Detailed information for compound 773040

Basic information

Technical information
  • TDR Targets ID: 773040
  • Name: 6-(4-methoxyphenyl)-N-(3-methoxypropyl)-3-phe nyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3 ,4]thiadiazine-7-carboxamide
  • MW: 439.531 | Formula: C22H25N5O3S
  • H donors: 2 H acceptors: 3 LogP: 3.21 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)C1Sc2nnc(n2NC1c1ccc(cc1)OC)c1ccccc1
  • InChi: 1S/C22H25N5O3S/c1-29-14-6-13-23-21(28)19-18(15-9-11-17(30-2)12-10-15)26-27-20(24-25-22(27)31-19)16-7-4-3-5-8-16/h3-5,7-12,18-19,26H,6,13-14H2,1-2H3,(H,23,28)
  • InChiKey: UWVHMCFILZXESM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0269 0.3684 0.5936
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0014 0.0023
Schistosoma mansoni ferritin 0.0025 0.0208 0.022
Schistosoma mansoni intermediate filament proteins 0.0029 0.026 0.0275
Schistosoma mansoni apoferritin-2 0.0025 0.0208 0.022
Echinococcus multilocularis mucolipin 3 0.007 0.0838 0.0887
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1831 0.1939
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0616 0.0652
Leishmania major pyruvate kinase 0.0039 0.0401 0.271
Echinococcus granulosus GPCR family 2 0.0084 0.105 0.1112
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1436 1
Mycobacterium ulcerans bacterioferritin BfrA 0.0025 0.0208 0.0521
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.105 0.1112
Loa Loa (eye worm) hypothetical protein 0.0039 0.0401 0.0424
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0149
Onchocerca volvulus 0.0111 0.1436 0.2313
Echinococcus granulosus pyruvate kinase 0.002 0.0131 0.0139
Loa Loa (eye worm) RNA binding protein 0.0207 0.2805 0.2969
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0575 0.3939
Mycobacterium tuberculosis Conserved protein 0.0111 0.1436 0.1327
Schistosoma mansoni apoferritin-2 0.0025 0.0208 0.022
Onchocerca volvulus 0.0029 0.026 0.0419
Loa Loa (eye worm) runx1 0.0056 0.0644 0.0682
Schistosoma mansoni importin-beta 2 0.0012 0.0016 0.0017
Echinococcus granulosus geminin 0.0172 0.23 0.2435
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0141 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.024 0.4009
Brugia malayi AMP-binding enzyme family protein 0.0028 0.024 0.0388
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1436 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.105 0.1112
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0046 0.0508 0.0819
Schistosoma mansoni pyruvate kinase 0.002 0.0131 0.0139
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1436 1
Chlamydia trachomatis pyruvate kinase 0.0039 0.0401 1
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2805 0.2969
Brugia malayi follicle stimulating hormone receptor 0.0236 0.3213 0.5178
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1436 0.1327
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0401 0.0646
Giardia lamblia Pyruvate kinase 0.0039 0.0401 0.7159
Loa Loa (eye worm) hypothetical protein 0.0446 0.6206 0.657
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0051 0.0575 0.3939
Mycobacterium ulcerans hypothetical protein 0.0111 0.1436 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Schistosoma mansoni hypothetical protein 0.0084 0.105 0.1112
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1436 1
Echinococcus multilocularis microtubule associated protein 2 0.067 0.9413 0.9965
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.024 0.1579
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2805 0.2969
Loa Loa (eye worm) hypothetical protein 0.0029 0.026 0.0275
Loa Loa (eye worm) hypothetical protein 0.0269 0.3684 0.39
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2805 0.2969
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0149
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1436 0.1327
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0401 0.271
Mycobacterium leprae Probable lipase LipE 0.0111 0.1436 1
Leishmania major pyruvate kinase 0.0039 0.0401 0.271
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0149
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.0255
Echinococcus granulosus translational activator gcn1 0.0012 0.0016 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0028 0.024 0.0388
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0345 0.0365
Echinococcus granulosus importin subunit beta 1 0.0063 0.0745 0.0789
Brugia malayi kap beta 3 protein 0.0012 0.0016 0.0026
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0182 0.2438 0.3929
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0616 0.0993
Mycobacterium ulcerans lipase LipD 0.0111 0.1436 1
Brugia malayi RNA, U transporter 1 0.0179 0.2403 0.3873
Echinococcus granulosus pyruvate kinase 0.002 0.0131 0.0139
Leishmania major GTP-binding protein, putative 0.0046 0.0508 0.3465
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.024 0.0263
