TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 437.474 | Formula: C23H27F4N3O
H donors: 2 H acceptors: 1 LogP: 5.01 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)C(F)(F)F)NCCCN1CCC(CC1)Cc1ccc(cc1)F
InChi: 1S/C23H27F4N3O/c24-20-6-2-17(3-7-20)16-18-10-14-30(15-11-18)13-1-12-28-22(31)29-21-8-4-19(5-9-21)23(25,26)27/h2-9,18H,1,10-16H2,(H2,28,29,31)
InChiKey: DFBQHFGWJQZXSF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Onchocerca volvulus		0.0073	0.0979	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0098	0.1353	0.1352
Brugia malayi	Carboxylesterase family protein	0.0073	0.0979	0.1523
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0048	0.0599	0.5359
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0052	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Schistosoma mansoni	nuclear receptor	0.0023	0.0215	0.0055
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0161	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0275	0.0425
Schistosoma mansoni	hypothetical protein	0.0395	0.5875	0.5807
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0414	0.0644
Onchocerca volvulus		0.0073	0.0979	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0048	0.0599	0.0446
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0765	0.0615
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0073	0.0979	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0023	0.0215	0.0213
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0979	0.0832
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0098	0.1353	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0161	0.0159
Brugia malayi	Carboxylesterase family protein	0.0073	0.0979	0.1523
Schistosoma mansoni	hypothetical protein	0.004	0.0484	0.0329
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0048	0.0599	0.0446
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0052	0.0081
Brugia malayi	orphan nuclear receptor NR2E1	0.0023	0.0215	0.0334
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0161	0.0159
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0414	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0215	0.0334
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0023	0.0215	0.0213
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0023	0.0215	0.066
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0052	0.0078
Onchocerca volvulus	Protein ultraspiracle homolog	0.0048	0.0599	0.5359
Onchocerca volvulus	Bile acid receptor homolog	0.0048	0.0599	0.5359
Brugia malayi	hypothetical protein	0.0025	0.0256	0.0398
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0979	0.1521
Brugia malayi	Carboxylesterase family protein	0.0432	0.6429	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0048	0.0599	0.0598
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0507	0.0506
Brugia malayi	hypothetical protein	0.0023	0.0215	0.0334
Echinococcus multilocularis	slit 2 protein	0.0027	0.0275	0.0273
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0161	0.0159
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0161	0.5
Echinococcus multilocularis	expressed conserved protein	0.0092	0.1263	0.1262
Echinococcus multilocularis	geminin	0.0181	0.2625	0.2624
Brugia malayi	nuclear receptor RXR	0.0023	0.0215	0.0334
Schistosoma mansoni	retinoic acid receptor RXR	0.0048	0.0599	0.0446
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0161	0.0159
Echinococcus granulosus	pikachurin	0.0027	0.0275	0.0273
Brugia malayi	laminin alpha chain	0.0027	0.0275	0.0427
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.0599	0.0446
Schistosoma mansoni	microtubule-associated protein tau	0.0667	1	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0023	0.0215	0.0213
Brugia malayi	nuclear hormone receptor family member odr-7	0.0023	0.0215	0.0334
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0048	0.0599	0.093
Echinococcus granulosus	thyroid hormone receptor alpha	0.0023	0.0215	0.0213
Schistosoma mansoni	acetylcholinesterase	0.0073	0.0979	0.0832
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0052	0.0081
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0048	0.0599	0.0446
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0215	0.0055
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0215	0.0213
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0048	0.0599	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0051	0.065	0.1009
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0215	0.0213
Echinococcus multilocularis	neurogenic locus notch protein	0.0027	0.0275	0.0273
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0073	0.0979	0.0978
Schistosoma mansoni	patched 1	0.0042	0.0507	0.0352
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0215	0.0334
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0414	0.0412
Brugia malayi	ecdysteroid receptor	0.0048	0.0599	0.0932
Echinococcus granulosus	geminin	0.0181	0.2625	0.2624
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0414	1
Echinococcus granulosus	neuroligin	0.0073	0.0979	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0256	0.0396
Brugia malayi	tailless protein	0.0023	0.0215	0.0334
Echinococcus granulosus	RUN	0.0019	0.0161	0.0159
Schistosoma mansoni	hypothetical protein	0.0122	0.1719	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0027	0.0275	0.0427
Echinococcus multilocularis	cpg binding protein	0.0029	0.0317	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0048	0.0599	0.0932
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0215	0.0213
Echinococcus multilocularis	para nitrobenzyl esterase	0.0073	0.0979	0.0978
Schistosoma mansoni	hypothetical protein	0.004	0.0484	0.0329
Schistosoma mansoni	coup transcription factor	0.0048	0.0599	0.0446
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0161	0.0159
Brugia malayi	conserved hypotetical protein	0.0023	0.0215	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0023	0.0215	0.0055
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.6429	0.6428
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0293	0.0455
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0048	0.0599	0.0932
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0979	0.5
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.1376	0.1235
