Detailed information for compound 773484

Basic information

Technical information
  • TDR Targets ID: 773484
  • Name: N-(2-fluorophenyl)-4-pyridin-4-yl-1,3-thiazol -2-amine
  • MW: 271.313 | Formula: C14H10FN3S
  • H donors: 1 H acceptors: 2 LogP: 3.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccccc1Nc1scc(n1)c1ccncc1
  • InChi: 1S/C14H10FN3S/c15-11-3-1-2-4-12(11)17-14-18-13(9-19-14)10-5-7-16-8-6-10/h1-9H,(H,17,18)
  • InChiKey: GXGKHWVAUVHMKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluorophenyl)-4-(4-pyridyl)thiazol-2-amine
  • N-(2-fluorophenyl)-4-(4-pyridyl)-2-thiazolamine
  • (2-fluorophenyl)-[4-(4-pyridyl)thiazol-2-yl]amine
  • A3432/0145623
  • ZINC00612858
  • (2-Fluoro-phenyl)-(4-pyridin-4-yl-thiazol-2-yl)-amine
  • BAS 08770327

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Conserved hypothetical protein 0.0033 0.1669 0.8047
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.1669 0.1767
Echinococcus granulosus transcription factor Dp 1 0.006 0.3344 0.3206
Loa Loa (eye worm) RecQ helicase 0.0024 0.1069 0.1044
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0012 0.0357 0.082
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.2212 0.8542
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1804 0.1634
Entamoeba histolytica hypothetical protein 0.0035 0.1804 0.2532
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.1069 0.2418
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.2555 0.24
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0592 0.1524
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2404 0.2246
Trypanosoma brucei DNA polymerase eta, putative 0.0033 0.1669 0.2452
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.2212 0.205
Schistosoma mansoni terminal deoxycytidyl transferase 0.0033 0.1669 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0382 0.0247
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0031 0.1543 0.1367
Toxoplasma gondii hypothetical protein 0.0048 0.2555 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0012 0.0357 0.0157
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0104 0.6072 0.5991
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.8245 0.8209
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0357 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0357 0.0203
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.8495 0.8464
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1994 0.7615
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1994 0.9574
Loa Loa (eye worm) hypothetical protein 0.0012 0.0357 0.0185
Leishmania major DNA polymerase kappa, putative 0.004 0.2074 0.3146
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.3302 1
Echinococcus granulosus bloom syndrome protein 0.0024 0.1069 0.0884
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Giardia lamblia DINP protein human, muc B family 0.004 0.2074 1
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0012 0.0357 0.0203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2404 0.2246
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.2212 0.852
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0644 0.1872
Entamoeba histolytica deoxycytidyl transferase, putative 0.0033 0.1669 0.2295
Giardia lamblia DNA damage repair protein 0.001 0.0239 0.0188
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.3302 0.5251
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0104 0.6072 0.7078
Leishmania major hypothetical protein, conserved 0.0012 0.0357 0.0203
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.2212 0.6301
Plasmodium falciparum DNA repair protein REV1, putative 0.001 0.0239 0.0149
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.2555 1
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.2555 0.24
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1804 0.1634
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0382 0.0247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2404 0.2246
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1871 0.2799
Brugia malayi ImpB/MucB/SamB family protein 0.0033 0.1669 0.1767
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0104 0.6072 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0104 0.6072 0.5991
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.143 0.2043
Schistosoma mansoni DNA polymerase IV / kappa 0.001 0.0239 0.0036
Echinococcus multilocularis transcription factor Dp 1 0.006 0.3344 0.3206
Echinococcus multilocularis 0.0012 0.0357 0.0157
Loa Loa (eye worm) hypothetical protein 0.0048 0.2555 0.2836
Loa Loa (eye worm) acetyltransferase 0.0143 0.8495 1
Entamoeba histolytica hypothetical protein 0.0035 0.1804 0.2532
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0759 0.0567
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Mycobacterium ulcerans DNA polymerase IV 0.006 0.3302 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.1069 0.2418
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.2074 0.3146
Echinococcus granulosus dna polymerase kappa 0.006 0.3302 0.3162
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.2212 0.6301
Echinococcus granulosus dna polymerase eta 0.0033 0.1669 0.1496
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.3302 0.5251
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0382 0.0247
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.8495 0.8464
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0357 0.0511
Schistosoma mansoni hypothetical protein 0.0035 0.1804 0.1634
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.058 0.1601
Loa Loa (eye worm) ThiF family protein 0.0031 0.1543 0.1615
Loa Loa (eye worm) hypothetical protein 0.0033 0.1669 0.1767