Treponema pallidum bacterioferrin (TpF1) 0.0025 0.0208 0.5
Echinococcus multilocularis pyruvate kinase 0.002 0.0131 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0028 0.024 0.0388
Echinococcus multilocularis ferritin 0.0025 0.0208 0.022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0616 0.0652
Loa Loa (eye worm) intermediate filament protein 0.0029 0.026 0.0275
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0025 0.0208 0.5
Echinococcus granulosus microtubule associated protein 2 0.067 0.9413 0.9965
Mycobacterium ulcerans hypothetical protein 0.0028 0.024 0.077
Schistosoma mansoni pyruvate kinase 0.0039 0.0401 0.0424
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0068 0.0072
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0068 0.0109
Echinococcus multilocularis tar DNA binding protein 0.0207 0.2805 0.2969
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1436 0.152
Schistosoma mansoni hypothetical protein 0.0055 0.0629 0.0666
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1436 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0508 0.1035
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0041
Schistosoma mansoni lamin 0.0029 0.026 0.0275
Toxoplasma gondii HEAT repeat-containing protein 0.0063 0.0745 0.5138
Loa Loa (eye worm) mucolipin 1 0.007 0.0838 0.0887
Echinococcus granulosus tumor protein p63 0.0399 0.5533 0.5857
Toxoplasma gondii ABC1 family protein 0.0111 0.1436 1
Onchocerca volvulus 0.0028 0.024 0.0388
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0025 0.0208 0.0085
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.024 0.1579
Loa Loa (eye worm) kap beta 3 protein 0.0012 0.0016 0.0017
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0046 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.024 0.4009
Schistosoma mansoni ferritin 0.0025 0.0208 0.022
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Schistosoma mansoni hypothetical protein 0.0172 0.23 0.2435
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0207 0.2805 0.2969
Mycobacterium tuberculosis Conserved protein 0.0111 0.1436 0.1327
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1436 1
Schistosoma mansoni ferritin light chain 0.0025 0.0208 0.022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1436 0.1327
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0131 0.0808
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0401 0.271
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1436 0.152
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0401 0.0424
Loa Loa (eye worm) hypothetical protein 0.0267 0.3652 0.3866
Echinococcus multilocularis Protein lozenge 0.0056 0.0644 0.0682
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0046 0.0508 0.3465
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.024 0.1579
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0401 0.0646
Brugia malayi Latrophilin receptor protein 2 0.0084 0.105 0.1693
Brugia malayi Calcitonin receptor-like protein seb-1 0.0267 0.3652 0.5885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0616 0.0652
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1436 0.1327
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0149
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.024 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1436 1
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0401 0.0646
Plasmodium falciparum pyruvate kinase 2 0.002 0.0131 0.1572
Echinococcus granulosus tar DNA binding protein 0.0207 0.2805 0.2969
Entamoeba histolytica hypothetical protein 0.0035 0.0345 0.5879
Schistosoma mansoni hypothetical protein 0.0084 0.105 0.1112
Echinococcus multilocularis translational activator gcn1 0.0012 0.0016 0.0017
Brugia malayi latrophilin 2 splice variant baaae 0.0182 0.2448 0.3945
Trichomonas vaginalis importin beta-1, putative 0.0051 0.0575 0.3939
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0401 0.028
Onchocerca volvulus 0.0029 0.026 0.0419
Echinococcus granulosus GTP binding nuclear protein Ran 0.0046 0.0508 0.0538
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1436 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.024 0.077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0267 0.3652 0.5885
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.024 0.0263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0616 0.0652
Loa Loa (eye worm) hypothetical protein 0.0014 0.0046 0.0049
Brugia malayi Importin beta-1 subunit 0.0063 0.0745 0.1201
Echinococcus multilocularis pyruvate kinase 0.0039 0.0401 0.0424
Entamoeba histolytica hypothetical protein 0.0035 0.0345 0.5879
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0046 0.0508 0.0538
Leishmania major hypothetical protein, conserved 0.0111 0.1436 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.024 0.077
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0401 0.0424
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0131 0.0808
