TDR Targets

Basic information

Technical information

TDR Targets ID: 773964
Name: Oprea1_523845
MW: 371.5 | Formula: C19H25N5OS
H donors: 1 H acceptors: 3 LogP: 3 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCNc1nc(C)nc2c1sc1c2cc2c(n1)CC(OC2)(C)C)C
InChi: 1S/C19H25N5OS/c1-11-21-15-13-8-12-10-25-19(2,3)9-14(12)23-18(13)26-16(15)17(22-11)20-6-7-24(4)5/h8H,6-7,9-10H2,1-5H3,(H,20,21,22)
InChiKey: QWMWWXQCOHPOIA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

BAS 04056942
STOCK2S-39542
EU-0080119

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Echinococcus multilocularis	3 ketodihydrosphingosine reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0004	0.5	0.5
Toxoplasma gondii	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0004	0.5	0.5
Schistosoma mansoni	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	estradiol 17 beta dehydrogenase 12	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Brugia malayi	Retinol dehydrogenase 12	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.5	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.5	0.5
Schistosoma mansoni	short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	oxidoreductase-like protein	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Leishmania major	dehydrogenase-like protein	0.0004	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 2	0.0004	0.5	0.5
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Echinococcus granulosus	3 ketodihydrosphingosine reductase	0.0004	0.5	0.5
Schistosoma mansoni	retinal dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Entamoeba histolytica	3-ketodihydrosphingosine reductase protein, putative	0.0004	0.5	0.5
Entamoeba histolytica	oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 30	0.0004	0.5	0.5
Schistosoma mansoni	oxidoreductase short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/reductase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Toxoplasma gondii	sterol carrier protein-2 HAD-2SCP-2	0.0004	0.5	0.5
Leishmania major	oxidoreductase-like protein	0.0004	0.5	0.5
Echinococcus multilocularis	epidermal retinal dehydrogenase 2	0.0004	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus multilocularis	Dehydrogenase:reductase SDR family	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0004	0.5	0.5
Echinococcus granulosus	WW domain containing oxidoreductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.5	0.5
Trypanosoma cruzi	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Echinococcus granulosus	Dehydrogenase:reductase SDR family	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Plasmodium falciparum	steroid dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 1 homolog	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Echinococcus granulosus	hypothetical protein	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Echinococcus multilocularis	conserved hypothetical protein	0.0004	0.5	0.5
Giardia lamblia	Oxidoreductase, short chain dehydrogenase/reductase family	0.0004	0.5	0.5
Trypanosoma cruzi	beta-ketoacyl-ACP reductase 2, putative	0.0004	0.5	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase	0.0004	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Onchocerca volvulus	Sepiapterin reductase homolog	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Entamoeba histolytica	estradiol 17-beta-dehydrogenase, putative	0.0004	0.5	0.5
Brugia malayi	hypothetical protein	0.0004	0.5	0.5
Brugia malayi	Dehydrogenases, short chain protein 2	0.0004	0.5	0.5
Trypanosoma brucei	3-ketoacyl-CoA reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0004	0.5	0.5
Toxoplasma gondii	carbonyl reductase 1, putative	0.0004	0.5	0.5
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.5	0.5
Loa Loa (eye worm)	dehydrogenase	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Onchocerca volvulus	Dehydrogenase\/reductase SDR family member 13 homolog	0.0004	0.5	0.5
Echinococcus multilocularis	oxidoreductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0004	0.5	0.5
Plasmodium falciparum	oxidoreductase, short-chain dehydrogenase family, putative	0.0004	0.5	0.5
Trypanosoma cruzi	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Schistosoma mansoni	carbonyl reductase	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Echinococcus granulosus	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Trichomonas vaginalis	hydroxyacyl dehydrogenase, putative	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Giardia lamblia	Hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Brugia malayi	Hypothetical oxidoreductase F56D1.5	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Trypanosoma cruzi	quinonoid dihydropteridine reductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Leishmania major	pteridine reductase 1	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Giardia lamblia	Short-chain dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus granulosus	epidermal retinal dehydrogenase 2	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0004	0.5	0.5
Trypanosoma brucei	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Entamoeba histolytica	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0004	0.5	0.5
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0004	0.5	0.5
Leishmania major	3-keto-dihydrosphingosine reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Echinococcus granulosus	steroid dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus granulosus	retinol dehydrogenase 11	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trichomonas vaginalis	steroid dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	short-chain dehydrogenases/reductase, putative	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 13	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase-like protein	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Echinococcus multilocularis	retinol dehydrogenase 11	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 3, putative	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0004	0.5	0.5
Loa Loa (eye worm)	short chain dehydrogenase/reductase family oxidoreductase	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible oxidoreductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0004	0.5	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0004	0.5	0.5
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Giardia lamblia	Reductase, putative	0.0004	0.5	0.5
Trypanosoma cruzi	short chain dehydrogenase/reductase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0004	0.5	0.5
Trichomonas vaginalis	estradiol 17 beta-dehydrogenase, putative	0.0004	0.5	0.5
Brugia malayi	dehydrogenases, short chain protein 9	0.0004	0.5	0.5
Loa Loa (eye worm)	oxidoreductase	0.0004	0.5	0.5
Toxoplasma gondii	oxidoreductase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0004	0.5	0.5
Leishmania major	hypothetical protein, conserved	0.0004	0.5	0.5
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0004	0.5	0.5
Entamoeba histolytica	short chain dehydrogenase family protein	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Brugia malayi	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Brugia malayi	hypothetical protein	0.0004	0.5	0.5
Mycobacterium ulcerans	short-chain dehydrogenase	0.0004	0.5	0.5
Schistosoma mansoni	short chain dehydrogenase	0.0004	0.5	0.5
Trypanosoma cruzi	NAD(P)-dependent oxidoreductase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0004	0.5	0.5
Plasmodium vivax	steroid dehydrogenase, putative	0.0004	0.5	0.5
Echinococcus multilocularis	steroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0004	0.5	0.5
Mycobacterium ulcerans	oxidoreductase	0.0004	0.5	0.5
Onchocerca volvulus		0.0004	0.5	0.5
Leishmania major	short chain dehydrogenase, putative	0.0004	0.5	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0004	0.5	0.5
Loa Loa (eye worm)	hypothetical protein	0.0004	0.5	0.5
Leishmania major	quinonoid dihydropteridine reductase	0.0004	0.5	0.5
Echinococcus granulosus	oxidoreductase	0.0004	0.5	0.5
Schistosoma mansoni	steroid dehydrogenase	0.0004	0.5	0.5
Trypanosoma brucei	beta-D-hydroxybutyrate dehydrogenase	0.0004	0.5	0.5
Echinococcus multilocularis	carbonyl reductase 1	0.0004	0.5	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0004	0.5	0.5
Trypanosoma brucei	beta-ketoacyl-ACP reductase 2	0.0004	0.5	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 773964