TDR Targets

Basic information

Technical information

TDR Targets ID: 773125
Name: 6-(4-ethoxyphenyl)-N-(2-methoxyphenyl)-3-phen yl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3, 4]thiadiazine-7-carboxamide
MW: 487.573 | Formula: C26H25N5O3S
H donors: 2 H acceptors: 3 LogP: 4.9 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C1Nn2c(SC1C(=O)Nc1ccccc1OC)nnc2c1ccccc1
InChi: 1S/C26H25N5O3S/c1-3-34-19-15-13-17(14-16-19)22-23(25(32)27-20-11-7-8-12-21(20)33-2)35-26-29-28-24(31(26)30-22)18-9-5-4-6-10-18/h4-16,22-23,30H,3H2,1-2H3,(H,27,32)
InChiKey: LGVKSPYJPLLEBC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Huntingtin homolog	0.0079	0.2858	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Onchocerca volvulus		0.0008	0.0127	0.0381
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0008	0.0127	0.2457
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0007	0.0082	0.0065
Onchocerca volvulus		0.0021	0.0619	0.2112
Mycobacterium leprae	Probable lipase LipE	0.0035	0.1188	0.2681
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1188	0.2495
Trypanosoma brucei	oxidoreductase-like protein	0.0008	0.0127	0.0925
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Echinococcus multilocularis	ecdysone induced protein 78C	0.0007	0.0082	0.0065
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1188	0.2713
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1188	0.2713
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0118	0.4378	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Mycobacterium tuberculosis	Possible oxidoreductase	0.0008	0.0127	0.0126
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1188	0.2713
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0094	0.3467	0.7909
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0118	0.4378	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1188	0.2681
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0007	0.0082	0.0221
Onchocerca volvulus		0.0008	0.0127	0.0381
Brugia malayi	Steroid receptor seven-up type 2	0.0007	0.0082	0.0221
Trichomonas vaginalis	esterase, putative	0.0035	0.1188	0.2713
Brugia malayi	hypothetical protein	0.0014	0.0343	0.114
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0008	0.0127	0.0313
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0017	0.0459	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Schistosoma mansoni	aldehyde dehydrogenase	0.0094	0.3467	0.3456
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0034	0.1147	0.3271
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0007	0.0082	0.0065
Toxoplasma gondii	exonuclease III APE	0.0017	0.0459	0.1009
Giardia lamblia	Kinase, CMGC MAPK	0.0034	0.1147	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0008	0.0127	0.0126
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Schistosoma mansoni	ap endonuclease	0.0017	0.0459	0.0442
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0008	0.0127	0.0248
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0008	0.0127	0.0248
Onchocerca volvulus		0.0035	0.1188	0.4116
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0007	0.0082	0.0065
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0007	0.0082	0.0065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0067	0.2427	0.2414
Brugia malayi	steroid hormone receptor	0.0007	0.0082	0.0221
Loa Loa (eye worm)	histone methyltransferase	0.0006	0.0066	0.0165
Trichomonas vaginalis	CMGC family protein kinase	0.0034	0.1147	0.262
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1188	0.1173
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0007	0.0082	0.0065
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0017	0.0459	0.1549
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0008	0.0127	0.0925
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0082	0.0221
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0034	0.1147	0.9651
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1188	0.1173
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0009	0.0183	0.0166
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1188	0.2681
Onchocerca volvulus		0.0035	0.1188	0.4116
Trichomonas vaginalis	CMGC family protein kinase	0.0034	0.1147	0.262
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0007	0.0082	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0082	0.0221
Schistosoma mansoni	aldehyde dehydrogenase	0.0005	0.0019	0.0002
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0034	0.1147	0.2587
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0008	0.0127	0.0248
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.8567	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1188	0.2681
Schistosoma mansoni	RAR-like nuclear receptor	0.0007	0.0082	0.0065
Trypanosoma brucei	PAB1-binding protein , putative	0.0021	0.0631	0.5232
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0067	0.2427	0.2414
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0082	0.0065
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0007	0.0082	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Mycobacterium tuberculosis	Probable oxidoreductase	0.0008	0.0127	0.0126
Schistosoma mansoni	cpg binding protein	0.0022	0.0665	0.0648
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0007	0.0082	0.0221
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0067	0.2427	0.8482
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0067	0.2427	0.2414
Leishmania major	hypothetical protein, conserved	0.0021	0.0631	0.1773
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0017	0.0459	0.1009
Plasmodium falciparum	ataxin-2 like protein, putative	0.0021	0.0631	0.1184
Trichomonas vaginalis	succinate semialdehyde dehydrogenase, putative	0.0005	0.0019	0.0044
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0067	0.2427	0.2414
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.1188	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Loa Loa (eye worm)	beta-lactamase	0.0035	0.1188	0.4116
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0017	0.0459	0.3763
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0007	0.0082	0.0221
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0008	0.0127	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0007	0.0082	0.0221
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Schistosoma mansoni	ap endonuclease	0.0017	0.0459	0.0442
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Schistosoma mansoni	hypothetical protein	0.0263	1	1
Onchocerca volvulus		0.0035	0.1188	0.4116
Loa Loa (eye worm)	oxidoreductase	0.0008	0.0127	0.0381
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0008	0.0127	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.1147	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2858	1