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0141 0.0877
Loa Loa (eye worm) hypothetical protein 0.0182 0.2438 0.2581
Echinococcus granulosus transportin 1 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Schistosoma mansoni survival motor neuron protein 0.0055 0.0629 0.0666
Loa Loa (eye worm) hypothetical protein 0.0013 0.0038 0.0041
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.024 0.077
Schistosoma mansoni ferritin light chain 0.0025 0.0208 0.022
Schistosoma mansoni hypothetical protein 0.0673 0.9446 1
Schistosoma mansoni mucolipin 0.0064 0.0755 0.08
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.024 0.077
Loa Loa (eye worm) importin-beta domain-containing protein 0.0012 0.0016 0.0017
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0025 0.0208 0.0085
Mycobacterium ulcerans bacterioferritin BfrB 0.0025 0.0208 0.0521
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.0255
Schistosoma mansoni ferritin 0.0025 0.0208 0.022
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0141 0.1707
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0616 0.0652
Echinococcus granulosus pyruvate kinase 0.0039 0.0401 0.0424
Echinococcus multilocularis pyruvate kinase 0.002 0.0131 0.0139
Brugia malayi beta-lactamase family protein 0.0111 0.1436 0.2313
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2805 0.2969
Plasmodium vivax importin-beta 2, putative 0.0063 0.0745 0.5138
Schistosoma mansoni hypothetical protein 0.0084 0.105 0.1112
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1831 0.1939
Brugia malayi N-terminal motif family protein 0.0182 0.2438 0.3929
Mycobacterium tuberculosis Conserved protein 0.0111 0.1436 0.1327
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0745 0.5138
Plasmodium falciparum pyruvate kinase 0.0039 0.0401 0.5275
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1436 1
Entamoeba histolytica Ran family GTPase 0.0046 0.0508 0.8795
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0149
Brugia malayi MH2 domain containing protein 0.0139 0.1831 0.2951
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0616 0.0652
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1436 1
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0679 0.0718
Schistosoma mansoni tar DNA-binding protein 0.0207 0.2805 0.2969
Leishmania major importin beta-1 subunit, putative 0.0051 0.0575 0.3939
Brugia malayi hypothetical protein 0.0446 0.6206 1
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0401 0.0646
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0046 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0063 0.0745 0.5138
Echinococcus multilocularis transportin 1 0.0012 0.0016 0.0017
Schistosoma mansoni hypothetical protein 0.0182 0.2448 0.2591
Schistosoma mansoni pyruvate kinase 0.0039 0.0401 0.0424
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0046 0.0508 0.3465
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.024 0.077
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0401 0.0424
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0673 0.9446 1
Mycobacterium ulcerans beta-lactamase 0.0111 0.1436 1
Schistosoma mansoni ran 0.0046 0.0508 0.0538
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0233 0.0247
Brugia malayi RNA binding protein 0.0207 0.2805 0.4519
Loa Loa (eye worm) hypothetical protein 0.0027 0.0233 0.0247
Loa Loa (eye worm) hypothetical protein 0.0111 0.1436 0.152
Onchocerca volvulus 0.0058 0.0679 0.1093
Loa Loa (eye worm) hypothetical protein 0.0182 0.2448 0.2591
Schistosoma mansoni importin beta-1 0.0063 0.0745 0.0789
Brugia malayi beta-lactamase 0.0111 0.1436 0.2313
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0046 0.0508 0.6744
Loa Loa (eye worm) TAR-binding protein 0.0207 0.2805 0.2969
Brugia malayi Coelomocyte uptake defective protein 5 0.007 0.0838 0.1351
Schistosoma mansoni ran 0.0046 0.0508 0.0538
Echinococcus multilocularis expressed protein 0.0025 0.0208 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0616 0.0652
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0401 0.157
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0629 0.1013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1436 0.1327
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.105 0.1112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0267 0.3652 0.3866
Onchocerca volvulus 0.0111 0.1436 0.2313
Brugia malayi intermediate filament protein 0.0029 0.026 0.0419
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.026 0.0275
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0401 0.271
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0046 0.0508 0.1035
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.024 0.4009
Echinococcus multilocularis geminin 0.0172 0.23 0.2435
Schistosoma mansoni lozenge 0.0056 0.0644 0.0682
Echinococcus multilocularis GPCR, family 2 0.0084 0.105 0.1112
