Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0146 | 0.1489 | 0.1754 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0163 | 0.1094 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0016 | 0.0019 |
Echinococcus granulosus | protein C ets 2 | 0.001 | 0.002 | 0.0055 |
Loa Loa (eye worm) | TAR-binding protein | 0.0255 | 0.2672 | 0.8217 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0139 | 0.0464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.2672 | 0.715 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0139 | 0.0373 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0146 | 0.1489 | 1 |
Schistosoma mansoni | ets-related | 0.0215 | 0.2238 | 0.5988 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0016 | 0.0019 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0146 | 0.1489 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0016 | 0.0044 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0016 | 0.0044 |
Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.0222 | 0.0775 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.1174 | 0.3581 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | DNA-binding protein D-ETS-3 | 0.001 | 0.002 | 0.0013 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.001 | 0.002 | 0.0024 |
Echinococcus multilocularis | protein C ets 2 | 0.001 | 0.002 | 0.0024 |
Echinococcus granulosus | tar DNA binding protein | 0.0255 | 0.2672 | 0.715 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0222 | 0.0612 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0163 | 0.1559 |
Toxoplasma gondii | ABC1 family protein | 0.0146 | 0.1489 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.029 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0308 | 0.3248 | 0.8692 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.3737 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0308 | 0.3248 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0308 | 0.3248 | 0.8692 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0016 | 0.0044 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.1174 | 0.3581 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.029 | 1 |
Loa Loa (eye worm) | D-ets-2 protein | 0.001 | 0.002 | 0.0013 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0146 | 0.1489 | 0.1489 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0016 | 0.0044 |
Brugia malayi | RNA binding protein | 0.0255 | 0.2672 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0146 | 0.1489 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0146 | 0.1489 | 1 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0222 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0071 | 0.0676 | 0.0797 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0016 | 0.0044 |
Mycobacterium ulcerans | beta-lactamase | 0.0146 | 0.1489 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0146 | 0.1489 | 1 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.1491 | 0.5554 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0146 | 0.1489 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0163 | 0.1094 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.002 | 0.0013 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.2672 | 0.715 |
Mycobacterium leprae | Probable lipase LipE | 0.0146 | 0.1489 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0146 | 0.1489 | 0.3984 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.1491 | 0.3991 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0146 | 0.1489 | 1 |
Schistosoma mansoni | polyomavirus enhancer activator 3 pea3 | 0.001 | 0.002 | 0.0055 |
Brugia malayi | beta-lactamase | 0.0146 | 0.1489 | 0.5544 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.001 | 0.002 | 0.0055 |
Echinococcus multilocularis | tar DNA binding protein | 0.0255 | 0.2672 | 0.3149 |
Echinococcus granulosus | ETS transcription factor Elf 2 | 0.001 | 0.002 | 0.0055 |
Echinococcus granulosus | ewsr:fli fusion protein type | 0.001 | 0.002 | 0.0055 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0146 | 0.1489 | 0.3984 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0016 | 0.0044 |
Brugia malayi | hypothetical protein | 0.0035 | 0.029 | 0.103 |
Echinococcus granulosus | ETS transcription factor Elf 5 | 0.001 | 0.002 | 0.0055 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0146 | 0.1489 | 0.1489 |
Echinococcus multilocularis | ETS transcription factor Elf 2 | 0.001 | 0.002 | 0.0024 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0146 | 0.1489 | 0.1489 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0016 | 0.0044 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0146 | 0.1489 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0139 | 0.0373 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0146 | 0.1489 | 0.1489 |
Echinococcus multilocularis | geminin | 0.0353 | 0.3737 | 0.4404 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0016 | 0.0044 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0146 | 0.1489 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0146 | 0.1489 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0146 | 0.1489 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0255 | 0.2672 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0139 | 0.0937 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0139 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.2672 | 0.715 |
Schistosoma mansoni | ets-related | 0.001 | 0.002 | 0.0055 |
Brugia malayi | TAR-binding protein | 0.0255 | 0.2672 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0146 | 0.1489 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0016 | 0.0019 |
Onchocerca volvulus | 0.0146 | 0.1489 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0146 | 0.1489 | 0.1489 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0071 | 0.0676 | 0.2042 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0016 | 0.0044 |
Schistosoma mansoni | hypothetical protein | 0.0353 | 0.3737 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0071 | 0.0676 | 0.181 |