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0118	0.4378	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0008	0.0127	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0082	0.0221
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0094	0.3467	0.7909
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0008	0.0127	0.0248
Brugia malayi	beta-lactamase	0.0035	0.1188	0.4116
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0008	0.0127	0.0925
Brugia malayi	nuclear receptor NHR-88	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.1188	0.1367
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0118	0.4378	1
Leishmania major	oxidoreductase-like protein	0.0008	0.0127	0.0313
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0017	0.0459	0.0442
Schistosoma mansoni	dihydropteridine reductase	0.0008	0.0127	0.011
Schistosoma mansoni	aldehyde dehydrogenase	0.0005	0.0019	0.0002
Echinococcus multilocularis	Fatty aldehyde dehydrogenase	0.0005	0.0019	0.0002
Schistosoma mansoni	aldehyde dehydrogenase	0.0094	0.3467	0.3456
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0007	0.0082	0.0065
Echinococcus granulosus	mitogen activated protein kinase	0.0034	0.1147	0.1132
Echinococcus granulosus	cpg binding protein	0.0022	0.0665	0.0648
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0034	0.1147	0.3973
Schistosoma mansoni	hypothetical protein	0.0009	0.0183	0.0166
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0008	0.0127	0.0248
Schistosoma mansoni	coup transcription factor	0.0007	0.0082	0.0065
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0094	0.3467	0.3456
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0008	0.0127	0.0248
Brugia malayi	F/Y-rich N-terminus family protein	0.0006	0.0063	0.0154
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0067	0.2427	0.2414
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0017	0.0459	0.3763
Trypanosoma cruzi	PAB1-binding protein , putative	0.0021	0.0631	0.5232
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0034	0.1147	0.3271
Schistosoma mansoni	nuclear hormone receptor	0.0007	0.0082	0.0065
Loa Loa (eye worm)	steroid hormone receptor	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0126
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0007	0.0082	0.0065
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0082	0.0065
Trichomonas vaginalis	ap endonuclease, putative	0.0017	0.0459	0.1049
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0017	0.0459	0.3763
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Echinococcus multilocularis	aldehyde dehydrogenase family 3 member B1	0.0005	0.0019	0.0002
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0034	0.1147	0.9651
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0007	0.0082	0.0065
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0094	0.3467	0.4033
Echinococcus multilocularis	FTZ F1 alpha	0.0007	0.0082	0.0065
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0008	0.0127	0.0248
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0007	0.0082	0.0065
Schistosoma mansoni	hypothetical protein	0.0263	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0021	0.0631	0.5232
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2858	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Echinococcus granulosus	FTZ F1 alpha	0.0007	0.0082	0.0065
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0007	0.0082	0.0221
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0007	0.0082	0.0221
Echinococcus multilocularis	betaine aldehyde dehydrogenase	0.0005	0.0019	0.0002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0067	0.2427	0.2414
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0127	0.0381
Toxoplasma gondii	LsmAD domain-containing protein	0.0021	0.0631	0.1403
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Schistosoma mansoni	hypothetical protein	0.0005	0.0019	0.0002
Onchocerca volvulus	Bile acid receptor homolog	0.0007	0.0082	0.0221
Schistosoma mansoni	cpg binding protein	0.0022	0.0665	0.0648
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1188	0.2713
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0006	0.0066	0.0049
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1188	0.1367
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0017	0.0459	0.0514
Onchocerca volvulus	Huntingtin homolog	0.0079	0.2858	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0007	0.0082	0.0221
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0005	0.0019	0.0002
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0008	0.0127	0.0248
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0008	0.0127	0.0126
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0118	0.4378	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0017	0.0459	0.3899
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0034	0.1147	0.9651
Toxoplasma gondii	aldehyde dehydrogenase	0.0094	0.3467	0.7909
Brugia malayi	CXXC zinc finger family protein	0.0021	0.0619	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.0005	0.0019	0.0002
Echinococcus granulosus	Fatty aldehyde dehydrogenase	0.0005	0.0019	0.0002
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.1188	0.1367
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0044	0.1516	0.1501
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0008	0.0127	0.011
Echinococcus granulosus	mitogen activated protein kinase 3	0.0034	0.1147	0.1132
Echinococcus multilocularis	geminin	0.0263	1	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0008	0.0127	0.0126
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1188	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0008	0.0127	0.0381
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0127	0.0381
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0017	0.0459	0.078
Mycobacterium ulcerans	lipase LipD	0.0035	0.1188	0.2681
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.1188	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1188	0.4116
Echinococcus granulosus	betaine aldehyde dehydrogenase	0.0005	0.0019	0.0002
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0094	0.3467	0.3456
Onchocerca volvulus		0.0007	0.0082	0.0221
Trypanosoma brucei	protein kinase, putative	0.0034	0.1147	0.9651
Trypanosoma brucei	pteridine reductase 1	0.0008	0.0127	0.0925
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0017	0.0459	0.1275
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0126
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0034	0.1147	0.9651
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0631	0.2154
Leishmania major	hypothetical protein, conserved	0.0035	0.1188	0.339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0007	0.0082	0.0221
