Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0165 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0117 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0117 | 0.5922 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0165 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0048 | 0 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0165 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0165 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0056 | 0.068 | 0.1148 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.5922 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0117 | 0.5922 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.5922 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.5922 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0165 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0056 | 0.068 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.5922 | 1 |
Brugia malayi | hypothetical protein | 0.0056 | 0.068 | 0.1148 |
Onchocerca volvulus | 0.0117 | 0.5922 | 0.5 | |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 3.09 | Calculated partition coefficient (clogP) | ChEMBL. | No reference |
ED50 (functional) | = 1.5 mg kg-1 | Antibacterial activity against E. coli (311) infection in mice after single oral dose, activity expressed as ED50 | ChEMBL. | No reference |
ED50 (functional) | = 1.5 mg kg-1 | Antibacterial activity against E. coli (311) infection in mice after single oral dose, activity expressed as ED50 | ChEMBL. | No reference |
ED50 (functional) | = 1.9 mg kg-1 | Antibacterial activity against E. coli (311) infection in mice after single subcutaneous dose, activity expressed as ED50 | ChEMBL. | No reference |
ED50 (functional) | = 1.9 mg kg-1 | Antibacterial activity against E. coli (311) infection in mice after single subcutaneous dose, activity expressed as ED50 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.