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0414	0.0412
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0073	0.0979	0.5
Schistosoma mansoni	hypothetical protein	0.0181	0.2625	0.2504
Schistosoma mansoni	cpg binding protein	0.0029	0.0317	0.0159
Echinococcus multilocularis	neuroligin	0.0073	0.0979	0.0978
Loa Loa (eye worm)	nuclear hormone receptor	0.0023	0.0215	0.0331
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0256	0.0097
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0073	0.0979	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0048	0.0599	0.093
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Brugia malayi	Steroid receptor seven-up type 2	0.0048	0.0599	0.0932
Loa Loa (eye worm)	carboxylesterase	0.0432	0.6429	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0161	0.0247
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.067	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0023	0.0215	0.0331
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0048	0.0599	0.0932
Onchocerca volvulus		0.0073	0.0979	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.1989	0.1988
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0256	0.0396
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0048	0.0599	0.0932
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0048	0.0599	0.0598
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0414	0.0412
Mycobacterium ulcerans	carboxylesterase, LipT	0.0073	0.0979	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0048	0.0599	0.0932
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0215	0.0055
Echinococcus granulosus	cpg binding protein	0.0029	0.0317	0.0315
Brugia malayi	nuclear hormone receptor	0.0048	0.0599	0.0932
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0048	0.0599	0.0598
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0979	0.0832
Brugia malayi	hypothetical protein	0.0019	0.0161	0.025
Brugia malayi	EGF-like domain containing protein	0.0027	0.0275	0.0427
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0599	0.0932
Echinococcus granulosus	expressed conserved protein	0.0092	0.1263	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0256	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0599	0.0932
Brugia malayi	Carboxylesterase family protein	0.0432	0.6429	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0507	0.0787
Brugia malayi	hypothetical protein	0.0019	0.0161	0.025
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Brugia malayi	nuclear hormone receptor	0.0023	0.0215	0.0334
Echinococcus granulosus	carboxylesterase 5A	0.0432	0.6429	0.6428
Brugia malayi	photoreceptor-specific nuclear receptor	0.0048	0.0599	0.0932
Brugia malayi	ecdysone receptor	0.0023	0.0215	0.0334
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.1719	0.1718
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0256	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0073	0.0979	0.0978
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0414	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0682	0.068
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0161	0.0247
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0023	0.0215	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0414	0.0642
Trichomonas vaginalis	spcc417.12 protein, putative	0.0073	0.0979	1
Onchocerca volvulus		0.0023	0.0215	0.066
Echinococcus granulosus	dnaJ subfamily B	0.0395	0.5875	0.5874
Brugia malayi	Niemann-Pick C1 protein precursor	0.0098	0.1353	0.2105
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0507	0.0506
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0293	0.0453
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0048	0.0599	0.0598
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0048	0.0599	0.0932
Brugia malayi	hypothetical protein	0.0073	0.0979	0.1523
Schistosoma mansoni	cpg binding protein	0.0028	0.0293	0.0134
Echinococcus granulosus	slit 2 protein	0.0027	0.0275	0.0273
Echinococcus multilocularis	dnaJ subfamily B	0.0395	0.5875	0.5874
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0432	0.6429	0.6371
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0256	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0256	0.0396
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0023	0.0215	0.0213
Brugia malayi	nuclear receptor NHR-67	0.0023	0.0215	0.0334
Echinococcus multilocularis	protein patched	0.0042	0.0507	0.0506
Schistosoma mansoni	BC026374 protein (S09 family)	0.0073	0.0979	0.0832
Brugia malayi	Doublecortin family protein	0.0019	0.0161	0.025
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0048	0.0599	0.0446
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0048	0.0599	0.093
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0048	0.0599	0.093
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0023	0.0215	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0599	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0414	0.0258
Echinococcus multilocularis	RUN	0.0019	0.0161	0.0159
Schistosoma mansoni	slit	0.0027	0.0275	0.0116
Onchocerca volvulus		0.0023	0.0215	0.066
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.1719	0.1718
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0599	0.0598
Brugia malayi	CHE-14 protein	0.0042	0.0507	0.0789
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0414	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0599	0.0932
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0027	0.0275	0.0116
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0414	0.0412
Echinococcus multilocularis	carboxylesterase 5A	0.0432	0.6429	0.6428
Schistosoma mansoni	gliotactin	0.0073	0.0979	0.0832
Echinococcus multilocularis	nuclear receptor nhr 48	0.0023	0.0215	0.0213
Brugia malayi	hypothetical protein	0.0023	0.0215	0.0334
Schistosoma mansoni	nuclear receptor	0.0023	0.0215	0.0055
Schistosoma mansoni	lipoxygenase	0.0053	0.0682	0.0529
Loa Loa (eye worm)	carboxylesterase	0.0073	0.0979	0.1521
Echinococcus multilocularis	FTZ F1 alpha	0.0048	0.0599	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Loa Loa (eye worm)	acetylcholinesterase 1	0.0432	0.6429	1
Echinococcus multilocularis	acetylcholinesterase	0.0432	0.6429	0.6428
Brugia malayi	nuclear receptor NHR-88	0.0048	0.0599	0.0932
