Detailed information for compound 773810

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 241.245 | Formula: C13H11N3O2
  • H donors: 2 H acceptors: 4 LogP: 2.81 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(C)c2c(n1)nn(c2O)c1ccccc1
  • InChi: 1S/C13H11N3O2/c1-8-7-10(17)14-12-11(8)13(18)16(15-12)9-5-3-2-4-6-9/h2-7,18H,1H3,(H,14,15,17)
  • InChiKey: CQQYMJFWZPLQLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.1211 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0137 0.0312
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0373 0.0941
Onchocerca volvulus 0.0039 0.0373 0.1676
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0137 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.003 0.0247 0.0464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0131 0.1194
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0373 0.081
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1211 0.3115
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0373 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0079 0.0079
Echinococcus multilocularis cpg binding protein 0.0032 0.0271 0.0271
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0079
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.058 0.1323
Schistosoma mansoni lipoxygenase 0.0091 0.106 0.106
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0137 0.0312
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0076 0.0866 0.1974
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0081
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.003 0.0247 0.0247
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0196 0.2457 0.5599
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Echinococcus multilocularis geminin 0.0178 0.2228 0.2228
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0373 0.3739
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0131 0.1194
Echinococcus granulosus tumor protein p63 0.037 0.4785 0.4785
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.003 0.0247 0.149
Loa Loa (eye worm) hypothetical protein 0.0076 0.0866 0.1974
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0131 0.1863
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.003 0.0247 0.0539
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0079 0.076
Brugia malayi isocitrate dehydrogenase 0.0018 0.0081 0.0184
Brugia malayi AMP-binding enzyme family protein 0.003 0.0247 0.0564
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.081 0.2338
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0102 0.1211 0.3115
Echinococcus granulosus arachidonate 5 lipoxygenase 0.013 0.1582 0.1582
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Loa Loa (eye worm) hypothetical protein 0.0102 0.1211 0.276
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.003 0.0247 0.3196
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0079
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0081 0.0808
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.1543 0.4677
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0137 0.0312
Brugia malayi hypothetical protein 0.0022 0.0137 0.0312
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0131 0.1863
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0197 0.2475 0.564
Echinococcus granulosus dna polymerase eta 0.0049 0.0506 0.0506
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0131 0.0131
Plasmodium falciparum thioredoxin reductase 0.005 0.0516 0.555
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.1543 0.4677
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.003 0.0247 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0137 0.0137
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0247 0.0464
Onchocerca volvulus Huntingtin homolog 0.0127 0.1547 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0247 0.3861
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0137 0.0137
Schistosoma mansoni coup transcription factor 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.2475 0.2475
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0373 0.085
Schistosoma mansoni tar DNA-binding protein 0.034 0.4387 0.4387
Loa Loa (eye worm) hypothetical protein 0.0102 0.1211 0.276
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.1211 0.7438
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0131 0.0131
Treponema pallidum NADH oxidase 0.0017 0.0079 0.5
Onchocerca volvulus 0.003 0.0247 0.0784
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0081 0.0043
Onchocerca volvulus 0.0039 0.0373 0.1676
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1211 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.003 0.0247 0.0464
Schistosoma mansoni hypothetical protein 0.0022 0.0137 0.0137
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0373 0.081
Brugia malayi hypothetical protein 0.0127 0.1547 0.3525
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0373 0.081
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0137 0.0312
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0247 0.0564
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0079 0.018
Echinococcus multilocularis tar DNA binding protein 0.034 0.4387 0.4387
Loa Loa (eye worm) glutaminase 2 0.029 0.3713 0.8464
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0131 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1372 0.4133
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0137 0.0312
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0081 0.0081
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0866 0.2166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0564
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0131 0.0144
Schistosoma mansoni tar DNA-binding protein 0.034 0.4387 0.4387
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.081 0.2338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Entamoeba histolytica hypothetical protein 0.004 0.038 0.2305
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0373 0.085
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.003 0.0247 0.0564
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0137 0.0137
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0137 0.0137
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0247 0.149
Brugia malayi acetyl-Coenzyme A synthetase 2 0.003 0.0247 0.0564
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0137 0.0741
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0081