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0382 0.0045
Leishmania major ubiquitin-activating enzyme-like protein 0.0031 0.1543 0.2235
Trypanosoma brucei DNA polymerase IV, putative 0.0053 0.2896 0.4556
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0033 0.1669 0.1496
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0239 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.1069 0.1044
Trypanosoma brucei unspecified product 0.0053 0.2896 0.4556
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0031 0.1543 0.2235
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.8495 1
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.2555 1
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.1271 0.1769
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0031 0.1543 0.1367
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0104 0.6072 0.5991
Entamoeba histolytica hypothetical protein 0.0035 0.1804 0.2532
Brugia malayi ThiF family protein 0.0048 0.2555 0.2836
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2404 0.2654
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0015 0.0518 0.1684
Loa Loa (eye worm) hypothetical protein 0.0037 0.1871 0.2012
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0012 0.0357 0.0511
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.1669 0.2452
Mycobacterium ulcerans DNA polymerase IV 0.006 0.3302 1
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0012 0.0357 0.0185
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1994 0.2865
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2404 0.2654
Loa Loa (eye worm) hypothetical protein 0.0012 0.0347 0.0174
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0104 0.6072 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0012 0.0357 0.0157
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0015 0.0518 0.0283
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.1871 0.2799
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0031 0.1543 0.1367
Brugia malayi polk-prov protein 0.0037 0.1871 0.2012
Toxoplasma gondii ThiF family protein 0.0031 0.1543 0.5695
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.2212 0.8542
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.2555 0.24
Echinococcus multilocularis bloom syndrome protein 0.0024 0.1069 0.0884
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0012 0.0357 0.0652
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0033 0.1669 0.1767
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.2074 1
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0031 0.1543 0.5695
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.2074 0.3146
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0104 0.6072 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0104 0.6072 0.7078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2404 0.2246
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0012 0.0357 0.0157
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.3302 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.3302 0.5251
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0031 0.1543 0.2235
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0104 0.6072 1
Echinococcus multilocularis dna polymerase kappa 0.006 0.3302 0.3162
Echinococcus granulosus CTD small phosphatase protein like 0.0012 0.0357 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.3302 0.5251
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0012 0.0357 0.0652
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1804 0.1634
Echinococcus multilocularis geminin 0.0167 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2404 0.2246
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0033 0.1669 0.1496
Brugia malayi ThiF family protein 0.0031 0.1543 0.1615
Toxoplasma gondii ImpB/MucB/SamB family protein 0.001 0.0239 0.0149
Leishmania major DNA polymerase eta, putative 0.0033 0.1669 0.2452
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0033 0.1669 0.1496
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0382 0.0087
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0015 0.0518 0.0549
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.3302 0.5251
Schistosoma mansoni hypothetical protein 0.0167 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.143 0.2043
Schistosoma mansoni DNA polymerase eta 0.0033 0.1669 0.1496
Echinococcus multilocularis dna polymerase eta 0.0033 0.1669 0.1496
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.143 0.2043
Schistosoma mansoni hypothetical protein 0.0167 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2404 0.2246
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0015 0.0518 0.048
Trypanosoma brucei unspecified product 0.0023 0.1025 0.1348
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0203 0.0000000011784
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0043 0.2283 0.2123
Entamoeba histolytica hypothetical protein 0.0035 0.1804 0.2532
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.089 0.292
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0104 0.6072 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.7015 0.8215
Brugia malayi hypothetical protein 0.0035 0.1804 0.1931
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.3302 0.5251
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.3302 0.5251
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0031 0.1543 0.563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2404 0.2246
Schistosoma mansoni hypothetical protein 0.0012 0.0347 0.0147
Trypanosoma brucei unspecified product 0.0023 0.1025 0.1348

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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