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0007	0.0082	0.0221
Plasmodium vivax	ataxin-2 like protein, putative	0.0021	0.0631	0.1184
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1188	1
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0082	0.0065
Plasmodium falciparum	ataxin-2 like protein, putative	0.0021	0.0631	0.1184
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1188	0.2713
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1188	0.2681
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0007	0.0082	0.0221
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0007	0.0082	0.0065
Brugia malayi	Nuclear hormone receptor-like 1	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1188	0.1367
Toxoplasma gondii	ABC1 family protein	0.0035	0.1188	0.2681
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0034	0.1147	0.9651
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1188	0.1173
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0118	0.4378	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1188	0.4116
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0007	0.0082	0.0221
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0007	0.0082	0.0065
Schistosoma mansoni	aldehyde dehydrogenase	0.0005	0.0019	0.0002
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0008	0.0127	0.011
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0008	0.0127	0.0248
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0008	0.0127	0.0248
Trichomonas vaginalis	CMGC family protein kinase	0.0034	0.1147	0.262
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0118	0.4378	0.51
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0017	0.0459	0.1009
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0008	0.0127	0.0313
Brugia malayi	photoreceptor-specific nuclear receptor	0.0007	0.0082	0.0221
Schistosoma mansoni	retinoic acid receptor RXR	0.0007	0.0082	0.0065
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0005	0.0019	0.0002
Mycobacterium ulcerans	oxidoreductase	0.0008	0.0127	0.0248
Leishmania major	pteridine reductase 1	0.0008	0.0127	0.0313
Echinococcus granulosus	aldehyde dehydrogenase family 3 member B1	0.0005	0.0019	0.0002
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0008	0.0127	0.0381
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0094	0.3467	1
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0118	0.4378	1
Trichomonas vaginalis	hypothetical protein	0.0118	0.4378	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1188	0.4116
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0008	0.0127	0.0248
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0017	0.0459	0.078
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0017	0.0459	0.0442
Schistosoma mansoni	thyroid hormone receptor	0.0007	0.0082	0.0065
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1188	0.1367
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0094	0.3467	0.7909
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0007	0.0082	0.0221
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0007	0.0082	0.0065
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.1188	0.2681
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.1188	0.1367
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0007	0.0082	0.0065
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0006	0.0066	0.0049
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0034	0.1147	0.1132
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1188	0.1173
Brugia malayi	MAP kinase sur-1	0.0034	0.1147	0.3973
Onchocerca volvulus	Protein ultraspiracle homolog	0.0007	0.0082	0.0221
Brugia malayi	hypothetical protein	0.0079	0.2858	1
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0008	0.0127	0.011
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0008	0.0127	0.0248
Brugia malayi	beta-lactamase family protein	0.0035	0.1188	0.4116
Brugia malayi	ecdysteroid receptor	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.1188	0.1367
Schistosoma mansoni	delta 1-pyrroline-5-carboxylate synthetase	0.0005	0.0019	0.0002
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0009	0.0183	0.0166
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0007	0.0082	0.0065
Echinococcus granulosus	ecdysone induced protein 78C	0.0007	0.0082	0.0065
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0008	0.0127	0.0248
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0007	0.0082	0.0065
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0067	0.2427	0.8482
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0008	0.0127	0.0248
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0008	0.0127	0.0313
Mycobacterium ulcerans	short chain dehydrogenase	0.0008	0.0127	0.0248
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0008	0.0127	0.0248
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0039	0.1335	0.3017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0007	0.0082	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0082	0.0221
Echinococcus multilocularis	cpg binding protein	0.0022	0.0665	0.0648
Brugia malayi	hypothetical protein	0.0021	0.0631	0.2154
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.1188	0.4116
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0007	0.0082	0.0221
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0067	0.2427	0.2414
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0007	0.0082	0.0221
Schistosoma mansoni	aldehyde dehydrogenase	0.0005	0.0019	0.0002
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0021	0.0619	0.2112
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0007	0.0082	0.0065
Echinococcus multilocularis	mitogen activated protein kinase	0.0034	0.1147	0.1132
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0007	0.0082	0.0221
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.1188	0.1367
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0005	0.0019	0.0002
Trichomonas vaginalis	CMGC family protein kinase	0.0034	0.1147	0.262
Schistosoma mansoni	aldehyde dehydrogenase	0.0005	0.0019	0.0002
Schistosoma mansoni	cpg binding protein	0.0021	0.0619	0.0602
Brugia malayi	exodeoxyribonuclease III family protein	0.0017	0.0459	0.1549
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0008	0.0127	0.0925
Brugia malayi	nuclear hormone receptor	0.0007	0.0082	0.0221
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1188	1
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0008	0.0127	0.0126
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0017	0.0459	1
Trichomonas vaginalis	ap endonuclease, putative	0.0017	0.0459	0.1049
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0007	0.0082	0.0065

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 773125