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0131 0.0298
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.031 0.529
Loa Loa (eye worm) glutaminase 0.029 0.3713 0.8464
Loa Loa (eye worm) hypothetical protein 0.0054 0.057 0.1298
Toxoplasma gondii thioredoxin reductase 0.005 0.0516 0.8277
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0079 0.0079
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0506 0.9788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.2475 0.2475
Mycobacterium ulcerans glutaminase 0.029 0.3713 1
Brugia malayi Doublecortin family protein 0.0022 0.0137 0.0312
Toxoplasma gondii propionate-CoA ligase 0.003 0.0247 0.3196
Schistosoma mansoni microtubule-associated protein tau 0.0761 1 1
Brugia malayi glutathione reductase 0.005 0.0516 0.1175
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.003 0.0247 0.4327
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.003 0.0247 0.0464
Brugia malayi hypothetical protein 0.0022 0.0137 0.0312
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.003 0.0247 0.3196
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.0808
Brugia malayi hypothetical protein 0.004 0.038 0.0866
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0137 0.0312
Brugia malayi beta-lactamase family protein 0.0039 0.0373 0.085
Onchocerca volvulus 0.0054 0.057 0.307
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Entamoeba histolytica hypothetical protein 0.004 0.038 0.2305
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.0941
Loa Loa (eye worm) hypothetical protein 0.0196 0.2457 0.5599
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0516 1
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0373 0.0971
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0373 0.0373
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.003 0.0247 0.0464
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0131 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.2475 0.2475
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0137 0.0137
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.003 0.0247 0.0464
Brugia malayi AMP-binding enzyme family protein 0.003 0.0247 0.0564
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0131 0.0298
Loa Loa (eye worm) hypothetical protein 0.0102 0.1211 0.276
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0137 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1211 0.276
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0131 0.0131
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.038 0.038
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0017 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0137 0.0312
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0373 0.0941
Loa Loa (eye worm) glutathione reductase 0.005 0.0516 0.1175
Schistosoma mansoni cpg binding protein 0.003 0.0248 0.0248
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0137 0.0312
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0197 0.2475 0.2475
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0137 0.0137
Trypanosoma brucei trypanothione reductase 0.005 0.0516 1
Leishmania major DNA polymerase eta, putative 0.0049 0.0506 0.3771
Loa Loa (eye worm) hypothetical protein 0.0049 0.0506 0.1152
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0137 0.0137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0102 0.1211 0.3115
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0102 0.1211 0.3115
Onchocerca volvulus 0.0102 0.1211 0.7618
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0102 0.1211 0.3115
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0137 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0506 0.977
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0197 0.2475 0.564
Trichomonas vaginalis conserved hypothetical protein 0.019 0.2385 0.6346
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0081 0.0029
Onchocerca volvulus 0.003 0.0248 0.0788
Brugia malayi CXXC zinc finger family protein 0.003 0.0248 0.0565
Brugia malayi Thioredoxin reductase 0.005 0.0516 0.1175
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0373 0.0941
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1211 0.3115
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0373 0.6738
Echinococcus multilocularis dna polymerase eta 0.0049 0.0506 0.0506
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.0941
Echinococcus multilocularis tumor protein p63 0.037 0.4785 0.4785
Brugia malayi steroid hormone receptor 0.0022 0.0137 0.0312
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0081 0.0043
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0076 0.0866 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0017 0.0039
Onchocerca volvulus 0.0022 0.0137 0.0001
Brugia malayi beta-lactamase 0.0039 0.0373 0.085
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0373 0.6986
Brugia malayi beta-lactamase family protein 0.0039 0.0373 0.085
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0081 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0373 0.6738
Leishmania major DNA polymerase eta, putative 0.0035 0.031 0.2042
Schistosoma mansoni transcription factor LCR-F1 0.004 0.038 0.038
Schistosoma mansoni tar DNA-binding protein 0.034 0.4387 0.4387
Entamoeba histolytica acyl-coA synthetase, putative 0.0102 0.1211 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.003 0.0247 0.0539
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0248 0.0565
Loa Loa (eye worm) hypothetical protein 0.0127 0.1547 0.3525
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0137 0.0312
Brugia malayi RNA binding protein 0.034 0.4387 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0137 0.0137
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0102 0.1211 0.3617
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.031 0.4378
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0373 0.0941
Loa Loa (eye worm) TAR-binding protein 0.034 0.4387 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.2475 0.2475
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0079 0.076
Onchocerca volvulus 0.003 0.0247 0.0784
Trichomonas vaginalis glutaminase, putative 0.029 0.3713 1
Leishmania major hypothetical protein, conserved 0.0039 0.0373 0.2601
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.0052
Brugia malayi AMP-binding enzyme family protein 0.003 0.0247 0.0564
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.081