Loa Loa (eye worm) hypothetical protein 0.0084 0.105 0.1112
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1436 0.152
Echinococcus multilocularis musashi 0.0029 0.026 0.0275
Echinococcus granulosus intermediate filament protein 0.0029 0.026 0.0275
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0345 0.0365
Echinococcus granulosus pyruvate kinase 0.002 0.0131 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.024 0.0117
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1436 0.1327
Brugia malayi RNA recognition motif domain containing protein 0.0207 0.2805 0.4519
Trichomonas vaginalis ran, putative 0.0046 0.0508 0.3465
Loa Loa (eye worm) hypothetical protein 0.0028 0.024 0.0255
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0046 0.0508 1
Schistosoma mansoni ferritin 0.0025 0.0208 0.022
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0401 0.2009
Schistosoma mansoni hypothetical protein 0.0172 0.23 0.2435
Echinococcus granulosus expressed protein 0.0025 0.0208 0.022
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.024 0.077
Brugia malayi beta-lactamase family protein 0.0111 0.1436 0.2313
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.024 0.077
Echinococcus multilocularis importin 5 0.0012 0.0016 0.0017
Schistosoma mansoni mucolipin 0.007 0.0838 0.0887
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0401 0.271
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0345 0.0365
Schistosoma mansoni microtubule-associated protein tau 0.067 0.9413 0.9965
Echinococcus granulosus pyruvate kinase 0.0039 0.0401 0.0424
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0401 0.271
Echinococcus multilocularis pyruvate kinase 0.0031 0.0284 0.0301
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1436 1
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.3684 0.39
Loa Loa (eye worm) hypothetical protein 0.0446 0.6206 0.657
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0233 0.3877
Echinococcus multilocularis lamin dm0 0.0029 0.026 0.0275
Echinococcus multilocularis lamin 0.0029 0.026 0.0275
Plasmodium falciparum importin beta, putative 0.0063 0.0745 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0401 0.0646
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0046 0.0508 0.3465
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.105 0.1112
Echinococcus granulosus mucolipin 3 0.007 0.0838 0.0887
Schistosoma mansoni hypothetical protein 0.0084 0.105 0.1112
Loa Loa (eye worm) hypothetical protein 0.0028 0.0252 0.0267
Trichomonas vaginalis esterase, putative 0.0111 0.1436 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0046 0.0508 0.0538
Entamoeba histolytica hypothetical protein 0.0051 0.0575 1
Echinococcus multilocularis pyruvate kinase 0.002 0.0131 0.0139
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1436 1
Echinococcus granulosus lamin 0.0029 0.026 0.0275
Schistosoma mansoni lamin 0.0029 0.026 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0616 0.0652
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.026 0.0419
Onchocerca volvulus 0.0055 0.0629 0.1013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.3213 0.3402
Echinococcus granulosus ferritin 0.0025 0.0208 0.022
Echinococcus multilocularis pyruvate kinase 0.0039 0.0401 0.0424
Echinococcus granulosus snurportin 1 0.0673 0.9446 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1436 0.152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.105 0.1112
Brugia malayi TAR-binding protein 0.0207 0.2805 0.4519
Entamoeba histolytica hypothetical protein 0.0035 0.0345 0.5879
Echinococcus multilocularis tumor protein p63 0.0399 0.5533 0.5857
Schistosoma mansoni hypothetical protein 0.0035 0.0345 0.0365
Echinococcus granulosus lamin dm0 0.0029 0.026 0.0275
Entamoeba histolytica hypothetical protein 0.0035 0.0345 0.5879
Trypanosoma cruzi importin beta-1 subunit, putative 0.0051 0.0575 0.1686
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.105 0.1693
Echinococcus granulosus importin 5 0.0012 0.0016 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1436 0.152
Loa Loa (eye worm) beta-lactamase 0.0111 0.1436 0.152
Loa Loa (eye worm) hypothetical protein 0.0058 0.0679 0.0718
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.3684 0.39
Onchocerca volvulus 0.0446 0.6206 1
Trichomonas vaginalis ferritin, putative 0.0025 0.0208 0.1352
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1436 0.2313
Onchocerca volvulus 0.0111 0.1436 0.2313
Brugia malayi hypothetical protein 0.0035 0.0345 0.0556
Loa Loa (eye worm) hypothetical protein 0.0063 0.0745 0.0789
Echinococcus multilocularis snurportin 1 0.0673 0.9446 1
Echinococcus multilocularis importin subunit beta 1 0.0063 0.0745 0.0789
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0401 0.271
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1436 0.1327

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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