Detailed information for compound 773389

Basic information

Technical information
  • TDR Targets ID: 773389
  • Name: 5-chloro-2-ethoxy-N-(pyridin-2-ylmethyl)benze nesulfonamide
  • MW: 326.799 | Formula: C14H15ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 2.31 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1S(=O)(=O)NCc1ccccn1)Cl
  • InChi: 1S/C14H15ClN2O3S/c1-2-20-13-7-6-11(15)9-14(13)21(18,19)17-10-12-5-3-4-8-16-12/h3-9,17H,2,10H2,1H3
  • InChiKey: BZLHCVHTKSCLPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-2-ethoxy-N-(2-pyridylmethyl)benzenesulfonamide
  • 5-chloro-2-ethoxy-N-(2-pyridinylmethyl)benzenesulfonamide
  • AP-263/12136534
  • 5-Chloro-2-ethoxy-N-pyridin-2-ylmethyl-benzenesulfonamide
  • BAS 00804502
  • MLS000715870
  • SMR000277387
  • ZINC00836082

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.1598 0.1473
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0961 0.2012
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1236 0.3113
Loa Loa (eye worm) DR-78 0.0011 0.0061 0.0028
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0061 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0117
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0117
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1472 0.3124
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.1085 0.2284
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0061 0.0153
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.1085 0.2357
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0296 0.0545
Mycobacterium ulcerans hypothetical protein 0.0171 0.5136 1
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0439 0.0954
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0639 0.0501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1535 0.3269
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0296 0.0643
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0439 0.0954
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1598 0.3111
Loa Loa (eye worm) hypothetical protein 0.0043 0.1085 0.2277
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0061 0.0038
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0995 1
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.1085 0.0954
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0609 0.493
Loa Loa (eye worm) hypothetical protein 0.0013 0.0146 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0439 0.0867
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.1085 0.0954
Brugia malayi hypothetical protein 0.0029 0.0639 0.1305
Brugia malayi polk-prov protein 0.0013 0.0146 0.0224
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0061 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0439 0.0867
Brugia malayi nuclear receptor NHR-88 0.0023 0.0439 0.0867
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Schistosoma mansoni hypothetical protein 0.0018 0.0296 0.0746
Loa Loa (eye worm) hypothetical protein 0.0029 0.0639 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0663 0.0524
Loa Loa (eye worm) RNA binding protein 0.0134 0.3971 0.8608
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0439 0.0954
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.1085 0.2357
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0439 0.1106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0439 0.0859
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0061 0.0132
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.1085 0.2277
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1168 0.1037
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0101 0.0126
Echinococcus granulosus muscleblind protein 0.0154 0.4605 1
Echinococcus granulosus tar DNA binding protein 0.0134 0.3971 0.8622
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0439 0.0867
Brugia malayi tailless protein 0.0011 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0639 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1236 0.2684
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0296 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0609 0.047
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0439 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Brugia malayi Muscleblind-like protein 0.0154 0.4605 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0439 0.0954
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0439 0.0867
Brugia malayi conserved hypotetical protein 0.0011 0.0061 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3971 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.1236 0.2614
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0439 0.0867
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0439 0.0867
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0995 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.1236 0.2607
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0101 0.0126
Mycobacterium ulcerans hypothetical protein 0.0013 0.0146 0.0284
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0995 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Schistosoma mansoni coup transcription factor 0.0023 0.0439 0.1106
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0663 0.0524
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.1085 0.2113
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.1085 0.2284
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0061 0.0132
Brugia malayi nuclear receptor RXR 0.0012 0.0101 0.0126
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0439 0.0867
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Brugia malayi hypothetical protein 0.0012 0.0101 0.0126
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3971 1
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0439 0.0954
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0439 0.0954
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0995 0.0862
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0439 0.0867
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1598 0.347
Schistosoma mansoni cpg binding protein 0.0033 0.0773 0.1948
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0061 0.0132
Onchocerca volvulus 0.0023 0.0439 0.5312
Schistosoma mansoni nuclear receptor 0.0011 0.0061 0.0153
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0995 0.216
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0296 0.0643
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0639 0.0501
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0439 0.0954