Toxoplasma gondii ABC1 family protein 0.0039 0.0373 0.5577
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0079 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0079 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0137 0.0137
Plasmodium falciparum acyl-CoA synthetase 0.0076 0.0866 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0516 0.0516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.081 0.2338
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Schistosoma mansoni hypothetical protein 0.0017 0.0079 0.0079
Echinococcus granulosus RUN 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0076 0.0866 0.1974
Plasmodium vivax glutathione reductase, putative 0.005 0.0516 0.555
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0079 0.0079
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.003 0.0247 0.3861
Schistosoma mansoni hypothetical protein 0.004 0.038 0.038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0607 1
Brugia malayi AMP-binding enzyme family protein 0.003 0.0247 0.0564
Brugia malayi ecdysteroid receptor 0.0022 0.0137 0.0312
Leishmania major trypanothione reductase 0.005 0.0516 0.386
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.058 0.1323
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0131 0.1863
Leishmania major acetyl-CoA synthetase, putative 0.003 0.0247 0.149
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1372 0.4133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0373 0.0941
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1372 0.4133
Schistosoma mansoni DNA polymerase eta 0.0049 0.0506 0.0506
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0079 0.018
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0079 0.0079
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1211 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0137 0.0312
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.1543 0.4677
Schistosoma mansoni tar DNA-binding protein 0.034 0.4387 0.4387
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0192 0.0361
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0081
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0137 0.0137
Plasmodium vivax acetyl-CoA synthetase, putative 0.003 0.0247 0.2143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0131 0.0167
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0247 0.0539
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0102 0.1211 0.3617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.081 0.2338
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Trypanosoma brucei unspecified product 0.0021 0.0131 0.1863
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1211 0.276
Loa Loa (eye worm) hypothetical protein 0.0127 0.1547 0.3525
Onchocerca volvulus 0.003 0.0247 0.0784
Loa Loa (eye worm) hypothetical protein 0.0038 0.0348 0.0794
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Mycobacterium ulcerans lipase LipD 0.0039 0.0373 0.081
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0079 0.0079
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0079 0.0179
Mycobacterium ulcerans hypothetical protein 0.0039 0.0373 0.081
Schistosoma mansoni loxhd1 0.0022 0.0137 0.0137
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0137 0.0312
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.003 0.0247 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0137 0.0312
Brugia malayi TAR-binding protein 0.034 0.4387 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0076 0.0866 0.1974
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0137 0.0312
Loa Loa (eye worm) beta-lactamase 0.0039 0.0373 0.085
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.081
Trypanosoma brucei acetyl-CoA synthetase, putative 0.003 0.0247 0.4327
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0247 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0137 0.0312
Trichomonas vaginalis esterase, putative 0.0039 0.0373 0.081
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.003 0.0247 0.0464
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0137 0.0137
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0081 0.0052
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0081 0.0029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.003 0.0247 0.0539
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Echinococcus granulosus dna polymerase kappa 0.0021 0.0131 0.0131
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0252 0.3209 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0131 0.1194
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0137 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0137 0.0137
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0081 0.0081
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0137 0.0741
Schistosoma mansoni hypothetical protein 0.0178 0.2228 0.2228
Brugia malayi nuclear hormone receptor 0.0022 0.0137 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0102 0.1211 0.276
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0079 0.076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.038 0.038
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.034 0.4387 1
Loa Loa (eye worm) oxidoreductase 0.003 0.0247 0.0564
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0516 0.1175
Onchocerca volvulus 0.0022 0.0137 0.0001
Brugia malayi glutaminase DH11.1 0.029 0.3713 0.8464
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.057 0.057
Trichomonas vaginalis antibiotic synthetase, putative 0.003 0.0247 0.0464
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0076 0.0866 0.2516
Echinococcus multilocularis microtubule associated protein 2 0.0761 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1372 0.4133
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0247 0.3861
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0079 0.076
Echinococcus granulosus GPCR family 2 0.0017 0.0079 0.0079
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0131 0.0144
Giardia lamblia DINP protein human, muc B family 0.0021 0.0131 1
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0081 0.0184
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0137 0.0137
Leishmania major 4-coumarate:coa ligase-like protein 0.0102 0.1211 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0137 0.0312
Onchocerca volvulus 0.003 0.0247 0.0784