Loa Loa (eye worm) | RNA binding protein | 0.0255 | 0.2672 | 0.8217 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0016 | 0.0044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.2672 | 0.715 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0016 | 0.0044 |
Onchocerca volvulus | 0.0146 | 0.1489 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.2672 | 0.715 |
Brugia malayi | beta-lactamase family protein | 0.0146 | 0.1489 | 0.5544 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0016 | 0.0019 |
Echinococcus multilocularis | ets variant gene 4 | 0.001 | 0.002 | 0.0024 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0146 | 0.1489 | 0.4556 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0792 | 0.8485 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.1174 | 0.4358 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0016 | 0.0044 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0146 | 0.1489 | 0.5544 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0222 | 0.0594 |
Echinococcus granulosus | ETS domain containing protein Elk 1 | 0.001 | 0.002 | 0.0055 |
Echinococcus multilocularis | ETS transcription factor Elf 5 | 0.001 | 0.002 | 0.0024 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.029 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.029 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0163 | 0.0174 |
Schistosoma mansoni | gabp alpha | 0.0071 | 0.0676 | 0.181 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0163 | 0.1094 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0222 | 0.0612 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.029 | 0.0775 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0016 | 0.0044 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0016 | 0.0044 |
Schistosoma mansoni | elf1 | 0.001 | 0.002 | 0.0055 |
Trichomonas vaginalis | esterase, putative | 0.0146 | 0.1489 | 1 |
Onchocerca volvulus | 0.0146 | 0.1489 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.002 | 0.0055 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0139 | 0.0381 |
Echinococcus multilocularis | snurportin 1 | 0.0308 | 0.3248 | 0.3828 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1491 | 0.4564 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0565 | 0.1698 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0016 | 0.0019 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0163 | 0.0174 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0016 | 0.0019 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.001 | 0.002 | 0.0013 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0222 | 0.0594 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0146 | 0.1489 | 1 |
Brugia malayi | transcription factor E74 isoform | 0.001 | 0.002 | 0.0016 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0146 | 0.1489 | 0.3984 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.029 | 0.0775 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0676 | 0.2485 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.029 | 0.0775 |
Schistosoma mansoni | ran | 0.0021 | 0.0139 | 0.0373 |
Brugia malayi | Fli-1 protein | 0.0215 | 0.2238 | 0.8365 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1491 | 0.4564 |
Mycobacterium tuberculosis | Conserved protein | 0.0146 | 0.1489 | 0.1489 |
Mycobacterium tuberculosis | Conserved protein | 0.0146 | 0.1489 | 0.1489 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0146 | 0.1489 | 0.1489 |
Echinococcus multilocularis | ETS transcription factor Elf 1 | 0.001 | 0.002 | 0.0024 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0139 | 0.0164 |
Echinococcus granulosus | ETS transcription factor Elf 1 | 0.001 | 0.002 | 0.0055 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0016 | 0.0019 |
Schistosoma mansoni | hypothetical protein | 0.001 | 0.002 | 0.0055 |
Brugia malayi | Ets-domain containing protein | 0.0071 | 0.0676 | 0.2485 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0255 | 0.2672 | 0.8217 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Brugia malayi | Ets-domain containing protein | 0.001 | 0.002 | 0.0016 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.1491 | 0.1758 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0016 | 0.0019 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0146 | 0.1489 | 0.1489 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | fli-1 protein | 0.0215 | 0.2238 | 0.6874 |
Brugia malayi | DNA-binding protein D-ETS-3 | 0.001 | 0.002 | 0.0016 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0016 | 0.0044 |
Echinococcus multilocularis | ewsr:fli fusion protein type | 0.001 | 0.002 | 0.0024 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0222 | 0.0262 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0146 | 0.1489 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0799 | 0.2946 |
Loa Loa (eye worm) | ets-domain-containing protein | 0.001 | 0.002 | 0.0013 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0146 | 0.1489 | 0.1489 |
Loa Loa (eye worm) | beta-lactamase | 0.0146 | 0.1489 | 0.4556 |
Echinococcus multilocularis | ETS domain containing protein Elk 1 | 0.001 | 0.002 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0222 | 0.0637 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.029 | 0.0341 |
Treponema pallidum | bacterioferrin (TpF1) | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0353 | 0.3737 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0016 | 0.0044 |
Schistosoma mansoni | ets | 0.001 | 0.002 | 0.0055 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0016 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0016 | 0.0019 |
Brugia malayi | beta-lactamase family protein | 0.0146 | 0.1489 | 0.5544 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.1491 | 0.1758 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.002 | 0.0013 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0222 | 0.0612 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0146 | 0.1489 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1489 | 0.4556 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0222 | 0.0612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.