.0381 0.3912 0.6752
Schistosoma mansoni tar DNA-binding protein 0.0332 0.339 0.339
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Entamoeba histolytica protein kinase, putative 0.01 0.0917 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0172 0.0172
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.0443 0.0443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0307 0.0307
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0172 0.0298
Onchocerca volvulus 0.0043 0.0307 0.1148
Brugia malayi glutathione reductase 0.0056 0.0443 0.0765
Brugia malayi Thioredoxin reductase 0.0056 0.0443 0.0765
Toxoplasma gondii ABC1 family protein 0.0043 0.0307 0.4879
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0137 0.0236
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0307 0.2939
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0142 0.136 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0172 0.0172
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0043 0.0307 0.053
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0172 0.0172
Echinococcus multilocularis dual specificity protein kinase clk2 0.0068 0.0573 0.0573
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0068 0.0573 0.6023
Loa Loa (eye worm) hypothetical protein 0.0067 0.0562 0.097
Echinococcus multilocularis geminin 0.0952 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0202 0.0202
Echinococcus multilocularis musashi 0.0027 0.0137 0.0137
Echinococcus granulosus tar DNA binding protein 0.0332 0.339 0.339
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0332 0.339 0.5852
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0172 0.0298
Brugia malayi glutaminase DH11.1 0.03 0.3051 0.5267
Trichomonas vaginalis esterase, putative 0.0043 0.0307 0.0846
Loa Loa (eye worm) hypothetical protein 0.0031 0.0172 0.0298
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0172 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0172 0.0172
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0176 0.1728 0.1728
Brugia malayi nuclear receptor RXR 0.0016 0.0018 0.0032
Loa Loa (eye worm) thioredoxin reductase 0.0056 0.0443 0.0765
Brugia malayi Protein kinase domain containing protein 0.0068 0.0573 0.0989
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0151 0.1139
Loa Loa (eye worm) TAR-binding protein 0.0332 0.339 0.5852
Loa Loa (eye worm) hypothetical protein 0.0381 0.3912 0.6752
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0307 0.0846
Mycobacterium tuberculosis Probable oxidoreductase 0.0142 0.136 0.4777
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0307 0.0846
Loa Loa (eye worm) glutathione reductase 0.0056 0.0443 0.0765
Schistosoma mansoni hypothetical protein 0.0952 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0573 0.0573
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0172 0.0645
Plasmodium falciparum protein serine/threonine kinase-1 0.0068 0.0573 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0202 0.0202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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