Loa Loa (eye worm) RNA binding protein 0.034 0.4387 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0131 0.0144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0102 0.1211 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Onchocerca volvulus Huntingtin homolog 0.0127 0.1547 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0081 0.002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.003 0.0247 0.1079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0373 0.0373
Mycobacterium leprae Probable lipase LipE 0.0039 0.0373 0.0971
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0137 0.0312
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0137 0.0312
Plasmodium falciparum acetyl-CoA synthetase, putative 0.003 0.0247 0.2143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Echinococcus granulosus geminin 0.0178 0.2228 0.2228
Mycobacterium tuberculosis Conserved protein 0.0039 0.0373 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0137 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.003 0.0247 0.0539
Schistosoma mansoni hypothetical protein 0.0178 0.2228 0.2228
Plasmodium falciparum glutathione reductase 0.005 0.0516 0.555
Schistosoma mansoni rab6-interacting 0.0022 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0137 0.0312
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0081 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0131 0.1194
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0516 0.1396
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0247 0.0539
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.1543 1
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0516 0.555
Schistosoma mansoni rab6-interacting 0.0022 0.0137 0.0137
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0137 0.0312
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.003 0.0247 0.0539
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0697 0.0697
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0137 0.0312
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0137 0.0137
Plasmodium vivax acyl-CoA synthetase, putative 0.0076 0.0866 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0137 0.0137
Mycobacterium ulcerans hypothetical protein 0.0102 0.1211 0.3115
Loa Loa (eye worm) AMP-binding enzyme family protein 0.003 0.0247 0.0564
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0102 0.1211 0.7438
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0131 0.0461
Entamoeba histolytica hypothetical protein 0.004 0.038 0.2305
Echinococcus multilocularis GPCR, family 2 0.0017 0.0079 0.0079
Entamoeba histolytica hypothetical protein 0.004 0.038 0.2305
Schistosoma mansoni cpg binding protein 0.0032 0.0271 0.0271
Mycobacterium ulcerans beta-lactamase 0.0039 0.0373 0.081
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0516 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0137 0.0312
Leishmania major DNA polymerase kappa, putative 0.0021 0.0131 0.0461
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0247 0.0539
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0137 0.0137
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0373 0.0941
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0506 0.1152
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1372 0.8686
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0137 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0137 0.0312
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0079 0.018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.003 0.0247 0.0539
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0131 0.1863
Schistosoma mansoni cpg binding protein 0.0032 0.0271 0.0271
Echinococcus granulosus tar DNA binding protein 0.034 0.4387 0.4387
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0373 0.081
Schistosoma mansoni lipoxygenase 0.013 0.1582 0.1582
Schistosoma mansoni tar DNA-binding protein 0.034 0.4387 0.4387
Schistosoma mansoni glutaminase 0.029 0.3713 0.3713
Loa Loa (eye worm) hypothetical protein 0.003 0.0247 0.0564
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0137 0.0137
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.003 0.0247 0.0464
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0373 0.081
Mycobacterium ulcerans acyl-CoA synthetase 0.0102 0.1211 0.3115
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0131 0.0167
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0079 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1372 0.4133
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.058 0.1323
Echinococcus multilocularis RUN 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0039 0.0373 0.085
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0137 0.0137
Brugia malayi RNA recognition motif domain containing protein 0.034 0.4387 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0081 0.0081
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.013 0.1582 0.1582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0076 0.0866 0.1974
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0081 0.0184
Schistosoma mansoni acetyl-CoA synthetase 0.003 0.0247 0.0247
Mycobacterium tuberculosis Probable reductase 0.0114 0.1372 0.4133
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.003 0.0247 0.3861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0312
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0137 0.0137
Brugia malayi nuclear receptor NHR-88 0.0022 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0055 0.058 0.1323
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.003 0.0247 0.0539
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0137 0.0137
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0079 0.5
Echinococcus granulosus cpg binding protein 0.0032 0.0271 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0197 0.2475 0.2475
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0197 0.2475 0.2475
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0137 0.0137
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0348 0.0794
Schistosoma mansoni hypothetical protein 0.0038 0.0348 0.0348
Onchocerca volvulus 0.0039 0.0373 0.1676
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.003 0.0247 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.003 0.0247 0.0464
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0137 0.0137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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