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0995 0.0862
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0146 0.0367
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0296 0.0643
Echinococcus multilocularis GPCR, family 2 0.0018 0.0296 0.0643
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Brugia malayi RNA binding protein 0.0134 0.3971 0.8609
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.1598 0.4024
Onchocerca volvulus 0.0033 0.0773 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0995 0.9035
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0995 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0439 0.0859
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.3971 0.8608
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0061 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0439 0.0954
Echinococcus granulosus GPCR family 2 0.0018 0.0296 0.0643
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0061 0.0153
Brugia malayi nuclear receptor RXR 0.0011 0.0061 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0995 0.9165
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.1085 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0061 0.0132
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0101 0.0117
Echinococcus granulosus flap endonuclease 1 0.0028 0.0609 0.1323
Schistosoma mansoni flap endonuclease-1 0.0025 0.0524 0.132
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3971 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0609 0.047
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0439 0.0954
Echinococcus multilocularis muscleblind protein 0.0154 0.4605 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1951 0.4914
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0439 0.0859
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.1085 0.0954
Brugia malayi Flap endonuclease-1 0.0028 0.0609 0.1239
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0439 0.5312
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0153 0.4587 0.4507
Brugia malayi nuclear receptor NHR-67 0.0011 0.0061 0.0038
Brugia malayi ecdysteroid receptor 0.0023 0.0439 0.0867
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.1236 0.2684
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0639 0.5809
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0439 0.0867
Loa Loa (eye worm) hypothetical protein 0.0154 0.4605 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.1085 0.2734
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0439 0.1106
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0439 0.5312
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0439 0.0859
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0439 0.0859
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Brugia malayi ecdysone receptor 0.0011 0.0061 0.0038
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.1085 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0773 0.1592
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0324 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0439 0.0867
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0439 0.0867
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) hypothetical protein 0.0018 0.0296 0.0545
Schistosoma mansoni ap endonuclease 0.004 0.0995 0.2505
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0439 0.0954
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.1598 0.3111
Loa Loa (eye worm) hypothetical protein 0.0039 0.0961 0.2005
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.1598 0.3407
Brugia malayi hypothetical protein 0.0011 0.0061 0.0038
Echinococcus granulosus dna polymerase eta 0.0043 0.1085 0.2357
Leishmania major DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Echinococcus multilocularis dna polymerase eta 0.0043 0.1085 0.2357
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0101 0.0255
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Schistosoma mansoni cpg binding protein 0.0035 0.0833 0.2099
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0995 0.2078
Echinococcus granulosus cpg binding protein 0.0035 0.0833 0.1809
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.1713 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0061 0.0038
Plasmodium falciparum flap endonuclease 1 0.0028 0.0609 0.5456
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0609 0.5611
Loa Loa (eye worm) hypothetical protein 0.0154 0.4605 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0061 0.0153
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0061 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0439 0.0954
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0439 0.0954
Brugia malayi hypothetical protein 0.0011 0.0061 0.0038
Leishmania major hypothetical protein, conserved 0.0029 0.0639 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Toxoplasma gondii hypothetical protein 0.0052 0.138 0.7878
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0439 0.0954
Schistosoma mansoni DNA polymerase eta 0.0043 0.1085 0.2734
Echinococcus multilocularis dna polymerase kappa 0.0043 0.1085 0.2357
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0439 0.1106
Schistosoma mansoni hypothetical protein 0.0018 0.0296 0.0746
Schistosoma mansoni nuclear receptor 0.0011 0.0061 0.0153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0101 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1236 0.3113
Echinococcus multilocularis muscleblind protein 1 0.0154 0.4605 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0061 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Echinococcus multilocularis cpg binding protein 0.0035 0.0833 0.1809
Brugia malayi nuclear hormone receptor 0.0023 0.0439 0.0867
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.1168 0.1037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.1236 0.3113
Toxoplasma gondii exonuclease III APE 0.004 0.0995 0.5417
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0439 0.1106
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0995 0.2085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0439 0.0867
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.1085 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0061 0.0038
Trypanosoma brucei unspecified product 0.003 0.0663 0.0524
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0134 0.0291