Loa Loa (eye worm)	steroid hormone receptor	0.0048	0.0599	0.093
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0052	0.0078
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0414	0.0412
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0599	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Echinococcus granulosus	neurogenic locus notch protein	0.0027	0.0275	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Loa Loa (eye worm)	hypothetical protein	0.0432	0.6429	1
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0597	0.0596
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0414	0.0258
Schistosoma mansoni	hypothetical protein	0.0181	0.2625	0.2504
Schistosoma mansoni	zinc finger protein	0.0023	0.0215	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Echinococcus granulosus	ecdysone induced protein 78C	0.0048	0.0599	0.0598
Echinococcus multilocularis	microtubule associated protein 2	0.0667	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0048	0.0599	0.0598
Schistosoma mansoni	nuclear receptor nhr-48	0.0023	0.0215	0.0055
Brugia malayi	Nuclear hormone receptor-like 1	0.0048	0.0599	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0256	0.0396
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0256	0.0398
Echinococcus multilocularis	ecdysone induced protein 78C	0.0048	0.0599	0.0598
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0027	0.0275	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0275	0.0425
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0256	0.0254
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0599	0.0598
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2447	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0275	0.0425
Echinococcus granulosus	acetylcholinesterase	0.0432	0.6429	0.6428
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0048	0.0599	0.0446
Onchocerca volvulus		0.0073	0.0979	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0048	0.0599	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0432	0.6429	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0048	0.0599	0.0598
Echinococcus multilocularis	pikachurin	0.0027	0.0275	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1353	0.2103
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0507	0.0506
Brugia malayi	Carboxylesterase family protein	0.0073	0.0979	0.1523
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0023	0.0215	0.0331
Schistosoma mansoni	cell polarity protein	0.0027	0.0275	0.0116
Echinococcus granulosus	BC026374 protein S09 family	0.0073	0.0979	0.0978
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0414	0.0412
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0507	0.165
Onchocerca volvulus		0.0028	0.0293	0.1614
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0023	0.0215	0.0213
Echinococcus granulosus	acetylcholinesterase	0.0432	0.6429	0.6428
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0507	0.0787
Onchocerca volvulus		0.0073	0.0979	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0048	0.0599	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0161	0.0247
Echinococcus multilocularis	Niemann Pick C1 protein	0.0098	0.1353	0.1352
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0023	0.0215	0.066
Brugia malayi	steroid hormone receptor	0.0048	0.0599	0.0932
Schistosoma mansoni	laminin gamma-3 chain	0.0027	0.0275	0.0116
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0161	0.5
Brugia malayi	Nuclear hormone receptor E75	0.0023	0.0215	0.0334
Loa Loa (eye worm)	DR-78	0.0023	0.0215	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0599	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0048	0.0599	0.093
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0682	0.068
Echinococcus granulosus	para nitrobenzyl esterase	0.0073	0.0979	0.0978
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0073	0.0979	0.0832
Echinococcus multilocularis	thyroid hormone receptor alpha	0.017	0.2447	0.2446
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0599	0.0598
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0048	0.0599	0.093
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0599	0.093
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0048	0.0599	0.0598
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0256	0.0398
Brugia malayi	nuclear receptor RXR	0.0025	0.0256	0.0398
Schistosoma mansoni	cpg binding protein	0.0029	0.0317	0.0159
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0073	0.0979	0.0832
Schistosoma mansoni	hypothetical protein	0.004	0.0484	0.0329
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0023	0.0215	0.0334
Brugia malayi	hypothetical protein	0.0025	0.0256	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0256	0.0396
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0048	0.0599	0.0932
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0048	0.0599	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0979	0.1521
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.1989	0.1988
Brugia malayi	Carboxylesterase family protein	0.0073	0.0979	0.1523
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0599	0.0598
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0414	1
Schistosoma mansoni	thyroid hormone receptor	0.017	0.2447	0.2324
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0215	0.0213
Schistosoma mansoni	RAR-like nuclear receptor	0.0048	0.0599	0.0446
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0073	0.0979	0.0978
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0356	0.5279	0.5202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0048	0.0599	0.093
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0048	0.0599	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0215	0.0331
Onchocerca volvulus		0.0048	0.0599	0.5359
Schistosoma mansoni	hypothetical protein	0.004	0.0484	0.0329
Loa Loa (eye worm)	abnormal epIthelia family member	0.0027	0.0275	0.0425

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.06 uM	In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin	ChEMBL.	12067561
IC50 (binding)	= 0.06 uM	In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin	ChEMBL.	12067561

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 77355