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0995 0.9165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0061 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0439 0.0954
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0639 0.5809
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0439 0.5312
Leishmania major DNA polymerase eta, putative 0.0043 0.1085 0.0954
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1236 0.2684
Brugia malayi TAR-binding protein 0.0134 0.3971 0.8609
Schistosoma mansoni hypothetical protein 0.0018 0.0296 0.0746
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.1085 0.2113
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0061 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0439 0.0867
Echinococcus granulosus dna polymerase kappa 0.0043 0.1085 0.2357
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0324 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.1085 0.2113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0439 0.1106
Schistosoma mansoni ap endonuclease 0.004 0.0995 0.2505
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0061 0.0132
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0995 1
Loa Loa (eye worm) TAR-binding protein 0.0134 0.3971 0.8608
Trypanosoma brucei unspecified product 0.003 0.0663 0.0524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0439 0.0859
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.4587 0.4507
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0048 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1535 0.3263
Schistosoma mansoni zinc finger protein 0.0011 0.0061 0.0153
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0061 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3971 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0439 0.0867
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0439 0.0954
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0609 0.5456
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0061 0.0132
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0101 0.022
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0061 0.0028
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0439 0.1106
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0439 0.0867
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0061 0.0028
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0639 0.3147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0995 0.0862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0439 0.0859
Brugia malayi CXXC zinc finger family protein 0.0033 0.0773 0.16
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0296 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0663 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0439 0.0954
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.1085 0.0954
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.1085 0.2113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0061 0.0132
Brugia malayi hypothetical protein 0.0019 0.0314 0.0593
Giardia lamblia DINP protein human, muc B family 0.0043 0.1085 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0995 0.1937
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0439 0.1106
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.1236 0.2684
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0995 0.8097
Brugia malayi nuclear hormone receptor 0.0011 0.0061 0.0038
Schistosoma mansoni hypothetical protein 0.0039 0.0961 0.2422
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.1598 0.347
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0439 0.0867
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1535 0.3269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0439 0.0954
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0609 0.2956
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0061 0.0038
Brugia malayi steroid hormone receptor 0.0023 0.0439 0.0867
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0061 0.0153
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0117
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0134 0.0291
Brugia malayi hypothetical protein 0.0012 0.0101 0.0126
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0117
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0439 0.1106
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0439 0.0954
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.1598 0.3111
Echinococcus multilocularis tar DNA binding protein 0.0134 0.3971 0.8622
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0048 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0296 0.0553
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0995 0.216
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0609 0.1231
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.1168 0.1037
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0439 0.1106
Schistosoma mansoni hypothetical protein 0.0013 0.0134 0.0337
Trypanosoma brucei unspecified product 0.0043 0.1085 0.0954
Loa Loa (eye worm) hypothetical protein 0.0057 0.1535 0.3263
Brugia malayi nuclear receptor NHR-88 0.0011 0.0061 0.0038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0439 0.0859
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.3971 0.8609
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0061 0.0132
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.1168 0.1037
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0995 0.1937
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.1085 0.2734
Schistosoma mansoni hypothetical protein 0.0018 0.0296 0.0746
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0609 0.1323
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0439 0.1106
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0153 0.4587 0.4507
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0609 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.1484 0.1358
Loa Loa (eye worm) hypothetical protein 0.0023 0.0439 0.0859
Schistosoma mansoni tar DNA-binding protein 0.0134 0.3971 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.5136 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0439 0.1106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0028
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.1085 0.0954
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0101 0.022
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0639 0.5809
Schistosoma mansoni cpg binding protein 0.0035 0.0833 0.2099

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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